LOCUS       NM_080633               2785 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aconitase 2, mitochondrial (Aco2), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_080633
VERSION     NM_080633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Zhu,J., Xu,F., Lai,H., Yuan,H., Li,X.Y., Hu,J., Li,W., Liu,L. and
            Wang,C.
  TITLE     ACO2 deficiency increases vulnerability to Parkinson's disease via
            dysregulating mitochondrial function and histone
            acetylation-mediated transcription of autophagy genes
  JOURNAL   Commun Biol 6 (1), 1201 (2023)
   PUBMED   38007539
  REMARK    GeneRIF: ACO2 deficiency increases vulnerability to Parkinson's
            disease via dysregulating mitochondrial function and histone
            acetylation-mediated transcription of autophagy genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2785)
  AUTHORS   Mirhadi,S., Zhang,W., Pham,N.A., Karimzadeh,F., Pintilie,M.,
            Tong,J., Taylor,P., Krieger,J., Pitcher,B., Sykes,J.,
            Wybenga-Groot,L., Fladd,C., Xu,J., Wang,T., Cabanero,M., Li,M.,
            Weiss,J., Sakashita,S., Zaslaver,O., Yu,M., Caudy,A.A.,
            St-Pierre,J., Hawkins,C., Kislinger,T., Liu,G., Shepherd,F.A.,
            Tsao,M.S. and Moran,M.F.
  TITLE     Mitochondrial Aconitase ACO2 Links Iron Homeostasis with
            Tumorigenicity in Non-Small Cell Lung Cancer
  JOURNAL   Mol Cancer Res 21 (1), 36-50 (2023)
   PUBMED   36214668
  REMARK    GeneRIF: Mitochondrial Aconitase ACO2 Links Iron Homeostasis with
            Tumorigenicity in Non-Small Cell Lung Cancer.
REFERENCE   5  (bases 1 to 2785)
  AUTHORS   Yook,J.S., You,M., Kim,J., Toney,A.M., Fan,R., Puniya,B.L.,
            Helikar,T., Vaulont,S., Deschemin,J.C., Okla,M., Xie,L.,
            Ghosh,M.C., Rouault,T.A., Lee,J. and Chung,S.
  TITLE     Essential role of systemic iron mobilization and redistribution for
            adaptive thermogenesis through HIF2-alpha/hepcidin axis
  JOURNAL   Proc Natl Acad Sci U S A 118 (40) (2021)
   PUBMED   34593646
REFERENCE   6  (bases 1 to 2785)
  AUTHORS   Peters,L.L., Weier,H.U., Walensky,L.D., Snyder,S.H., Parra,M.,
            Mohandas,N. and Conboy,J.G.
  TITLE     Four paralogous protein 4.1 genes map to distinct chromosomes in
            mouse and human
  JOURNAL   Genomics 54 (2), 348-350 (1998)
   PUBMED   9828140
REFERENCE   7  (bases 1 to 2785)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   8  (bases 1 to 2785)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 2785)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (bases 1 to 2785)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI987806.1, BY732916.1, CA750686.1, CO426953.1, CO429053.1 and
            BQ031215.1.
            
            On Aug 31, 2005 this sequence version replaced NM_080633.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145511.1, BC004645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BI987806.1         1-102
            103-653             BY732916.1         86-636
            654-1066            CA750686.1         40-452
            1067-1754           CO426953.1         1-688
            1755-2258           CO429053.1         146-649
            2259-2785           BQ031215.1         1-527               c
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.26 cM"
     gene            1..2785
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /note="aconitase 2, mitochondrial"
                     /db_xref="GeneID:11429"
                     /db_xref="MGI:MGI:87880"
     exon            1..86
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2393
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /EC_number="4.2.1.3"
                     /note="aconitate hydratase, mitochondrial; citrate
                     hydro-lyase"
                     /codon_start=1
                     /product="aconitate hydratase, mitochondrial precursor"
                     /protein_id="NP_542364.1"
                     /db_xref="CCDS:CCDS27675.1"
                     /db_xref="GeneID:11429"
                     /db_xref="MGI:MGI:87880"
                     /translation="MAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPSEYIR
                     YDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDAT
                     AQMAMLQFISSGLPKVAVPSTIHCDHLIEAQVGGEKDLRRAKDINQEVYNFLATAGAK
                     YGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMA
                     GIPWELKCPKVIGVKLTGSLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSIS
                     CTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRTDIANLAEEFKDHLVPDPGCQY
                     DQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEKEGWPLDIRVGLIGSCTNSSYED
                     MGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGP
                     CIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFN
                     PETDFLTGKDGKKFKLEAPDADELPRSDFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQ
                     LLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINI
                     ENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLG
                     GRAIITKSFARIHETNLKKQGLLPLTFADPSDYNKIHPVDKLTIQGLKDFAPGKPLKC
                     VIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ"
     exon            87..223
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..482
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..575
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..734
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..885
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..990
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1082
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1188
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1346
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1420
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1532
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1655
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1811
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2003
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2136
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2258
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2768
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /note="hexamer: AAGAAA"
     polyA_site      2764
                     /gene="Aco2"
                     /gene_synonym="Aco-2; Aco3; D10Wsu183e; Irp1"
                     /note="major polyA site"
ORIGIN      
        1 gccatttgtc acgtcacttt catgcgacct catctttgtc agtgcacaaa atggcgcctt
       61 acagcctcct ggtcacccgg ctgcagaagg ccctgggtgt gcggcagtac catgtggcct
      121 ctgtcctgtg ccaacgggcc aaggtggcca tgagccattt tgagcccagt gagtacatcc
      181 gatatgacct gctagagaag aacattaaca ttgtccgtaa acggttgaac cggcctctta
      241 ctctctcaga gaagattgta tatggacacc tggatgaccc agccaaccag gagatcgagc
      301 ggggaaagac atacctgcgt ttacggcccg accgggtggc catgcaggat gccacagccc
      361 agatggctat gctacagttc attagcagtg ggctgcctaa ggtggctgta ccatcaacca
      421 tccactgtga tcatctgatt gaggcccagg ttgggggtga gaaagacctg cgcagggcca
      481 aggacataaa ccaggaagtg tataatttcc tggcaactgc aggtgccaag tatggtgtgg
      541 gcttctggag gcctggatct gggatcattc accagatcat tctagaaaac tatgcatacc
      601 ctggagttct tctgatcggc actgattcgc acacccccaa tggtggtggc ctgggaggca
      661 tctgcattgg agtagggggt gctgatgctg tggatgtcat ggctgggatc ccctgggagc
      721 tgaagtgtcc caaggtgatc ggtgtgaagc tgacaggctc cctctctggt tggacctcac
      781 ccaaagatgt gatcctgaaa gtggcaggta tcctcacggt gaaaggtggc acaggtgcta
      841 ttgtggaata ccacggaccc ggtgtcgatt ccatctcctg cactggcatg gcaactatct
      901 gcaacatggg tgcagaaatt ggggccacta cgtcagtgtt cccatacaac cacaggatga
      961 aaaagtacct gagcaagaca ggccgaacag acattgccaa cctagcagaa gaattcaagg
     1021 atcacttagt gcctgatcct ggctgccagt atgaccaagt gattgaaatt aacctcaatg
     1081 agctaaagcc acatatcaat gggcccttta cccctgactt ggctcaccca gtggcagatg
     1141 tggggactgt ggcagagaag gaaggctggc ctctggacat cagagtaggt ttgattggca
     1201 gctgcaccaa ttcaagctat gaggacatgg gacgatcagc agctgtggct aagcaggcat
     1261 tggcccacgg actcaagtgc aagtcccagt tcaccatcac cccaggctct gagcagatcc
     1321 gtgccactat tgagcgggat ggctatgcac agatcttaag ggatgtgggt ggaatcgttt
     1381 tggccaatgc ctgtggccct tgcatcggcc agtgggacag aaaagacatc aagaaggggg
     1441 agaagaatac aatcgtcacc tcttacaaca ggaacttcac aggccgtaat gatgcaaacc
     1501 ctgagaccca tgcctttgtc acatccccag agattgtcac agctctggcc attgcaggaa
     1561 ccctgaagtt caatccagaa actgacttct taacaggcaa ggacggcaag aagttcaagt
     1621 tggaggctcc agatgcagac gagcttcccc gatcggactt tgatccaggg caggacacat
     1681 accagcaccc ccctaaggac agcagtgggc agcgggtgga cgtgagccct accagccagc
     1741 gcctgcagct cctggagcct ttcgacaagt gggacggcaa agacctcgag gacctgcaaa
     1801 tcctcatcaa ggtcaaaggg aagtgcacca cagaccacat ttctgctgcc ggcccctggc
     1861 tcaagttccg tgggcatctg gataacatct ctaacaacct gctcatcggt gccatcaaca
     1921 tcgaaaatgg caaagccaac tctgtacgca atgctgtcac ccaggagttt ggccctgtac
     1981 ctgacactgc tcgctactac aagaaacatg gcatcaggtg ggtggtgatt ggagatgaga
     2041 actatggtga gggctcaagc cgggagcatg cagcactgga gcctcgccac cttgggggcc
     2101 gggccatcat caccaagagc ttcgccagga tccacgaaac caatctaaag aagcagggct
     2161 tgctgcccct caccttcgct gacccctccg actataacaa gattcatcca gtggacaagc
     2221 tgaccattca aggcctgaag gactttgccc ctggaaagcc tctgaagtgc gtcatcaagc
     2281 accccaatgg gacccaggag accatcctcc tgaaccacac cttcaacgag acccagatcg
     2341 agtggttccg tgcaggcagt gccctcaaca ggatgaagga gctgcagcag tgaggagcca
     2401 ggctggctgt cctgacccac tctggaccct gctggatgtc acttttgtca caggtccatg
     2461 tgcatcatca gagcctaatc tggtctgtgc agcatgacct cctgctctaa gatggtgacc
     2521 agacctgctt cctgcctagc ctcagcccag tgaaccacca ttgagggcgt ttaagataat
     2581 gttccagccc cgccttcctg ttcagtttgg tttctctttg agcagcccat gcaactgtat
     2641 ttatttttga tgacagcact ccctctacag aagtttttat tctgcctgat catttcactg
     2701 gtggctgaag gattttagag aaacttgttc ttaaaagaaa aaaaaaaaga tccatatcta
     2761 ttaatgttaa aaaaaaaaaa aaaaa
//
