LOCUS       NM_139306               4206 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus alkaline ceramidase 2 (Acer2), transcript variant 1,
            mRNA.
ACCESSION   NM_139306
VERSION     NM_139306.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4206)
  AUTHORS   Guo,J., Yang,X., Chen,J., Wang,C., Sun,Y., Yan,C., Ren,S.,
            Xiong,H., Xiang,K., Zhang,M., Li,C., Jiang,G., Xiang,X., Wan,G.,
            Jiang,T., Kang,Y., Xu,X., Chen,Z. and Li,W.
  TITLE     Exosomal miR-125b-5p derived from adipose-derived mesenchymal stem
            cells enhance diabetic hindlimb ischemia repair via targeting
            alkaline ceramidase 2
  JOURNAL   J Nanobiotechnology 21 (1), 189 (2023)
   PUBMED   37308908
  REMARK    GeneRIF: Exosomal miR-125b-5p derived from adipose-derived
            mesenchymal stem cells enhance diabetic hindlimb ischemia repair
            via targeting alkaline ceramidase 2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4206)
  AUTHORS   Li,F., Xu,R., Lin,C.L., Low,B.E., Cai,L., Li,S., Ji,P., Huang,L.,
            Wiles,M.V., Hannun,Y.A., Obeid,L.M., Chen,Y. and Mao,C.
  TITLE     Maternal and fetal alkaline ceramidase 2 is required for placental
            vascular integrity in mice
  JOURNAL   FASEB J 34 (11), 15252-15268 (2020)
   PUBMED   32959379
  REMARK    GeneRIF: Maternal and fetal alkaline ceramidase 2 is required for
            placental vascular integrity in mice.
REFERENCE   3  (bases 1 to 4206)
  AUTHORS   de Groot,T., Ebert,L.K., Christensen,B.M., Andralojc,K., Cheval,L.,
            Doucet,A., Mao,C., Baumgarten,R., Low,B.E., Sandhoff,R.,
            Wiles,M.V., Deen,P.M.T. and Korstanje,R.
  TITLE     Identification of Acer2 as a First Susceptibility Gene for
            Lithium-Induced Nephrogenic Diabetes Insipidus in Mice
  JOURNAL   J Am Soc Nephrol 30 (12), 2322-2336 (2019)
   PUBMED   31558682
  REMARK    GeneRIF: Using genome-wide association analyses, we identified
            eight gene-containing loci, including a locus containing Acer2,
            which encodes a ceramidase and is specifically expressed in the
            collecting duct. Knockout of Acer2 led to increased susceptibility
            for lithium-induced diabetes insipidus development.
REFERENCE   4  (bases 1 to 4206)
  AUTHORS   Li,F., Xu,R., Low,B.E., Lin,C.L., Garcia-Barros,M., Schrandt,J.,
            Mileva,I., Snider,A., Luo,C.K., Jiang,X.C., Li,M.S., Hannun,Y.A.,
            Obeid,L.M., Wiles,M.V. and Mao,C.
  TITLE     Alkaline ceramidase 2 is essential for the homeostasis of plasma
            sphingoid bases and their phosphates
  JOURNAL   FASEB J 32 (6), 3058-3069 (2018)
   PUBMED   29401619
  REMARK    GeneRIF: results suggest that ACER2 plays a key role in the
            maintenance of high plasma levels of sphingoid
            base-1-phosphates-S1P and dhS1P-by controlling the generation of
            sphingoid bases-SPH and dhSPH-in hematopoietic cells.
REFERENCE   5  (bases 1 to 4206)
  AUTHORS   Lin,C.L., Xu,R., Yi,J.K., Li,F., Chen,J., Jones,E.C., Slutsky,J.B.,
            Huang,L., Rigas,B., Cao,J., Zhong,X., Snider,A.J., Obeid,L.M.,
            Hannun,Y.A. and Mao,C.
  TITLE     Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by
            Maintaining the Homeostasis of Hair Follicle Stem Cells
  JOURNAL   Stem Cell Reports 9 (5), 1488-1500 (2017)
   PUBMED   29056331
REFERENCE   6  (bases 1 to 4206)
  AUTHORS   Wang,Z., Kirkwood,J.S., Taylor,A.W., Stevens,J.F., Leid,M.,
            Ganguli-Indra,G. and Indra,A.K.
  TITLE     Transcription factor Ctip2 controls epidermal lipid metabolism and
            regulates expression of genes involved in sphingolipid biosynthesis
            during skin development
  JOURNAL   J Invest Dermatol 133 (3), 668-676 (2013)
   PUBMED   23096701
REFERENCE   7  (bases 1 to 4206)
  AUTHORS   Graveel,C.R., Jatkoe,T., Madore,S.J., Holt,A.L. and Farnham,P.J.
  TITLE     Expression profiling and identification of novel genes in
            hepatocellular carcinomas
  JOURNAL   Oncogene 20 (21), 2704-2712 (2001)
   PUBMED   11420682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059819.1, AK085306.1 and BB028627.1.
            
            On Mar 14, 2014 this sequence version replaced NM_139306.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF282864.1, BU511164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BC059819.1         1-5
            6-716               AK085306.1         2-712
            717-4198            BC059819.1         579-4060
            4199-4206           BB028627.1         238-245
FEATURES             Location/Qualifiers
     source          1..4206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.69 cM"
     gene            1..4206
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /note="alkaline ceramidase 2"
                     /db_xref="GeneID:230379"
                     /db_xref="MGI:MGI:1920932"
     exon            1..183
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..903
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /EC_number="3.5.1.23"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer related gene-liver 1 (CRG-L1); ceramide hydrolase;
                     alkCDase 2; alkaline CDase 2; cancer-related gene liver 1
                     protein"
                     /codon_start=1
                     /product="alkaline ceramidase 2 isoform 1"
                     /protein_id="NP_647467.1"
                     /db_xref="CCDS:CCDS18311.1"
                     /db_xref="GeneID:230379"
                     /db_xref="MGI:MGI:1920932"
                     /translation="MGAPHWWDHLRAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFI
                     LPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAILWVLM
                     CALAMWFPRRYLPKIFRNDRGRFKAVVCVLSAITTCLAFIKPAINNISLMILGLPCTA
                     LLVAELKRCDNVRVFKLGLFSGLWWTLALFCWISDQAFCELLSSFHFPYLHCVWHILI
                     CLASYLGCVCFAYFDAASEIPEQGPVIRFWPSEKWAFIGVPYVSLLCAHKKSPVKIT"
     exon            184..298
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..440
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..578
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..716
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /inference="alignment:Splign:2.1.0"
     exon            717..4206
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4177..4182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /note="hexamer: AATAAA"
     polyA_site      4198
                     /gene="Acer2"
                     /gene_synonym="2410116I05Rik; Asah3l; CRG-L1; maCER2"
                     /note="major polyA site"
ORIGIN      
        1 gacgcacagt gtgcctcgca gccgctcggg ccggtcgccg ctgcagagaa gctgctccga
       61 tgctccagag cggccatggg cgccccgcac tggtgggacc acctgcgggc tggcagttcg
      121 gaggtggatt ggtgcgagga caactacact atcgtgcctg ccattgccga gttctacaac
      181 acgatcagca acgtcttgtt tttcatttta cctcccatct gcatgtgctt gttccgccag
      241 tacgcaacgt gcttcaacag cggcatctac ttaatatgga cgctcctagt tgtagtgggg
      301 attggatctg tctacttcca tgcaacgctg agtttcctgg gtcagatgct tgatgaactt
      361 gccattctgt gggttctgat gtgtgctttg gccatgtggt ttcccaggag gtatttacca
      421 aagatctttc ggaatgacag gggcaggttc aaggcagtgg tgtgtgtcct gtctgcaatt
      481 acaacgtgct tggcgtttat caagcccgcc atcaacaata tttccctgat gattctggga
      541 cttccatgca ctgcgctgct tgttgcagag ctgaagaggt gtgacaatgt gcgtgtgttt
      601 aagctgggcc tcttctctgg cctctggtgg actctggctc tcttctgctg gatcagcgac
      661 caagccttct gtgagctgct ctcctccttt cacttcccct acctgcactg tgtgtggcat
      721 attctcatct gccttgcttc gtacctgggc tgtgtgtgct tcgcctactt tgatgctgcc
      781 tcagagatac ctgagcaagg tccagtcatc agattctggc ccagcgagaa atgggctttt
      841 attggtgtcc cttatgtgtc ccttctgtgt gcccacaaga agtcgccagt caagatcacg
      901 tgatggcaag gcagtgacca gcttctctac ttacttctat tcgagtgcgc gctgggcttc
      961 gtttgctagc aaagatggct gagggggttg aggaattggt gtggtgtggg tgtttaaaat
     1021 tctgctcctt tgtgatctaa ctggaccact gtgcctgacc tccctaggtt aagtagaggg
     1081 ctcagggaca taaggtgtct tcctcagtat cctttccagg catacgggct tgctgggtta
     1141 tgtccataat gacatcaaca gagtagttct ttgggagacc tagggcaacc caaagtttct
     1201 tgctggagag ggtagcttgc tgtttccacc atttccagac tctcaacccc ctgataaaca
     1261 agaccttctg atttggtgat gaaaggttcc agaacttttc attttgccgg gagaaactgt
     1321 ccttcaacaa aaccaagtgg gcaaaacacg tgtggggggt gtgactaaga cgggtggctt
     1381 gtcactcgca cctcttagct ttcccaggtt ctccacgtgt ttgtggatcc ttccactacc
     1441 tctgctgaga gatggagcca cggcttcaga gggcaaagct ggcaacaccc tctatgccaa
     1501 aagctacact cctctttaag cacacattac atatagacac tatttctgct cttccagagt
     1561 gcagcagcct cagacccaca gagaatcctt caggttatgt gaagattcca cacacagccc
     1621 cctcttgtga cctctgtgag agcaaggcct cgttgtaatc gcggaggcag ctctggaggc
     1681 ttgactgtgg agcgcctgtg aagattttgg aaagcttttc ttattggaag cttttggtgt
     1741 gtcgttacct ccaagattct gaccccgttt ctctgctgtt tttaggggat atgtgcttcc
     1801 tgagtgacgt agcctcccta ggatgtgggc ctccggcttt tgttttcata atacctggtg
     1861 ctaactggtt tctcagagca ctttgctctt cttgatgctg ggcggtcact acactctgat
     1921 tggctggctg gggatcccag ggaggaaggg gcagactctg acatgaatgt ctctcacctg
     1981 catcctactg tcttcactgg gctctcttca gggtatgaag tgggtatggg gtatctcagg
     2041 gatgtttgta actcaggcac cttctgcttt ctgacattcc attgtcagtg gtgagactgc
     2101 actcagggga ctggagttgg aacaccgttc tgagtggtgt cctgagtctg aaggagctag
     2161 ctgcgggttc tggcacttct aggatctctt actctgttta gaaccttcac agggtacaaa
     2221 gtgggaactg gacttaaaga gtttttaaat gaatagactt cattctgctt ttgtggcttt
     2281 ggagttttag aagtaacttg ctgggctatt tcttgtttat agtcacaaat atttatagaa
     2341 catgaaggtg taaaataagt tgtcttttat taaattcata gcatttacca actctcccag
     2401 gtagcaaaca cacagtcatt tgattggcga tttacaaggc aggaatactt ggttttgaat
     2461 gattgtatat gtcattttac tgtagcttaa aatatgttta aaatgacttt gagtgaaatg
     2521 tttgtggcaa cctaggggtt tatggatcag aattgcggct gagtcctttg gtttttgagt
     2581 ctagaagttt tcagagggca aaatcaaact agccttgttt ctggttcatc ttaccaggct
     2641 cgggagctgc ccttatatat tctacataag gacttattat acataagtct gtataaatgt
     2701 cctgaagatg acacctagct gccttcatct ggaagggtcg tctggggctg gagagttggt
     2761 tcaacagtta agaacccgtg ttgctctctc ccagacgacc cagcgacttg tgaggctcat
     2821 aaccagcaac tccagccctg gggcatctga cgccctcttc tgacttctaa gggcatttgg
     2881 tgcacacgta catacaggca ggcaaaacat ttatacatgt aacgtaataa atgcataagt
     2941 tagtgagacg gctgaaggaa aggagtttta gatgcaaggt ttagtctgac ctgagtgccc
     3001 ttccttagcc gcgatggtgt cctcaaagtc agggaagaac catttctttt ttatcaggaa
     3061 aaggacttat tccctagggc ctctgctgac atccctagga acagagataa aatacggatg
     3121 gatgtgaatg aacatgcttg ggtgaaagga gccgagtacc tgactggacc cagtgggcca
     3181 cttccacaag cgaagcccgg taaccgatgt gcactccaga atcttctccc ttctggtaga
     3241 gatgacatcg atgagtgatg tcgtgaccac tgggccctgc atgggtgtcg ggctctgttc
     3301 tgttccgaat ctacctgaga tctcaggaca gaggaagcca tgaatgttac caagtggtca
     3361 tggctgtcag tgattttaca gttttgaacc attattggtt tttaggagaa ttcttctctc
     3421 tctagtgccc tgtgatgcca aagccagccc ttcagaagtg ttccttctgt ctgcttccct
     3481 ttgtaatgtg atccactcgg ggaaatgggt gtctacccag ggaaaagtgc ctaccccagt
     3541 cacgggtcaa cagtgttgtg ttgaggatca aacatggctc tgtgaaaata ctgccaccca
     3601 ttctattggt tggatttctc aggagtctga atcttccctc acgagtcctc ttctcccaac
     3661 ccctacccag agccaacact gggatttgaa ccttctctga ctctcttctt ccctcaggtc
     3721 tgacaactaa tggtctctgg ggacacccag ctagggcctt ccccaactcc ttatccagct
     3781 gaacttggat tcttcccaac cagggcttga cctgggtgct gttggtccca ctggccaaca
     3841 acacatcttt ggccagattg ggattctcaa tagattttat agacattatt ctcccacaga
     3901 ctttaaaaca tggcttgtgt ctttccatac acatccggtc agatttaaaa ctattttata
     3961 accacaggaa ttaaaccaag caaatagagt actttcagat ataaactgtg tttcatactt
     4021 tatgtagagt gtgctatgta taggcggtat gtaccctggc tgaagtaata ttaaccatag
     4081 ctctgggagg atttacagac cttttgcact ttatgctttt ttgtgaactc tgataaccat
     4141 ggtcaatatt aaagccaata actggcattt tctgtgaata aacatgcata tgtatctatt
     4201 tctgaa
//
