LOCUS       NP_031748                362 aa            linear   ROD 12-NOV-2024
DEFINITION  atypical chemokine receptor 3 [Mus musculus].
ACCESSION   NP_031748
VERSION     NP_031748.2
DBSOURCE    REFSEQ: accession NM_007722.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 362)
  AUTHORS   Meng,P., Liu,C., Li,J., Fang,P., Yang,B., Sun,W. and Zhang,Y.
  TITLE     CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting
            beta-catenin signaling and epithelial-to-mesenchymal transition in
            tubular epithelial cells
  JOURNAL   Ren Fail 46 (1), 2300727 (2024)
   PUBMED   38189094
  REMARK    GeneRIF: CXC chemokine receptor 7 ameliorates renal fibrosis by
            inhibiting beta-catenin signaling and epithelial-to-mesenchymal
            transition in tubular epithelial cells.
REFERENCE   2  (residues 1 to 362)
  AUTHORS   Pineiro-Sabaris,R., MacGrogan,D. and de la Pompa,J.L.
  TITLE     Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve
  JOURNAL   Dis Model Mech 17 (9) (2024)
   PUBMED   39253784
  REMARK    GeneRIF: Deficient GATA6-CXCR7 signaling leads to bicuspid aortic
            valve.
REFERENCE   3  (residues 1 to 362)
  AUTHORS   Dietz,A., Senf,K. and Neuhaus,E.M.
  TITLE     ACKR3 in olfactory glia cells shapes the immune defense of the
            olfactory mucosa
  JOURNAL   Glia 72 (6), 1183-1200 (2024)
   PUBMED   38477581
  REMARK    GeneRIF: ACKR3 in olfactory glia cells shapes the immune defense of
            the olfactory mucosa.
REFERENCE   4  (residues 1 to 362)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 362)
  AUTHORS   Fukuoka,A., Wilson,G.J., Pitmon,E., Koumbas Foley,L., Johnsson,H.,
            Pingen,M. and Graham,G.J.
  TITLE     Disruption of placental ACKR3 impairs growth and hematopoietic
            development of offspring
  JOURNAL   Development 151 (4) (2024)
   PUBMED   38300826
  REMARK    GeneRIF: Disruption of placental ACKR3 impairs growth and
            hematopoietic development of offspring.
REFERENCE   6  (residues 1 to 362)
  AUTHORS   Gerrits,H., van Ingen Schenau,D.S., Bakker,N.E., van
            Disseldorp,A.J., Strik,A., Hermens,L.S., Koenen,T.B.,
            Krajnc-Franken,M.A. and Gossen,J.A.
  TITLE     Early postnatal lethality and cardiovascular defects in
            CXCR7-deficient mice
  JOURNAL   Genesis 46 (5), 235-245 (2008)
   PUBMED   18442043
  REMARK    GeneRIF: Seems to play an unimportant role in bone; however, an
            important role is indicated for CXCR7 in the cardiovascular system
            during embryonic and early postnatal development.
REFERENCE   7  (residues 1 to 362)
  AUTHORS   Sierro,F., Biben,C., Martinez-Munoz,L., Mellado,M., Ransohoff,R.M.,
            Li,M., Woehl,B., Leung,H., Groom,J., Batten,M., Harvey,R.P.,
            Martinez-A,C., Mackay,C.R. and Mackay,F.
  TITLE     Disrupted cardiac development but normal hematopoiesis in mice
            deficient in the second CXCL12/SDF-1 receptor, CXCR7
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14759-14764 (2007)
   PUBMED   17804806
  REMARK    GeneRIF: Disfrupted cardiac development but normal hematopoiesis in
            mice deficient in Cxcr7.
REFERENCE   8  (residues 1 to 362)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   9  (residues 1 to 362)
  AUTHORS   Burns,J.M., Summers,B.C., Wang,Y., Melikian,A., Berahovich,R.,
            Miao,Z., Penfold,M.E., Sunshine,M.J., Littman,D.R., Kuo,C.J.,
            Wei,K., McMaster,B.E., Wright,K., Howard,M.C. and Schall,T.J.
  TITLE     A novel chemokine receptor for SDF-1 and I-TAC involved in cell
            survival, cell adhesion, and tumor development
  JOURNAL   J Exp Med 203 (9), 2201-2213 (2006)
   PUBMED   16940167
REFERENCE   10 (residues 1 to 362)
  AUTHORS   Heesen,M., Berman,M.A., Charest,A., Housman,D., Gerard,C. and
            Dorf,M.E.
  TITLE     Cloning and chromosomal mapping of an orphan chemokine receptor:
            mouse RDC1
  JOURNAL   Immunogenetics 47 (5), 364-370 (1998)
   PUBMED   9510554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110261.25, AK031100.1 and BQ033958.1.
            
            On Jun 10, 2003 this sequence version replaced NP_031748.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015254.1, AK031100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..362
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 45.28 cM"
     Protein         1..362
                     /product="atypical chemokine receptor 3"
                     /note="C-X-C chemokine receptor type 7; G-protein coupled
                     receptor RDC1 homolog; chemokine orphan receptor 1;
                     chemokine (C-X-C motif) receptor 7"
                     /calculated_mol_wt=41505
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P56485.2)"
     Site            22
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P56485.2)"
     Region          45..326
                     /region_name="7tmA_ACKR3_CXCR7"
                     /note="CXC chemokine receptor 7, member of the class A
                     family of seven-transmembrane G protein-coupled receptors;
                     cd14987"
                     /db_xref="CDD:320118"
     Region          46..72
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320118"
     Site            48..68
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56485.2)"
     Region          79..103
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320118"
     Site            82..102
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56485.2)"
     Site            order(100,103..104,117..122,124..125,128,173,175..179,209,
                     212..214,216..218,220..221,265,268..269,271..272,275,
                     293..294,296..298,301,304..305)
                     /site_type="other"
                     /note="putative peptide ligand binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:320118"
     Region          117..147
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320118"
     Site            119..139
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56485.2)"
     Region          160..181
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320118"
     Site            163..183
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56485.2)"
     Region          209..236
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320118"
     Site            214..234
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56485.2)"
     Region          245..275
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320118"
     Site            253..273
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56485.2)"
     Region          294..319
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320118"
     Site            297..319
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P56485.2)"
     Region          324..362
                     /region_name="C-terminal cytoplasmic tail.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P56485.2)"
     Site            347
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P56485.2)"
     Site            350
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P56485.2)"
     Site            355
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P56485.2)"
     CDS             1..362
                     /gene="Ackr3"
                     /gene_synonym="Cmkor1; CXC-R7; CXCR-7; Cxcr7; RDC-1; Rdc1"
                     /coded_by="NM_007722.4:135..1223"
                     /db_xref="CCDS:CCDS15152.1"
                     /db_xref="GeneID:12778"
                     /db_xref="MGI:MGI:109562"
ORIGIN      
        1 mdvhlfdyae pgnysdinwp cnssdcivvd tvqcptmpnk nvllytlsfi yififvigmi
       61 ansvvvwvni qakttgydth cyilnlaiad lwvvitipvw vvslvqhnqw pmgeltckit
      121 hlifsinlfg sifflacmsv drylsityft gtssykkkmv rrvvcilvwl laffvslpdt
      181 yylktvtsas nnetycrsfy pehsikewli gmelvsvilg favpftiiai fyfllarams
      241 asgdqekhss rkiifsyvvv flvcwlpyhf vvlldifsil hyipftcqle nvlftalhvt
      301 qclslvhccv npvlysfinr nyryelmkaf ifkysaktgl tklidasrvs eteysaleqn
      361 tk
//
