LOCUS       NP_663419                421 aa            linear   ROD 27-APR-2025
DEFINITION  acyl-coenzyme A thioesterase 5 isoform 1 [Mus musculus].
ACCESSION   NP_663419
VERSION     NP_663419.3
DBSOURCE    REFSEQ: accession NM_145444.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 421)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 421)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 421)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   4  (residues 1 to 421)
  AUTHORS   Hunt,M.C., Rautanen,A., Westin,M.A., Svensson,L.T. and Alexson,S.E.
  TITLE     Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene
            clusters shows that convergent, functional evolution results in a
            reduced number of human peroxisomal ACOTs
  JOURNAL   FASEB J 20 (11), 1855-1864 (2006)
   PUBMED   16940157
REFERENCE   5  (residues 1 to 421)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   6  (residues 1 to 421)
  AUTHORS   Westin,M.A., Alexson,S.E. and Hunt,M.C.
  TITLE     Molecular cloning and characterization of two mouse peroxisome
            proliferator-activated receptor alpha (PPARalpha)-regulated
            peroxisomal acyl-CoA thioesterases
  JOURNAL   J Biol Chem 279 (21), 21841-21848 (2004)
   PUBMED   15007068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125071.3.
            
            On May 28, 2009 this sequence version replaced NP_663419.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY563099.1, ERR3363660.656969.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..421
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.03 cM"
     Protein         1..421
                     /product="acyl-coenzyme A thioesterase 5 isoform 1"
                     /EC_number="3.1.2.2"
                     /note="acyl-coenzyme A thioesterase 5; peroxisomal
                     acyl-CoA thioesterase Ic; peroxisomal acyl-coenzyme A
                     thioester hydrolase Ic"
                     /calculated_mol_wt=46442
     Region          16..141
                     /region_name="Bile_Hydr_Trans"
                     /note="Acyl-CoA thioester hydrolase/BAAT N-terminal
                     region; pfam04775"
                     /db_xref="CDD:461422"
     Region          145..>259
                     /region_name="alpha/beta hydrolases"
                     /note="A functionally diverse superfamily containing
                     proteases, lipases, peroxidases, esterases, epoxide
                     hydrolases and dehalogenases. The catalytic apparatus
                     typically involves three residues (catalytic triad): a
                     serine, a glutamate or aspartate and a...; cl21494"
                     /db_xref="CDD:473884"
     Region          203..412
                     /region_name="BAAT_C"
                     /note="BAAT / Acyl-CoA thioester hydrolase C terminal;
                     pfam08840"
                     /db_xref="CDD:430252"
     Region          419..421
                     /region_name="Microbody targeting signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6Q2Z6.2)"
     CDS             1..421
                     /gene="Acot5"
                     /gene_synonym="PTE-Ic"
                     /coded_by="NM_145444.3:143..1408"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS26037.1"
                     /db_xref="GeneID:217698"
                     /db_xref="MGI:MGI:2384969"
ORIGIN      
        1 mvptvslept ghscwdepls iavrglapeq pvtlrtalrd ekgalfraha ryradshgel
       61 dlartpalgg sfsglepmgl lwamepdrpf wrlikrdvqt pfvvelevld ghepdggrll
      121 aravherhfm apgvrrvpvr egrvratlfl ppgtgpfpgi idlfgvgggl leyrasllag
      181 kgfavmalay ykyddlpkvi dilhleyfee avtyllshpq vkgpgvgllg iskgaelsls
      241 masflkgita avvingatvn vistlyykee slpglgmhle rikvtkdgfk diidilnvpl
      301 eapdqkslip lersdtaflf lvgqddhnwk sefyareask rlqahgkekp qivcypktgh
      361 hieppyipws iaaphsyfdk pillggepra hamaqvdawq rlqtffhkhl sgdkrpspak
      421 l
//
