LOCUS       NP_036136                419 aa            linear   ROD 10-FEB-2025
DEFINITION  acyl-coenzyme A thioesterase 1 [Mus musculus].
ACCESSION   NP_036136 XP_911014
VERSION     NP_036136.1
DBSOURCE    REFSEQ: accession NM_012006.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 419)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 419)
  AUTHORS   Heden,T.D., Franklin,M.P., Dailey,C., Mashek,M.T., Chen,C. and
            Mashek,D.G.
  TITLE     ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by
            increasing energy expenditure
  JOURNAL   JCI Insight 8 (18), e160987 (2023)
   PUBMED   37561578
  REMARK    GeneRIF: ACOT1 deficiency attenuates high-fat diet-induced fat mass
            gain by increasing energy expenditure.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 419)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   4  (residues 1 to 419)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 419)
  AUTHORS   Lu,J., Xu,Q., Ji,M., Guo,X., Xu,X., Fargo,D.C. and Li,X.
  TITLE     The phosphorylation status of T522 modulates tissue-specific
            functions of SIRT1 in energy metabolism in mice
  JOURNAL   EMBO Rep 18 (5), 841-857 (2017)
   PUBMED   28364022
REFERENCE   6  (residues 1 to 419)
  AUTHORS   Lindquist,P.J., Svensson,L.T. and Alexson,S.E.
  TITLE     Molecular cloning of the peroxisome proliferator-induced 46-kDa
            cytosolic acyl-CoA thioesterase from mouse and rat
            liver--recombinant expression in Escherichia coli, tissue
            expression, and nutritional regulation
  JOURNAL   Eur J Biochem 251 (3), 631-640 (1998)
   PUBMED   9490035
REFERENCE   7  (residues 1 to 419)
  AUTHORS   Nicoll,D.A., Quednau,B.D., Qui,Z., Xia,Y.R., Lusis,A.J. and
            Philipson,K.D.
  TITLE     Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3
  JOURNAL   J Biol Chem 271 (40), 24914-24921 (1996)
   PUBMED   8798769
REFERENCE   8  (residues 1 to 419)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   9  (residues 1 to 419)
  AUTHORS   Jiang,Y., Yu,V.C., Buchholz,F., O'Connell,S., Rhodes,S.J.,
            Candeloro,C., Xia,Y.R., Lusis,A.J. and Rosenfeld,M.G.
  TITLE     A novel family of Cys-Cys, His-Cys zinc finger transcription
            factors expressed in developing nervous system and pituitary gland
  JOURNAL   J Biol Chem 271 (18), 10723-10730 (1996)
   PUBMED   8631881
REFERENCE   10 (residues 1 to 419)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC133183.3.
            
            On Dec 7, 2005 this sequence version replaced XP_911014.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y14004.1, BC003911.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..419
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.0 cM"
     Protein         1..419
                     /product="acyl-coenzyme A thioesterase 1"
                     /EC_number="3.1.2.2"
                     /note="acyl-CoA thioesterase 1, cytosolic; cytosolic
                     acyl-CoA thioesterase 1; long chain acyl-CoA hydrolase;
                     long chain acyl-CoA thioester hydrolase; inducible
                     cytosolic acyl-coenzyme A thioester hydrolase;
                     palmitoyl-coenzyme A thioesterase"
                     /calculated_mol_wt=46005
     Region          16..141
                     /region_name="Bile_Hydr_Trans"
                     /note="Acyl-CoA thioester hydrolase/BAAT N-terminal
                     region; pfam04775"
                     /db_xref="CDD:461422"
     Region          139..>253
                     /region_name="Axe1"
                     /note="Cephalosporin-C deacetylase or related acetyl
                     esterase [Secondary metabolites biosynthesis, transport
                     and catabolism]; COG3458"
                     /db_xref="CDD:442681"
     Region          203..410
                     /region_name="BAAT_C"
                     /note="BAAT / Acyl-CoA thioester hydrolase C terminal;
                     pfam08840"
                     /db_xref="CDD:430252"
     Site            416
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O88267; propagated from
                     UniProtKB/Swiss-Prot (O55137.1)"
     CDS             1..419
                     /gene="Acot1"
                     /gene_synonym="ACH2; CTE-1; CTE-I; Cte1; D12Ucla1"
                     /coded_by="NM_012006.2:9..1268"
                     /db_xref="CCDS:CCDS36487.1"
                     /db_xref="GeneID:26897"
                     /db_xref="MGI:MGI:1349396"
ORIGIN      
        1 meatlnleps grscwdepls iavrglapeq pvtlrsvlrd ekgalfraha ryradshgel
       61 dlartpalgg sfsglepmgl lwamepdrpf wrlvkrdvqt pfvvelevld ghepdggqrl
      121 ahavherhfl apgvrrvpvr egrvratlfl ppepgpfpgi idlfgvgggl leyrasllag
      181 kgfavmalay ynyddlpknm etmhmeyfee avnylrshpe vkgpgigllg iskggelgla
      241 masflkgita avvingsvaa vgntisykde tippvtilrn qvkmtkdglk dvvdalqspl
      301 vdkksfipve rsdttflflv gqddhnwkse fyadeiskrl qahgkekpqi icypaaghyi
      361 eppyfplcsa gmhllvgani tfggepkpha maqldawqql qtffhkqlgs eclhvspki
//
