LOCUS       NM_012006               1559 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus acyl-CoA thioesterase 1 (Acot1), mRNA.
ACCESSION   NM_012006 XM_905921
VERSION     NM_012006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1559)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1559)
  AUTHORS   Heden,T.D., Franklin,M.P., Dailey,C., Mashek,M.T., Chen,C. and
            Mashek,D.G.
  TITLE     ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by
            increasing energy expenditure
  JOURNAL   JCI Insight 8 (18), e160987 (2023)
   PUBMED   37561578
  REMARK    GeneRIF: ACOT1 deficiency attenuates high-fat diet-induced fat mass
            gain by increasing energy expenditure.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1559)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   4  (bases 1 to 1559)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1559)
  AUTHORS   Lu,J., Xu,Q., Ji,M., Guo,X., Xu,X., Fargo,D.C. and Li,X.
  TITLE     The phosphorylation status of T522 modulates tissue-specific
            functions of SIRT1 in energy metabolism in mice
  JOURNAL   EMBO Rep 18 (5), 841-857 (2017)
   PUBMED   28364022
REFERENCE   6  (bases 1 to 1559)
  AUTHORS   Lindquist,P.J., Svensson,L.T. and Alexson,S.E.
  TITLE     Molecular cloning of the peroxisome proliferator-induced 46-kDa
            cytosolic acyl-CoA thioesterase from mouse and rat
            liver--recombinant expression in Escherichia coli, tissue
            expression, and nutritional regulation
  JOURNAL   Eur J Biochem 251 (3), 631-640 (1998)
   PUBMED   9490035
REFERENCE   7  (bases 1 to 1559)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
REFERENCE   8  (bases 1 to 1559)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (bases 1 to 1559)
  AUTHORS   Jiang,Y., Yu,V.C., Buchholz,F., O'Connell,S., Rhodes,S.J.,
            Candeloro,C., Xia,Y.R., Lusis,A.J. and Rosenfeld,M.G.
  TITLE     A novel family of Cys-Cys, His-Cys zinc finger transcription
            factors expressed in developing nervous system and pituitary gland
  JOURNAL   J Biol Chem 271 (18), 10723-10730 (1996)
   PUBMED   8631881
REFERENCE   10 (bases 1 to 1559)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC133183.3.
            
            On Nov 17, 2006 this sequence version replaced NM_012006.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y14004.1, BC003911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               AC133183.3         54890-55354         c
            466-668             AC133183.3         50275-50477         c
            669-1559            AC133183.3         47186-48076         c
FEATURES             Location/Qualifiers
     source          1..1559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.0 cM"
     gene            1..1559
                     /gene="Acot1"
                     /gene_synonym="ACH2; CTE-1; CTE-I; Cte1; D12Ucla1"
                     /note="acyl-CoA thioesterase 1"
                     /db_xref="GeneID:26897"
                     /db_xref="MGI:MGI:1349396"
     exon            1..465
                     /gene="Acot1"
                     /gene_synonym="ACH2; CTE-1; CTE-I; Cte1; D12Ucla1"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1268
                     /gene="Acot1"
                     /gene_synonym="ACH2; CTE-1; CTE-I; Cte1; D12Ucla1"
                     /EC_number="3.1.2.2"
                     /note="acyl-CoA thioesterase 1, cytosolic; cytosolic
                     acyl-CoA thioesterase 1; long chain acyl-CoA hydrolase;
                     long chain acyl-CoA thioester hydrolase; inducible
                     cytosolic acyl-coenzyme A thioester hydrolase;
                     palmitoyl-coenzyme A thioesterase"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase 1"
                     /protein_id="NP_036136.1"
                     /db_xref="CCDS:CCDS36487.1"
                     /db_xref="GeneID:26897"
                     /db_xref="MGI:MGI:1349396"
                     /translation="MEATLNLEPSGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGA
                     LFRAHARYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLVKRDVQTPF
                     VVELEVLDGHEPDGGQRLAHAVHERHFLAPGVRRVPVREGRVRATLFLPPEPGPFPGI
                     IDLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKNMETMHMEYFEEAVNYLRSH
                     PEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVAAVGNTISYKDETIPPVT
                     ILRNQVKMTKDGLKDVVDALQSPLVDKKSFIPVERSDTTFLFLVGQDDHNWKSEFYAD
                     EISKRLQAHGKEKPQIICYPAAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHAMA
                     QLDAWQQLQTFFHKQLGSECLHVSPKI"
     exon            466..668
                     /gene="Acot1"
                     /gene_synonym="ACH2; CTE-1; CTE-I; Cte1; D12Ucla1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..1559
                     /gene="Acot1"
                     /gene_synonym="ACH2; CTE-1; CTE-I; Cte1; D12Ucla1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcgagat ggaggcgacg ctgaaccttg agccctcggg ccgcagctgc tgggacgaac
       61 cgctgagcat cgccgtgcgc ggcctggccc cggagcagcc cgtcacgctg cgctctgtcc
      121 tgcgcgacga gaagggcgcg ctcttccgag cccacgcgcg ctaccgcgcg gactcccacg
      181 gcgagctgga cctggcgcgc acgcccgcgc tgggcggcag cttctcgggg ctcgagccca
      241 tggggctgct ctgggccatg gagcccgatc ggcctttttg gcgattggtc aagcgcgacg
      301 tgcagacgcc cttcgtggtg gagctggagg tgctggacgg acacgagccc gacggcgggc
      361 agcggcttgc acatgcggtg cacgagcgtc acttcttggc tccgggggtg cggcgcgtgc
      421 ccgtacgaga gggccgggtg cgcgccacgc tcttcctgcc cccagaacct ggaccctttc
      481 ctgggatcat agaccttttt ggagttggag gtggccttct ggagtatcgg gcgagcctgc
      541 tggctgggaa gggctttgcc gtcatggctc tggcttatta caactacgat gacctcccca
      601 agaacatgga aaccatgcac atggagtact ttgaagaagc cgtgaactac ctgcgcagcc
      661 accccgaggt aaaaggacct ggaattgggc tgcttgggat ttccaaaggg ggtgaacttg
      721 gccttgctat ggcctccttc ctgaagggca tcacagctgc tgtggtcatc aatggctccg
      781 tggctgctgt tgggaacacc atctcctaca aggatgagac tataccccct gtgactatcc
      841 tgagaaatca ggtcaaaatg accaaggatg gcctcaagga tgttgtagat gctttgcaaa
      901 gccctctggt agacaagaag agcttcattc ccgtggaaag gtctgacacg accttcctgt
      961 tcctcgtagg tcaggacgac cacaactgga agagcgagtt ctatgctgat gagatctcca
     1021 aacgcctgca ggcgcacggg aaggagaagc cccagatcat ctgctaccca gcagcagggc
     1081 attacatcga gcccccttac ttcccgctgt gcagcgctgg catgcacctc ctggtgggtg
     1141 ccaacatcac ctttggaggg gagcccaagc ctcatgccat ggcccagttg gatgcatggc
     1201 agcagctcca gactttcttc cacaaacagt tgggtagtga gtgtttgcat gtgtctccta
     1261 aaatataacc tattatatga tggtttggag gttggggaaa ggtacaaata cattgtaaga
     1321 atatcatttc agatgacttc atctgaacat aaaactgctt tagatttaca tttaaaaaaa
     1381 ttgatataat tatcaaaata gtgctgattc aagggctggg aatggagttt cattgtcaag
     1441 tccttgactg gcgcatgcag gatcctgggt tcaatccagc tgcgagaaat aaagcacgtt
     1501 ctatggaaac tggagctatc caagaaaagt gccaggaata aaaaggaacc atgattaaa
//
