LOCUS       NM_007722               2052 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus atypical chemokine receptor 3 (Ackr3), transcript
            variant 2, mRNA.
ACCESSION   NM_007722
VERSION     NM_007722.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Meng,P., Liu,C., Li,J., Fang,P., Yang,B., Sun,W. and Zhang,Y.
  TITLE     CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting
            beta-catenin signaling and epithelial-to-mesenchymal transition in
            tubular epithelial cells
  JOURNAL   Ren Fail 46 (1), 2300727 (2024)
   PUBMED   38189094
  REMARK    GeneRIF: CXC chemokine receptor 7 ameliorates renal fibrosis by
            inhibiting beta-catenin signaling and epithelial-to-mesenchymal
            transition in tubular epithelial cells.
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Pineiro-Sabaris,R., MacGrogan,D. and de la Pompa,J.L.
  TITLE     Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve
  JOURNAL   Dis Model Mech 17 (9) (2024)
   PUBMED   39253784
  REMARK    GeneRIF: Deficient GATA6-CXCR7 signaling leads to bicuspid aortic
            valve.
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Dietz,A., Senf,K. and Neuhaus,E.M.
  TITLE     ACKR3 in olfactory glia cells shapes the immune defense of the
            olfactory mucosa
  JOURNAL   Glia 72 (6), 1183-1200 (2024)
   PUBMED   38477581
  REMARK    GeneRIF: ACKR3 in olfactory glia cells shapes the immune defense of
            the olfactory mucosa.
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Fukuoka,A., Wilson,G.J., Pitmon,E., Koumbas Foley,L., Johnsson,H.,
            Pingen,M. and Graham,G.J.
  TITLE     Disruption of placental ACKR3 impairs growth and hematopoietic
            development of offspring
  JOURNAL   Development 151 (4) (2024)
   PUBMED   38300826
  REMARK    GeneRIF: Disruption of placental ACKR3 impairs growth and
            hematopoietic development of offspring.
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Gerrits,H., van Ingen Schenau,D.S., Bakker,N.E., van
            Disseldorp,A.J., Strik,A., Hermens,L.S., Koenen,T.B.,
            Krajnc-Franken,M.A. and Gossen,J.A.
  TITLE     Early postnatal lethality and cardiovascular defects in
            CXCR7-deficient mice
  JOURNAL   Genesis 46 (5), 235-245 (2008)
   PUBMED   18442043
  REMARK    GeneRIF: Seems to play an unimportant role in bone; however, an
            important role is indicated for CXCR7 in the cardiovascular system
            during embryonic and early postnatal development.
REFERENCE   7  (bases 1 to 2052)
  AUTHORS   Sierro,F., Biben,C., Martinez-Munoz,L., Mellado,M., Ransohoff,R.M.,
            Li,M., Woehl,B., Leung,H., Groom,J., Batten,M., Harvey,R.P.,
            Martinez-A,C., Mackay,C.R. and Mackay,F.
  TITLE     Disrupted cardiac development but normal hematopoiesis in mice
            deficient in the second CXCL12/SDF-1 receptor, CXCR7
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14759-14764 (2007)
   PUBMED   17804806
  REMARK    GeneRIF: Disfrupted cardiac development but normal hematopoiesis in
            mice deficient in Cxcr7.
REFERENCE   8  (bases 1 to 2052)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (bases 1 to 2052)
  AUTHORS   Burns,J.M., Summers,B.C., Wang,Y., Melikian,A., Berahovich,R.,
            Miao,Z., Penfold,M.E., Sunshine,M.J., Littman,D.R., Kuo,C.J.,
            Wei,K., McMaster,B.E., Wright,K., Howard,M.C. and Schall,T.J.
  TITLE     A novel chemokine receptor for SDF-1 and I-TAC involved in cell
            survival, cell adhesion, and tumor development
  JOURNAL   J Exp Med 203 (9), 2201-2213 (2006)
   PUBMED   16940167
REFERENCE   10 (bases 1 to 2052)
  AUTHORS   Heesen,M., Berman,M.A., Charest,A., Housman,D., Gerard,C. and
            Dorf,M.E.
  TITLE     Cloning and chromosomal mapping of an orphan chemokine receptor:
            mouse RDC1
  JOURNAL   Immunogenetics 47 (5), 364-370 (1998)
   PUBMED   9510554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110261.25, AK031100.1 and BQ033958.1.
            
            On Oct 24, 2012 this sequence version replaced NM_007722.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015254.1, AK031100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC110261.25        205605-205627
            24-2031             AK031100.1         2-2009
            2032-2052           BQ033958.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 45.28 cM"
     gene            1..2052
                     /gene="Ackr3"
                     /gene_synonym="Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1"
                     /note="atypical chemokine receptor 3"
                     /db_xref="GeneID:12778"
                     /db_xref="MGI:MGI:109562"
     exon            1..108
                     /gene="Ackr3"
                     /gene_synonym="Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            109..2038
                     /gene="Ackr3"
                     /gene_synonym="Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1223
                     /gene="Ackr3"
                     /gene_synonym="Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1"
                     /note="C-X-C chemokine receptor type 7; G-protein coupled
                     receptor RDC1 homolog; chemokine orphan receptor 1;
                     chemokine (C-X-C motif) receptor 7"
                     /codon_start=1
                     /product="atypical chemokine receptor 3"
                     /protein_id="NP_031748.2"
                     /db_xref="CCDS:CCDS15152.1"
                     /db_xref="GeneID:12778"
                     /db_xref="MGI:MGI:109562"
                     /translation="MDVHLFDYAEPGNYSDINWPCNSSDCIVVDTVQCPTMPNKNVLL
                     YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVV
                     SLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTGTSSYKKKMV
                     RRVVCILVWLLAFFVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVI
                     LGFAVPFTIIAIFYFLLARAMSASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDI
                     FSILHYIPFTCQLENVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKY
                     SAKTGLTKLIDASRVSETEYSALEQNTK"
     regulatory      2016..2021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ackr3"
                     /gene_synonym="Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1"
                     /note="hexamer: AATAAA"
     polyA_site      2038
                     /gene="Ackr3"
                     /gene_synonym="Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1"
                     /note="major polyA site"
ORIGIN      
        1 gcaagtccgg agccctgaga gatctcagtt gctacaaact gctcagcact gaaggagcct
       61 gcagcgctca ccgtcaggaa ggcaaaccac agcccaggaa gccctgaggt cacttggtcg
      121 ctctcctcaa gaccatggat gtgcacttgt ttgactatgc agagcctggc aactactctg
      181 acatcaactg gccatgtaac agcagcgact gcattgtggt ggacactgtg cagtgtccca
      241 ccatgcctaa caagaacgtg cttctgtata ccctctcctt catctacatt ttcatcttcg
      301 tgatcggcat gattgccaac tctgtggtgg tctgggtgaa tatccaggct aagaccacag
      361 gctacgacac gcactgctac atcttgaacc tggccattgc agacctgtgg gtcgtcatca
      421 ccatccccgt ctgggtggtc agtctcgtgc agcataacca gtggcccatg ggggagctca
      481 catgcaagat cacacacctc attttctcca tcaacctctt tgggagcatc ttcttcctcg
      541 cctgcatgag cgtggaccgc tatctctcca tcacctactt caccggcacc tccagctata
      601 agaagaagat ggtacgccgt gttgtatgca tcttggtgtg gctgctggcc ttctttgtgt
      661 ccctgcctga tacctactac ctgaagacgg tcacatctgc ttccaacaat gagacctact
      721 gcaggtcctt ctaccccgag cacagcatca aggagtggct gatcggcatg gagctggtct
      781 ctgtcatctt gggctttgct gtccccttca ctatcattgc gatcttctac ttcctgctcg
      841 ctagagccat gtcagcatca ggcgaccagg agaagcacag tagccggaag atcatcttct
      901 cctacgtggt ggtcttcctg gtatgttggc tgccgtacca ttttgtggtt ctgctggaca
      961 tcttctccat cttacactac atcccgttta cctgtcagct ggagaatgtg ctctttacag
     1021 cgttgcatgt cacccagtgc ctgtccttgg tgcactgctg tgtcaacccc gtgctctaca
     1081 gcttcatcaa ccgcaactac aggtacgagc tgatgaaggc cttcatcttc aagtactcgg
     1141 ccaaaacagg tctcaccaag ctcattgatg cctccagagt gtcagagaca gagtactctg
     1201 ccctggaaca gaacaccaag tgatccatca ttctgcagag gtcgggggga cacgtgcatg
     1261 ttgcaaatgg ggcggctggg tcctgtggtt tcttcaagaa agcaatgtag ctttgggtct
     1321 ggttgcttga gtggtatgaa gaggagaagg catgtgacca tgcttcctgt ctctcattct
     1381 ccagccaaga tggctgccgc ctggatgccc atcctgacag ctggcagctg gcagctggca
     1441 gctggcagca ggcagggctg tgctgtgctg tgctgtgctg cgctgtgctg tgctgtgcag
     1501 ccagagctgc gtatcaaagc cagcaccagg acaggctctt atggacatgt gtacagtaga
     1561 atcttctgtg tttcttcaag tttttacttg gtgacttttt gtatttaagt tttaagactt
     1621 tattttctca ctatggatgt accttataaa tgtatttgaa agctaaatat attttaaata
     1681 ttgtatggga ggtgtaaggc tgttgtattc agaccatgta ggcctcagat tagctggact
     1741 tgagttttga ctaaggatga cattaattgt tagctgattt gaaattatat atataaatat
     1801 aaaaatatat ataaatttat gccagtctcg gctgaaaggt tttatttaca atagttttat
     1861 atctgtgcaa tgtttaatgc tggcacagca tatgaaacaa caactgccca gcaatgcagt
     1921 ttgttacatg aaccatattg tagagttaca cttcgggctg caaacccgtg aacaagggaa
     1981 acagagcgtt ctgttgattt gtaagttatt tttttaataa agattttgtt tcctaaaaaa
     2041 aaaaaaaaaa aa
//
