LOCUS       NM_172580               3283 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus acyl-CoA thioesterase 6 (Acot6), transcript variant 1,
            mRNA.
ACCESSION   NM_172580 XM_126946 XM_900185 XM_907178 XM_920238 XM_992647
            XM_992672 XM_992697
VERSION     NM_172580.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3283)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3283)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3283)
  AUTHORS   Adissu,H.A., Estabel,J., Sunter,D., Tuck,E., Hooks,Y.,
            Carragher,D.M., Clarke,K., Karp,N.A., Newbigging,S., Jones,N.,
            Morikawa,L., White,J.K. and McKerlie,C.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Histopathology reveals correlative and unique phenotypes in a
            high-throughput mouse phenotyping screen
  JOURNAL   Dis Model Mech 7 (5), 515-524 (2014)
   PUBMED   24652767
REFERENCE   4  (bases 1 to 3283)
  AUTHORS   Westin,M.A.K., Hunt,M.C. and Alexson,S.E.H.
  TITLE     Peroxisomes contain a specific phytanoyl-CoA/pristanoyl-CoA
            thioesterase acting as a novel auxiliary enzyme in alpha- and
            beta-oxidation of methyl-branched fatty acids in mouse
  JOURNAL   J Biol Chem 282 (37), 26707-26716 (2007)
   PUBMED   17613526
  REMARK    GeneRIF: Acot6 was identified as a target gene of the peroxisome
            proliferator-activated receptor alpha (PPARalpha) and is
            up-regulated in mouse liver in a PPARalpha-dependent manner.
REFERENCE   5  (bases 1 to 3283)
  AUTHORS   Hunt,M.C., Rautanen,A., Westin,M.A., Svensson,L.T. and Alexson,S.E.
  TITLE     Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene
            clusters shows that convergent, functional evolution results in a
            reduced number of human peroxisomal ACOTs
  JOURNAL   FASEB J 20 (11), 1855-1864 (2006)
   PUBMED   16940157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125071.3.
            
            On Mar 18, 2023 this sequence version replaced NM_172580.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014558.1, SRR7345562.1039748.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-665               AC125071.3         93222-93886         c
            666-868             AC125071.3         88005-88207         c
            869-3283            AC125071.3         83296-85710         c
FEATURES             Location/Qualifiers
     source          1..3283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.04 cM"
     gene            1..3283
                     /gene="Acot6"
                     /gene_synonym="4632408A20Rik; A330054B07"
                     /note="acyl-CoA thioesterase 6"
                     /db_xref="GeneID:217700"
                     /db_xref="MGI:MGI:1921287"
     exon            1..665
                     /gene="Acot6"
                     /gene_synonym="4632408A20Rik; A330054B07"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1468
                     /gene="Acot6"
                     /gene_synonym="4632408A20Rik; A330054B07"
                     /EC_number="3.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acyl-coenzyme A thioesterase 6"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 6 isoform 1"
                     /protein_id="NP_766168.1"
                     /db_xref="CCDS:CCDS26038.1"
                     /db_xref="GeneID:217700"
                     /db_xref="MGI:MGI:1921287"
                     /translation="MAATLSVEPAGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGM
                     LFRAHARYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQIPF
                     VVELEVLDGHEPDGGQRLARAVHERHFMAPGVRRVPVREGRVRATLFLPPGKGQFPGI
                     IDLYGSIGGLCEHRASLLAGHGFAVLALAYFQFEDLPENLSDVRLEYFEEALALMLRH
                     PQVKGPNIGLIGVSKGADLCLSMAAFLKDNITATVLINACVANTLVPLYYKDLFVPEL
                     GCDQTKNKSGLMDLRDMWNNPLEEPNHQSLIPLEKAQGPFLFLVGMDDHNWKSDVYAR
                     IACERLQAHGKDRPQIIYYPETGHCIEPPYFPPPIATVHFVLGEAVFNGGKPRAQSRA
                     QLDAWQRIQTFFQKYLNGEKPARHSKL"
     exon            666..868
                     /gene="Acot6"
                     /gene_synonym="4632408A20Rik; A330054B07"
                     /inference="alignment:Splign:2.1.0"
     exon            869..3283
                     /gene="Acot6"
                     /gene_synonym="4632408A20Rik; A330054B07"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3257..3262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acot6"
                     /gene_synonym="4632408A20Rik; A330054B07"
                     /note="hexamer: AATAAA"
     polyA_site      3283
                     /gene="Acot6"
                     /gene_synonym="4632408A20Rik; A330054B07"
                     /note="major polyA site"
ORIGIN      
        1 agcagaatcc tctgtcctgg cagagctccg ctgctacttt gacttcacac atctttcctg
       61 tatagagtca gccggttttc tgttcctgtc ttgtctgagg cacgggagcc aggggtcggg
      121 aactcccaga gacgcaccag gtcggctcca cagcaggcca ggctccgctc cggactcgcg
      181 tggcgctccc cgaggcctcc agctcctaat ggcggcgaca ctgagcgtgg agcccgcggg
      241 ccgcagctgc tgggacgaac cgctgagcat cgccgtgcgc ggcctggccc ccgagcagcc
      301 cgtcacgctg cgctctgtcc tgcgcgacga gaagggcatg ctcttccgag cccacgcgcg
      361 ctaccgcgcg gactcccacg gcgagctgga cctggcgcgc acgcccgcgc tgggcggcag
      421 cttctcgggg ctcgagccca tggggctgct ctgggccatg gagcccgatc ggcctttctg
      481 gcgcctgatc aagcgcgatg tgcagatacc cttcgtggtg gagctggagg tgctggacgg
      541 acacgagccg gatggcgggc agcggctggc gcgggcggtg cacgagcgtc acttcatggc
      601 tcccggggtg cggcgcgtgc ccgtgcgcga gggccgggtg cgcgccacgc tcttcctgcc
      661 cccaggcaag ggccagttcc ctgggatcat cgatttgtat ggaagtatcg gtggcttatg
      721 tgaacataga gccagccttc tggctgggca tggttttgcc gtgcttgccc tggcttattt
      781 ccagtttgaa gacctccctg aaaatctgag tgacgttcgc ctggagtact ttgaagaagc
      841 cttagctttg atgctacgcc atcctcaggt gaaaggccca aatattggac ttattggtgt
      901 ctccaaaggt gctgatctgt gcctctcgat ggctgctttc ctgaaggaca acatcacagc
      961 cactgtcctt ataaatgcct gtgtggccaa cacattagta cctctgtatt acaaggatct
     1021 gtttgttcct gagcttgggt gtgatcaaac aaaaaataag tcaggcctta tggatttgag
     1081 ggatatgtgg aacaatccac tggaggaacc caaccaccag agtcttatcc cattggaaaa
     1141 ggcccaggga cccttcctgt ttcttgtggg catggatgat cacaactgga agagtgacgt
     1201 ctatgctcgt atagcctgtg aacgcctgca agcccatgga aaagacagac cccagataat
     1261 ctactatcca gaaactggtc actgtattga gccaccttat tttcctcctc ccatagccac
     1321 tgtacacttc gtgttgggtg aagcagtctt caatggaggt aagccacgtg ctcaatcaag
     1381 ggcacagctg gatgcctggc aacgcattca aactttcttc caaaaatatc tcaatggtga
     1441 aaagcctgcc aggcacagca aactgtaaca ttgtaattat atcgaaagtt ctaatcatgc
     1501 cacacagatt cttctgggtt ttcggaatac taaggaagtt tgggtttttt gggggggagg
     1561 gcaggggtgg tggggaccca gattaggtct cacattcaca atgtagacaa ggaagaactt
     1621 ctaatcctcc agcttccacc atgcgtgtgc tgatattgta gttctacacg gtcatgccta
     1681 gtgctatgcc ttgccaagga caaaacccag agttttcata ggatgaacat caagggacta
     1741 agggttaatc tatgacaggc tacaaactgg caatttggga gactaggcct aagtttctgt
     1801 ttctcagaaa tgagaaccca gaacctgtgg tcatccaacc acggcgtcag gcattctatc
     1861 caagaacacc ttgtcatctg gcctgaagtt aaaatagata gctaagataa atgaacaacc
     1921 cttcagtgag gtctccagag cctaaccaat tataaaatta gttagacccc tattgataga
     1981 actaaccaat caagataaag ggcacatccc cctccttcaa attccccaga caataaaagc
     2041 tgggccttta agcccactag aggtctccac tcccaaatgg ggagacagct ccatattatt
     2101 attattattc agctaaataa atgctctttg ctttgacata ctatttaaat ctgagatatc
     2161 attctctggt gagtcttata ccctaacagg catgcatcca gccagcaaag ctgcatcccc
     2221 agctccctac gaagctcata ggaagctcag cctccttgta aggctcccac tggactctgg
     2281 gcctttgcaa tgactctcct ctcagtgctg gggtttctct ctcctctgaa gttcagctaa
     2341 tggatctgtt taactctgta agaccaactt taaccttaag taaaagaata taagaagtat
     2401 ttatgcaact cccagttact ggactgtctt ttattctgct tgtgagggaa cccacctgcc
     2461 gaagacatac aacaaataga ttctctctcg gttttttgtt ttgttttgtt ttttgggttt
     2521 ttttttgttt gtttttgttt ttagcagttt ttaacatgcc tgaaatttgc tcaagacttc
     2581 accctgaccc ccaagatact tatcaatata gttaccgtct tgtctgaatt accgatcact
     2641 gtgtgatatt ttcctgtctg ggaaaaaggt tttgatgtca agatgactat gactatgaaa
     2701 tgtgagccag agcctatggc tttgggcaca gttctaccca cggagtcact ttctcctatc
     2761 cctgtctgct cttattacaa ccgagaagac tagttgcttc ccctagttgt agtgaagcgt
     2821 tatctagtcc tgagattcca gagtagagga tcatccctga gcacaagaaa gtcttccaag
     2881 acttcaggtc aaaccccatg gtttcctggc tgtacacaga acctttcgcc aagccagtag
     2941 ctttcacttc tcttttctct gagcggtagg ctaagaactc ttgcatcttg catgctgtcc
     3001 cactgttaaa cataaacatg accatccaag ccttgttgtt gcttatatag ccagacaaac
     3061 ttgtaacctc atgatctgag ctttcatgat aaagccttga acccaactac agtcaaattc
     3121 tctgagctct ggtcttctag ccattcctca aacatgggct gagtgaataa atctgtgcgt
     3181 tataatttgg gttcattgtg gctgctgttt tcactgttgg tttgtttctc cttaaacaag
     3241 gcctatttgt tttgaaaata aaatgtgttt tggacaaact tga
//
