LOCUS       NM_001276719            3012 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Mus musculus atypical chemokine receptor 2 (Ackr2), transcript
            variant 1, mRNA.
ACCESSION   NM_001276719
VERSION     NM_001276719.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3012)
  AUTHORS   Xia,W., Eltrich,N. and Vielhauer,V.
  TITLE     The atypical chemokine receptor 2 reduces T cell expansion and
            tertiary lymphoid tissue but does not limit autoimmune organ injury
            in lupus-prone B6lpr mice
  JOURNAL   Front Immunol 15, 1377913 (2024)
   PUBMED   38799420
  REMARK    GeneRIF: The atypical chemokine receptor 2 reduces T cell expansion
            and tertiary lymphoid tissue but does not limit autoimmune organ
            injury in lupus-prone B6lpr mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3012)
  AUTHORS   Yu,T., Schuette,F., Christofi,M., Forrester,J.V., Graham,G.J. and
            Kuffova,L.
  TITLE     The atypical chemokine receptor-2 fine-tunes the immune response in
            herpes stromal keratitis
  JOURNAL   Front Immunol 13, 1054260 (2022)
   PUBMED   36518752
  REMARK    GeneRIF: The atypical chemokine receptor-2 fine-tunes the immune
            response in herpes stromal keratitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3012)
  AUTHORS   Butenko,S., Ben Jashar,N., Sheffer,T., Sabo,E., Schif-Zuck,S. and
            Ariel,A.
  TITLE     ACKR2 limits skin fibrosis and hair loss through IFN-beta
  JOURNAL   FASEB J 35 (10), e21917 (2021)
   PUBMED   34533865
  REMARK    GeneRIF: ACKR2 limits skin fibrosis and hair loss through IFN-beta.
REFERENCE   4  (bases 1 to 3012)
  AUTHORS   Hansell,C.A.H., Love,S., Pingen,M., Wilson,G.J., MacLeod,M. and
            Graham,G.J.
  TITLE     Analysis of lung stromal expression of the atypical chemokine
            receptor ACKR2 reveals unanticipated expression in murine blood
            endothelial cells
  JOURNAL   Eur J Immunol 50 (5), 666-675 (2020)
   PUBMED   32114694
  REMARK    GeneRIF: Analysis of lung stromal expression of the atypical
            chemokine receptor ACKR2 reveals unanticipated expression in murine
            blood endothelial cells.
REFERENCE   5  (bases 1 to 3012)
  AUTHORS   Tavares,L.P., Garcia,C.C., Goncalves,A.P.F., Kraemer,L.R.,
            Melo,E.M., Oliveira,F.M.S., Freitas,C.S., Lopes,G.A.O., Reis,D.C.,
            Cassali,G.D., Machado,A.M., Mantovani,A., Locati,M., Teixeira,M.M.
            and Russo,R.C.
  TITLE     ACKR2 contributes to pulmonary dysfunction by shaping
            CCL5:CCR5-dependent recruitment of lymphocytes during influenza A
            infection in mice
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 318 (4), L655-L670 (2020)
   PUBMED   31995405
  REMARK    GeneRIF: ACKR2 dampens CCL5 levels and the consequent recruitment
            of CCR5(+) T helper 1 (Th1).
REFERENCE   6  (bases 1 to 3012)
  AUTHORS   Jamieson,T., Cook,D.N., Nibbs,R.J., Rot,A., Nixon,C., McLean,P.,
            Alcami,A., Lira,S.A., Wiekowski,M. and Graham,G.J.
  TITLE     The chemokine receptor D6 limits the inflammatory response in vivo
  JOURNAL   Nat Immunol 6 (4), 403-411 (2005)
   PUBMED   15750596
  REMARK    GeneRIF: The chemokine receptor D6 limits the inflammatory response
            in vivo.
REFERENCE   7  (bases 1 to 3012)
  AUTHORS   Pabst,O., Ohl,L., Wendland,M., Wurbel,M.A., Kremmer,E., Malissen,B.
            and Forster,R.
  TITLE     Chemokine receptor CCR9 contributes to the localization of plasma
            cells to the small intestine
  JOURNAL   J Exp Med 199 (3), 411-416 (2004)
   PUBMED   14744993
  REMARK    GeneRIF: CCR9-deficient IgA+ plasma cells show reduced migration
            into the small intestine compared with wild-type controls.
REFERENCE   8  (bases 1 to 3012)
  AUTHORS   Murakami,T., Cardones,A.R., Finkelstein,S.E., Restifo,N.P.,
            Klaunberg,B.A., Nestle,F.O., Castillo,S.S., Dennis,P.A. and
            Hwang,S.T.
  TITLE     Immune evasion by murine melanoma mediated through CC chemokine
            receptor-10
  JOURNAL   J Exp Med 198 (9), 1337-1347 (2003)
   PUBMED   14581607
  REMARK    GeneRIF: CCR10 engagement by locally produced CCL27 allows melanoma
            cells to escape host immune antitumor killing mechanisms (possibly
            through activation of PI3K/Akt), thereby providing a means for
            tumor progression
REFERENCE   9  (bases 1 to 3012)
  AUTHORS   Zlotnik,A. and Yoshie,O.
  TITLE     Chemokines: a new classification system and their role in immunity
  JOURNAL   Immunity 12 (2), 121-127 (2000)
   PUBMED   10714678
  REMARK    Review article
REFERENCE   10 (bases 1 to 3012)
  AUTHORS   Nibbs,R.J., Wylie,S.M., Pragnell,I.B. and Graham,G.J.
  TITLE     Cloning and characterization of a novel murine beta chemokine
            receptor, D6. Comparison to three other related macrophage
            inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
  JOURNAL   J Biol Chem 272 (19), 12495-12504 (1997)
   PUBMED   9139699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165080.4 and AC164092.3.
            
            [WARNING] On Aug 6, 2024 this sequence was replaced by
            NM_001276719.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157140.1, AK147166.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC165080.4         11207-11355         c
            150-261             AC165080.4         7562-7673           c
            262-490             AC165080.4         3128-3356           c
            491-1650            AC165080.4         1-1160              c
            1651-3012           AC164092.3         127465-128826       c
FEATURES             Location/Qualifiers
     source          1..3012
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 72.71 cM"
     gene            1..3012
                     /gene="Ackr2"
                     /gene_synonym="Ccbp2; CCR10; CCR9; Cmkbr9; D6"
                     /note="atypical chemokine receptor 2"
                     /db_xref="GeneID:59289"
                     /db_xref="MGI:MGI:1891697"
     exon            1..149
                     /gene="Ackr2"
                     /gene_synonym="Ccbp2; CCR10; CCR9; Cmkbr9; D6"
                     /inference="alignment:Splign:2.1.0"
     exon            150..261
                     /gene="Ackr2"
                     /gene_synonym="Ccbp2; CCR10; CCR9; Cmkbr9; D6"
                     /inference="alignment:Splign:2.1.0"
     exon            262..490
                     /gene="Ackr2"
                     /gene_synonym="Ccbp2; CCR10; CCR9; Cmkbr9; D6"
                     /inference="alignment:Splign:2.1.0"
     exon            491..3012
                     /gene="Ackr2"
                     /gene_synonym="Ccbp2; CCR10; CCR9; Cmkbr9; D6"
                     /inference="alignment:Splign:2.1.0"
     CDS             502..1638
                     /gene="Ackr2"
                     /gene_synonym="Ccbp2; CCR10; CCR9; Cmkbr9; D6"
                     /note="chemokine-binding protein 2; C-C chemokine receptor
                     D6; chemokine decoy receptor D6; chemokine-binding protein
                     D6; D6 beta-chemokine receptor"
                     /codon_start=1
                     /product="atypical chemokine receptor 2"
                     /protein_id="NP_001263648.1"
                     /db_xref="CCDS:CCDS23640.1"
                     /db_xref="GeneID:59289"
                     /db_xref="MGI:MGI:1891697"
                     /translation="MPTVASPLPLTTVGSENSSSIYDYDYLDDMTILVCRKDEVLSFG
                     RVFLPVVYSLIFVLGLAGNLLLLVVLLHSAPRRRTMELYLLNLAVSNLLFVVTMPFWA
                     ISVAWHWVFGSFLCKVISTLYSINFYCGIFFITCMSLDKYLEIVHAQPLHRPKAQFRN
                     LLLIVMVWITSLAISVPEMVFVQIHQTLDGVWHCYADFGGHATIWKLYLRFQLNLLGF
                     LLPLLAMIFFYSRIGCVLVRLRPPGQGRALRMAAALVIVFFMLWFPYNLTLFLHSLLD
                     LHVFGNCEISHRLDYTLQVTESLAFSHCCFTPVLYAFCSHRFRRYLKAFLSVMLRWHQ
                     APGTPSSNHSESSRVTAQEDVVSMNDLGERQSEDSLNKGEMGNT"
     regulatory      2986..2991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ackr2"
                     /gene_synonym="Ccbp2; CCR10; CCR9; Cmkbr9; D6"
                     /note="hexamer: ATTAAA"
     polyA_site      3012
                     /gene="Ackr2"
                     /gene_synonym="Ccbp2; CCR10; CCR9; Cmkbr9; D6"
                     /note="major polyA site"
ORIGIN      
        1 accagggaag agcgacttcc ccaaccccag gaaaccagga tgtgtgtcct gagactcctg
       61 ctcactctgc acgtccctga agaagagaca acagccactg ggccctctca gactccggcg
      121 gatgtcctgg ggcaaacagt ctggctctgt cctgttctga ggagttctgg agacacagct
      181 gtcacatttg cagcccccag acttaggagg agccagctct gtgtccagag ggtgacggaa
      241 agctgtccag gagtaccttg tcttgaagac agattctcat tagagtcgga gagaagcact
      301 tgtcccacaa ctctgcaagc gaggagtcag ggcaacaagg agagagaatt ctgagaagag
      361 aggaaaaagc aaagcagcag gagagctgga ggaaagggga gcagaggaac caacaaacca
      421 gcaatccgca gctaaccagt taagcccagc tctctagctg ggggcagaga ccagatcctg
      481 caagcatcag agctcgagga catgcccacc gttgcttccc cactgcctct caccaccgtc
      541 ggttccgaga acagcagctc catctacgac tacgactact tagatgatat gaccatcttg
      601 gtttgcagga aggacgaggt cctgtccttt ggaagagtct ttctgccggt cgtctacagc
      661 ctgatcttcg tgctgggctt ggctggaaac ctcctcctcc tggtggtgtt gctccactct
      721 gcacctcgaa gacggacgat ggagctttac ctgctgaacc tggccgtctc caacctcttg
      781 tttgtagtga ctatgccctt ctgggccatc tctgtggcct ggcattgggt ttttggtagt
      841 ttcctgtgca aggtgataag cactctctac tctattaact tttactgtgg tatcttcttc
      901 atcacctgca tgagcctgga caaatacctg gagattgtcc acgctcagcc tctccacaga
      961 ccgaaggccc agttcaggaa cctgcttctc attgtcatgg tgtggatcac atccctggcc
     1021 atctctgtcc cagaaatggt ctttgtgcag atccaccaga ccttagatgg tgtgtggcac
     1081 tgctatgcgg attttggcgg acatgcgacc atttggaagc tgtacctgcg cttccagctg
     1141 aaccttctgg ggtttctcct cccactcttg gccatgatct tcttttactc ccgcatcggt
     1201 tgcgttctgg tcaggctgag gccgccaggc cagggccggg ctctgaggat ggccgcggcc
     1261 ctggtgatag ttttcttcat gctgtggttc ccatataacc tcaccttgtt tctgcactcg
     1321 ttgctggacc tgcatgtctt tgggaactgt gagatcagcc accgtctgga ctatacgttg
     1381 caggtgacag agagcctggc cttctcccac tgctgcttca ccccggtcct ctacgccttc
     1441 tgcagtcacc gcttccgccg gtacctgaag gcatttctgt ctgtgatgtt gagatggcac
     1501 caggcacctg gcaccccttc ctctaaccat tctgagagca gcagggttac tgcccaggaa
     1561 gacgtggtca gcatgaatga ccttggggag aggcagtctg aggactccct taacaagggg
     1621 gagatgggga atacttaggc ccgagtgatc agccacggtc tgggaacagc actgctctct
     1681 ctgagggaca gcgtgactgt gctgctcgcc ccagtggttc ccaaccacca gcaggcctta
     1741 ctcattactg tctcttcctc cttctgcttc ctggacccca tcctctctgc tgaaccactt
     1801 cagctcttca ctgatctccc tccacttcca ccccagcgct tctgtggctt cctggccctc
     1861 agcagccaat gaggtcactc cactcttagc cttcagacct tcaagggcca tgtgatcatt
     1921 ctgtgacttt atctccaccg tactccctcc tggtctctgg gttcagggca cactggcttc
     1981 cactcgtttc tgaagcattc caggttcact ccagtaggga gagttcagct atgccatctc
     2041 tctggacatc ttcttcgccg gcctttctcc ttgggaagag tttggctcat tcctttactt
     2101 cctggagtca tggctcagat ctcaccttgt tggtgaggaa ggaggcactg tgcccaccct
     2161 gctcaatgcc ctgtctatac actgatgctc atgtgcttct gcacacacaa tattttcact
     2221 ctgtacaggg atttctcctg tcgtgctccc tgcagactgc ctcgagccca cccacgcagg
     2281 tgagctgcag agtaaggctc tcggtgaaca gctccctgct ctcctcagac tcctaccaca
     2341 gaagcttgtg tgtggaaagc ctttggaaag ctgctgtgga atgtgagtta gcactgtgca
     2401 tttctgggga cagtcacagg ttctccatcc tccagggccc ctttctctgt agctcagaca
     2461 ggaggatact ttctgccctt gtgtgaggtc tagccagtga atgacccgga cgtgtgcatc
     2521 ccgcaggagg aaggttggga ccatctcagc tctggtcttg gggactatca gtcaagttca
     2581 aagttttaga ctttacaaaa cacatgccag tgagcaggca tccccttaaa acatcctgct
     2641 gagaacacta ggtatccaca tgtagaagat taaagctaga ttcctgtctc tcatctgata
     2701 caaagatcag ctaaaattgg atcaaggact ctaacatatc acctgaagcc tcgaaaccat
     2761 cagagaaaaa cacaggggaa acaactaaaa acatcatcag aagcaaggtc tttctgagca
     2821 gagaccccca tagccaggga atactcagat cacatgaaat tagagtctcc gtggtacaga
     2881 gacagggtca gaatgaagag actgtttaca gacaacttgg ccagctttca cctcacgggg
     2941 cccaatattc aaattgtaca ggggacaaaa atgttgaata atccaattaa aaaaatgggt
     3001 aagtgatttg aa
//
