LOCUS       NM_025790                686 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus acyl-CoA thioesterase 13 (Acot13), mRNA.
ACCESSION   NM_025790
VERSION     NM_025790.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 686)
  AUTHORS   Imai,N., Nicholls,H.T., Alves-Bezerra,M., Li,Y., Ivanova,A.A.,
            Ortlund,E.A. and Cohen,D.E.
  TITLE     Up-regulation of thioesterase superfamily member 2 in skeletal
            muscle promotes hepatic steatosis and insulin resistance in mice
  JOURNAL   Hepatology 75 (1), 154-169 (2022)
   PUBMED   34433228
  REMARK    GeneRIF: Up-regulation of thioesterase superfamily member 2 in
            skeletal muscle promotes hepatic steatosis and insulin resistance
            in mice.
REFERENCE   2  (bases 1 to 686)
  AUTHORS   Bekeova,C., Anderson-Pullinger,L., Boye,K., Boos,F.,
            Sharpadskaya,Y., Herrmann,J.M. and Seifert,E.L.
  TITLE     Multiple mitochondrial thioesterases have distinct tissue and
            substrate specificity and CoA regulation, suggesting unique
            functional roles
  JOURNAL   J Biol Chem 294 (50), 19034-19047 (2019)
   PUBMED   31676684
REFERENCE   3  (bases 1 to 686)
  AUTHORS   Alves-Bezerra,M., Li,Y., Acuna,M., Ivanova,A.A., Corey,K.E.,
            Ortlund,E.A. and Cohen,D.E.
  TITLE     Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion
            by Channeling Fatty Acids Into Triglyceride Biosynthesis
  JOURNAL   Hepatology 70 (2), 496-510 (2019)
   PUBMED   30516845
REFERENCE   4  (bases 1 to 686)
  AUTHORS   Tillander,V., Miniami,A., Alves-Bezerra,M., Coleman,R.A. and
            Cohen,D.E.
  TITLE     Thioesterase superfamily member 2 promotes hepatic insulin
            resistance in the setting of glycerol-3-phosphate acyltransferase
            1-induced steatosis
  JOURNAL   J Biol Chem 294 (6), 2009-2020 (2019)
   PUBMED   30523156
  REMARK    GeneRIF: t a pathogenic role of Them2 in the biosynthesis of
            glycerolipid metabolites that promote hepatic insulin resistance
REFERENCE   5  (bases 1 to 686)
  AUTHORS   Li,J., Deng,S.P., Wei,G. and Yu,P.
  TITLE     CITGeneDB: a comprehensive database of human and mouse genes
            enhancing or suppressing cold-induced thermogenesis validated by
            perturbation experiments in mice
  JOURNAL   Database (Oxford) 2018 (2018)
   PUBMED   29688375
REFERENCE   6  (bases 1 to 686)
  AUTHORS   Ersoy,B.A., Tarun,A., D'Aquino,K., Hancer,N.J., Ukomadu,C.,
            White,M.F., Michel,T., Manning,B.D. and Cohen,D.E.
  TITLE     Phosphatidylcholine transfer protein interacts with thioesterase
            superfamily member 2 to attenuate insulin signaling
  JOURNAL   Sci Signal 6 (286), ra64 (2013)
   PUBMED   23901139
  REMARK    GeneRIF: PC-TP-THEM2 complex reduces phosphorylation and stability
            of IRS2 and increases stability of the TSC1-TSC2 complex
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 686)
  AUTHORS   Kang,H.W., Niepel,M.W., Han,S., Kawano,Y. and Cohen,D.E.
  TITLE     Thioesterase superfamily member 2/acyl-CoA thioesterase 13
            (Them2/Acot13) regulates hepatic lipid and glucose metabolism
  JOURNAL   FASEB J 26 (5), 2209-2221 (2012)
   PUBMED   22345407
REFERENCE   8  (bases 1 to 686)
  AUTHORS   Wei,J., Kang,H.W. and Cohen,D.E.
  TITLE     Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13
            (Acot13): a homotetrameric hotdog fold thioesterase with
            selectivity for long-chain fatty acyl-CoAs
  JOURNAL   Biochem J 421 (2), 311-322 (2009)
   PUBMED   19405909
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 686)
  AUTHORS   Kanno,K., Wu,M.K., Agate,D.S., Fanelli,B.J., Wagle,N., Scapa,E.F.,
            Ukomadu,C. and Cohen,D.E.
  TITLE     Interacting proteins dictate function of the minimal START domain
            phosphatidylcholine transfer protein/StarD2
  JOURNAL   J Biol Chem 282 (42), 30728-30736 (2007)
   PUBMED   17704541
  REMARK    GeneRIF: Yeast two-hybrid screening using libraries prepared from
            mouse liver and embryo identified Them2 (thioesterase superfamily
            member 2) and the homeodomain transcription factor Pax3 (paired box
            gene 3), respectively, as PC-TP-interacting proteins.
REFERENCE   10 (bases 1 to 686)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK002261.1.
            
            On Apr 5, 2007 this sequence version replaced NM_025790.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002261.1, AK144523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-686               AK002261.1         3-688
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.69 cM"
     gene            1..686
                     /gene="Acot13"
                     /gene_synonym="0610006O17Rik; Them2"
                     /note="acyl-CoA thioesterase 13"
                     /db_xref="GeneID:66834"
                     /db_xref="MGI:MGI:1914084"
     exon            1..264
                     /gene="Acot13"
                     /gene_synonym="0610006O17Rik; Them2"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..606
                     /gene="Acot13"
                     /gene_synonym="0610006O17Rik; Them2"
                     /EC_number="3.1.2.2"
                     /note="thioesterase superfamily member 2; palmitoyl-CoA
                     hydrolase; hotdog-fold thioesterase superfamily member 2"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 13"
                     /protein_id="NP_080066.1"
                     /db_xref="CCDS:CCDS26380.1"
                     /db_xref="GeneID:66834"
                     /db_xref="MGI:MGI:1914084"
                     /translation="MSSMTQNLREVMKVMFKVPGFDRVLEKVTLVSAAPEKLICEMKV
                     EEQHTNKLGTLHGGLTATLVDSISTMALMCTERGAPGVSVDMNITYMSPAKIGEEIVI
                     TAHILKQGKTLAFASVDLTNKTTGKLIAQGRHTKHLGN"
     exon            265..449
                     /gene="Acot13"
                     /gene_synonym="0610006O17Rik; Them2"
                     /inference="alignment:Splign:2.1.0"
     exon            450..686
                     /gene="Acot13"
                     /gene_synonym="0610006O17Rik; Them2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      686
                     /gene="Acot13"
                     /gene_synonym="0610006O17Rik; Them2"
                     /note="putative"
ORIGIN      
        1 aaagagtgaa ggtaacccgt gatcatctag gaccagggcg accggggcgc gcgatccttt
       61 ctcccgagca cgacgcgaca gcggccgggc ttgcagactt gaccttccac acccttgtcc
      121 tctcacaaac gtctcttcca gagttcattc tcgcagagcc cagactcttg ctttgcgtcc
      181 acgatgagca gcatgaccca gaacctacga gaagtaatga aggttatgtt caaagttccc
      241 ggttttgata gagttttgga aaaggtgacg cttgtctcgg ctgctcctga gaaactaatc
      301 tgtgagatga aggtggaaga gcagcatact aataaactgg gcacgctcca tggaggcttg
      361 acagcaacct tagtggacag catctcgacc atggctctaa tgtgcacaga aagaggagca
      421 cccggagtca gtgtggacat gaacataacg tacatgtcac ctgctaagat aggagaagaa
      481 atagtgatca cagcacacat tctgaagcaa ggaaagacac ttgcatttgc ctcagtggat
      541 ctgaccaaca agaccacagg aaaattaata gcacaaggca gacacacaaa acacctgggg
      601 aactgagaac agcgggaaga cccgaagaag cccaacaatg ccaagtatgg tttgtgaaca
      661 actttctgaa ataaattatc aaaacc
//
