LOCUS       NM_001033041            2726 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus amino carboxymuconate semialdehyde decarboxylase
            (Acmsd), mRNA.
ACCESSION   NM_001033041
VERSION     NM_001033041.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2726)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2726)
  AUTHORS   Koshiguchi,M., Hirai,S. and Egashira,Y.
  TITLE     PGC1alpha regulates ACMSD expression through cooperation with
            HNF4alpha
  JOURNAL   Amino Acids 50 (12), 1769-1773 (2018)
   PUBMED   30232574
  REMARK    GeneRIF: These results indicate that PGC1alpha is involved in Acmsd
            expression through cooperation with HNF4alpha.
REFERENCE   3  (bases 1 to 2726)
  AUTHORS   Katsyuba,E., Mottis,A., Zietak,M., De Franco,F., van der Velpen,V.,
            Gariani,K., Ryu,D., Cialabrini,L., Matilainen,O., Liscio,P.,
            Giacche,N., Stokar-Regenscheit,N., Legouis,D., de Seigneux,S.,
            Ivanisevic,J., Raffaelli,N., Schoonjans,K., Pellicciari,R. and
            Auwerx,J.
  TITLE     De novo NAD+ synthesis enhances mitochondrial function and improves
            health
  JOURNAL   Nature 563 (7731), 354-359 (2018)
   PUBMED   30356218
  REMARK    GeneRIF: alpha-amino-beta-carboxymuconate-epsilon-semialdehyde
            decarboxylase (ACMSD), the enzyme that limits spontaneous
            cyclization of
            alpha-amino-beta-carboxymuconate-epsilon-semialdehyde in the de
            novo NAD(+) synthesis pathway, controls cellular NAD(+) levels via
            an evolutionarily conserved mechanism in Caenorhabditis elegans and
            mouse
REFERENCE   4  (bases 1 to 2726)
  AUTHORS   Shin,M., Kim,I., Inoue,Y., Kimura,S. and Gonzalez,F.J.
  TITLE     Regulation of mouse hepatic
            alpha-amino-beta-carboxymuconate-epsilon-semialdehyde
            decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine
            dinucleotide pathway, by hepatocyte nuclear factor 4alpha and
            peroxisome proliferator-activated receptor alpha
  JOURNAL   Mol Pharmacol 70 (4), 1281-1290 (2006)
   PUBMED   16807375
  REMARK    GeneRIF: Acmsd gene expression was found to be under the control of
            both hepatocyte nuclear factor 4alpha (HNF4alpha) and peroxisome
            proliferator-activated receptor alpha (PPARalpha).
REFERENCE   5  (bases 1 to 2726)
  AUTHORS   Fukuoka,S., Ishiguro,K., Yanagihara,K., Tanabe,A., Egashira,Y.,
            Sanada,H. and Shibata,K.
  TITLE     Identification and expression of a cDNA encoding human
            alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
            (ACMSD). A key enzyme for the tryptophan-niacine pathway and
            'quinolinate hypothesis'
  JOURNAL   J Biol Chem 277 (38), 35162-35167 (2002)
   PUBMED   12140278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132109.3 and AC121883.2.
            
            On Oct 12, 2022 this sequence version replaced NM_001033041.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143962.1, BC139281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC132109.3         12696-12826         c
            132-176             AC132109.3         3643-3687           c
            177-273             AC132109.3         2199-2295           c
            274-323             AC121883.2         112204-112253
            324-560             AC121883.2         115417-115653
            561-654             AC121883.2         120216-120309
            655-750             AC121883.2         124432-124527
            751-923             AC121883.2         126087-126259
            924-1022            AC121883.2         132308-132406
            1023-2726           AC121883.2         132711-134414
FEATURES             Location/Qualifiers
     source          1..2726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 55.8 cM"
     gene            1..2726
                     /gene="Acmsd"
                     /note="amino carboxymuconate semialdehyde decarboxylase"
                     /db_xref="GeneID:266645"
                     /db_xref="MGI:MGI:2386323"
     exon            1..131
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1085
                     /gene="Acmsd"
                     /EC_number="4.1.1.45"
                     /note="picolinate carboxylase"
                     /codon_start=1
                     /product="2-amino-3-carboxymuconate-6-semialdehyde
                     decarboxylase"
                     /protein_id="NP_001028213.1"
                     /db_xref="CCDS:CCDS15247.1"
                     /db_xref="GeneID:266645"
                     /db_xref="MGI:MGI:2386323"
                     /translation="MKIDIHTHILPKEWPDLEKRFGYGGWVQLQQQGKGEAKMIKDGK
                     LFRVIQQNCWDPEVRIREMNQKGVTVQALSTVPVMFSYWAKPKDTLELCQFLNNDLAA
                     TVARYPRRFVGLGTLPMQAPELAVEEMERCVKALGFPGIQIGSHINTWDLNDPELFPI
                     YAAAERLNCSLFVHPWDMQMDGRMAKYWLPWLVGMPSETTMAICSMIMGGVFEKFPKL
                     KVCFAHGGGAFPFTIGRIAHGFNMRPDLCAQDNPSDPRKYLGSFYTDSLVHDPLSLKL
                     LTDVIGKDKVMLGTDYPFPLGEQEPGKLIESMAEFDEETKDKLTAGNALAFLGLERKL
                     FE"
     exon            132..176
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     exon            177..273
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     exon            274..323
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     exon            324..560
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     exon            561..654
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     exon            655..750
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     exon            751..923
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1022
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..2726
                     /gene="Acmsd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2698..2703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acmsd"
                     /note="hexamer: AATAAA"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acmsd"
                     /note="hexamer: AACAAA"
     polyA_site      2719
                     /gene="Acmsd"
                     /note="major polyA site"
     polyA_site      2726
                     /gene="Acmsd"
ORIGIN      
        1 gattttcacg ctgatctctc catatcagaa tttccctttt tgtatgtaca cgtgtctcct
       61 ctggtcctgt ggagatgaaa attgacatcc acactcatat tctaccaaag gaatggcccg
      121 atctagaaaa gaggtttggc tatggaggct gggtgcagct ccaacagcaa ggcaagggag
      181 aagcaaagat gataaaagat gggaagctct tcagagtgat ccaacagaac tgctgggacc
      241 cagaagttcg tatcagagaa atgaaccaga aaggagtgac agtccaagct ctttccacag
      301 ttcctgtcat gtttagctac tgggccaaac ctaaggatac tttggagctg tgccagtttt
      361 taaacaatga cctagctgcc accgttgcca gataccctcg aaggtttgtg ggtttgggga
      421 cgttgcctat gcaagccccg gagctggccg tcgaggagat ggagcgttgt gttaaggcgc
      481 taggatttcc aggaatccag attggctccc acatcaacac atgggacctg aatgacccgg
      541 aactcttccc aatctatgct gcggccgaga ggctgaactg ttctctgttc gtgcatccct
      601 gggatatgca gatggatgga cgaatggcca aatactggct gccttggctc gtaggaatgc
      661 catcggagac caccatggcc atttgctcca tgatcatggg tggggtgttt gagaagtttc
      721 ccaaactcaa agtgtgcttc gcacacggag gtggtgcttt ccccttcacc ataggaagaa
      781 ttgcccatgg attcaacatg cgcccagatc tctgtgccca ggacaatccg tctgacccca
      841 gaaaatacct tggctccttc tacacagact ccctggttca cgatcctctg tctctcaagc
      901 tattgacaga tgtcatagga aaggataaag tcatgctggg aactgattac ccctttcctc
      961 tgggcgagca ggagcctggg aagctgatag agtccatggc agagtttgat gaagaaacaa
     1021 aggataaact tacagctggc aatgccttgg cttttttggg tcttgagaga aaactatttg
     1081 aatgacagaa ttaagcacac acaaaaaaac tttcgagaag ctacgtcact tctgtttttg
     1141 aacatgagct atacacacat ctattttgaa ttatgttacc ccaaaaatgg aatatccccc
     1201 tcaggatgaa gcaagaggat cagcaattca agttccagac cagtctgggc tacttgagac
     1261 tgtctaaaac aagggtgggg gtaatatttt caatattcta acttattaat aacaaaatgt
     1321 tttataaggt ctttattctg aaatgtaata ttctgagaag tgtatattac tacatagcaa
     1381 atcaaaacca tttgatttga aagagataaa aaattaatat ataattaatg atttaaatag
     1441 aaaaatccaa taccagcttt attctagaag gctcggggtc tctatgttga ctgaagatat
     1501 gggaaatgta cccaaataat aaggtttttt ccagttgtaa ccctttctgc tagcctagtc
     1561 attcaatggg aatgttttta tctttgtaaa gtacacatag gctatgcaca agctcaaatg
     1621 ttctaaaagc cagttaagaa agcaaggtaa atgcttatgg aataaatgct gacccaacac
     1681 aaaatggttt tgatttgcat atgtagtaat gtactacaaa ctcattttag cctcccacag
     1741 ttggatagat cttagaattt gacctgagtc tggaaggatg gatgaacatt tctttaaaaa
     1801 gtaaaaagat gttggtcggg catcacggta catgcctctt acatcagcac tcaggaggca
     1861 gagacaggca atgggtctgt gtttgaggcc agcttggtct gcatagcaag ctctaggata
     1921 gccagccagt gatacacagt gaaaccttgc ctcaaaaaga aataggtagg cttggagaga
     1981 tggctcagca attaagaaca ctgattgctc ttccagaggt cctgagttca attcccagca
     2041 accacatggt ggctcacaac catttgtaat gggatctgat gtcctcttct ggtgtcactg
     2101 aagaaagtga cagtgtactc acatacataa aataaataat gtttctttta aaaaataaat
     2161 atgtaaacag aagatgggag ctggaccaga agagaagaag tttgaaacca caggtgtgac
     2221 ttaagagcgg atgaaacttt tctaaaagga atgtcatcta tacgtttccc tttagcagag
     2281 caggaggcag agttaactct ggggagggag gaacaccatg acacccttgt tctaggccct
     2341 tactgctcca cctgagtagc tgtaaaggaa cttgggcatg gggtggggtg gcaggcagca
     2401 tctctcctcc acatgcctat ggctgcatca aataatcctt ccatagcaca cgcttaactt
     2461 tggactcacg cataactccc ttcctttcca ttctagtaca aagccaggct ccctattaac
     2521 aggtgactgg agctgcctcg atgacagaga aagaagagag ctaactaata cccatgaccc
     2581 cattctgctc ttctccccat ccatgtctca atgctccatc tccttcctga tctcttgttt
     2641 tctagaattt tcaccaacta tgactctact tactagtcta atctgtcttg aaagaaaaat
     2701 aaagttgaac aaaacaacac ttggaa
//
