LOCUS       NM_145700               2109 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus atypical chemokine receptor 4 (Ackr4), mRNA.
ACCESSION   NM_145700
VERSION     NM_145700.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2109)
  AUTHORS   Melgrati,S., Gerken,O.J., Artinger,M., Radice,E., Szpakowska,M.,
            Chevigne,A., D'Uonnolo,G., Antonello,P., Thelen,S., Pelczar,P.,
            Legler,D.F. and Thelen,M.
  TITLE     GPR182 is a broadly scavenging atypical chemokine receptor
            influencing T-independent immunity
  JOURNAL   Front Immunol 14, 1242531 (2023)
   PUBMED   37554323
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2109)
  AUTHORS   Jiang,C.Y., Wu,L.W., Liu,Y.W., Feng,B., Ye,L.C., Huang,X., He,Y.Y.,
            Shen,Y., Zhu,Y.F., Zhou,X.L., Jiang,D.J., Qi,H.K., Zhang,H. and
            Yan,Y.
  TITLE     Identification of ACKR4 as an immune checkpoint in pulmonary
            arterial hypertension
  JOURNAL   Front Immunol 14, 1153573 (2023)
   PUBMED   37449198
  REMARK    GeneRIF: Identification of ACKR4 as an immune checkpoint in
            pulmonary arterial hypertension.
            Erratum:[Front Immunol. 2024 Feb 20;15:1382832. doi:
            10.3389/fimmu.2024.1382832.. PMID: 38444849]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2109)
  AUTHORS   Melgrati,S., Radice,E., Ameti,R., Hub,E., Thelen,S., Pelczar,P.,
            Jarrossay,D., Rot,A. and Thelen,M.
  TITLE     Atlas of the anatomical localization of atypical chemokine
            receptors in healthy mice
  JOURNAL   PLoS Biol 21 (5), e3002111 (2023)
   PUBMED   37159457
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2109)
  AUTHORS   Paerregaard,S.I., Wulff,L., Schussek,S., Niss,K., Morbe,U.,
            Jendholm,J., Wendland,K., Andrusaite,A.T., Brulois,K.F.,
            Nibbs,R.J.B., Sitnik,K., Mowat,A.M., Butcher,E.C., Brunak,S. and
            Agace,W.W.
  TITLE     The small and large intestine contain related mesenchymal subsets
            that derive from embryonic Gli1+ precursors
  JOURNAL   Nat Commun 14 (1), 2307 (2023)
   PUBMED   37085516
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2109)
  AUTHORS   Sibler,E., He,Y., Ducoli,L., Rihs,V., Sidler,P., Puig-Moreno,C.,
            Frey,J., Fujimoto,N., Detmar,M. and Dieterich,L.C.
  TITLE     Immunomodulatory Responses of Subcapsular Sinus Floor Lymphatic
            Endothelial Cells in Tumor-Draining Lymph Nodes
  JOURNAL   Cancers (Basel) 14 (15), 3602 (2022)
   PUBMED   35892863
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2109)
  AUTHORS   Rode,I. and Boehm,T.
  TITLE     Regenerative capacity of adult cortical thymic epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 109 (9), 3463-3468 (2012)
   PUBMED   22331880
REFERENCE   7  (bases 1 to 2109)
  AUTHORS   Comerford,I., Nibbs,R.J., Litchfield,W., Bunting,M., Harata-Lee,Y.,
            Haylock-Jacobs,S., Forrow,S., Korner,H. and McColl,S.R.
  TITLE     The atypical chemokine receptor CCX-CKR scavenges homeostatic
            chemokines in circulation and tissues and suppresses Th17 responses
  JOURNAL   Blood 116 (20), 4130-4140 (2010)
   PUBMED   20562329
  REMARK    GeneRIF: CCX-CKR(-/-) have a 5-fold increase in the level of CCL21
            protein in blood, and 2- to 3-fold increases in CCL19 and CCL21 in
            peripheral lymph nodes.
REFERENCE   8  (bases 1 to 2109)
  AUTHORS   Heinzel,K., Benz,C. and Bleul,C.C.
  TITLE     A silent chemokine receptor regulates steady-state leukocyte homing
            in vivo
  JOURNAL   Proc Natl Acad Sci U S A 104 (20), 8421-8426 (2007)
   PUBMED   17485674
  REMARK    GeneRIF: These observations indicate that the silent chemokine
            receptor CCX-CKR1, regulates homeostatic leukocyte migration by
            controlling the availability of chemokines in the extracellular
            space.
REFERENCE   9  (bases 1 to 2109)
  AUTHORS   Townson,J.R. and Nibbs,R.J.
  TITLE     Characterization of mouse CCX-CKR, a receptor for the
            lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and
            MIP-3beta/mCCL19: comparison to human CCX-CKR
  JOURNAL   Eur J Immunol 32 (5), 1230-1241 (2002)
   PUBMED   11981810
  REMARK    GeneRIF: Characterization of mouse CCX-CKR, a receptor for the
            lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and
            MIP-3beta/mCCL19: comparison to human CCX-CKR.  (CCX-CKR)
REFERENCE   10 (bases 1 to 2109)
  AUTHORS   Dorf,M.E., Berman,M.A., Tanabe,S., Heesen,M. and Luo,Y.
  TITLE     Astrocytes express functional chemokine receptors
  JOURNAL   J Neuroimmunol 111 (1-2), 109-121 (2000)
   PUBMED   11063828
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC140999.1, AC145736.4, AK042430.1, AK030643.1 and BB151172.1.
            
            On Mar 27, 2009 this sequence version replaced NM_145700.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC140999.1, AY072938.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849389
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BC140999.1         1-28
            29-119              AC145736.4         61936-62026         c
            120-513             BC140999.1         120-513
            514-1626            AK042430.1         185-1297
            1627-2099           AK030643.1         1193-1665
            2100-2109           BB151172.1         215-224
FEATURES             Location/Qualifiers
     source          1..2109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.47 cM"
     gene            1..2109
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /note="atypical chemokine receptor 4"
                     /db_xref="GeneID:252837"
                     /db_xref="MGI:MGI:2181676"
     exon            1..225
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /inference="alignment:Splign:2.1.0"
     exon            226..491
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..2109
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             501..1553
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /note="chemokine (C-C) receptor-like 1; C-C chemokine
                     receptor type 11; CCR-11; CCX CKR; CC-CKR-11; C-C CKR-11;
                     CC chemokine receptor-like 1; chemokine receptor CCR11;
                     chemokine (C-C motif) receptor-like 1"
                     /codon_start=1
                     /product="atypical chemokine receptor 4"
                     /protein_id="NP_663746.2"
                     /db_xref="CCDS:CCDS23459.1"
                     /db_xref="GeneID:252837"
                     /db_xref="MGI:MGI:2181676"
                     /translation="MALELNQSAEYYYEENEMNYTHDYSQYEVICIKEEVRQFAKVFL
                     PAFFTVAFVTGLAGNSVVVAIYAYYKKQRTKTDVYILNLAVADLLLLITLPFWAVNAV
                     HGWILGKMMCKVTSALYTVNFVSGMQFLACISIDRYWAITKAPSQSGAGRPCWIICCC
                     VWMAAILLSIPQLVFYTVNQNARCTPIFPHHLGTSLKASIQMLEIGIGFVVPFLIMGV
                     CYASTARALIKMPNIKKSRPLRVLLAVVVVFIVTQLPYNVVKFCQAIDAIYLLITSCD
                     MSKRMDVAIQVTESIALFHSCLNPILYVFMGASFKNYIMKVAKKYGSWRRQRQNVEEI
                     PFDSEGPTEPTSSFTI"
     regulatory      2081..2086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /note="hexamer: AATAAA"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /note="hexamer: AAGAAA"
     polyA_site      2097
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /note="major polyA site"
     polyA_site      2106
                     /gene="Ackr4"
                     /gene_synonym="A630091E18Rik; CCBP2; CCR11; Ccrl1;
                     CCX-CKR; CCX-CKR1; Cmkbrl1; PPR1; VSHK1"
                     /note="major polyA site"
ORIGIN      
        1 tcgctgagag gtggacttcg tcagggccgt ctgccaagcg cagggtgcgt atgatggcgt
       61 acctgagaga atggggtcag agttatcaga gagcacaaca ccgtcatgtc atgctcactc
      121 caaaccaagg aaaaggaaca tgaagagaaa ggccaaaggc ttctgaagct gccattttaa
      181 agatctcagc tcagggagat tcaagatggc tacccagagg cgaagctgag tggaaacgga
      241 tgatcctgca gtttgggagc cagactggaa ctccctccat ctgcatccca ggacatttag
      301 gaatttggat ggactccaca ggaaggtttt acagagcact taatcaaggg ctccggaggc
      361 tacgtttcag gaaagctctc ttggatccaa gataaaggcg gggtgtaaaa tagaaaacaa
      421 gagttgcctg actcagagag gtcctctgat ttcctctgcg ctccagacgg cacctctccc
      481 agcttaaaca gctcggtacc atggctctgg agctgaacca gtcagcggaa tactattatg
      541 aggagaatga gatgaactac actcacgact acagccagta cgaagtgatc tgcataaaag
      601 aagaggtcag gcagttcgca aaagtcttcc tgcctgcctt cttcacagtg gcctttgtca
      661 ctgggctcgc agggaactcc gtagttgtgg cgatttacgc ctattacaag aagcagagga
      721 ccaagaccga tgtgtacatc ctgaacctgg ctgtagcaga cttgttactt ctgatcacgc
      781 tgcctttctg ggcagttaat gcagttcacg gatggattct aggcaaaatg atgtgcaaag
      841 taacgtcagc cctgtacacg gtaaactttg tctctgggat gcagttcctg gcttgtatca
      901 gcattgacag atattgggca attaccaaag cccccagcca atcaggagcg gggagaccct
      961 gttggatcat ctgttgctgt gtgtggatgg ccgccatctt gctgagcata ccccagctgg
     1021 ttttttacac agtgaatcag aatgctaggt gcactcccat ctttccccac cacctaggaa
     1081 catccctgaa agcatccatt cagatgctgg aaatcggcat cggctttgtg gtcccgtttc
     1141 tcatcatggg cgtgtgctat gccagtaccg ccagggcgct catcaagatg cccaacatta
     1201 aaaagtctcg ccccctcagg gttctgctcg cggtggtggt ggttttcatt gtcacccagc
     1261 tgccctataa cgttgttaag ttctgccaag ccatagatgc catctacctg ctgatcacca
     1321 gctgcgatat gagcaaacgc atggatgtcg ccatccaagt cacagagagc atcgcgctct
     1381 tccacagctg cctcaacccc atcctgtatg tcttcatggg ggcctccttc aaaaactata
     1441 tcatgaaagt ggccaagaaa tatggatcct ggagaagaca gagacagaac gtggaagaaa
     1501 ttccttttga ttctgagggt cctacagagc caaccagttc ttttaccatt taaatataaa
     1561 actgctctct gcctctgctt tttgcttaga cacacacaca cacacacaca cacacacaca
     1621 cacacaaagt gatgtttcct cctcaaataa aatatttgtg ttacaccgag acccaaccat
     1681 caacaaatac tgttgttgca atttataaca aagaaggagt aaggggtggg gcagggtaag
     1741 gaagacagac gccagagagt aaacaagtgg gcaaagtgtg gaaactaaat ctaatgacag
     1801 gaaaacagct tggcaggagg gagaaacaac gcattgtgcc acaaagagga agtctgtgtg
     1861 tgtgtgtgtg tgtgatggga ggggggtgtt ttgcatcttc accacagtgg tggttattca
     1921 aatctgacag caactgtaat tctgtaatat aaaaccctgg gtaatgcgtg cccacgacca
     1981 tcctgtacta tctctgtaac ttcctgtgag taaacaactt cataataaaa agttaaaaga
     2041 agaaacatca tgctgtgagc ctagcaacct aaaaccaatt aataaagaaa cttatgctaa
     2101 gagaaattt
//
