LOCUS       NM_175731               2429 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus alkaline ceramidase 1 (Acer1), mRNA.
ACCESSION   NM_175731 NM_134162
VERSION     NM_175731.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2429)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2429)
  AUTHORS   Zhang,X., Gong,Z., Shen,Y., Cai,Z., Yang,L., Zhang,T., Li,W.,
            Zhao,Y., Zhu,S., Liu,C., Wang,J., Wang,X., Qi,R., Liu,J., Lei,X.,
            Wang,W., Jiang,C., Fu,Y. and Kong,W.
  TITLE     Alkaline ceramidase 1-mediated platelet ceramide catabolism
            mitigates vascular inflammation and abdominal aortic aneurysm
            formation
  JOURNAL   Nat Cardiovasc Res 2 (12), 1173-1189 (2023)
   PUBMED   39196139
  REMARK    GeneRIF: Alkaline ceramidase 1-mediated platelet ceramide
            catabolism mitigates vascular inflammation and abdominal aortic
            aneurysm formation.
REFERENCE   3  (bases 1 to 2429)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2429)
  AUTHORS   Munzer,P., Mittelstadt,S., Geue,S., Manke,M.C., Walker-Allgaier,B.,
            Lang,F., Gawaz,M. and Borst,O.
  TITLE     Ceramidase critically affects GPVI-dependent platelet activation
            and thrombus formation
  JOURNAL   Biochem Biophys Res Commun 496 (3), 792-798 (2018)
   PUBMED   29395079
  REMARK    GeneRIF: In conclusion, the present study unraveled ceramidase as a
            crucial player in sphingosine-induced platelet activation following
            GPVI-dependent signaling.
REFERENCE   5  (bases 1 to 2429)
  AUTHORS   Lin,C.L., Xu,R., Yi,J.K., Li,F., Chen,J., Jones,E.C., Slutsky,J.B.,
            Huang,L., Rigas,B., Cao,J., Zhong,X., Snider,A.J., Obeid,L.M.,
            Hannun,Y.A. and Mao,C.
  TITLE     Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by
            Maintaining the Homeostasis of Hair Follicle Stem Cells
  JOURNAL   Stem Cell Reports 9 (5), 1488-1500 (2017)
   PUBMED   29056331
  REMARK    GeneRIF: Loss of Acer1 elevated the levels of various ceramides and
            sphingoid bases in the skin and caused progressive hair loss in
            mice.
REFERENCE   6  (bases 1 to 2429)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Lelliott,C.J., Speak,A.O.,
            Lafont,D., Protheroe,H.J., Ingvorsen,C., Galli,A., Green,A.,
            Gleeson,D., Ryder,E., Glover,L., Vizcay-Barrena,G., Karp,N.A.,
            Arends,M.J., Brenn,T., Spiegel,S., Adams,D.J., Watt,F.M. and van
            der Weyden,L.
  TITLE     Alkaline ceramidase 1 is essential for mammalian skin homeostasis
            and regulating whole-body energy expenditure
  JOURNAL   J Pathol 239 (3), 374-383 (2016)
   PUBMED   27126290
REFERENCE   7  (bases 1 to 2429)
  AUTHORS   Wang,Z., Kirkwood,J.S., Taylor,A.W., Stevens,J.F., Leid,M.,
            Ganguli-Indra,G. and Indra,A.K.
  TITLE     Transcription factor Ctip2 controls epidermal lipid metabolism and
            regulates expression of genes involved in sphingolipid biosynthesis
            during skin development
  JOURNAL   J Invest Dermatol 133 (3), 668-676 (2013)
   PUBMED   23096701
REFERENCE   8  (bases 1 to 2429)
  AUTHORS   Weber,S., Niessen,M.T., Prox,J., Lullmann-Rauch,R., Schmitz,A.,
            Schwanbeck,R., Blobel,C.P., Jorissen,E., de Strooper,B.,
            Niessen,C.M. and Saftig,P.
  TITLE     The disintegrin/metalloproteinase Adam10 is essential for epidermal
            integrity and Notch-mediated signaling
  JOURNAL   Development 138 (3), 495-505 (2011)
   PUBMED   21205794
REFERENCE   9  (bases 1 to 2429)
  AUTHORS   Mao,C., Xu,R., Szulc,Z.M., Bielawski,J., Becker,K.P., Bielawska,A.,
            Galadari,S.H., Hu,W. and Obeid,L.M.
  TITLE     Cloning and characterization of a mouse endoplasmic reticulum
            alkaline ceramidase: an enzyme that preferentially regulates
            metabolism of very long chain ceramides
  JOURNAL   J Biol Chem 278 (33), 31184-31191 (2003)
   PUBMED   12783875
  REMARK    GeneRIF: novel alkaline ceramidase with a stringent substrate
            specificity and is selectively expressed in skin and may have a
            role in regulating the levels of bioactive lipids ceramide and
            sphingosine-1-p, as well as complex sphingolipids.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028901.1 and AC073683.3.
            
            On Jan 14, 2010 this sequence version replaced NM_175731.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028901.1, BC130254.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1065              AK028901.1         2-1066
            1066-1066           AC073683.3         52979-52979
            1067-2429           AK028901.1         1067-2429
FEATURES             Location/Qualifiers
     source          1..2429
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.59 cM"
     gene            1..2429
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /note="alkaline ceramidase 1"
                     /db_xref="GeneID:171168"
                     /db_xref="MGI:MGI:2181962"
     exon            1..138
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..840
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /EC_number="3.5.1.23"
                     /note="N-acylsphingosine amidohydrolase 3; alkaline cdase
                     1; maCER1; alkCDase 1; acylsphingosine deacylase 3"
                     /codon_start=1
                     /product="alkaline ceramidase 1"
                     /protein_id="NP_783858.1"
                     /db_xref="CCDS:CCDS28919.1"
                     /db_xref="GeneID:171168"
                     /db_xref="MGI:MGI:2181962"
                     /translation="MHVPGTRAKMSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNV
                     FFLIFGPLMMFLMHPYAQKRTRCFYGVSVLFMLIGLFSMYFHMTLSFLGQLLDEISIL
                     WLLASGYSVWLPRCYFPKFVKGNRFYFSCLVTITTIISTFLTFVKPTVNAYALNSIAI
                     HILYIVRTEYKKIRDDDLRHLIAVSVVLWAAALTSWISDRVLCSFWQRIHFYYLHSIW
                     HVLISITFPYGIVTMALVDAKYEMPDKTLKVHYWPRDSWVIGLPYVEIQENDKNC"
     exon            139..253
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /inference="alignment:Splign:2.1.0"
     exon            254..395
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..533
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..671
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..2429
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1533..1538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /note="hexamer: AATAAA"
     regulatory      1567..1572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /note="hexamer: ATTAAA"
     polyA_site      1573
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /note="major polyA site"
     polyA_site      1586
                     /gene="Acer1"
                     /gene_synonym="2310024P18Rik; Alkcdase1; Asah3; Cer1"
                     /note="major polyA site"
ORIGIN      
        1 acctctgcca ggcacaggat gcatgtaccg ggcaccagag caaagatgtc cagcatcttt
       61 gcctatcaga gttctgaggt ggattggtgt gagagtaatt tccagcactc agagttggtg
      121 gccgagttct acaatacgtt cagcaatgtg ttcttcctca tctttggacc cctcatgatg
      181 ttcctcatgc atccgtatgc ccagaagcgt acccggtgtt tctatggagt gtcagtcctc
      241 ttcatgctca taggtctgtt ctccatgtat ttccacatga cactcagctt tctgggacag
      301 ctgctggatg agatctccat cctgtggttg ttggccagtg gatacagtgt gtggctgccc
      361 cgttgctatt ttcccaagtt cgtcaagggg aacaggttct acttcagctg cctggtaact
      421 ataaccacta ttatcagcac cttcttgacg ttcgtgaagc ccacagtcaa tgcatatgct
      481 ctcaacagca tcgccatcca catcctctac attgtgcgca cagagtacaa gaagattagg
      541 gatgatgatc ttcggcatct gattgcggtt tctgtggtct tatgggccgc tgcactgacc
      601 agctggatca gtgaccgtgt actttgcagc ttctggcagc ggattcactt ctactacctg
      661 cacagcattt ggcacgtcct cataagcatc acatttcctt atggtatcgt gaccatggcc
      721 ctggtggatg caaagtatga gatgccagat aaaaccctca aagtccacta ctggccccgg
      781 gacagctggg tcatcgggct accctatgtg gagatccagg agaatgacaa gaactgctga
      841 gctctgctgt agtctctgct ctctggccag ccaccgagtc tcctgtgtac tgaggataca
      901 gggcaggaca aggctttcag tgggcacact tgcagcaccc atcccccggc ccatgctcct
      961 tgccctgctc gtcagcacag ggtagattta cttgtggctc agggtactag tttggtgact
     1021 gagggacagg ggctgcctgg tgtgtgggat gactggcctg tgtccaccta tgagaccaca
     1081 gcttcttcat ggccacggat gtggtgaaca gatgggtgtg tggctgatac agcacctgcc
     1141 tgaagcataa tgcttgctct ctgtcagctc gcacatctgg gactgtttat gagtgttata
     1201 gattcaactg gatcatgact gtattctggg aaactgggga gtatccaaag aacattccag
     1261 gccccaccac ctacagatag atattcgtat agagacctct ttgaaccacc acatgcactc
     1321 agggcaaagt gttgaacatg agagccatga atgaggataa tagagggcta acctgggcaa
     1381 catcatgggg cacttagagg atagggtatt ggggaaaggg tctccgtgat ggctaaggac
     1441 acagagttag acatgccaaa gcttgatttt ctgctccaca gtattcagct tgcatagccc
     1501 tgagggatgt gatgtttcaa atgctgtttg taaataaaat gtcattccct cctgggactt
     1561 ctgttgatta aaattaggtc acgtgtgaag tatttggaat agccttgaaa atatccaccc
     1621 acccacttat caaccattca ccattttaac aacctatcca tcaacccacc catccattca
     1681 tccacctgtc catccatcca ttcacccgtc catccatcca tccatccatc catccatcca
     1741 tccatccatc cacccacctt ctctccctct ctctttcccc tccttcttcc atctacctcc
     1801 ctccttatat ccatccattc attccacctc ccccttaatc cacctacaca aattaaaatt
     1861 gcaagtgtgg gttgctcaga tggctctgat ggcttgcagt tcaatatgat gacctgaatc
     1921 tgaaccccag aatttgcatg agaaagagaa tagaaggcaa ctcctacaca ttgtcttctg
     1981 acctgcacac acatgcagta gcacacacag tgtggcaggt gcatagacca aagtttgttt
     2041 gtttggttgg ttggttttgg tttttcgaga cagggtttct ctgtatagct ctggctgtcc
     2101 tggaactcac tttgtagacc aggctggcct tgaactcaga aatctgcctg cctctgcctc
     2161 tcaagtgctg ggattaaagg cgtgtgccac cacgctcggc agacaaaggt ttttaacatg
     2221 taaaaaaatg caagtaagga gctggaggct cagcaattaa gagcactggc agctcttgta
     2281 gaggacccag gtttgagtcc cagaactcat gtggcagtcc caggagatcc aacctcctct
     2341 cctggcatct atgggtcctc acagacatgg ttctcagata cacattcagg caaacattca
     2401 catacataaa ataaaataac ccacaaatg
//
