LOCUS       NM_010045               1163 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus atypical chemokine receptor 1 (Duffy blood group)
            (Ackr1), mRNA.
ACCESSION   NM_010045
VERSION     NM_010045.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1163)
  AUTHORS   Kwon,Y.W., Chae,C.W., Lee,H., Shin,D., Yoo,H., Lee,C.S., Lee,Y.,
            Seong,K.M. and Kim,H.S.
  TITLE     A subset of macrophages and monocytes in the mouse bone marrow
            express atypical chemokine receptor 1
  JOURNAL   Cell Stem Cell 29 (7), 1016-1017 (2022)
   PUBMED   35803223
  REMARK    GeneRIF: A subset of macrophages and monocytes in the mouse bone
            marrow express atypical chemokine receptor 1.
REFERENCE   2  (bases 1 to 1163)
  AUTHORS   Marchetti,L., Francisco,D., Soldati,S., Haghayegh Jahromi,N.,
            Barcos,S., Gruber,I., Pareja,J.R., Thiriot,A., von Andrian,U.,
            Deutsch,U., Lyck,R., Bruggmann,R. and Engelhardt,B.
  TITLE     ACKR1 favors transcellular over paracellular T-cell diapedesis
            across the blood-brain barrier in neuroinflammation in vitro
  JOURNAL   Eur J Immunol 52 (1), 161-177 (2022)
   PUBMED   34524684
  REMARK    GeneRIF: ACKR1 favors transcellular over paracellular T-cell
            diapedesis across the blood-brain barrier in neuroinflammation in
            vitro.
REFERENCE   3  (bases 1 to 1163)
  AUTHORS   Barkaway,A., Rolas,L., Joulia,R., Bodkin,J., Lenn,T.,
            Owen-Woods,C., Reglero-Real,N., Stein,M., Vazquez-Martinez,L.,
            Girbl,T., Poston,R.N., Golding,M., Saleeb,R.S., Thiriot,A., von
            Andrian,U.H., Duchene,J., Voisin,M.B., Bishop,C.L., Voehringer,D.,
            Roers,A., Rot,A., Lammermann,T. and Nourshargh,S.
  TITLE     Age-related changes in the local milieu of inflamed tissues cause
            aberrant neutrophil trafficking and subsequent remote organ damage
  JOURNAL   Immunity 54 (7), 1494-1510 (2021)
   PUBMED   34033752
REFERENCE   4  (bases 1 to 1163)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1163)
  AUTHORS   Vasquez,M.T., Lubkin,A., Reyes-Robles,T., Day,C.J., Lacey,K.A.,
            Jennings,M.P. and Torres,V.J.
  TITLE     Identification of a domain critical for Staphylococcus aureus LukED
            receptor targeting and lysis of erythrocytes
  JOURNAL   J Biol Chem 295 (50), 17241-17250 (2020)
   PUBMED   33051210
REFERENCE   6  (bases 1 to 1163)
  AUTHORS   Dawson,T.C., Lentsch,A.B., Wang,Z., Cowhig,J.E., Rot,A., Maeda,N.
            and Peiper,S.C.
  TITLE     Exaggerated response to endotoxin in mice lacking the Duffy
            antigen/receptor for chemokines (DARC)
  JOURNAL   Blood 96 (5), 1681-1684 (2000)
   PUBMED   10961863
REFERENCE   7  (bases 1 to 1163)
  AUTHORS   Luo,H., Chaudhuri,A., Zbrzezna,V., He,Y. and Pogo,A.O.
  TITLE     Deletion of the murine Duffy gene (Dfy) reveals that the Duffy
            receptor is functionally redundant
  JOURNAL   Mol Cell Biol 20 (9), 3097-3101 (2000)
   PUBMED   10757794
  REMARK    Erratum:[Mol Cell Biol. 2003 Apr;23(8):3030]
REFERENCE   8  (bases 1 to 1163)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   9  (bases 1 to 1163)
  AUTHORS   Tang,T., Owen,J.D., Du,J., Walker,C.L. and Richmond,A.
  TITLE     Molecular cloning and characterization of a mouse gene with
            homology to the Duffy-antigen receptor for chemokines
  JOURNAL   DNA Seq 9 (3), 129-143 (1998)
   PUBMED   10520743
REFERENCE   10 (bases 1 to 1163)
  AUTHORS   Luo,H., Chaudhuri,A., Johnson,K.R., Neote,K., Zbrzezna,V., He,Y.
            and Pogo,A.O.
  TITLE     Cloning, characterization, and mapping of a murine promiscuous
            chemokine receptor gene: homolog of the human Duffy gene
  JOURNAL   Genome Res 7 (9), 932-941 (1997)
   PUBMED   9314499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084073.22.
            
            On Dec 22, 2021 this sequence version replaced NM_010045.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005583.1, AF016584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC084073.22        25073-25195         c
            124-1163            AC084073.22        23573-24612         c
FEATURES             Location/Qualifiers
     source          1..1163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.33 cM"
     gene            1..1163
                     /gene="Ackr1"
                     /gene_synonym="CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD"
                     /note="atypical chemokine receptor 1 (Duffy blood group)"
                     /db_xref="GeneID:13349"
                     /db_xref="MGI:MGI:1097689"
     exon            1..123
                     /gene="Ackr1"
                     /gene_synonym="CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1107
                     /gene="Ackr1"
                     /gene_synonym="CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD"
                     /note="duffy antigen/chemokine receptor; Duffy antigen
                     receptor for chemokines; glycoprotein D; Duffy blood
                     group, chemokine receptor"
                     /codon_start=1
                     /product="atypical chemokine receptor 1"
                     /protein_id="NP_034175.2"
                     /db_xref="CCDS:CCDS35789.1"
                     /db_xref="GeneID:13349"
                     /db_xref="MGI:MGI:1097689"
                     /translation="MGNCLYPVENLSLDKNGTQFTFDSWNYSFEDNYSYELSSDYSLT
                     PAAPCYSCNLLGRSSLPFFMLTSVLGMLASGGILFAILRPFFHWQICPSWPILAELAV
                     GSALFSIAVPILAPGLHSAHSTALCNLGYWVWYTSAFAQALLIGCYACLNPRLNIGQL
                     RGFTLGLSVGLWGAAALLGLPVALASDAYNGFCAFPSSRDMEALKYMHYAICFTIFTV
                     LPPTLLAAKGLKIALSKGPGPWVSVLWIWFIFWWPHGMVLIFDALVRSKIVLLYTCQS
                     QKILDAMLNVTEALSMLHCVATPLLLALFCHQTTRRSLSSLSLPTRQASQMDALAGKS
                     "
     exon            124..1163
                     /gene="Ackr1"
                     /gene_synonym="CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1142..1147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ackr1"
                     /gene_synonym="CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD"
                     /note="hexamer: ATTAAA"
     polyA_site      1163
                     /gene="Ackr1"
                     /gene_synonym="CCBP1; CD234; Darc; Dfy; ESTM35; FY; GPD"
                     /note="major polyA site"
ORIGIN      
        1 ctagaacccg agagaagtca ttagccctgg gcacttatct tggagccaca gctgctgaca
       61 gagtccaggc cctgtacttc tctgccctga gcctgcagtg ccatggggaa ctgtctgtat
      121 ccggtggaaa acctttcact agacaagaat ggaactcagt ttactttcga cagctggaat
      181 tattcgtttg aagataacta ctcctatgaa ctctcgagtg actacagcct gacaccagct
      241 gctccctgct actcctgtaa tctgcttggc aggtcttccc ttcccttctt catgctcacc
      301 agtgtcctgg gcatgctggc aagtggcggc atcctcttcg cgattctcag acctttcttc
      361 cactggcaga tttgccccag ctggcccatt ctggcagagt tagcagtggg cagtgccctg
      421 ttcagcattg cagtgcccat cctggcacca ggcttacaca gcgcccacag cacagcccta
      481 tgcaacctgg gctactgggt atggtatact tctgcttttg cccaagctct gttgatagga
      541 tgctatgctt gcctgaaccc cagactgaat attggtcaac tccgtggctt caccttggga
      601 ctcagtgtgg gactttgggg agcagctgcc ctcttagggc tgccagtcgc cctggccagt
      661 gatgcttaca atggcttctg cgcctttcca tcctccagag acatggaagc tttgaagtac
      721 atgcattatg ccatctgttt taccatcttc actgtattgc caccgactct tttggcagcc
      781 aaggggctga agatagcact gagcaagggg cctggcccct gggttagtgt cttgtggatc
      841 tggttcattt tctggtggcc tcatgggatg gttctcatat ttgatgcttt ggtgaggtcc
      901 aaaattgttc ttctgtatac atgccaatcc cagaagattc ttgatgcgat gctgaatgtg
      961 acagaagccc tgagtatgct gcactgtgtg gctaccccac tgctcctggc cctgttctgc
     1021 catcagacca cccgtagatc cttgtcctca ctctccctcc ctacaagaca ggcttctcaa
     1081 atggatgccc ttgcaggcaa gtcctagttt tgttttgttt tttccctaca tgtcaactta
     1141 aattaaagtc tatactgctt tta
//
