LOCUS       NM_134037               4408 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus ATP citrate lyase (Acly), transcript variant 2, mRNA.
ACCESSION   NM_134037
VERSION     NM_134037.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4408)
  AUTHORS   Rauckhorst,A.J., Sheldon,R.D., Pape,D.J., Ahmed,A.,
            Falls-Hubert,K.C., Merrill,R.A., Brown,R.F., Deshmukh,K.,
            Vallim,T.A., Deja,S., Burgess,S.C. and Taylor,E.B.
  TITLE     A hierarchical hepatic de novo lipogenesis substrate supply network
            utilizing pyruvate, acetate, and ketones
  JOURNAL   Cell Metab 37 (1), 255-273 (2025)
   PUBMED   39471817
REFERENCE   2  (bases 1 to 4408)
  AUTHORS   Schneider,A., Won,S., Armstrong,E.A., Cooper,A.J., Suresh,A.,
            Rivera,R., Barrett-Wilt,G., Denu,J.M., Simcox,J.A. and Svaren,J.
  TITLE     The role of ATP citrate lyase in myelin formation and maintenance
  JOURNAL   Glia 73 (1), 105-121 (2025)
   PUBMED   39318247
REFERENCE   3  (bases 1 to 4408)
  AUTHORS   Kaymak,I., Watson,M.J., Oswald,B.M., Ma,S., Johnson,B.K.,
            DeCamp,L.M., Mabvakure,B.M., Luda,K.M., Ma,E.H., Lau,K., Fu,Z.,
            Muhire,B., Kitchen-Goosen,S.M., Vander Ark,A., Dahabieh,M.S.,
            Samborska,B., Vos,M., Shen,H., Fan,Z.P., Roddy,T.P.,
            Kingsbury,G.A., Sousa,C.M., Krawczyk,C.M., Williams,K.S.,
            Sheldon,R.D., Kaech,S.M., Roy,D.G. and Jones,R.G.
  TITLE     ACLY and ACSS2 link nutrient-dependent chromatin accessibility to
            CD8 T cell effector responses
  JOURNAL   J Exp Med 221 (9) (2024)
   PUBMED   39150482
REFERENCE   4  (bases 1 to 4408)
  AUTHORS   Lazaropoulos,M.P., Gibb,A.A., Chapski,D.J., Nair,A.A., Reiter,A.N.,
            Roy,R., Eaton,D.M., Bedi,K.C. Jr., Margulies,K.B., Wellen,K.E.,
            Estaras,C., Vondriska,T.M. and Elrod,J.W.
  TITLE     Nuclear ATP-citrate lyase regulates chromatin-dependent activation
            and maintenance of the myofibroblast gene program
  JOURNAL   Nat Cardiovasc Res 3 (7), 869-882 (2024)
   PUBMED   39196175
REFERENCE   5  (bases 1 to 4408)
  AUTHORS   Supplee,J.G., Affronti,H.C., Duan,R., Brooks,R.C., Stine,Z.E.,
            Nguyen,P.T.T., Pinheiro,L.V., Noji,M.C., Drummond,J.M., Huang,K.,
            Schultz,K., Dang,C.V., Marmorstein,R. and Wellen,K.E.
  TITLE     ACLY alternative splicing correlates with cancer phenotypes
  JOURNAL   J Biol Chem 300 (7), 107418 (2024)
   PUBMED   38815867
REFERENCE   6  (bases 1 to 4408)
  AUTHORS   Ehringer,M.A., Thompson,J., Conroy,O., Xu,Y., Yang,F., Canniff,J.,
            Beeson,M., Gordon,L., Bennett,B., Johnson,T.E. and Sikela,J.M.
  TITLE     High-throughput sequence identification of gene coding variants
            within alcohol-related QTLs
  JOURNAL   Mamm Genome 12 (8), 657-663 (2001)
   PUBMED   11471062
REFERENCE   7  (bases 1 to 4408)
  AUTHORS   Shimomura,I., Shimano,H., Korn,B.S., Bashmakov,Y. and Horton,J.D.
  TITLE     Nuclear sterol regulatory element-binding proteins activate genes
            responsible for the entire program of unsaturated fatty acid
            biosynthesis in transgenic mouse liver
  JOURNAL   J Biol Chem 273 (52), 35299-35306 (1998)
   PUBMED   9857071
REFERENCE   8  (bases 1 to 4408)
  AUTHORS   Nomura,M., Takihara,Y. and Shimada,K.
  TITLE     Isolation and characterization of retinoic acid-inducible cDNA
            clones in F9 cells: one of the early inducible clones encodes a
            novel protein sharing several highly homologous regions with a
            Drosophila polyhomeotic protein
  JOURNAL   Differentiation 57 (1), 39-50 (1994)
   PUBMED   8070621
REFERENCE   9  (bases 1 to 4408)
  AUTHORS   Couch,F.J., Abel,K.J., Brody,L.C., Boehnke,M., Collins,F.S. and
            Weber,B.L.
  TITLE     Localization of the gene for ATP citrate lyase (ACLY) distal to
            gastrin(GAS) and proximal to D17S856 on chromosome 17q12-q21
  JOURNAL   Genomics 21 (2), 444-446 (1994)
   PUBMED   8088842
REFERENCE   10 (bases 1 to 4408)
  AUTHORS   Elshourbagy,N.A., Near,J.C., Kmetz,P.J., Wells,T.N., Groot,P.H.,
            Saxty,B.A., Hughes,S.A., Franklin,M. and Gloger,I.S.
  TITLE     Cloning and expression of a human ATP-citrate lyase cDNA
  JOURNAL   Eur J Biochem 204 (2), 491-499 (1992)
   PUBMED   1371749
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX842667.2, BC056378.1 and BE623317.1.
            
            On Dec 2, 2010 this sequence version replaced NM_134037.2.
            
            Transcript Variant: This variant (2) lacks an alternate, in-frame,
            exon in the middle of the coding region, compared to variant 1. The
            resulting protein (isoform 2) is shorter when it is compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056378.1, AK169703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                BX842667.2         29786-29884         c
            100-4393            BC056378.1         1-4294
            4394-4408           BE623317.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..4408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 63.47 cM"
     gene            1..4408
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /note="ATP citrate lyase"
                     /db_xref="GeneID:104112"
                     /db_xref="MGI:MGI:103251"
     exon            1..206
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            207..388
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..3505
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /EC_number="2.3.3.8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ATP-citrate synthase; citrate cleavage enzyme; ATP-citrate
                     (pro-S-)-lyase"
                     /codon_start=1
                     /product="ATP-citrate synthase isoform 2"
                     /protein_id="NP_598798.1"
                     /db_xref="CCDS:CCDS25425.1"
                     /db_xref="GeneID:104112"
                     /db_xref="MGI:MGI:103251"
                     /translation="MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWAHLL
                     QDHPWLLSQSLVVKPDQLIKRRGKLGLVGVNLSLDGVKSWLKPRLGHEATVGKAKGFL
                     KNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKL
                     NTEDIKRHLLVHAPEDKKEVLASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLA
                     AKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIW
                     TMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPE
                     GKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMG
                     EVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAP
                     SRTASFSESRADEVAPAKKAKPAMPQGKSATLFSRHTKAIVWGMQTRAVQGMLDFDYV
                     CSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMKKHPEVDVLINFASLR
                     SAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCF
                     KIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRY
                     PGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPVVCWCIGTCAT
                     MFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVAKG
                     AIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEE
                     MGIGGVLGLLWFQRRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSL
                     TSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINN
                     PDMRVQILKDFVKQHFPATPLLDYALEVEKITTSKKPNLILNVDGFIGVAFVDMLRNC
                     GSFTREEADEYVDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEH
                     MSM"
     exon            389..511
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            512..574
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            575..765
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            766..845
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            846..976
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1095
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1232
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1294
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1412
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1567
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1658
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1800
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1969
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2074
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2271
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2353
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2464
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2592
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2686
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2841
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2842..2992
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3136
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3250
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3333
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3334..3410
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3411..4397
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4374..4379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4393
                     /gene="Acly"
                     /gene_synonym="A730098H14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggaggagcct agagctcagg ctagggaacg cgtgtgccca atcgccgggc tgcttagcct
       61 gtgagctgat ggggggcggg gaggagccca cttgggccgg aacaaaagcc ggatccccgg
      121 ctgctgcagg cggctggagc gatccgaaga gttggggtga gctggtgctt acggacagag
      181 agccacactc aggctttctc gaagaggtaa accaggtctc tctgcagcca tgtcagccaa
      241 ggcaatttca gagcagaccg gcaaagaact cctgtacaag tacatctgca ccacctcggc
      301 catccagaac cggttcaagt acgcccgggt gactcccgac acagactggg cccatctgct
      361 gcaggaccac ccgtggctgc tcagccagag cttggttgtc aagccagacc agttaatcaa
      421 acgtcgagga aagcttggcc tcgtcggggt caatctctct ctggatggag tcaaatcctg
      481 gctaaaacct cgcctgggac atgaagccac tgtcggcaag gccaaaggct tcctcaagaa
      541 ctttctcatt gaacccttcg tcccccacag tcaggcggag gagttctacg tgtgcatcta
      601 tgctacccgg gaaggagact acgtcctgtt ccaccatgaa gggggtgtgg atgtgggcga
      661 tgtggatgcc aaagcccaga agctgcttgt gggtgtggac gaaaagctga ataccgagga
      721 cattaagaga cacctgttgg tccatgcacc tgaggacaag aaagaagtcc tggccagctt
      781 catctctggt ctattcaatt tctacgagga tctgtacttc acctaccttg agatcaaccc
      841 ccttgtggtg accaaagatg gtgtctacat ccttgacttg gcggccaagg tggatgccac
      901 agctgactac atctgtaaag tcaagtgggg tgatatagag ttccctcccc cctttgggcg
      961 tgaggcgtac cccgaggaag cctacattgc agacctggat gccaaaagtg gagcaagctt
     1021 gaagctgacc ttgctgaacc ccaaggggcg gatctggacc atggttgctg ggggtggcgc
     1081 ctccgtcgtg tacagtgaca ccatctgtga tcttggaggt gtcaatgaac tggcgaatta
     1141 cggggaatac tcgggtgccc ccagtgaaca acagacctat gactatgcca agaccatcct
     1201 ctcacttatg actcgagaga agcacccaga aggcaagatc ctcatcattg gaggcagcat
     1261 tgcaaacttc accaatgtgg ccgccacctt caagggcatt gtgagagcga ttcgagatta
     1321 ccagggtccc ctgaaggagc atgaggtcac catctttgtc cgaagaggtg gccccaacta
     1381 tcaagaggga ttacgagtga tgggagaagt tgggaagacc actgggatcc ccatccatgt
     1441 ctttggcaca gaaactcaca tgacggccat tgtgggcatg gccctgggcc accggcccat
     1501 tcccaaccag ccacccacag cagctcacac tgccaacttc ctccttaatg ccagcgggag
     1561 cacatcgact ccagcaccca gtaggacagc atctttttct gagtcccgag ctgatgaagt
     1621 ggcacctgca aagaaagcca agccagctat gccccaagga aagagtgcca ccctcttcag
     1681 ccgacatacc aaggccatcg tgtggggcat gcagacccgg gctgtgcagg gcatgctgga
     1741 ctttgactac gtgtgttccc gagacgagcc ctcagtggct gccatggtct accctttcac
     1801 tggggatcac aagcagaagt tttactgggg acacaaggaa atcctgatcc ctgtcttcaa
     1861 gaacatggct gacgccatga agaagcaccc ggaggtagac gtgctgatca actttgcgtc
     1921 tctgcggtcc gcttacgaca gcaccatgga gaccatgaac tatgcccaga tccgcaccat
     1981 agccatcata gcagaaggta tccctgaggc cctcacacgg aagctcatca agaaggccga
     2041 ccagaaggga gtgaccatca ttgggccagc tacggttggg ggcattaagc ctggatgctt
     2101 taagatcggg aatactggtg gaatgctgga caacatcctg gcctccaaac tgtaccgccc
     2161 aggcagcgtg gcctacgtct cacgttcagg aggcatgtct aatgaactca ataacatcat
     2221 ctctcggacc acagatggtg tctatgaggg cgtggccatc ggcggggaca ggtaccctgg
     2281 gtccacattc atggatcacg tgctgcgcta ccaggacact ccaggagtca agatgatcgt
     2341 agttcttggg gagatagggg gcacagagga atataagatc tgccggggca tcaaggaggg
     2401 ccgcctcacc aagccagtgg tctgctggtg tatcgggacc tgtgccacca tgttctcctc
     2461 cgaggtccag tttggccatg ctggagcttg tgccaaccag gcttctgaaa ctgcagtagc
     2521 caagaaccag gccttgaagg aagcaggagt gtttgtgccc cgaagcttcg atgagcttgg
     2581 agaaatcatt cagtctgtgt atgaagatct ggtggccaaa ggagccattg tacctgccca
     2641 ggaagtgcca cctccaacag tgcccatgga ctactcttgg gccagagagc tgggtttgat
     2701 ccgaaaacct gcctcattca tgaccagcat ctgtgatgag cgagggcagg agctcattta
     2761 tgcgggcatg cccatcaccg aggtcttcaa ggaggagatg ggcatcggtg gtgtcctcgg
     2821 cctcctctgg ttccagagaa ggttgcccaa gtattcctgc cagttcattg agatgtgtct
     2881 gatggtcaca gctgatcacg ggccagctgt ctctggagcc cataacacca tcatctgtgc
     2941 tcgggctggg aaggacctgg tctccagcct cacctcaggg ctgctcacca ttggagaccg
     3001 gtttgggggt gccttggatg ccgcagcaaa gatgttcagt aaagcctttg acagcggcat
     3061 cattcccatg gagttcgtca acaagatgaa gaaggagggg aagctgatca tgggcatcgg
     3121 ccatcgagta aaatcgataa acaacccaga catgcgagtg cagatcctca aggacttcgt
     3181 caaacagcac ttccccgcca ccccgctgct cgactatgcc ctggaagtgg agaagattac
     3241 cacctccaag aagccaaatc ttatcctgaa tgtggacggc ttcatcggcg ttgcgtttgt
     3301 ggacatgctc aggaactgtg gctccttcac ccgggaggaa gctgatgaat atgttgacat
     3361 tggagccctc aatggcatct ttgtgctagg aaggagtatg ggcttcattg ggcactacct
     3421 tgaccagaag aggctgaagc aagggctgta tcgtcacccc tgggatgaca tttcctatgt
     3481 tcttccagaa cacatgagca tgtaactgag ccaggagccc tactgtagga aaaggaagac
     3541 aaaaaccccc tcctcaacaa tatagtggac agatagctgg aagcagagtc cagtataggc
     3601 tgggcctgga gcggaaatag ccattgatgt gcaggcatgg aaggccgaca cccacaggcc
     3661 cattcagtcc acacaaagaa gcttagtatt ttttttatat atctctctat atataagcat
     3721 agaaatttaa aaccaagcca atacctgtga catttgctct gctacctgct gtatctatta
     3781 tatggaaaag tctcagcaag cactgtcaga atagtgttct tctagggcct tatgatgttg
     3841 ctttcttttt tttaattagt taaaaaattt atttttcctc tagaggaagg gaatgcaagt
     3901 tttaagattt taagatacta tctgtaggac cactgtctgg tatcccattt cccgttcagc
     3961 ttcacacaac gtgaagaaca ctgtattaat ctgattttta aggatctttt ttttttctat
     4021 gttatgtgtt aagggtttat ttagtatccc actgaaatgt tccatgttac agaccagtgt
     4081 ctacttatgt caaggggagg agggctggga ccattgtatc cttagccatt gttgcacatg
     4141 tggtgtagta acttaaatgt caagttgtaa catacaagtg tttaaaatgg aaacgcaaag
     4201 caaaaagctg tgaaatgtct tgtgtcagtg tcctctgtgt tcatgcagcc gacttgtctg
     4261 ttactgaagt gtgggtccaa agactcacag ctgttctgca tctgtaaccc acaaagattc
     4321 tgggcagctg ccacctcagt ctcttctctg tgttatctat catgtttgct ttaaataaac
     4381 tagatagtaa caatggcaaa aaaaaaaa
//
