LOCUS       NM_001101453            2862 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus angiotensin I converting enzyme 3 (Ace3), mRNA.
ACCESSION   NM_001101453 XM_006533055 XM_110936 XM_907217
VERSION     NM_001101453.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2862)
  AUTHORS   Yu CJ, Tang LL, Liang C, Chen X, Song SY, Ding XQ, Zhang KY, Song
            BL, Zhao D, Zhu XY, Li HL and Zhang ZR.
  TITLE     Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure
            Overload-Induced Cardiac Hypertrophy
  JOURNAL   J Am Heart Assoc 5 (2), e002680 (2016)
   PUBMED   26892527
  REMARK    GeneRIF: ACE3 inhibits pressure overload-induced cardiac
            hypertrophy by blocking the MEK-ERK1/2 signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2862)
  AUTHORS   Inoue N, Kasahara T, Ikawa M and Okabe M.
  TITLE     Identification and disruption of sperm-specific angiotensin
            converting enzyme-3 (ACE3) in mouse
  JOURNAL   PLoS One 5 (4), e10301 (2010)
   PUBMED   20421979
  REMARK    GeneRIF: identified an IZUMO1-interacting protein in sperm, which
            was identified as testis specific ACE homologue ACE3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2862)
  AUTHORS   Weiss D, Bernstein KE, Fuchs S, Adams J, Synetos A and Taylor WR.
  TITLE     Vascular wall ACE is not required for atherogenesis in ApoE(-/-)
            mice
  JOURNAL   Atherosclerosis 209 (2), 352-358 (2010)
   PUBMED   19880118
  REMARK    GeneRIF: In the ACE 3/3 animals, atherosclerotic lesion area was
            not different from wild type controls despite reduced plasma ACE
            activity.
REFERENCE   4  (bases 1 to 2862)
  AUTHORS   Rella M, Elliot JL, Revett TJ, Lanfear J, Phelan A, Jackson RM,
            Turner AJ and Hooper NM.
  TITLE     Identification and characterisation of the angiotensin converting
            enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE
  JOURNAL   BMC Genomics 8, 194 (2007)
   PUBMED   17597519
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596331.15.
            
            On or before Jun 21, 2019 this sequence version replaced
            XM_006533055.3, NM_001101453.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB531024.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AL596331.15        3089-3202
            115-251             AL596331.15        3298-3434
            252-410             AL596331.15        3820-3978
            411-498             AL596331.15        4240-4327
            499-642             AL596331.15        4446-4589
            643-834             AL596331.15        5330-5521
            835-932             AL596331.15        5603-5700
            933-1105            AL596331.15        5812-5984
            1106-1329           AL596331.15        6313-6536
            1330-1474           AL596331.15        6689-6833
            1475-1573           AL596331.15        8377-8475
            1574-1696           AL596331.15        8649-8771
            1697-1881           AL596331.15        12864-13048
            1882-2261           AL596331.15        13525-13904
            2262-2862           AL596331.15        15390-15990
FEATURES             Location/Qualifiers
     source          1..2862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.86 cM"
     gene            1..2862
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /note="angiotensin I converting enzyme 3"
                     /db_xref="GeneID:217246"
                     /db_xref="MGI:MGI:3644400"
     exon            1..114
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..2240
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /EC_number="3.4.15.1"
                     /note="angiotensin-converting enzyme-like protein Ace3;
                     angiotensin I converting enzyme (peptidyl-dipeptidase A)
                     3"
                     /codon_start=1
                     /product="angiotensin-converting enzyme-like protein Ace3
                     precursor"
                     /protein_id="NP_001094923.2"
                     /db_xref="CCDS:CCDS59570.1"
                     /db_xref="GeneID:217246"
                     /db_xref="MGI:MGI:3644400"
                     /translation="MNLPWALLLVLLSHRQLLPWLRTVGETSLNDFYSEAQAKLFLQF
                     YEQTAQVVLNEFMEATWNYVTNITKQNQKNMLQKEADRSQFMLYFSTRARMFRTDHFL
                     NQDVKRMLRKLQNIDKSALPTEDLLEYNRLLTYMETAYNRAEVCLDEGPCLTLEPDLQ
                     EIMATSRDQKELLWAWQGWRDAVGRQLRPVFEDYVRLSNKAAQYNGYKDMGALWRSKY
                     ESDTLEEDLEQLYKELQPLYLNLHAYVRRSLYRYYGPELIDLRGPIPAHLLGNMWAQS
                     WNNILDLVLPYPTKAPEDITAIMKIQHWRPEKMFEEANLFFTSMGMLPAPPAFWIKSM
                     MEKPADGREVECHTSSWNFYKFNDFRVKKCTEVTLEDLLSVFHQMGHIQYFLQYQNLS
                     VIYQEGASPAFEEAVGSVIALSVSSHKYLLARGLLSQPHQDSEEEVNFLLGIALEKIA
                     FIPFSYLVDKFRWKIFDGTISKITYNQEWWNFRLKYQGLCPPVPRSDDDFDPGAKFHI
                     PANVPYIRYFLGLILQFQLHEALCEASGHVGPLHQCDNYNSKVAGKILGDLLKLGSSR
                     PWREVLQEVTGESNISTKAFLTYFKPLMDWLVTENVKQGDTLGWPDFSCSFEEKITSK
                     VSFLGTDTEPEQAYLGQWVLLSMSFFMLVLILALGFRLHYLEKQLLDEDTMILKTLPY
                     SYFLGIAMEPHQAARKQWLLLGLCCILMLCCIGLLIRIVTQNTENTPWMKNEGQS"
     exon            115..251
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            252..410
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            411..498
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            499..642
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            643..834
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            835..932
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1105
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1329
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1474
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1573
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1696
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1881
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2261
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2862
                     /gene="Ace3"
                     /gene_synonym="EG217246"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgttctct tggtcatggg aacaagatga acttgccctg ggccttgcta cttgtgctcc
       61 tctctcaccg gcaactcttg ccatggctca ggactgtggg agagacaagc ttaaatgatt
      121 tctacagcga ggctcaggct aagttgttcc tgcagtttta tgagcaaaca gcccaggtcg
      181 tgttgaatga gtttatggaa gccacttgga actacgtcac caacatcacc aagcagaatc
      241 aaaagaacat gctgcagaag gaggcggaca ggtctcagtt tatgttatac ttcagcaccc
      301 gggcccgcat gtttaggaca gaccatttcc tgaaccagga cgtgaagcgc atgctgagga
      361 agctgcagaa catagacaag tcggccttgc ccacggagga tctcctagag tacaacagac
      421 ttctgaccta catggagaca gcatataacc gagctgaggt gtgcctggat gagggtccct
      481 gcttgaccct agagcctgac ctccaagaaa tcatggccac ctccagggac cagaaggagc
      541 tgctgtgggc ctggcagggc tggcgggatg ctgttggccg acaactccgc cctgtctttg
      601 aggactacgt acgtctcagc aacaaggctg cccaatataa tggatacaaa gacatggggg
      661 ctttatggcg atccaagtat gaatctgaca cgctggagga agacctagag cagctctata
      721 aggagctgca gcctctctac ctgaacctcc atgcctatgt gcgccgctca ctgtaccgct
      781 actacgggcc tgagctcatt gacctgaggg ggcccatccc tgcccacctc ctggggaaca
      841 tgtgggctca gtcctggaat aatatcctag atctggtcct gccctatccg actaaagccc
      901 cagaggacat cacagcgatc atgaagatcc agcactggag gcctgagaaa atgtttgaag
      961 aggctaactt attctttacc tcaatgggca tgctacccgc cccgcctgct ttctggataa
     1021 agtctatgat ggagaagcca gctgacgggc gggaagtgga gtgccacacc tcatcctgga
     1081 acttctacaa gttcaatgac ttcagggtaa agaagtgcac ggaagtgacc ttagaagacc
     1141 tgctctccgt cttccaccag atgggccata tccagtactt cttgcagtat cagaatctct
     1201 ctgtcatcta ccaggaaggt gccagcccag cctttgaaga ggctgtgggg tcggtgatcg
     1261 ccctctcagt ctcttcccac aagtacctgc tcgccagagg tctgctcagc caacctcacc
     1321 aggattcaga ggaggaggtc aacttcctgt taggcattgc cctggagaag attgccttca
     1381 tccccttcag ctacctggta gacaagtttc gttggaagat ctttgatggc actatttcga
     1441 agattacata caaccaggag tggtggaact tcaggttgaa gtaccaaggc ctgtgcccac
     1501 ctgtccctcg atcagacgat gattttgacc caggtgccaa gtttcacatc cctgccaatg
     1561 tgccctatat ccgatacttt cttggtctga tactgcagtt tcaacttcat gaagcactat
     1621 gcgaagcctc cggccacgtg ggccctctgc accagtgcga taactacaac tccaaggttg
     1681 cagggaagat cttgggggat ctcctgaagt tgggctccag ccggccctgg cgggaggtcc
     1741 tccaggaggt gactggagag tccaatatat ccaccaaggc ctttttgacc tacttcaagc
     1801 cactgatgga ctggctggtg actgaaaacg tgaagcaagg ggacaccctt ggctggccag
     1861 acttcagctg ttcttttgaa gaaaaaatca caagcaaagt atcgtttctg ggcacagaca
     1921 cagagcctga gcaggcgtac ctggggcagt gggtgttgct gagcatgagt tttttcatgt
     1981 tggtcctcat cctggcactg ggcttcaggc tgcactactt ggaaaaacag ttactggacg
     2041 aagacacaat gattcttaag accctgccct actcctactt cctgggcata gccatggaac
     2101 cccatcaggc agcccggaaa cagtggcttc tgctgggcct ctgctgcatc cttatgctgt
     2161 gctgtattgg cctgctcatt cggatagtca cgcagaacac cgagaacact ccatggatga
     2221 aaaatgaagg gcagagctga gaggagccac catggagatg gccagcctgc tccccacatt
     2281 cagggacagc caagacatct ctgccccccc aggaaaccac acttggcagc cctctcatct
     2341 ctcaaccact gtggccaagg tcccccacca ggtattgtgg caaggacaca tcccgcccag
     2401 gactctaagc ctctcacctg gacttcagtg gaaacctcac tgagcctcct tggccacccc
     2461 ctccaccccc ccatccactt tgtaaagttt atatttctgc cagaatattt gcttcaaagg
     2521 ccttcaaatt tccttccgaa cctcagactt cttaaaaacg tagctgtcca tcaattaaat
     2581 ctggatgttc aaactagcac tggatgctgc ttgtcatttt tttctcctgc attttcacct
     2641 cctccattgg ccagttcagc ccctctgcat tgacaccacc cttgggcctt ttccgaaggt
     2701 gcatgtttca ttttgaatgc ttgctactaa aatgtggctc aaaattggtc ttgggaccct
     2761 ctgcaaagtt ccaagtccac caaggtgctt aatgaactgt ggcccttctt ttctcctctc
     2821 agaaaacccc cctttttttc aataaacttc accccacccc aa
//
