LOCUS       NM_145444               1518 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus acyl-CoA thioesterase 5 (Acot5), transcript variant 1,
            mRNA.
ACCESSION   NM_145444
VERSION     NM_145444.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1518)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1518)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1518)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   4  (bases 1 to 1518)
  AUTHORS   Hunt,M.C., Rautanen,A., Westin,M.A., Svensson,L.T. and Alexson,S.E.
  TITLE     Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene
            clusters shows that convergent, functional evolution results in a
            reduced number of human peroxisomal ACOTs
  JOURNAL   FASEB J 20 (11), 1855-1864 (2006)
   PUBMED   16940157
REFERENCE   5  (bases 1 to 1518)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   6  (bases 1 to 1518)
  AUTHORS   Westin,M.A., Alexson,S.E. and Hunt,M.C.
  TITLE     Molecular cloning and characterization of two mouse peroxisome
            proliferator-activated receptor alpha (PPARalpha)-regulated
            peroxisomal acyl-CoA thioesterases
  JOURNAL   J Biol Chem 279 (21), 21841-21848 (2004)
   PUBMED   15007068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125071.3.
            
            On May 28, 2009 this sequence version replaced NM_145444.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY563099.1, ERR3363660.656969.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-599               AC125071.3         124727-125325       c
            600-802             AC125071.3         121118-121320       c
            803-1518            AC125071.3         118631-119346       c
FEATURES             Location/Qualifiers
     source          1..1518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.03 cM"
     gene            1..1518
                     /gene="Acot5"
                     /gene_synonym="PTE-Ic"
                     /note="acyl-CoA thioesterase 5"
                     /db_xref="GeneID:217698"
                     /db_xref="MGI:MGI:2384969"
     exon            1..599
                     /gene="Acot5"
                     /gene_synonym="PTE-Ic"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1408
                     /gene="Acot5"
                     /gene_synonym="PTE-Ic"
                     /EC_number="3.1.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acyl-coenzyme A thioesterase 5; peroxisomal acyl-CoA
                     thioesterase Ic; peroxisomal acyl-coenzyme A thioester
                     hydrolase Ic"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 5 isoform 1"
                     /protein_id="NP_663419.3"
                     /db_xref="CCDS:CCDS26037.1"
                     /db_xref="GeneID:217698"
                     /db_xref="MGI:MGI:2384969"
                     /translation="MVPTVSLEPTGHSCWDEPLSIAVRGLAPEQPVTLRTALRDEKGA
                     LFRAHARYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLIKRDVQTPF
                     VVELEVLDGHEPDGGRLLARAVHERHFMAPGVRRVPVREGRVRATLFLPPGTGPFPGI
                     IDLFGVGGGLLEYRASLLAGKGFAVMALAYYKYDDLPKVIDILHLEYFEEAVTYLLSH
                     PQVKGPGVGLLGISKGAELSLSMASFLKGITAAVVINGATVNVISTLYYKEESLPGLG
                     MHLERIKVTKDGFKDIIDILNVPLEAPDQKSLIPLERSDTAFLFLVGQDDHNWKSEFY
                     AREASKRLQAHGKEKPQIVCYPKTGHHIEPPYIPWSIAAPHSYFDKPILLGGEPRAHA
                     MAQVDAWQRLQTFFHKHLSGDKRPSPAKL"
     exon            600..802
                     /gene="Acot5"
                     /gene_synonym="PTE-Ic"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1518
                     /gene="Acot5"
                     /gene_synonym="PTE-Ic"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcactgcat cccttaaatt ttggagagtt tcgcacctcg attgccaacg cagacaagta
       61 ggataagggt tcatggtcac agcctccaga agtcgagaga cactattcac ccgacagtat
      121 cctgattttt cactttgtca ggatggtgcc aacagtaagc ctggagccca cgggccacag
      181 ctgctgggac gaaccgctga gcatcgctgt gcgcggcttg gccccggagc agcccgtcac
      241 actgcgcact gccctgcgcg acgagaaggg cgcgctcttc cgagcccacg cgcgctaccg
      301 cgcggactcc cacggcgagc tggacctggc gcgcacgccc gcgctgggcg gcagcttctc
      361 ggggctcgag cccatggggc tgctctgggc catggagccc gatcggcctt tctggcgcct
      421 gatcaagcgc gacgtgcaga cgcccttcgt ggtggagctg gaggtgctgg acggacacga
      481 gcccgacggc gggcggctgc tggcgcgggc ggtgcacgag cgtcacttca tggctcccgg
      541 ggtgcggcgc gtgcccgtgc gcgagggccg ggtgcgcgcc acgctctttc tgcccccagg
      601 aactggaccc tttcctggga tcatagacct ttttggagtt ggaggtggcc ttctggagta
      661 tcgggcgagc ctgctggctg ggaagggctt tgccgtcatg gctctggctt attataaata
      721 tgatgacctc cctaaggtta tagacatcct tcatctggag tactttgagg aagctgtgac
      781 ctacctgctc agtcaccctc aggtcaaggg tccaggagtt ggcctgctag ggatttccaa
      841 aggggctgaa ctctccctct ccatggcttc tttcctgaaa ggcatcacgg ccgctgtcgt
      901 aatcaatggc gccacggtca acgttatttc aacattatac tacaaggaag agagtctgcc
      961 tggtttgggc atgcacctag aaaggatcaa ggtgaccaaa gatgggttta aagatattat
     1021 agatatcctg aatgtccctc tagaagctcc agaccagaag agcctcatcc ccttggaaag
     1081 gtctgacacg gccttcctgt tcctcgtagg tcaggacgac cacaactgga agagcgagtt
     1141 ctatgccaga gaggcctcca aacgcctgca ggcgcacggg aaggagaagc cccagattgt
     1201 ctgctacccc aaaacaggac accacattga acccccttac atcccttggt ccatagctgc
     1261 cccccacagc tattttgata agcctatcct ccttggaggg gagcctaggg ctcatgccat
     1321 ggcccaggtg gacgcctggc agcggctcca gacttttttc cataaacatt tgagtgggga
     1381 caagaggcca agcccagcaa aactatgatt ttctttgagt agtgacattg ctggtgacat
     1441 tgctggtgct gttcccctga gaattaggat atatatgcat tgttttcttc ttttaataaa
     1501 atcttgaagt tttcctcc
//
