LOCUS       NM_019736               1768 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus acyl-CoA thioesterase 9 (Acot9), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_019736
VERSION     NM_019736.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1768)
  AUTHORS   Dearden,L., Furigo,I.C., Pantaleao,L.C., Wong,L.W.P.,
            Fernandez-Twinn,D.S., de Almeida-Faria,J., Kentistou,K.A.,
            Carreira,M.V., Bidault,G., Vidal-Puig,A., Ong,K.K., Perry,J.R.B.,
            Donato,J. Jr. and Ozanne,S.E.
  TITLE     Maternal obesity increases hypothalamic miR-505-5p expression in
            mouse offspring leading to altered fatty acid sensing and increased
            intake of high-fat food
  JOURNAL   PLoS Biol 22 (6), e3002641 (2024)
   PUBMED   38833481
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1768)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1768)
  AUTHORS   Bekeova,C., Anderson-Pullinger,L., Boye,K., Boos,F.,
            Sharpadskaya,Y., Herrmann,J.M. and Seifert,E.L.
  TITLE     Multiple mitochondrial thioesterases have distinct tissue and
            substrate specificity and CoA regulation, suggesting unique
            functional roles
  JOURNAL   J Biol Chem 294 (50), 19034-19047 (2019)
   PUBMED   31676684
REFERENCE   4  (bases 1 to 1768)
  AUTHORS   Tillander,V., Arvidsson Nordstrom,E., Reilly,J., Strozyk,M., Van
            Veldhoven,P.P., Hunt,M.C. and Alexson,S.E.
  TITLE     Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link
            between fatty acid and amino acid metabolism in mitochondria
  JOURNAL   Cell Mol Life Sci 71 (5), 933-948 (2014)
   PUBMED   23864032
  REMARK    GeneRIF: Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a
            novel link between fatty acid and amino acid metabolism in
            mitochondria.
REFERENCE   5  (bases 1 to 1768)
  AUTHORS   Yokoyama,K., Tezuka,T., Kotani,M., Nakazawa,T., Hoshina,N.,
            Shimoda,Y., Kakuta,S., Sudo,K., Watanabe,K., Iwakura,Y. and
            Yamamoto,T.
  TITLE     NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling
            in neurons
  JOURNAL   EMBO J 30 (23), 4739-4754 (2011)
   PUBMED   21946561
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1768)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   7  (bases 1 to 1768)
  AUTHORS   Poupon,V., Begue,B., Gagnon,J., Dautry-Varsat,A., Cerf-Bensussan,N.
            and Benmerah,A.
  TITLE     Molecular cloning and characterization of MT-ACT48, a novel
            mitochondrial acyl-CoA thioesterase
  JOURNAL   J Biol Chem 274 (27), 19188-19194 (1999)
   PUBMED   10383425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY288219.1, AK168713.1 and AI854821.1.
            
            On Aug 27, 2015 this sequence version replaced NM_019736.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021763.1, AK002892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BY288219.1         1-57
            58-1605             AK168713.1         3-1550
            1606-1768           AI854821.1         1-163               c
FEATURES             Location/Qualifiers
     source          1..1768
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.38 cM"
     gene            1..1768
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /note="acyl-CoA thioesterase 9"
                     /db_xref="GeneID:56360"
                     /db_xref="MGI:MGI:1928939"
     exon            1..232
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1532
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acyl-Coenzyme A thioesterase 2, mitochondrial;
                     mitochondrial acyl-CoA thioesterase; acyl-coenzyme A
                     thioesterase 9, mitochondrial; acyl coenzyme A thioester
                     hydrolase 2; mitochondrial 48 kDa acyl-CoA thioester
                     hydrolase 1; protein U8; acyl-CoA thioester hydrolase 9"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 9, mitochondrial
                     isoform 1"
                     /protein_id="NP_062710.2"
                     /db_xref="CCDS:CCDS41187.1"
                     /db_xref="GeneID:56360"
                     /db_xref="MGI:MGI:1928939"
                     /translation="MKRAAIRLWTLNKGLLTHGRGLSQGSQYKISEPLHIHQVRDKLR
                     EIVGVSTVWRDHVKAMEERKLLHSFLPKSQKVLPPRKMRDSYIEVLLPLGTDPELRDK
                     YVTVQNTVRFGRILEDLDSLGVLVCYMHNHNHSTKMSPLSIVTVLVDKIDMCKHSLSP
                     EQDIKFTGHVSWVGNTSMEVKMKMFQLHNDEKYWPVLDATFVMVARDSENKGPAFVNP
                     LIPENKEEEELFKQGELNKSRRIAFSTSSLLKVAPSSEERNIIHELFLTTLDPKTISF
                     QSRILPPKAVWMEDTKLKSLDICHPQERNVFNRIFGGFLMRKAYELAWATACSFGGSR
                     PYVVTVDDIMFQKPVEVGSLLFLSSQVCFTQDNYIQVRVHSEVSSLDSREHMTTNVFH
                     FTFMSEKEVPLIFPKTYGESMLYLDGQRHFKSMSTPVTLKKDYPVEP"
     exon            233..327
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            328..373
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            374..544
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            545..582
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            583..666
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            667..770
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            771..847
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            848..915
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1027
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1118
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1204
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1292
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1443
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1752
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /note="hexamer: AATAAA"
     polyA_site      1606
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /note="major polyA site"
     regulatory      1728..1733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /note="hexamer: AATAAA"
     polyA_site      1746
                     /gene="Acot9"
                     /gene_synonym="0610041P13Rik; Acate2; MT-ACT48; MTE-2;
                     p48; U8"
                     /note="major polyA site"
ORIGIN      
        1 taccccgggc agcgcagccc cgcccttcct gcagtgaggc cctccctatc ccgggccctc
       61 ttgtggcgtc acctagaagg tgggaaccaa gattcagtcc ggcgcggttg ccggtgtttg
      121 gaggtgtcct cacgctcacg ctcttctgct accggtttgt ctctacccgg gaggaccttg
      181 gttgtccacc cgtgggtagg cagtggagtg ccatgaagcg ggcagcgata cggctttgga
      241 ccttgaacaa ggggcttctt actcatggca gaggactgtc tcaaggatcc caatacaaaa
      301 taagtgaacc cttacacatc catcaagttc gagacaagct gcgggagata gtaggcgtat
      361 ccacagtctg gagagaccat gtaaaagcaa tggaggaaag gaagttactt catagttttt
      421 tgcctaaatc acagaaagtc ctaccaccga ggaaaatgag ggatagttac atcgaagttc
      481 tcctaccttt gggtactgac cctgaactac gagacaaata tgtgactgtt caaaatacag
      541 taagatttgg caggattctt gaggaccttg acagcctagg agttcttgtt tgctacatgc
      601 acaaccacaa tcattctacc aagatgtctc ctttatcaat agttacagtc ctggtggaca
      661 agattgatat gtgtaaacac agcttaagcc ctgaacagga cattaagttc actggccatg
      721 ttagctgggt tggaaataca tccatggaag tgaagatgaa aatgttccag ctgcacaatg
      781 atgagaaata ttggcctgtt ttggatgcaa cctttgtaat ggtggctcga gattctgaaa
      841 ataaggggcc ggcatttgta aatccactca ttccggaaaa taaagaggaa gaagagctct
      901 ttaaacaagg agaattgaac aagagccgaa ggattgcctt tagcaccagt tcattactga
      961 aagtggctcc cagttctgag gagaggaata tcatacatga actgttcctt accacactgg
     1021 atccaaagac tataagtttt cagagtcgaa ttttgcctcc taaagcagtg tggatggagg
     1081 atacaaaact caagagcttg gatatttgtc accctcagga acgaaacgta ttcaatcgga
     1141 tctttggtgg ttttcttatg agaaaagcat atgaacttgc atgggctact gcttgtagct
     1201 ttggcggttc ccggccatat gtggtaacag tggatgatat catgtttcag aagcctgttg
     1261 aagttggttc attgctcttt ctttcttcac aggtatgctt cacccaggac aattacatcc
     1321 aagtcagagt ccatagtgaa gtgtcttctc ttgacagtcg tgagcatatg accaccaatg
     1381 tctttcattt tacattcatg tcggaaaaag aagtaccctt gattttccct aaaacatatg
     1441 gagagtccat gttgtattta gatggacagc gacatttcaa gtctatgagt accccagtga
     1501 ccttgaaaaa ggactaccct gtggagccct aggaaaatct cacttgttgc aaactagcac
     1561 tcccggcact gtgacatagt gcctaataaa ggtgtgctga gaagtactga tgttcacttt
     1621 gctttgttta tcctccatag agggggctat atttcaagtt tttagaatga tcggaagagc
     1681 agaatgagtg actggatgga gccgaggggg tgaaagaatg attaaacaat aaaacctttt
     1741 acagtactac gaaaaaaaaa aaaaaaaa
//
