LOCUS       NM_133348               1494 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus acyl-CoA thioesterase 7 (Acot7), transcript variant 2,
            mRNA.
ACCESSION   NM_133348
VERSION     NM_133348.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1494)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1494)
  AUTHORS   Bekeova,C., Anderson-Pullinger,L., Boye,K., Boos,F.,
            Sharpadskaya,Y., Herrmann,J.M. and Seifert,E.L.
  TITLE     Multiple mitochondrial thioesterases have distinct tissue and
            substrate specificity and CoA regulation, suggesting unique
            functional roles
  JOURNAL   J Biol Chem 294 (50), 19034-19047 (2019)
   PUBMED   31676684
REFERENCE   3  (bases 1 to 1494)
  AUTHORS   Bowman,C.E., Selen Alpergin,E.S., Ellis,J.M. and Wolfgang,M.J.
  TITLE     Loss of ACOT7 potentiates seizures and metabolic dysfunction
  JOURNAL   Am J Physiol Endocrinol Metab 317 (5), E941-E951 (2019)
   PUBMED   31039008
  REMARK    GeneRIF: Acot7, a fatty acid metabolic enzyme highly enriched in
            neurons, regulates both brain-specific metabolic processes related
            to seizure susceptibility and the whole body response to dietary
            lipid
REFERENCE   4  (bases 1 to 1494)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   5  (bases 1 to 1494)
  AUTHORS   Wall,V.Z., Barnhart,S., Kramer,F., Kanter,J.E.,
            Vivekanandan-Giri,A., Pennathur,S., Bolego,C., Ellis,J.M.,
            Gijon,M.A., Wolfgang,M.J. and Bornfeldt,K.E.
  TITLE     Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling
            of phospholipids containing unsaturated long (>/=C20)-acyl chains
            in macrophages
  JOURNAL   J Lipid Res 58 (6), 1174-1185 (2017)
   PUBMED   28416579
  REMARK    GeneRIF: downstream effects of LPS-induced induction of ACOT7 and
            its role in inflammatory settings in myeloid cells
REFERENCE   6  (bases 1 to 1494)
  AUTHORS   Takagi,M., Ohtomo,T., Hiratsuka,K., Kuramochi,Y., Suga,T. and
            Yamada,J.
  TITLE     Localization of a long-chain acyl-CoA hydrolase in spermatogenic
            cells in mice
  JOURNAL   Arch Biochem Biophys 446 (2), 161-166 (2006)
   PUBMED   16455042
REFERENCE   7  (bases 1 to 1494)
  AUTHORS   Takagi,M., Kawabe,K., Suga,T. and Yamada,J.
  TITLE     A 50-kDa isoform of mouse brain acyl-CoA hydrolase: expression and
            molecular properties
  JOURNAL   Arch Biochem Biophys 429 (1), 100-105 (2004)
   PUBMED   15288813
REFERENCE   8  (bases 1 to 1494)
  AUTHORS   Yamada,J., Kuramochi,Y., Takagi,M. and Suga,T.
  TITLE     Expression of acyl-CoA hydrolase in the developing mouse brain
  JOURNAL   Neurosci Lett 355 (1-2), 89-92 (2004)
   PUBMED   14729242
REFERENCE   9  (bases 1 to 1494)
  AUTHORS   Yamada,J., Kuramochi,Y., Takagi,M., Watanabe,T. and Suga,T.
  TITLE     Human brain acyl-CoA hydrolase isoforms encoded by a single gene
  JOURNAL   Biochem Biophys Res Commun 299 (1), 49-56 (2002)
   PUBMED   12435388
REFERENCE   10 (bases 1 to 1494)
  AUTHORS   Kuramochi,Y., Takagi-Sakuma,M., Kitahara,M., Emori,R., Asaba,Y.,
            Sakaguchi,R., Watanabe,T., Kuroda,J., Hiratsuka,K., Nagae,Y.,
            Suga,T. and Yamada,J.
  TITLE     Characterization of mouse homolog of brain acyl-CoA hydrolase:
            molecular cloning and neuronal localization
  JOURNAL   Brain Res Mol Brain Res 98 (1-2), 81-92 (2002)
   PUBMED   11834298
  REMARK    GeneRIF: mBACH cDNA encoded a 338-AA pp >95% identical to human and
            rat homologs. mBACH was distributed throughboth central and
            peripheral cell body and neurites. Another 50-kDa pp made from
            mBACH mRNA used different in-frame ATGs as initiation codon.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA463703.1, AK152277.1, CX235974.1 and BQ748599.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_133348.3.
            
            On Mar 26, 2009 this sequence version replaced NM_133348.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            coding region, compared to variant 1, resulting in an isoform (2)
            with a distinct and shorter N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049821.1, AB207243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               CA463703.1         4-123
            121-622             AK152277.1         2-503
            623-768             CX235974.1         515-660
            769-1486            AK152277.1         650-1367
            1487-1494           BQ748599.1         458-465
FEATURES             Location/Qualifiers
     source          1..1494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 82.93 cM"
     gene            1..1494
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /note="acyl-CoA thioesterase 7"
                     /db_xref="GeneID:70025"
                     /db_xref="MGI:MGI:1917275"
     exon            1..241
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1211
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /EC_number="3.1.2.2"
                     /note="isoform 2 is encoded by transcript variant 2; brain
                     acyl-CoA hydrolase; cytosolic acyl coenzyme A thioester
                     hydrolase; 50-kDa brain acyl-CoA hydrolase; long chain
                     acyl-CoA thioester hydrolase"
                     /codon_start=1
                     /product="cytosolic acyl coenzyme A thioester hydrolase
                     isoform 2"
                     /protein_id="NP_579926.2"
                     /db_xref="CCDS:CCDS51390.1"
                     /db_xref="GeneID:70025"
                     /db_xref="MGI:MGI:1917275"
                     /translation="MAPPLPSSSMAPPRLIHSGTGLLDTCSQIPPPPPSSAVAAKMSG
                     PTTDTPAAIQICRIMRPDDANVAGNVHGGTILKMIEEAGAIISTRHCNSQNGERCVAA
                     LARVERTDFLSPMCIGEVAHVSAEITYTSKHSVEVQVHVMSENILTGTKKLTNKATLW
                     YVPLSLKNVDKVLEVPPIVYLRQEQEEEGRKRYEAQKLERMETKWRNGDIVQPVLNPE
                     PNTVSYSQSSLIHLVGPSDCTLHGFVHGGVTMKLMDEVAGIVAARHCKTNIVTASVDA
                     INFHDKIRKGCVITISGRMTFTSNKSMEIEVLVDADPVVDNSQKRYRAASAFFTYVSL
                     NQEGKPMPVPQLVPETEDEKKRFEEGKGRYLQMKAKRQGHTEPQP"
     exon            242..359
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..516
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..608
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..723
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..810
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
     exon            811..927
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1112
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1494
                     /gene="Acot7"
                     /gene_synonym="2410041A17Rik; Ach1; Act; Bach; Cte-II;
                     CTE-IIa; Lach1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagggcggag accccgaggg gcggccgcct ctgattcgcc gcctccgcgc aggccccgcc
       61 tgtctggcgc catggccccg cctcttccct cctcctctat ggcgcctccc aggctcattc
      121 attcggggac gggcctgctg gacacctgtt ctcagattcc gccgccgccg ccgtcgtccg
      181 ccgtcgcagc caagatgtcc ggccccacca cagacacgcc ggccgccatc cagatctgcc
      241 ggatcatgcg tccagatgat gccaatgtgg ctggcaatgt tcatggaggg accattctga
      301 agatgattga ggaggccggg gccatcatca gcacgcggca ctgtaacagc cagaatgggg
      361 agcgctgtgt ggctgccctg gcacgggtgg agcgcactga cttcctgtca cccatgtgca
      421 tcggcgaggt ggctcatgtc agtgcagaga tcacctacac ttccaagcac tctgtggagg
      481 tccaggtcca cgtgatgtcg gagaacatcc tcacaggtac caaaaagctg accaataaag
      541 ccaccttgtg gtatgtgccc ctgtcattga agaatgtgga caaggtcctt gaggtgcctc
      601 ccattgtgta tttacggcag gagcaggagg aggagggtcg gaaacgctat gaagcccaga
      661 agctggaacg catggagacc aagtggagga acggagacat tgtccagcct gtcctgaacc
      721 cagagccgaa cacggtgagc tacagccagt ccagcctgat ccacctggtg gggccctcgg
      781 actgcaccct tcatggcttc gtgcacggag gtgtcaccat gaagctcatg gatgaggtgg
      841 ctgggattgt ggctgcacgc cactgcaaga ccaacatagt aactgcctct gtggatgcca
      901 tcaatttcca cgacaagatc cggaaaggct gtgtcatcac catctccgga cgcatgacct
      961 tcacaagcaa taagtccatg gagattgagg tcctggtgga cgctgaccct gtggtggaca
     1021 actcacaaaa gcgctaccgg gccgccagtg ccttcttcac ctacgtgtcc ctgaaccagg
     1081 agggcaagcc aatgcctgtg cctcagcttg tgccagagac ggaggatgag aagaagcgct
     1141 tcgaagaagg caaaggccgt tatctgcaga tgaaggcgaa gcgacagggc cacacagagc
     1201 ctcagcccta ggtgtcttcc tcctgtcccg ggtcagcaca gttgtggcaa tagcccagta
     1261 tgcagtcact tagaaattgc ccccttggcc aaacccccga tttccactga gagctggtgt
     1321 tgtgtgaagt gttgagtggc agtgttccct atggcccatc cccaaaacct gtgcaccaaa
     1381 gctttattta tgtccccagt gttgtcccaa aggccaccat ggacaccaga gcacaccgac
     1441 tggcctgaag aagccagcat cactaataaa gctgctgtct ggctggaccc atga
//
