LOCUS       NM_008392               2588 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus aconitate decarboxylase 1 (Acod1), mRNA.
ACCESSION   NM_008392 XM_127883 XM_905897
VERSION     NM_008392.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2588)
  AUTHORS   McBride,M.A., Caja,K.R., Patil,T.K., Owen,A.M., Luan,L.,
            Bohannon,J.K., Hernandez,A., Stothers,C.L., Trenary,I.A., Rahim,M.,
            Young,J.D., Calcutt,M.W., Stephens,V.R., Davis,X., Oliver,M.A.,
            Hao,D., Si,C., McRae,M., Nguyen,K.K., Davis,N.S., Wang,J.,
            Patil,N.K. and Sherwood,E.R.
  TITLE     Immunoresponsive gene 1 facilitates TLR4 agonist-induced
            augmentation of innate antimicrobial immunity
  JOURNAL   J Leukoc Biol 117 (2) (2025)
   PUBMED   39351765
REFERENCE   2  (bases 1 to 2588)
  AUTHORS   Beielstein,A.C., Izquierdo,E., Blakemore,S., Nickel,N.,
            Michalik,M., Chawan,S., Brinker,R., Bartel,H.H., Vorholt,D.,
            Albert,L., Nolte,J.L., Linke,R., Costa Picossi,C.R., Saiz,J.,
            Picard,F., Florin,A., Meinel,J., Buttner,R., Diefenhardt,P.,
            Brahler,S., Villasenor,A., Winkels,H., Hallek,M., Kruger,M.,
            Barbas,C. and Pallasch,C.P.
  TITLE     Macrophages are activated toward phagocytic lymphoma cell clearance
            by pentose phosphate pathway inhibition
  JOURNAL   Cell Rep Med 5 (12), 101830 (2024)
   PUBMED   39603243
REFERENCE   3  (bases 1 to 2588)
  AUTHORS   Lin,H., Tison,K., Du,Y., Kirchhoff,P., Kim,C., Wang,W., Yang,H.,
            Pitter,M., Yu,J., Liao,P., Zhou,J., Vatan,L., Grove,S., Wei,S.,
            Vigil,T., Shah,Y.M., Mortensen,R., Kryczek,I., Garmire,L.,
            Sivaccumar,J.P., Ramesh,A.K., Zhang,N., An,Z., Wang,S. and Zou,W.
  TITLE     Itaconate transporter SLC13A3 impairs tumor immunity via endowing
            ferroptosis resistance
  JOURNAL   Cancer Cell 42 (12), 2032-2044 (2024)
   PUBMED   39515327
REFERENCE   4  (bases 1 to 2588)
  AUTHORS   Sun,X., Zhang,B., Yuan,P., Ye,H. and Shi,P.
  TITLE     Irg1 regulates bone homeostasis via regulating the Grk5 expression
  JOURNAL   Biochem Biophys Res Commun 734, 150786 (2024)
   PUBMED   39383830
  REMARK    GeneRIF: Irg1 regulates bone homeostasis via regulating the Grk5
            expression.
REFERENCE   5  (bases 1 to 2588)
  AUTHORS   O'Carroll,S.M., Peace,C.G., Toller-Kawahisa,J.E., Min,Y.,
            Hooftman,A., Charki,S., Kehoe,L., O'Sullivan,M.J., Zoller,A.,
            Mcgettrick,A.F., Zotta,A., Day,E.A., Simarro,M., Armstrong,N.,
            Annes,J.P. and O'Neill,L.A.J.
  TITLE     Itaconate drives mtRNA-mediated type I interferon production
            through inhibition of succinate dehydrogenase
  JOURNAL   Nat Metab 6 (11), 2060-2069 (2024)
   PUBMED   39406969
  REMARK    Erratum:[Nat Metab. 2025 Jan;7(1):228. doi:
            10.1038/s42255-024-01204-7. PMID: 39668260]
REFERENCE   6  (bases 1 to 2588)
  AUTHORS   Chen,B., Zhang,D. and Pollard,J.W.
  TITLE     Progesterone regulation of the mammalian ortholog of methylcitrate
            dehydratase (immune response gene 1) in the uterine epithelium
            during implantation through the protein kinase C pathway
  JOURNAL   Mol Endocrinol 17 (11), 2340-2354 (2003)
   PUBMED   12893884
  REMARK    GeneRIF: PKC pathway is induced in the uterine epithelium at
            implantation by the synergistic action of progesterone and estrogen
            and is responsible for the hormone induction of Irg1
REFERENCE   7  (bases 1 to 2588)
  AUTHORS   Peterson,K.A., King,B.L., Hagge-Greenberg,A., Roix,J.J., Bult,C.J.
            and O'Brien,T.P.
  TITLE     Functional and comparative genomic analysis of the piebald deletion
            region of mouse chromosome 14
  JOURNAL   Genomics 80 (2), 172-184 (2002)
   PUBMED   12160731
REFERENCE   8  (bases 1 to 2588)
  AUTHORS   Smallwood,P.M., Munoz-Sanjuan,I., Tong,P., Macke,J.P., Hendry,S.H.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     Fibroblast growth factor (FGF) homologous factors: new members of
            the FGF family implicated in nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9850-9857 (1996)
   PUBMED   8790420
REFERENCE   9  (bases 1 to 2588)
  AUTHORS   Lee,C.G., Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and
            O'Brien,W.E.
  TITLE     Cloning and analysis of gene regulation of a novel LPS-inducible
            cDNA
  JOURNAL   Immunogenetics 41 (5), 263-270 (1995)
   PUBMED   7721348
REFERENCE   10 (bases 1 to 2588)
  AUTHORS   Lee,C.G., Demarquoy,J., Jackson,M.J. and O'Brien,W.E.
  TITLE     Molecular cloning and characterization of a murine LPS-inducible
            cDNA
  JOURNAL   J Immunol 152 (12), 5758-5767 (1994)
   PUBMED   8207206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036446.1 and AK152177.1.
            
            On or before Mar 2, 2008 this sequence version replaced
            XM_905897.2, XM_127883.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152177.1, AK036446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2111              AK036446.1         37-2147
            2112-2588           AK152177.1         2111-2587
FEATURES             Location/Qualifiers
     source          1..2588
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 51.67 cM"
     gene            1..2588
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /note="aconitate decarboxylase 1"
                     /db_xref="GeneID:16365"
                     /db_xref="MGI:MGI:103206"
     exon            1..68
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1523
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /EC_number="4.1.1.6"
                     /note="immune-responsive gene 1 protein; cis-aconitic acid
                     decarboxylase; immunoresponsive gene 1"
                     /codon_start=1
                     /product="cis-aconitate decarboxylase"
                     /protein_id="NP_032418.1"
                     /db_xref="CCDS:CCDS49558.1"
                     /db_xref="GeneID:16365"
                     /db_xref="MGI:MGI:103206"
                     /translation="MMLKSVTESFAGMIHGLKVNHLTDGIIRRSKRMILDSLGVGFLG
                     TGTEVFHKVTQYSKIYSSNTSSTVWGRPDFRLPPTYAAFVNGVAVHSMDFDDTWHPAT
                     HPSGAVLPVLTALSEALPQTPKFSGLDLLLAFNVGIEVQGRLMHFSKEAKDIPKRFHP
                     PSVVGTLGSAAAASKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPLHIGNAAKHG
                     MEATFLAMLGLQGNKQILDLGSGFGAFYANYSPEDLPSLDSHIWLLDQQDVAFKSFPA
                     HLATHWVADAAAAVRKHLVTPERALFPADHIERIVLRIPDVQYVNRPFPDSEHEARHS
                     FQYVACASLLDGSITVPSFHSQQVNRPQVRELLKKVKLEHPPDNPPSFDTLYCEISIT
                     LKDGTTFTERSDTFYGHWRKPLSQEDLRNKFRANASKMLCRDTVESLITVVEKLEDLE
                     DCSVLTRLLKGPSVQDEASKLSSMSSFDHTTLPRFTNI"
     exon            69..230
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /inference="alignment:Splign:2.1.0"
     exon            231..320
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..526
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..2588
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /note="hexamer: AATAAA"
     polyA_site      2114
                     /gene="Acod1"
                     /gene_synonym="CAD; Irg1"
                     /note="major polyA site"
ORIGIN      
        1 ccagccagca actactcctg ccatccactc ctgagccagt taccctccag agcaacatga
       61 tgctcaagtc tgtcacagag agctttgctg gtatgattca cggcttgaaa gtgaaccacc
      121 tgacagatgg tatcattcgg aggagcaaga ggatgatcct ggattctctg ggcgttggct
      181 tcctggggac aggcacagaa gtgttccata aagtcaccca atatagtaaa atctacagtt
      241 ccaacacctc cagcactgtt tggggtcgac cagacttcag gctcccaccg acatatgctg
      301 cttttgttaa tggtgttgct gttcactcca tggattttga tgacacatgg caccctgcca
      361 cccacccttc tggggctgtc ctacctgtcc tcacagctct atcggaagcc ctgcctcaga
      421 ctcccaagtt ttctggcctc gacctgctgc tggcgttcaa cgttggtatt gaagtacagg
      481 gacgattaat gcacttctcc aaggaagcca aagacatacc aaagagattc caccctccct
      541 ctgtggtggg gactctggga agtgctgctg ctgcgtccaa gtttctgggg ctcagcttga
      601 caaagtgccg cgaggcattg gctattgctg tttcccacgc aggggcaccc atagcgaacg
      661 ctgccactca gactaagccc cttcatattg gcaatgcagc caagcatggg atggaagcca
      721 cgtttctggc aatgctgggc ctccaaggaa acaaacagat cttggacctg gggtcagggt
      781 tcggtgcctt ctatgccaac tactcccccg aagaccttcc aagcctggat tctcacatct
      841 ggctgttgga ccagcaggat gtggccttta agagcttccc ggcacatctg gctacccact
      901 gggtggcaga tgcagctgca gccgtgagaa agcaccttgt gacaccagaa agagccctgt
      961 tccctgctga ccacatcgag agaatcgtgc tcaggatccc tgacgtccag tacgtaaaca
     1021 ggcccttccc ggactcagag catgaagccc gtcattcttt ccagtatgtg gcctgtgcct
     1081 cgctgctcga cggtagcatc actgtcccat ccttccacag ccagcaggtc aataggcctc
     1141 aggtgagaga gttgctcaag aaggtgaagc tggagcatcc tcctgacaac ccgccaagct
     1201 tcgacacgct atactgtgaa ataagcatca ctctaaagga cgggaccact ttcaccgagc
     1261 gctctgacac cttctatggt cactggagga aaccactgag ccaggaagat ctgcgcaaca
     1321 agttccgagc caatgcctca aagatgctat gcagggacac ggtggaaagc cttataacgg
     1381 tagtagaaaa gctagaagac ctagaagact gctctgtgct aaccagactt ctgaaaggac
     1441 cctctgtcca agatgaagct tcaaaactat ccagcatgtc ctcattcgat cacacaacgt
     1501 tgcccaggtt taccaatatc taaacgacgt tgcactggaa gaaatacatt gttttggttt
     1561 cctgctccac cttcccagca atgagctcag caaagtagag agtccagaaa cagagacaag
     1621 cgtatatgga aagaggcttg tctataattt gataaaaacc agtcctacta ccttcaagat
     1681 atcaaagaaa caaacaacac aggatctgat gtgtatttca taggggtaca gtctaagtca
     1741 cctgttgtct gcttgtaatg ttttctgagg aattatttat taactctggg aacttcacag
     1801 atgtagagga agtggaacgt gctggctggc tgcagatgga gcaagcttgg tctgcccatg
     1861 acttatccag acagggtgcc caaccaaccc ctcttttttt tttctttcca cacagagcct
     1921 taagtgtgta gccaagaatc cttctgctca gcttctctac tgcagatcag acagtttgac
     1981 ttggggtggt gaagcagtgt ggcataagac ccaaggtttc attctctata ttagatagcc
     2041 tgttagctca aaaaaaaaaa gcattttgag aatatttgac aagttgaaga cacaataaac
     2101 atgaaaaggg gaaagttgta aacgtgtcac attagcaacc acgctgaatg tcttctgaat
     2161 ccctagtgtt ctcaagaaaa gaacgggttc taagtcccag atgttgcctg gcgagcatcc
     2221 tcagggaaat agtgtgggta gccatttgac aactccagca agaatatatc agttctcagt
     2281 tcataggagt agaaaatata gttagaaaaa tgataatcca atggaagaaa ggaaaaaaag
     2341 agggagtggt aaacaaagaa aatatgatgt ttggaaatca ccatataaac agaaagaatc
     2401 ttgagtatat ccacagtgcc aacaaacaaa aacaaaagcc aaacaagaaa tgctcctgct
     2461 agctagaatc aagattgtta gaacatgctt cgtttttaaa atgcttagca gttttattga
     2521 tgttttatta atcacccacc tgaagtatac catccaacga catatagtaa atttgtgctc
     2581 acattgcc
//
