LOCUS       NM_001271898            3721 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus acyl-Coenzyme A oxidase 1, palmitoyl (Acox1),
            transcript variant 2, mRNA.
ACCESSION   NM_001271898
VERSION     NM_001271898.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3721)
  AUTHORS   Lu,D., He,A., Tan,M., Mrad,M., El Daibani,A., Hu,D., Liu,X.,
            Kleiboeker,B., Che,T., Hsu,F.F., Bambouskova,M., Semenkovich,C.F.
            and Lodhi,I.J.
  TITLE     Liver ACOX1 regulates levels of circulating lipids that promote
            metabolic health through adipose remodeling
  JOURNAL   Nat Commun 15 (1), 4214 (2024)
   PUBMED   38760332
  REMARK    GeneRIF: Liver ACOX1 regulates levels of circulating lipids that
            promote metabolic health through adipose remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3721)
  AUTHORS   Chen,X., Denning,K.L., Mazur,A., Lawrence,L.M., Wang,X. and Lu,Y.
  TITLE     Under peroxisome proliferation acyl-CoA oxidase coordinates with
            catalase to enhance ethanol metabolism
  JOURNAL   Free Radic Biol Med 208, 221-228 (2023)
   PUBMED   37567517
  REMARK    GeneRIF: Under peroxisome proliferation acyl-CoA oxidase
            coordinates with catalase to enhance ethanol metabolism.
REFERENCE   3  (bases 1 to 3721)
  AUTHORS   Jacobs,H.T., Szibor,M., Rathkolb,B., da Silva-Buttkus,P.,
            Aguilar-Pimentel,J.A., Amarie,O.V., Becker,L., Calzada-Wack,J.,
            Dragano,N., Garrett,L., Gerlini,R., Holter,S.M., Klein-Rodewald,T.,
            Kraiger,M., Leuchtenberger,S., Marschall,S., Ostereicher,M.A.,
            Pfannes,K., Sanz-Moreno,A., Seisenberger,C., Spielmann,N.,
            Stoeger,C., Wurst,W., Fuchs,H., Hrabe de Angelis,M. and
            Gailus-Durner,V.
  TITLE     AOX delays the onset of the lethal phenotype in a mouse model of
            Uqcrh (complex III) disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (7), 166760 (2023)
   PUBMED   37230398
  REMARK    GeneRIF: AOX delays the onset of the lethal phenotype in a mouse
            model of Uqcrh (complex III) disease.
REFERENCE   4  (bases 1 to 3721)
  AUTHORS   Wu,C.C., Chen,W.C., Hsiao,W.P., Huang,K.F., Liao,Y.S., Lin,H.B.,
            Wu,Y.J., Kao,C.H. and Chen,S.L.
  TITLE     Reciprocal Regulation of Peroxisome Biogenesis and Myogenic Factors
            Is Critical for Myogenesis
  JOURNAL   Int J Mol Sci 24 (15), 12262 (2023)
   PUBMED   37569637
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3721)
  AUTHORS   Wang,S., Zeng,Y., He,X., Liu,F., Pei,P. and Zhang,T.
  TITLE     Folate-deficiency induced acyl-CoA synthetase short-chain family
            member 2 increases lysine crotonylome involved in neural tube
            defects
  JOURNAL   Front Mol Neurosci 15, 1064509 (2023)
   PUBMED   36743291
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3721)
  AUTHORS   Berger,J., Albet,S., Bentejac,M., Netik,A., Holzinger,A.,
            Roscher,A.A., Bugaut,M. and Forss-Petter,S.
  TITLE     The four murine peroxisomal ABC-transporter genes differ in
            constitutive, inducible and developmental expression
  JOURNAL   Eur J Biochem 265 (2), 719-727 (1999)
   PUBMED   10504404
REFERENCE   7  (bases 1 to 3721)
  AUTHORS   Hashimoto,T., Fujita,T., Usuda,N., Cook,W., Qi,C., Peters,J.M.,
            Gonzalez,F.J., Yeldandi,A.V., Rao,M.S. and Reddy,J.K.
  TITLE     Peroxisomal and mitochondrial fatty acid beta-oxidation in mice
            nullizygous for both peroxisome proliferator-activated receptor
            alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation
            with fatty liver phenotype
  JOURNAL   J Biol Chem 274 (27), 19228-19236 (1999)
   PUBMED   10383430
REFERENCE   8  (bases 1 to 3721)
  AUTHORS   Bass,N.M.
  TITLE     Three for the price of one knockout--a mouse model of a congenital
            peroxisomal disorder, steatohepatitis, and hepatocarcinogenesis
  JOURNAL   Hepatology 29 (2), 606-608 (1999)
   PUBMED   9918944
REFERENCE   9  (bases 1 to 3721)
  AUTHORS   Fan,C.Y., Pan,J., Usuda,N., Yeldandi,A.V., Rao,M.S. and Reddy,J.K.
  TITLE     Steatohepatitis, spontaneous peroxisome proliferation and liver
            tumors in mice lacking peroxisomal fatty acyl-CoA oxidase.
            Implications for peroxisome proliferator-activated receptor alpha
            natural ligand metabolism
  JOURNAL   J Biol Chem 273 (25), 15639-15645 (1998)
   PUBMED   9624157
REFERENCE   10 (bases 1 to 3721)
  AUTHORS   Fan,C.Y., Pan,J., Chu,R., Lee,D., Kluckman,K.D., Usuda,N.,
            Singh,I., Yeldandi,A.V., Rao,M.S., Maeda,N. and Reddy,J.K.
  TITLE     Hepatocellular and hepatic peroxisomal alterations in mice with a
            disrupted peroxisomal fatty acyl-coenzyme A oxidase gene
  JOURNAL   J Biol Chem 271 (40), 24698-24710 (1996)
   PUBMED   8798738
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL669925.8 and AL607108.17.
            
            On Nov 14, 2022 this sequence version replaced NM_001271898.1.
            
            Summary: This gene encodes a member of the acyl-coenzyme A oxidase
            family. The encoded protein is localized to peroxisomes and is the
            first enzyme of the fatty acid beta-oxidation pathway, which
            catalyzes the desaturation of acyl-coenzyme A to
            2-trans-enoyl-coenzyme A. Disruption of this gene results in
            microvesicular steatohepatitis, spontaneous peroxisome
            proliferation, and the eventual development of hepatocellular
            carcinomas. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Dec 2012].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128941.1, AF006688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AL669925.8         14111-14294         c
            185-344             AL669925.8         13737-13896         c
            345-505             AL669925.8         4930-5090           c
            506-613             AL607108.17        198270-198377       c
            614-733             AL607108.17        197300-197419       c
            734-849             AL607108.17        196648-196763       c
            850-1019            AL607108.17        195965-196134       c
            1020-1182           AL607108.17        195039-195201       c
            1183-1373           AL607108.17        194477-194667       c
            1374-1553           AL607108.17        191562-191741       c
            1554-1659           AL607108.17        191345-191450       c
            1660-1803           AL607108.17        190988-191131       c
            1804-2010           AL607108.17        190650-190856       c
            2011-3721           AL607108.17        188245-189955       c
FEATURES             Location/Qualifiers
     source          1..3721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.96 cM"
     gene            1..3721
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /note="acyl-Coenzyme A oxidase 1, palmitoyl"
                     /db_xref="GeneID:11430"
                     /db_xref="MGI:MGI:1330812"
     exon            1..184
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2061
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /EC_number="1.3.3.6"
                     /note="isoform 2 is encoded by transcript variant 2;
                     peroxisomal acyl-coenzyme A oxidase 1; palmitoyl-CoA
                     oxidase; peroxisomal straight-chain Acyl-CoA oxidase;
                     peroxisomal fatty acyl-coenzyme A oxidase; straight-chain
                     acyl-CoA oxidase; peroxisomal fatty acyl-CoA oxidase"
                     /codon_start=1
                     /product="peroxisomal acyl-coenzyme A oxidase 1 isoform 2"
                     /protein_id="NP_001258827.1"
                     /db_xref="CCDS:CCDS70354.1"
                     /db_xref="GeneID:11430"
                     /db_xref="MGI:MGI:1330812"
                     /translation="MNPDLRKERAAATFNPELITHILDGSPENTRRRREIENLILNDP
                     DFQHEDYNFLTRSQRYEVAVKKSATMVKKMREFGIADPEEIMWFKKLHMVNFVEPVGL
                     NYSMFIPTLLNQGTTAQQEKWMHPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKT
                     QEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITRGECYGLHAFVVPIREIGTHKPL
                     PGITVGDIGPKFGYEEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYG
                     TMVFVRSFLVGSAAQSLSKACTIAIRYSAVRRQSEIKRSEPEPQILDFQTQQYKLFPL
                     LATAYAFHFLGRYIKETYMRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEEC
                     RMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTARFLMKIYDQVQSGKLVGG
                     MVSYLNDLPSQRIQPQQVAVWPTLVDINSLDSLTEAYKLRAARLVEIAAKNLQAQVSH
                     RKSKEVAWNLTSVDLVRASEAHCHYVTVKVFADKLPKIQDRAVQAVLRNLCLLYSLYG
                     ISQKGGDFLEGNIITGAQMSQVNSRILELLTVTRPNAVALVDAFDFKDVTLGSVLGRY
                     DGNVYENLFEWAKKSPLNKTEVHESYYKHLKPLQSKL"
     exon            185..344
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            345..505
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            506..613
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            614..733
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            734..849
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1019
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1182
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1373
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1553
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1659
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1803
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2010
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..3721
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3702..3707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /note="hexamer: AATAAA"
     polyA_site      3721
                     /gene="Acox1"
                     /gene_synonym="Acox; AOX; D130055E20Rik; Paox"
                     /note="major polyA site"
ORIGIN      
        1 ggagacaggt tgtcatcgct ttggtgcctg tcacttctgt cgccacctcc tctgccccca
       61 gcactggtct ccgtcatgaa tcccgatctg cgcaaggagc gggccgccgc caccttcaat
      121 ccagagttaa tcacgcacat cttggatggt agtccggaga acacccggcg ccgtcgagaa
      181 atcgagaact tgattctgaa cgatccagac ttccaacatg aggactataa cttcctcact
      241 cgaagccagc gttacgaggt ggctgttaag aagagtgcca ccatggtgaa gaagatgagg
      301 gaatttggca tcgcagaccc tgaagaaatc atgtggttta aaaaactaca tatggtcaat
      361 tttgtggaac ctgttggcct caattactcc atgtttatcc ctaccttgct gaatcagggc
      421 accactgctc agcaggagaa atggatgcac ccgtcccaag aactccagat aattggcacc
      481 tacgcccaga cggagatggg ccacggaact catcttcgag gcttggaaac cactgccaca
      541 tatgacccca agacccaaga gttcattctc aacagcccaa ctgtgacttc catcaagtgg
      601 tggcctgggg ggcttgggaa gacttccaat catgcgatag tcctggctca gctcatcact
      661 cgaggggagt gctacgggtt acatgccttt gttgtcccta tccgtgagat tgggacccac
      721 aagcctctgc caggcatcac tgttggggat atcggcccca agtttggtta tgaagagatg
      781 gataatggct acctgaagat ggacaattac cgtattccta gagagaacat gttgatgaaa
      841 tatgcccagg tgaagcctga cggcacgtat gtaaaacctc tgagtaacaa gctgacatat
      901 gggaccatgg ttttcgtaag gtccttcctc gtgggaagtg cagctcagag tctgtccaag
      961 gcatgcacca ttgccattcg atacagtgct gtgaggcgcc agtctgaaat caagagaagc
     1021 gagccagagc cccagatttt ggattttcag acgcagcagt ataaactctt cccgctcctg
     1081 gccaccgcct atgccttcca ctttctcgga agatacataa aggagaccta catgcggatt
     1141 aatgagagca ttggccaagg cgacctgagt gagctgcctg agcttcatgc cctcacagct
     1201 gggctgaagg cttttactac ctggacagcc aatgctggta tcgaagaatg tcggatggct
     1261 tgcggtgggc acggctattc tcacagcagt gggattccaa atatttacgt cacgtttacc
     1321 ccggcctgca ccttcgaggg ggagaacact gttatgatgc tgcagacggc caggttcttg
     1381 atgaaaatct atgaccaggt tcagtcgggg aagctggtgg gtggtatggt gtcgtacttg
     1441 aatgacctgc cgagccagcg tatccagccg cagcaggtgg cagtctggcc aactctggtg
     1501 gacattaaca gcctggacag cctgacagaa gcctacaagc tacgtgcagc cagattggta
     1561 gaaattgctg caaaaaacct tcaggcccaa gtgagtcaca ggaagagcaa ggaagtggcg
     1621 tggaacttga cttctgtcga ccttgttcgc gcaagtgagg cgcactgcca ctacgtgacc
     1681 gttaaggtct ttgcagataa actccccaag attcaagaca gagccgtgca agccgtgctg
     1741 aggaacctgt gtctcttata ttctctctat gggatcagcc agaaaggagg ggattttctt
     1801 gaggggaaca tcatcacagg ggctcagatg tcacaggtaa acagtcggat cctggagctg
     1861 ctcacagtga ctcgccccaa cgctgtggct ttggtggatg cctttgactt taaggatgtg
     1921 acccttggct ctgttctcgg ccgctatgat ggcaatgtgt atgaaaactt gtttgagtgg
     1981 gccaagaagt ccccactgaa caagacagag gtccacgaat cttactacaa gcacttgaag
     2041 cccctgcagt cgaagctttg aagtttcccc agggacaagt ctgagctcca cagagaggcc
     2101 gaatctctcc ttgattcact aatccttgtg aaatcgtctt cagacttgtg tagctataga
     2161 gcaaatgatg ggctggcctt tccctctcta taagtaaaga gaaatgagca gacttagaga
     2221 tgaaatgaga atccagtgtt gtaggtgcag tagtagccca ggccgacgta ggacctcggg
     2281 aagccactgc cgcgctgtgg cctggctgac gttatttgtt ctgctgctaa tctctgtagg
     2341 ccttgactct gggggaatta acagagttta actactaaat acttagtaat tttcacattt
     2401 tcactgctaa tcactggata tatgtttttt aaacaaaggt gttctataga gctggacttt
     2461 ccaggctttc ttgcctagca ctttctgatc taccactaag agcaggagtt tgggggccag
     2521 aaactaatag aaacccagat gtgagtgtgt ggcccttaca tatgcccctg ctgcctgctg
     2581 tgtgggtatg tcattcctac caactgtcac actaacatat caacaagagg agtccttaaa
     2641 cacccaccca ccaagaaagc agcgctccgg gactaagctc ccactctggt cttcctggca
     2701 atggcatgca cccgcccatg accccacttc ctgacacagc taagttgctt gtctttacct
     2761 ccaggctttc ggccgttgcc tggacttcaa tcatggtggc tgaccttccc tttcttgctt
     2821 tgcttctcct caaagagata atagagacaa tgaccagtct ttcctcatag atcaagtatg
     2881 gggagagccc tcagctatgg tattcctgta ttttggtgac ttatttaagt aaatttcctg
     2941 ggacaatcca gatttgaaag attctgtctt cttgttgtca taaactatta aaatgcttgg
     3001 tggtcaccaa agtatttgac ataaaaataa ataaataaat cattcaggcc accttttaca
     3061 ccagaaatca caggaaagcc ctgggcccca gccatctgct gagtgttagt tgagaagatg
     3121 gatcctaagc cagctgaaga atgagtgcag gctgtgggga ggttcttgct gagtagctgg
     3181 ctttgtggta agctgctagc agccttacag ggtggcgaag cagcccccct ttggatgcag
     3241 agcagcctct acaatcattc tgaccttaaa ggtagagtat ggaccttttg tggtatgtgt
     3301 gtgtatgctt ttttttatgt agtgattttt tttttcttga gacagggccc agagtggcct
     3361 tgacctctga tcctcagcct cccagatgct ggggttacag gtttgcgctg acatgcctgg
     3421 ctagttggaa ctctttgttc ttaaaagcac agtagagaga tcattgtgac ctattaagtc
     3481 tgtgtctgtg gcattggcat cgtgagaaca gttctttcag agcagttctg agaacacagt
     3541 attaatggag tggaaatgac atcaagtcaa agccatcaga tttgctgaca cagtcttaac
     3601 ctttctcctg gaatgactga taatccctga agattgacag taagcagcat gtcacctgtg
     3661 gggtttctat ttgacagtaa ttcatattct ggaaaatagc caataaattt aaatgactgg
     3721 a
//
