LOCUS       NM_025590               5668 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus acyl-CoA thioesterase 11 (Acot11), transcript variant
            2, mRNA.
ACCESSION   NM_025590
VERSION     NM_025590.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5668)
  AUTHORS   Li,Y., Imai,N., Nicholls,H.T., Roberts,B.R., Goyal,S., Krisko,T.I.,
            Ang,L.H., Tillman,M.C., Roberts,A.M., Baqai,M., Ortlund,E.A.,
            Cohen,D.E. and Hagen,S.J.
  TITLE     Thioesterase superfamily member 1 undergoes stimulus-coupled
            conformational reorganization to regulate metabolism in mice
  JOURNAL   Nat Commun 12 (1), 3493 (2021)
   PUBMED   34108467
  REMARK    GeneRIF: Thioesterase superfamily member 1 undergoes
            stimulus-coupled conformational reorganization to regulate
            metabolism in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5668)
  AUTHORS   Desai,A., Alves-Bezerra,M., Li,Y., Ozdemir,C., Bare,C.J., Li,Y.,
            Hagen,S.J. and Cohen,D.E.
  TITLE     Regulation of fatty acid trafficking in liver by thioesterase
            superfamily member 1
  JOURNAL   J Lipid Res 59 (2), 368-379 (2018)
   PUBMED   29208699
  REMARK    GeneRIF: The liver-specific Them1 expression did not influence
            glucose tolerance or insulin sensitivity, but did promote hepatic
            gluconeogenesis in high-fat-fed animals.
REFERENCE   3  (bases 1 to 5668)
  AUTHORS   Li,J., Deng,S.P., Wei,G. and Yu,P.
  TITLE     CITGeneDB: a comprehensive database of human and mouse genes
            enhancing or suppressing cold-induced thermogenesis validated by
            perturbation experiments in mice
  JOURNAL   Database (Oxford) 2018 (2018)
   PUBMED   29688375
REFERENCE   4  (bases 1 to 5668)
  AUTHORS   Okada,K., LeClair,K.B., Zhang,Y., Li,Y., Ozdemir,C., Krisko,T.I.,
            Hagen,S.J., Betensky,R.A., Banks,A.S. and Cohen,D.E.
  TITLE     Thioesterase superfamily member 1 suppresses cold thermogenesis by
            limiting the oxidation of lipid droplet-derived fatty acids in
            brown adipose tissue
  JOURNAL   Mol Metab 5 (5), 340-351 (2016)
   PUBMED   27110486
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5668)
  AUTHORS   Han,S. and Cohen,D.E.
  TITLE     Functional characterization of thioesterase superfamily member
            1/Acyl-CoA thioesterase 11: implications for metabolic regulation
  JOURNAL   J Lipid Res 53 (12), 2620-2631 (2012)
   PUBMED   22993230
REFERENCE   6  (bases 1 to 5668)
  AUTHORS   Zhang,Y., Li,Y., Niepel,M.W., Kawano,Y., Han,S., Liu,S.,
            Marsili,A., Larsen,P.R., Lee,C.H. and Cohen,D.E.
  TITLE     Targeted deletion of thioesterase superfamily member 1 promotes
            energy expenditure and protects against obesity and insulin
            resistance
  JOURNAL   Proc Natl Acad Sci U S A 109 (14), 5417-5422 (2012)
   PUBMED   22427358
REFERENCE   7  (bases 1 to 5668)
  AUTHORS   Hunt,M.C., Yamada,J., Maltais,L.J., Wright,M.W., Podesta,E.J. and
            Alexson,S.E.
  TITLE     A revised nomenclature for mammalian acyl-CoA
            thioesterases/hydrolases
  JOURNAL   J Lipid Res 46 (9), 2029-2032 (2005)
   PUBMED   16103133
REFERENCE   8  (bases 1 to 5668)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 5668)
  AUTHORS   Adams,S.H., Chui,C., Schilbach,S.L., Yu,X.X., Goddard,A.D.,
            Grimaldi,J.C., Lee,J., Dowd,P., Colman,S. and Lewin,D.A.
  TITLE     BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown
            adipose tissue: cloning, organization of the human gene and
            assessment of a potential link to obesity
  JOURNAL   Biochem J 360 (Pt 1), 135-142 (2001)
   PUBMED   11696000
  REMARK    GeneRIF: BFIT supports the transition of thermogenic brown adipose
            tissue towards increased metabolic activity, probably through
            alteration of intracellular fatty acyl-CoA concentration.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048670.1 and AL929585.11.
            
            On Jul 30, 2009 this sequence version replaced NM_025590.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to variant 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048670.1, BC042492.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2993              AK048670.1         1-2993
            2994-5668           AL929585.11        184053-186727       c
FEATURES             Location/Qualifiers
     source          1..5668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 49.75 cM"
     gene            1..5668
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /note="acyl-CoA thioesterase 11"
                     /db_xref="GeneID:329910"
                     /db_xref="MGI:MGI:1913736"
     exon            1..148
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1900
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /EC_number="3.1.2.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     acyl-coenzyme A thioesterase 11; acyl-CoA thioester
                     hydrolase 11; adipose-associated thioesterase; brown
                     fat-inducible thioesterase; thioesterase, adipose
                     associated; palmitoyl-coenzyme A thioesterase"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 11 isoform 2"
                     /protein_id="NP_079866.2"
                     /db_xref="CCDS:CCDS18426.1"
                     /db_xref="GeneID:329910"
                     /db_xref="MGI:MGI:1913736"
                     /translation="MIQNVGNHLRRGFASMFSNRTSRKSISHPESGDPPTMAEGEGYR
                     NPTEVQMSQLVLPCHTNHRGELSIGQLLKWIDTTACLSAERHAGCPCVTASMDDIYFD
                     HTISVGQVVNIKAKVNRAFNSSMEVGIQVVSEDLCSEKQWSVCKALATFVAHRELSKV
                     KLKQVIPLTEEEKTEHGVAAERRRMRLVYADTIKDLLTHCVIQDDLDKDCSNMVPAEK
                     TRVESVELVLPPHANHQGNTFGGQIMAWMENVATIAASRLCHAHPTLKAIEMFHFRGP
                     SQVGDRLVLKAIVNNAFKHSMEVGVCVEAYRQEAETQRRHINSAFMTFVVLDKDDQPQ
                     KLPWIRPQPGEGERRYREASARKKIRLDRKYLVSCKQAEVALSVPWDPSNQVYLSYYN
                     VSSLKTLMAKDNWVLSVEISEVRLYILEEDFLSFHLEMVVNVDAAQVFQLLSDLRRRP
                     EWDKHYRSVELVQQVDEDDAIYHVISPALSGNTKPQDFVILASRRKPCDNGDPYVIAL
                     RSVTLPTHHETPEYQRGETLCSGFCLWREGDQMTKVSYYNQATPGFLNYVTTNVSGLS
                     SEFYNTFKACESFLLDNRNDLAPSLQTL"
     exon            149..362
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..432
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..493
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..592
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..728
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..882
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1002
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1147
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1203
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1270
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1354
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1485
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1617
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1744
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..5668
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2722
                     /gene="Acot11"
                     /gene_synonym="1110020M10Rik; 2010309H15Rik; BFIT; BFIT1;
                     mKIAA0707; Thea; Them1"
                     /note="major polyA site"
ORIGIN      
        1 aggagaagcc ggctgctttt ggacttgctg gcagtcccag ggctcaggtg accagcggcc
       61 ctttaggagc ctacagaccc ccccacagcc tggcaaccca gcaaacggag cagcaatgat
      121 tcagaatgtg ggcaaccact tgcgaagggg cttcgcctct atgttctcta atcgcacatc
      181 ccggaagtca atctcccatc cggagtctgg agaccctcct accatggcag agggtgaagg
      241 ataccggaac cccacggagg tgcagatgag ccagctggta ctgccctgcc acaccaacca
      301 ccgtggggag ctgagcattg gacagttgct caagtggatc gacaccacag cctgcctatc
      361 agcggagagg catgctggct gtccctgcgt cacagcctct atggatgaca tctacttcga
      421 ccataccatt agtgtcggcc aagtggtgaa tatcaaggcc aaggtgaacc gggccttcaa
      481 ctccagcatg gaggtgggaa tccaggtggt ctctgaggat ctgtgctctg agaagcagtg
      541 gagtgtctgc aaggccttgg ccacctttgt ggcccaccgg gagctctcca aggtgaagct
      601 gaagcaggtc atcccattga ccgaggagga gaagactgaa catggggtgg cggctgagcg
      661 ccggcgtatg cgactggtct atgcagacac catcaaagat ctcctaaccc actgtgtcat
      721 ccaggacgat ttggacaagg actgcagcaa tatggtgcca gccgagaaga cccgagtgga
      781 gagtgtggag ctggtgctgc ctcctcacgc caatcatcag ggcaatacct tcgggggaca
      841 gatcatggct tggatggaga atgtggccac cattgcagcc agccggctct gtcacgccca
      901 ccctacgctc aaggccatcg agatgttcca tttccgaggc ccgtctcagg tgggggaccg
      961 tctggtgctc aaggccatcg tgaataacgc ctttaagcac agcatggagg tgggtgtgtg
     1021 tgtggaggcg taccgccagg aagctgagac ccagcgccgg cacatcaaca gcgccttcat
     1081 gaccttcgtg gtcctggaca aagatgacca gcctcagaag ctgccctgga ttcgtcccca
     1141 gcctggagag ggtgaacggc gataccgaga agccagtgcc aggaagaaga tccgcctgga
     1201 caggaaatac cttgtgtcct gtaagcaggc agaagtggcc ctgtctgtcc cctgggaccc
     1261 tagcaaccag gtatacctga gctactacaa cgtgtcctct ctgaagacgc tcatggccaa
     1321 ggacaactgg gtgctgtccg tggagatcag cgaggtccgc ctgtacatcc tagaagagga
     1381 cttcctctcc tttcacttgg agatggtggt aaatgtggat gccgcccagg tctttcagct
     1441 gctgtcagac ctgcgcagga gaccagagtg ggacaagcat taccggagtg tggagctggt
     1501 gcagcaagtg gatgaggatg acgccatcta ccacgtcatc agccccgccc tgagcgggaa
     1561 caccaagccc caggactttg tgatcctggc ctctaggcgg aagccttgtg acaatgggga
     1621 cccctatgtc attgccctga ggtcggtcac gctgcccacg caccatgaga caccggaata
     1681 ccaacgtggg gagactctct gttcaggctt ctgtctgtgg cgtgaggggg accagatgac
     1741 taaggtttct tactacaacc aggccacccc cggctttctc aactatgtga ccaccaatgt
     1801 gtccggcctg tcctcagaat tctacaacac tttcaaggct tgtgagagtt ttctgttgga
     1861 caaccggaat gacctagctc ccagcctcca gaccctctag acaccaccca tgctgcccca
     1921 ggtcttacac agtgcgtgga acaaagcaga gacatttatt caccttgact ccccagggaa
     1981 gccttccaca ctagatggtc caatcctact ggatggtcgg ttgctgctca catctgcctg
     2041 caagtctttc cagtactcct gggatatcct gtaatagact cgggtcctgt ccacggccct
     2101 ggccgcccac aatccagccc acaaatccac atggctgttc ccagcagtgc tgtggtacac
     2161 tgtgacagtg gctctagggg aggaggccag gagcctggcc acagtgttgg ctggactctg
     2221 actcagtggc ccagcctgca gctggaagga cacaggttgc cggagtccct gacacagctc
     2281 cagcatatct gtgaccatct gctcctgata accactgtcc agcatctctt cgggccagcc
     2341 cggtgccacg gtcacatggg ggaagacttc agccacagct gtgagcagct ctctgccagc
     2401 tatgtggcca gggaccacaa aactaccatg tgagactgtg gaccccaccc acacaggcca
     2461 gggcagatgg ccaagggtag aaaggtgtgc taacgtggcc agggatggcc ggagagcttc
     2521 gggttccact atgttcacat ggatgcccca gcgcctgggg tgaacagcca gacgcagcag
     2581 acacgactcc agtgtcagag cagggccacc tggggtgtgt aggatgggta cagggttccc
     2641 agcctcaggt tcctggaggc caatgtccag caagatcatg ccttctctgt ctggaagagg
     2701 caacagtttg gagatcctgt catcatggga cgtcagtgtt ttttgttaaa ggggacatac
     2761 atgggggcat gtcatgggga tagatcaaga ggcaccagcc attcttgagt ttgccagctc
     2821 catcccaggc tccaagtgct gtgactggtg actctcaggc aggcatgaca aattgctggc
     2881 ctccattctt ggccttccta atcactcccc actcctctag tcacagtgtg gctgaggact
     2941 caaggctgtg aagaccagga gttcctgctc ttgacattat tcctcccact ttgtatccag
     3001 tgtgtggctt attgtgttgc catggtaaca gagaatcaag ttacccaccc aagcaaatga
     3061 cagacctgtg ggtgagggta gccaggagct ttagagctgc aggcagactc accaggaact
     3121 gtaatggctg ctcttctccc actgccattc acttccagaa ctagccactc tacctccaga
     3181 ccatcaccct tgggctgctg gagaagaggg atcaggctgc cacctgtgta gtaggttcgc
     3241 ttccgggtgg tgttcactgt gggacccaaa attgccaatg tgaagggacc actctccaca
     3301 aattgccttg tgtatgcact ggctctcccg catcctaagc cctgtggctg tcacttctcc
     3361 cttttgggta gattggaagt cattgtctca tggcctgaca ttcaacagaa tttactgggc
     3421 cagaaaccaa acagagctag agatgagggg agggggctcc aaagcttgtc tcctcccttt
     3481 cccaggcaca actccctcaa taggagtgga atctgatgtg actccttggg atgacttaag
     3541 tgtagatgcc cctagacaca gggtcaagag aacagggcat agtggcatct ggctcatgaa
     3601 ctagtgggca cgtaagaggg ctgtgcttga gaccctattg ccaaaggtga atggtgctgt
     3661 ggaagccagg gcactcgagt gcgtgcatgt gtgtgtgtat gtgtgtgtat gtatgtgtgt
     3721 gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgaga cttggctagg ttgtgatcag
     3781 attgcactcc tacaaaatcc ttgtggtttt ggacttccat tgccctctct atcaaccaga
     3841 ctcctgttct gaggacatcg cttggataac ataatatccc aggggcagaa gacaaattct
     3901 cagaatagct cctgtctcct gttccacgca gaattttccc catctagacc accctttctc
     3961 cgcttccatg cccacccaag gctgccctga gcagaacaca gcccacaatt cccctcccag
     4021 gctcccttct tacaggccag ctgcttaaac tgcgacaaga caggctcaaa gaggtcatag
     4081 tagatttggt gagcggcact gttgtcccgg atgaagagga gatcttctac tgacacgggg
     4141 tctgaggcac cctgccacag tgttaggctg tacctggaac cagagagctg actcagggcc
     4201 cgcctgactc ttggctctac ttgtgcgctc agaactgaat gccagctgag cccaggagtg
     4261 gagcatctgt tctctagatt cccaccagag gatgatggag agcggaggtt cagagggcag
     4321 gaggatgtgc acccctggga tgtctgtttc tgagttaccc accaatggaa gcagtgacca
     4381 gccagtgccc agaagagtac aagccagagg ccgagcatag gaggtcgtta gggcagtggg
     4441 actgggacaa gatgatcttt aggacccctc ttgacgtgtt catcttgggg cagagcccag
     4501 gataggtttg ggaccagtag aggggtttca cctctcagat tggctcagaa gccagctgaa
     4561 gtggggccaa gcagcccgtg tcatgacagc tctcactggg aaggtgacct tctgtggcag
     4621 cgctccgacc agctcctgca ttgtttccac catggcttgg gtgtatgtgc tgtttggcaa
     4681 ctgaggcaca taaagagtgg taaagcctgg agaaatggtg gcctttggat atttctcctg
     4741 gacaagagtc agaaacctgc agagagagac cagagcagag atacccatct ttcccttctt
     4801 gtaggctctt gccacagcga caggaacagt caggcctatt gagactcagc ttggagattg
     4861 acatcagagc cctaaagagc agcagtgatt tgtacatcct cctgctgata tcaccaccct
     4921 gtgcagtcag agaggtctgg gatccggtct ctactctgca tctggtgatc catctgattc
     4981 tcaaagatag tgactgtcag ggcagggcct tttaaacatc cccacatcga cagaggggct
     5041 tgagtgagac ttgtaaggtg tgcagatctg catgctgaca gatggcttcg agtctccaaa
     5101 gtttcagatt cctaattttt tttttcatat gagaagagcc tgtgccacat gtctataatc
     5161 tcagcacttg gggggtggga ggcaggaggt tcagggcttc cttcatcccc agatacatag
     5221 caagtgcagg gctagcctag gctacatgaa actgccacaa agcaacacat tgaaaagagt
     5281 tatttgaatt ttgttctgat gcaaattttc aataggaaat taatgtcacc cactgctcgg
     5341 cccccagata tataactcag taccctgagg agagaatcct tgtttgtctt gggccctagc
     5401 ctacattttc caaatataac tcattttgag aatcagtaaa tgttggccgg gcagatggag
     5461 gtgtctgcag agcacaaaac tcgaggacgg aaagacctgt gggaaccttt gctctgccgt
     5521 tttgtagact tagaccattc atttaacctt tcaaagatag tttctatact tacaagatga
     5581 atatgactag ttgctacctc attctcttaa gagttcagct gtattctgca aataaaatgc
     5641 ttgaaaccgt gcctggggta cactaacc
//
