LOCUS       NM_027286               3418 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus angiotensin converting enzyme 2 (Ace2), transcript
            variant 2, mRNA.
ACCESSION   NM_027286 XM_136130
VERSION     NM_027286.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3418)
  AUTHORS   Scavuzzo,M.A., Szlachcic,W.J., Hill,M.C., Ziojla,N.M., Teaw,J.,
            Carlson,J.C., Tiessen,J., Chmielowiec,J., Martin,J.F. and
            Borowiak,M.
  TITLE     Pancreatic organogenesis mapped through space and time
  JOURNAL   Exp Mol Med 57 (1), 204-220 (2025)
   PUBMED   39779976
REFERENCE   2  (bases 1 to 3418)
  AUTHORS   Yan,K., Dumenil,T., Stewart,R., Bishop,C.R., Tang,B., Nguyen,W.,
            Suhrbier,A. and Rawle,D.J.
  TITLE     TMEM106B-mediated SARS-CoV-2 infection allows for robust
            ACE2-independent infection in vitro but not in vivo
  JOURNAL   Cell Rep 43 (11), 114921 (2024)
   PUBMED   39480813
REFERENCE   3  (bases 1 to 3418)
  AUTHORS   Zhang,L., Huang,T., He,H., Xu,F., Yang,C., Lu,L., Tian,G., Wang,L.
            and Mi,J.
  TITLE     Unraveling the molecular mechanisms of Ace2-mediated post-COVID-19
            cognitive dysfunction through systems genetics approach
  JOURNAL   Exp Neurol 381, 114921 (2024)
   PUBMED   39142369
  REMARK    GeneRIF: Unraveling the molecular mechanisms of Ace2-mediated
            post-COVID-19 cognitive dysfunction through systems genetics
            approach.
REFERENCE   4  (bases 1 to 3418)
  AUTHORS   Nunes-Souza,V., Alenina,N., Qadri,F., Mosienko,V., Santos,R.A.S.,
            Bader,M. and Rabelo,L.A.
  TITLE     ACE2 Knockout Mice Are Resistant to High-Fat Diet-Induced Obesity
            in an Age-Dependent Manner
  JOURNAL   Int J Mol Sci 25 (17), 9515 (2024)
   PUBMED   39273464
  REMARK    GeneRIF: ACE2 Knockout Mice Are Resistant to High-Fat Diet-Induced
            Obesity in an Age-Dependent Manner.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3418)
  AUTHORS   Song,L., Ji,W. and Cao,X.
  TITLE     Integrated analysis of gut microbiome and its metabolites in
            ACE2-knockout and ACE2-overexpressed mice
  JOURNAL   Front Cell Infect Microbiol 14, 1404678 (2024)
   PUBMED   39086603
  REMARK    GeneRIF: Integrated analysis of gut microbiome and its metabolites
            in ACE2-knockout and ACE2-overexpressed mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3418)
  AUTHORS   Li,W., Greenough,T.C., Moore,M.J., Vasilieva,N., Somasundaran,M.,
            Sullivan,J.L., Farzan,M. and Choe,H.
  TITLE     Efficient replication of severe acute respiratory syndrome
            coronavirus in mouse cells is limited by murine
            angiotensin-converting enzyme 2
  JOURNAL   J Virol 78 (20), 11429-11433 (2004)
   PUBMED   15452268
  REMARK    GeneRIF: Murine ACE2 less efficiently bound the S1 domain of
            SARS-CoV and supported less-efficient S protein-mediated infection.
REFERENCE   7  (bases 1 to 3418)
  AUTHORS   Glass,W.G., Subbarao,K., Murphy,B. and Murphy,P.M.
  TITLE     Mechanisms of host defense following severe acute respiratory
            syndrome-coronavirus (SARS-CoV) pulmonary infection of mice
  JOURNAL   J Immunol 173 (6), 4030-4039 (2004)
   PUBMED   15356152
REFERENCE   8  (bases 1 to 3418)
  AUTHORS   Donoghue,M., Wakimoto,H., Maguire,C.T., Acton,S., Hales,P.,
            Stagliano,N., Fairchild-Huntress,V., Xu,J., Lorenz,J.N.,
            Kadambi,V., Berul,C.I. and Breitbart,R.E.
  TITLE     Heart block, ventricular tachycardia, and sudden death in ACE2
            transgenic mice with downregulated connexins
  JOURNAL   J Mol Cell Cardiol 35 (9), 1043-1053 (2003)
   PUBMED   12967627
REFERENCE   9  (bases 1 to 3418)
  AUTHORS   Komatsu,T., Suzuki,Y., Imai,J., Sugano,S., Hida,M., Tanigami,A.,
            Muroi,S., Yamada,Y. and Hanaoka,K.
  TITLE     Molecular cloning, mRNA expression and chromosomal localization of
            mouse angiotensin-converting enzyme-related carboxypeptidase
            (mACE2)
  JOURNAL   DNA Seq 13 (4), 217-220 (2002)
   PUBMED   12487024
  REMARK    GeneRIF: ACE2 gene is expressed mainly in the kidney and the lungs.
REFERENCE   10 (bases 1 to 3418)
  AUTHORS   Crackower,M.A., Sarao,R., Oudit,G.Y., Yagil,C., Kozieradzki,I.,
            Scanga,S.E., Oliveira-dos-Santos,A.J., da Costa,J., Zhang,L.,
            Pei,Y., Scholey,J., Ferrario,C.M., Manoukian,A.S., Chappell,M.C.,
            Backx,P.H., Yagil,Y. and Penninger,J.M.
  TITLE     Angiotensin-converting enzyme 2 is an essential regulator of heart
            function
  JOURNAL   Nature 417 (6891), 822-828 (2002)
   PUBMED   12075344
  REMARK    GeneRIF: Angiotensin-converting enzyme 2 is an essential regulator
            of heart function.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI115946.1 and AK141604.1.
            
            On Jul 26, 2008 this sequence version replaced NM_027286.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141604.1, AB053181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AI115946.1         2-153
            153-3418            AK141604.1         2-3267
FEATURES             Location/Qualifiers
     source          1..3418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 76.12 cM"
     gene            1..3418
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /note="angiotensin converting enzyme 2"
                     /db_xref="GeneID:70008"
                     /db_xref="MGI:MGI:1917258"
     exon            1..368
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..2600
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /EC_number="3.4.17.23"
                     /note="angiotensin I converting enzyme 2; ACE-related
                     carboxypeptidase; angiotensin I converting enzyme
                     (peptidyl-dipeptidase A) 2"
                     /codon_start=1
                     /product="angiotensin-converting enzyme 2 precursor"
                     /protein_id="NP_081562.2"
                     /db_xref="CCDS:CCDS30518.1"
                     /db_xref="GeneID:70008"
                     /db_xref="MGI:MGI:1917258"
                     /translation="MSSSSWLLLSLVAVTTAQSLTEENAKTFLNNFNQEAEDLSYQSS
                     LASWNYNTNITEENAQKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQ
                     SGSSALSADKNKQLNTILNTMSTIYSTGKVCNPKNPQECLLLEPGLDEIMATSTDYNS
                     RLWAWEGWRAEVGKQLRPLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYN
                     RNQLIEDVERTFAEIKPLYEHLHAYVRRKLMDTYPSYISPTGCLPAHLLGDMWGRFWT
                     NLYPLTVPFAQKPNIDVTDAMMNQGWDAERIFQEAEKFFVSVGLPHMTQGFWANSMLT
                     EPADGRKVVCHPTAWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLL
                     RNGANEGFHEAVGEIMSLSAATPKHLKSIGLLPSDFQEDSETEINFLLKQALTIVGTL
                     PFTYMLEKWRWMVFRGEIPKEQWMKKWWEMKREIVGVVEPLPHDETYCDPASLFHVSN
                     DYSFIRYYTRTIYQFQFQEALCQAAKYNGSLHKCDISNSTEAGQKLLKMLSLGNSEPW
                     TKALENVVGARNMDVKPLLNYFQPLFDWLKEQNRNSFVGWNTEWSPYADQSIKVRISL
                     KSALGANAYEWTNNEMFLFRSSVAYAMRKYFSIIKNQTVPFLEEDVRVSDLKPRVSFY
                     FFVTSPQNVSDVIPRSEVEDAIRMSRGRINDVFGLNDNSLEFLGIHPTLEPPYQPPVT
                     IWLIIFGVVMALVVVGIIILIVTGIKGRKKKNETKREENPYDSMDIGKGESNAGFQNS
                     DDAQTSF"
     exon            369..527
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            528..621
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            622..765
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            766..878
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            879..984
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1082
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1252
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1479
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1624
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1723
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1846
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2019
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2078
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2179
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2296
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2491
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2492..3418
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2701..2706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2722
                     /gene="Ace2"
                     /gene_synonym="2010305L05Rik"
                     /note="major polyA site"
ORIGIN      
        1 ttaacttcat attggtccag cagcttgttt actgttctct tctgtttctt cttctgcttt
       61 ttttttcttc tcttctcagt gcccaaccca agttcaaagg ctgatgagag agaaaaactc
      121 atgaagagat tttactctag ggaaagttgc tcagtggatg ggatcttggc gcacggggaa
      181 agatgtccag ctcctcctgg ctccttctca gccttgttgc tgttactact gctcagtccc
      241 tcaccgagga aaatgccaag acatttttaa acaactttaa tcaggaagct gaagacctgt
      301 cttatcaaag ttcacttgct tcttggaatt ataatactaa cattactgaa gaaaatgccc
      361 aaaagatgag tgaggctgca gccaaatggt ctgcctttta tgaagaacag tctaagactg
      421 cccaaagttt ctcactacaa gaaatccaga ctccgatcat caagcgtcaa ctacaggccc
      481 ttcagcaaag tgggtcttca gcactctcag cagacaagaa caaacagttg aacacaattc
      541 tgaacaccat gagcaccatt tacagtactg gaaaagtttg caacccaaag aacccacaag
      601 aatgcttatt acttgagcca ggattggatg aaataatggc gacaagcaca gactacaact
      661 ctaggctctg ggcatgggag ggctggaggg ctgaggttgg caagcagctg aggccgttgt
      721 atgaagagta tgtggtcctg aaaaacgaga tggcaagagc aaacaattat aacgactatg
      781 gggattattg gagaggggac tatgaagcag agggagcaga tggctacaac tataaccgta
      841 accagttgat tgaagatgta gaacgtacct tcgcagagat caagccattg tatgagcatc
      901 ttcatgccta tgtgaggagg aagttgatgg atacctaccc ttcctacatc agccccactg
      961 gatgcctccc tgcccatttg cttggtgata tgtggggtag attttggaca aatctgtacc
     1021 ctttgactgt tccctttgca cagaaaccaa acatagatgt tactgatgca atgatgaatc
     1081 agggctggga tgcagaaagg atatttcaag aggcagagaa attctttgtt tctgttggcc
     1141 ttcctcatat gactcaagga ttctgggcaa actctatgct gactgagcca gcagatggcc
     1201 ggaaagttgt ctgccacccc acagcttggg atctgggaca cggagacttc agaatcaaga
     1261 tgtgtacaaa ggtcacaatg gacaacttct tgacagccca tcacgagatg ggacacatcc
     1321 aatatgacat ggcatatgcc aggcaacctt tcctgctaag aaacggagcc aatgaagggt
     1381 tccatgaagc tgttggagaa atcatgtcac tttctgcagc tacccccaag catctgaaat
     1441 ccattggtct tctgccatcc gattttcaag aagatagcga aacagagata aacttcctac
     1501 tgaaacaggc attgacaatt gttggaacac taccgtttac ttacatgtta gagaagtgga
     1561 ggtggatggt ctttcggggt gaaattccca aagagcagtg gatgaaaaag tggtgggaga
     1621 tgaagcggga gatcgttggt gtggtggagc ctctgcctca tgatgaaaca tactgtgacc
     1681 ctgcatctct gttccatgtt tctaatgatt actcattcat tcgatattac acaaggacca
     1741 tttaccaatt ccagtttcaa gaagctcttt gtcaagcagc taagtataat ggttctctgc
     1801 acaaatgtga catctcaaat tccactgaag ctgggcagaa gttgctcaag atgctgagtc
     1861 ttggaaattc agagccctgg accaaagcct tggaaaatgt ggtaggagca aggaatatgg
     1921 atgtaaaacc actgctcaat tacttccaac cgttgtttga ctggctgaaa gagcagaaca
     1981 gaaattcttt tgtggggtgg aacactgaat ggagcccata tgccgaccaa agcattaaag
     2041 tgaggataag cctaaaatca gctcttggag ctaatgcata tgaatggacc aacaacgaaa
     2101 tgttcctgtt ccgatcatct gttgcatatg ccatgagaaa gtatttttca ataatcaaaa
     2161 accagacagt tccttttcta gaggaagatg tacgagtgag tgatttgaaa ccaagagtct
     2221 ccttctactt ctttgtcacc tcaccccaaa atgtgtctga tgtcattcct agaagtgaag
     2281 ttgaagatgc catcaggatg tctcggggcc gcatcaatga tgtctttggc ctgaatgata
     2341 acagcctgga gtttctgggg attcacccaa cacttgagcc accttaccag cctcctgtca
     2401 ccatatggct gattattttt ggtgttgtga tggcactggt agtggttggc atcatcatcc
     2461 tgattgtcac tgggatcaaa ggtcgaaaga agaaaaatga aacaaaaaga gaagagaacc
     2521 cttatgactc gatggacatt ggaaaaggag aaagcaatgc aggattccaa aacagtgatg
     2581 atgctcagac ttccttttag caaagcactt gtcatcttcc tgtatgtaaa tgctaacttc
     2641 atagtacaca aaatatgaga gtatacacat gtcattagct atcaaaacta tgatctgttc
     2701 agtaaacgtt gtccaaagag catcagactt gagtggacat cttcactgac attgctttca
     2761 gtatttattt ctgcctaagg atttgacatc tcttctgttt attaatagag atgtttatct
     2821 tagcataaaa gagggaaatg tgcctttggc ctcacagtct atccagggtg atatggttgg
     2881 gtaactggag ttagaagatg agatgatgtc tcttgggggc aagtgttggc ttcggtgtgg
     2941 catctgggct gtgaactggt gggactgttg aggttgagaa tggtgctcgc tggtcacttg
     3001 aatccaagtg tgacgtcatg ctctgtggct tctgccttca cacttctcac ttcaagtact
     3061 gtaggaattt gttcacagta atacttgaaa tggactgtcc cttctttgga ggtgcagttc
     3121 aacggagaaa gaagccagac atcaggtaga gaccatgacc ttttctcttc caaacttgat
     3181 caacatctct ctaacaagac acagctagca caggaaactc cacgaaccca gagcatgcct
     3241 gtcagaaact acttccatta ttctcccatt gtggagtaag ggaaaattcc agatgaatgc
     3301 tcgatctgtg agatgggtgc ccagtctctg aaattgtttg tattttctca cagggtctga
     3361 gcaatggtga acacaaagcc gacctcaata aatacttatt agatttagac actcctct
//
