LOCUS       NM_134188               2215 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus acyl-CoA thioesterase 2 (Acot2), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_134188
VERSION     NM_134188.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Bekeova,C., Anderson-Pullinger,L., Boye,K., Boos,F.,
            Sharpadskaya,Y., Herrmann,J.M. and Seifert,E.L.
  TITLE     Multiple mitochondrial thioesterases have distinct tissue and
            substrate specificity and CoA regulation, suggesting unique
            functional roles
  JOURNAL   J Biol Chem 294 (50), 19034-19047 (2019)
   PUBMED   31676684
  REMARK    GeneRIF: The CoA-insensitive Acot2 could provide a constitutive
            siphon for long-chain fatty acyl-CoAs.
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Murata,Y., Yamashiro,T., Kessoku,T., Jahan,I., Usuda,H., Tanaka,T.,
            Okamoto,T., Nakajima,A. and Wada,K.
  TITLE     Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via
            Induction of Acyl-CoA Thioesterase 2 Expression
  JOURNAL   Biomed Res Int 2019, 2916243 (2019)
   PUBMED   31930115
  REMARK    GeneRIF: MiR-27b-3p induces acyl-CoA thioesterase 2 (ACOT2)
            expression in 3T3-L1 cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Zurkirchen,L., Varum,S., Giger,S., Klug,A., Hausel,J., Bossart,R.,
            Zemke,M., Cantu,C., Atak,Z.K., Zamboni,N., Basler,K. and Sommer,L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2215)
  AUTHORS   Lu,J., Xu,Q., Ji,M., Guo,X., Xu,X., Fargo,D.C. and Li,X.
  TITLE     The phosphorylation status of T522 modulates tissue-specific
            functions of SIRT1 in energy metabolism in mice
  JOURNAL   EMBO Rep 18 (5), 841-857 (2017)
   PUBMED   28364022
REFERENCE   6  (bases 1 to 2215)
  AUTHORS   Hunt,M.C., Rautanen,A., Westin,M.A., Svensson,L.T. and Alexson,S.E.
  TITLE     Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene
            clusters shows that convergent, functional evolution results in a
            reduced number of human peroxisomal ACOTs
  JOURNAL   FASEB J 20 (11), 1855-1864 (2006)
   PUBMED   16940157
REFERENCE   7  (bases 1 to 2215)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   8  (bases 1 to 2215)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 2215)
  AUTHORS   Hunt,M.C., Lindquist,P.J., Nousiainen,S., Huttunen,M., Orii,K.,
            Svensson,T.L., Aoyama,T., Hashimoto,T., Diczfalusy,U. and
            Alexson,S.E.
  TITLE     Acyl-CoA thioesterases belong to a novel gene family of peroxisome
            proliferator-regulated enzymes involved in lipid metabolism
  JOURNAL   Cell Biochem Biophys 32 Spring, 317-324 (2000)
   PUBMED   11330065
REFERENCE   10 (bases 1 to 2215)
  AUTHORS   Hunt,M.C., Nousiainen,S.E., Huttunen,M.K., Orii,K.E., Svensson,L.T.
            and Alexson,S.E.
  TITLE     Peroxisome proliferator-induced long chain acyl-CoA thioesterases
            comprise a highly conserved novel multi-gene family involved in
            lipid metabolism
  JOURNAL   J Biol Chem 274 (48), 34317-34326 (1999)
   PUBMED   10567408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133183.3, AK141651.1 and BC064469.1.
            
            On May 29, 2009 this sequence version replaced NM_134188.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064469.1, AK172617.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC133183.3         76985-76995         c
            12-1578             AK141651.1         2-1568
            1579-1581           AC133183.3         71598-71600         c
            1582-2092           AK141651.1         1569-2079
            2093-2103           AC133183.3         71076-71086         c
            2104-2215           BC064469.1         2096-2207
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.99 cM"
     gene            1..2215
                     /gene="Acot2"
                     /gene_synonym="MTE-I; Mte1"
                     /note="acyl-CoA thioesterase 2"
                     /db_xref="GeneID:171210"
                     /db_xref="MGI:MGI:2159605"
     exon            1..621
                     /gene="Acot2"
                     /gene_synonym="MTE-I; Mte1"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1403
                     /gene="Acot2"
                     /gene_synonym="MTE-I; Mte1"
                     /EC_number="3.1.2.2"
                     /note="mitochondrial acyl-CoA thioesterase 1;
                     acyl-coenzyme A thioesterase 2, mitochondrial; acyl
                     coenzyme A thioester hydrolase; very-long-chain acyl-CoA
                     thioesterase"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 2, mitochondrial
                     precursor"
                     /protein_id="NP_598949.3"
                     /db_xref="CCDS:CCDS26034.1"
                     /db_xref="GeneID:171210"
                     /db_xref="MGI:MGI:2159605"
                     /translation="MVASSFAVLRASRLCQQDWKSWARLFVPPPLSTGGRTTWARTNA
                     TLSVEPEGRSCWDEPLSIAVRGLAPEQPVTLRSALRDEKGALFRAHARYRADAGGELN
                     LARAPALGGSFSGLEPMGLLWAMEPERPLWRLIKRDVQTPFLVELEVLDGHEPDGGQR
                     LAQAVHERHFLAPGVRRVPVREGRVRATLFLPPEPGPFPGIIDLFGVGGGLLEYRASL
                     LAGKGFAVMALAYYNYDDLPKSIETMHMEYFEEAVNYLRSHPEVKGPGIGLLGISKGG
                     ELGLAMASFLKGITAAVVINGSVAAVGNTISYKDETIPPVSLLRNQVKMTKDGLLDVV
                     EALQSPLVDKKSFIPVERSDTTFLFLVGQDDHNWKSEFYADEISKRLQAHGKEKPQII
                     CYPAAGHYIEPPYFPLCSAGMHLLVGANITFGGEPRAHAVAQVDAWQQLQTFFHKQLG
                     SKS"
     exon            622..824
                     /gene="Acot2"
                     /gene_synonym="MTE-I; Mte1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..2200
                     /gene="Acot2"
                     /gene_synonym="MTE-I; Mte1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2173..2178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acot2"
                     /gene_synonym="MTE-I; Mte1"
                     /note="hexamer: AATAAA"
     polyA_site      2200
                     /gene="Acot2"
                     /gene_synonym="MTE-I; Mte1"
                     /note="major polyA site"
ORIGIN      
        1 actttctctg cggaaccgag ggctgaagtc aacgacgcaa aatggtggcc tcgtctttcg
       61 ctgtcctgag agcaagcagg ttgtgccaac aggattggaa gagctgggcg cggctgtttg
      121 tacctccgcc gctcagcact ggtggccgga ccacttgggc gcggacaaat gcgacgctga
      181 gcgtagagcc cgagggccgc agctgctggg acgagccgct gagcatcgcc gtgcgcggcc
      241 tggcccccga gcagcccgtc acgctgcgct ctgccttgcg cgacgagaag ggcgcgctct
      301 tccgagccca cgcgcgctac cgcgccgacg ctggcggcga gctgaacctg gcgcgcgcgc
      361 ccgcgctggg cggcagcttc tcggggctcg agcccatggg gctgctctgg gccatggagc
      421 ccgaacggcc tctctggcgc ctgatcaagc gcgacgtgca gacgcccttc ttggtggagc
      481 tggaggtgct ggacggacac gagcccgatg gcgggcagcg gctggcgcag gcggtgcacg
      541 agcgtcactt cttggctccc ggggtgcggc gcgtgcccgt acgagagggc cgggtgcgcg
      601 ccacgctctt cctgccccca gaacctggac cctttcctgg gatcatagac ctttttggag
      661 ttggaggtgg ccttctggag tatcgggcga gcctgctggc tgggaagggc tttgccgtga
      721 tggctctggc ttattacaac tacgacgacc tccccaagag catagaaacc atgcacatgg
      781 agtactttga agaagccgtg aactacctgc gcagccaccc cgaggtaaaa ggacctggaa
      841 ttgggctgct tgggatttcc aaagggggtg aacttggcct tgctatggcc tccttcctga
      901 agggcatcac agctgctgtg gtcatcaatg gctccgtggc tgctgttggg aacaccatct
      961 cctacaagga tgagactata ccccctgtgt cccttctgag aaaccaagtc aaaatgacca
     1021 aagatggtct cttggatgtc gtggaagctc tgcaaagccc tctggtagac aagaagagct
     1081 tcattcccgt ggaaaggtct gacacgacct tcctgttcct cgtaggtcag gacgaccaca
     1141 actggaagag cgagttctat gctgatgaga tctccaaacg cctgcaggcg cacgggaagg
     1201 agaagcccca gatcatctgc tacccagcag cagggcatta catcgagccc ccttacttcc
     1261 cgctgtgcag cgctggcatg cacctcctgg tgggtgccaa catcaccttt ggaggggagc
     1321 ccagggctca tgccgtggcc caggtggacg catggcagca gctccagact ttcttccaca
     1381 aacagttggg tagcaagagt tagggactgt cctctaaaat ataacctatt agttgatggt
     1441 ttgggggaaa cctcatatat attatcacaa tgtcagttca ggttagttca tttgaacata
     1501 ttctaatttt ttaaagtttc tttctttttt cttttttctt tttctttttt tcttttcttt
     1561 tttttttttt tttttttttt tgagacaggg tttctctgtg tacccttggc cgagaccagg
     1621 ctgggcctga attcagagat cggcctgcct ctgcctccca agtgctggga gtaaagccac
     1681 gcccagctta tgttttttct caatataata agtgcctatg aaggactgag gatatataga
     1741 gcttggtggt aatgcattcg tctttcttcc atagtgccca gaattcattc cccagtgccg
     1801 taagacgaca aagaaattaa aactttctta taaaaatgtg cctgtggacc tggtgagatg
     1861 gctccgtggt aaaggtgctt tctgccaagc ctgacaactt aagatttttt tcccccaggg
     1921 tctacatggt agaaggagag aacaaactct gacaagttgt cctctgacac acacaagtgc
     1981 ttgtgcgcgt gtgcgtacgc gcgcacgcac acacacacac acacacacac acacacacac
     2041 acacacacgc gcacacacac accacatgtg taattttaaa atgtgcctat ccaaaaaaaa
     2101 aaaaaaaaaa aaaacagaat tcttttatgt catgaattaa gggggaacct taagtgtaaa
     2161 tattcttatt aaaataaaaa ctagctcatt atagacaaaa aaaaaaaaaa aaaaa
//
