LOCUS       NM_207624               4903 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus angiotensin I converting enzyme (Ace), transcript
            variant 1, mRNA.
ACCESSION   NM_207624
VERSION     NM_207624.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4903)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4903)
  AUTHORS   Shibata,T., Bhat,S.A., Cao,D., Saito,S., Bernstein,E.A., Nishi,E.,
            Medenilla,J.D., Wang,E.T., Chan,J.L., Pisarska,M.D.,
            Tourtellotte,W.G., Giani,J.F., Bernstein,K.E. and Khan,Z.
  TITLE     Testicular ACE regulates sperm metabolism and fertilization through
            the transcription factor PPARgamma
  JOURNAL   J Biol Chem 300 (1), 105486 (2024)
   PUBMED   37992807
  REMARK    GeneRIF: Testicular ACE regulates sperm metabolism and
            fertilization through the transcription factor PPARgamma.
REFERENCE   3  (bases 1 to 4903)
  AUTHORS   Cao,D., Saito,S., Xu,L., Fan,W., Li,X., Ahmed,F., Jovanovic,P.,
            Shibata,T., Che,M., Bernstein,E.A., Gianni,J., Divakaruni,A.S.,
            Okwan-Duodu,D., Khan,Z., Riera,C.E., Chen,F. and Bernstein,K.E.
  TITLE     Myeloid cell ACE shapes cellular metabolism and function in PCSK-9
            induced atherosclerosis
  JOURNAL   Front Immunol 14, 1278383 (2023)
   PUBMED   37928535
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4903)
  AUTHORS   Juretzko,A., Steinbach,A., Witte,J., Hannemann,A., Miehe,B.,
            Siegerist,F., Wolke,C., Stracke,S. and Rettig,R.
  TITLE     Renal angiotensin I-converting enzyme-deficient mice are protected
            against aristolochic acid nephropathy
  JOURNAL   Pflugers Arch 475 (3), 391-403 (2023)
   PUBMED   36520238
  REMARK    GeneRIF: Renal angiotensin I-converting enzyme-deficient mice are
            protected against aristolochic acid nephropathy.
REFERENCE   5  (bases 1 to 4903)
  AUTHORS   Gao,Y., Sun,Y., Islam,S., Nakamura,T., Tomita,T., Zou,K. and
            Michikawa,M.
  TITLE     Presenilin 1 deficiency impairs Abeta42-to-Abeta40- and
            angiotensin-converting activities of ACE
  JOURNAL   Front Aging Neurosci 15, 1098034 (2023)
   PUBMED   36875692
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4903)
  AUTHORS   Cambien,F., Poirier,O., Lecerf,L., Evans,A., Cambou,J.P.,
            Arveiler,D., Luc,G., Bard,J.M., Bara,L., Ricard,S. et al.
  TITLE     Deletion polymorphism in the gene for angiotensin-converting enzyme
            is a potent risk factor for myocardial infarction
  JOURNAL   Nature 359 (6396), 641-644 (1992)
   PUBMED   1328889
REFERENCE   7  (bases 1 to 4903)
  AUTHORS   Langford,K.G., Shai,S.Y., Howard,T.E., Kovac,M.J., Overbeek,P.A.
            and Bernstein,K.E.
  TITLE     Transgenic mice demonstrate a testis-specific promoter for
            angiotensin-converting enzyme
  JOURNAL   J Biol Chem 266 (24), 15559-15562 (1991)
   PUBMED   1651914
REFERENCE   8  (bases 1 to 4903)
  AUTHORS   Howard,T.E., Shai,S.Y., Langford,K.G., Martin,B.M. and
            Bernstein,K.E.
  TITLE     Transcription of testicular angiotensin-converting enzyme (ACE) is
            initiated within the 12th intron of the somatic ACE gene
  JOURNAL   Mol Cell Biol 10 (8), 4294-4302 (1990)
   PUBMED   2164636
REFERENCE   9  (bases 1 to 4903)
  AUTHORS   Shai,S.Y., Langford,K.G., Martin,B.M. and Bernstein,K.E.
  TITLE     Genomic DNA 5' to the mouse and human angiotensin-converting enzyme
            genes contains two distinct regions of conserved sequence
  JOURNAL   Biochem Biophys Res Commun 167 (3), 1128-1133 (1990)
   PUBMED   2157425
REFERENCE   10 (bases 1 to 4903)
  AUTHORS   Bernstein,K.E., Martin,B.M., Edwards,A.S. and Bernstein,E.A.
  TITLE     Mouse angiotensin-converting enzyme is a protein composed of two
            homologous domains
  JOURNAL   J Biol Chem 264 (20), 11945-11951 (1989)
   PUBMED   2545691
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596246.10 and AL731865.9.
            
            On Jun 18, 2019 this sequence version replaced NM_207624.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161020.1, AK154632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AL596246.10        128198-128495
            299-466             AL596246.10        129157-129324
            467-560             AL596246.10        129951-130044
            561-704             AL596246.10        130803-130946
            705-896             AL596246.10        131542-131733
            897-994             AL596246.10        132267-132364
            995-1167            AL596246.10        132611-132783
            1168-1391           AL596246.10        133111-133334
            1392-1536           AL596246.10        133642-133786
            1537-1635           AL596246.10        134029-134127
            1636-1758           AL596246.10        134354-134476
            1759-1970           AL596246.10        134917-135128
            1971-2107           AL596246.10        135786-135922
            2108-2266           AL596246.10        136795-136953
            2267-2354           AL596246.10        137202-137289
            2355-2498           AL596246.10        139420-139563
            2499-2690           AL596246.10        139731-139922
            2691-2788           AL596246.10        141748-141845
            2789-2961           AL596246.10        142018-142190
            2962-3185           AL731865.9         3159-3382
            3186-3330           AL731865.9         3687-3831
            3331-3429           AL731865.9         4104-4202
            3430-3552           AL731865.9         6130-6252
            3553-3740           AL731865.9         6543-6730
            3741-4903           AL731865.9         6916-8078
FEATURES             Location/Qualifiers
     source          1..4903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.84 cM"
     gene            1..4903
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /note="angiotensin I converting enzyme"
                     /db_xref="GeneID:11421"
                     /db_xref="MGI:MGI:87874"
     exon            1..298
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..3973
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /EC_number="3.4.15.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; dipeptidyl peptidase; kininase II; dipeptidyl
                     carboxypeptidase I; angiotensin-converting enzyme;
                     angiotensin I converting enzyme (peptidyl-dipeptidase A)
                     1"
                     /codon_start=1
                     /product="angiotensin-converting enzyme isoform 1
                     precursor"
                     /protein_id="NP_997507.1"
                     /db_xref="CCDS:CCDS25543.1"
                     /db_xref="GeneID:11421"
                     /db_xref="MGI:MGI:87874"
                     /translation="MGAASGQRGRWPLSPPLLMLSLLVLLLQPSPAPALDPGLQPGNF
                     SPDEAGAQLFAESYNSSAEVVMFQSTVASWAHDTNITEENARRQEEAALVSQEFAEVW
                     GKKAKELYESIWQNFTDSKLRRIIGSIRTLGPANLPLAQRQQYNSLLSNMSRIYSTGK
                     VCFPNKTATCWSLDPELTNILASSRSYAKLLFAWEGWHDAVGIPLKPLYQDFTAISNE
                     AYRQDDFSDTGAFWRSWYESPSFEESLEHIYHQLEPLYLNLHAYVRRALHRRYGDKYV
                     NLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMVQKGWNATHMFRVSEEF
                     FTSLGLSPMPPEFWAESMLEKPTDGREVVCHASAWDFYNRKDFRIKQCTRVTMEQLAT
                     VHHEMGHVQYYLQYKDLHVSLRRGANPGFHEAIGDVLALSVSTPAHLHKIGLLDHVTN
                     DIESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGIC
                     PPVARNETHFDAGAKFHIPNVTPYIRYFVSFVLQFQFHQALCKEAGHQGPLHQCDIYQ
                     SAQAGAKLKQVLQAGCSRPWQEVLKDLVGSDALDAKALLEYFQPVSQWLEEQNQRNGE
                     VLGWPENQWRPPLPDNYPEGIDLETDEAKADRFVEEYDRTAQVLLNEYAEANWQYNTN
                     ITIEGSKILLEKSTEVSNHTLKYGTRAKTFDVSNFQNSSIKRIIKKLQNLDRAVLPPK
                     ELEEYNQILLDMETTYSLSNICYTNGTCMPLEPDLTNMMATSRKYEELLWAWKSWRDK
                     VGRAILPFFPKYVEFSNKIAKLNGYTDAGDSWRSLYESDNLEQDLEKLYQELQPLYLN
                     LHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPFPSAPNIDATEA
                     MIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHPSAWDFYNG
                     KDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDIMALS
                     VSTPKHLYSLNLLSTEGSGYEYDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITK
                     ENYNQEWWSLRLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYVRYFVSFIIQFQFHEA
                     LCRAAGHTGPLHKCDIYQSKEAGKLLADAMKLGYSKPWPEAMKLITGQPNMSASAMMN
                     YFKPLTEWLVTENRRHGETLGWPEYNWAPNTARAEGSTAESNRVNFLGLYLEPQQARV
                     GQWVLLFLGVALLVATVGLAHRLYNIRNHHSLRRPHRGPQFGSEVELRHS"
     exon            299..466
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            467..560
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            561..704
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            705..896
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            897..994
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1167
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1391
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1536
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1635
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1758
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1970
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2107
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2266
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2354
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2498
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2690
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2788
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2961
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3185
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3330
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            3331..3429
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3552
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            3553..3740
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..4903
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4182..4187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /note="hexamer: ATTAAA"
     polyA_site      4199
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /note="major polyA site"
     regulatory      4852..4857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ace"
                     /gene_synonym="CD143"
                     /note="hexamer: AATAAA"
     polyA_site      4888
                     /gene="Ace"
                     /gene_synonym="CD143"
ORIGIN      
        1 agaaggggca gcgccgcacc gcgcgcaccg cgccatgggg gccgcgtccg gccagcgggg
       61 gcggtggccg ttgtcgcctc cgctcttgat gctgtcgctg ctggtgctgt tgctgcagcc
      121 gtcgcccgcc ccggcactcg accctggatt gcagccgggc aacttttccc cggacgaggc
      181 aggggcgcag cttttcgctg aaagctataa ctcgagtgcc gaggtggtga tgttccagag
      241 caccgtggcc agttgggcgc acgacaccaa catcacggag gagaacgcgc gacgccagga
      301 ggaagcggcc ctggtcagcc aggagtttgc agaggtctgg ggcaagaagg ccaaggagtt
      361 gtatgagtcc atttggcaga actttactga ctcaaagctg cgaaggatca tcggatctat
      421 tcggacccta ggacctgcca atctgcccct ggcccagcgg cagcagtaca actctctgct
      481 aagcaacatg agcagaatct actccactgg caaggtctgc ttccccaaca agactgccac
      541 ctgctggtcc ctggacccag agctcaccaa catcctggct tcctcacgaa gctatgccaa
      601 gttgttgttt gcctgggagg gctggcatga tgctgtgggt atcccactga aacccctcta
      661 tcaagacttt actgccatca gtaacgaagc ctacagacaa gacgacttct cagacacagg
      721 agccttctgg cgctcctggt atgagtcccc ctcctttgag gagagtctgg aacatatcta
      781 ccaccaacta gagcccctct acctgaacct ccatgcctac gtccgccgcg cactgcaccg
      841 ccgctatggg gacaaatacg tcaatctcag ggggcctatt cctgcccatt tgctgggaga
      901 catgtgggcc cagagctggg agaacatcta cgacatggta gtgcctttcc cagacaaacc
      961 caacctcgat gtcaccagta caatggtaca gaagggctgg aacgccacac acatgttccg
     1021 ggtatcagag gaattcttca cctcgctggg gctctcaccc atgcctcctg agttctgggc
     1081 ggagtcaatg ctggagaaac caacggatgg acgggaggtg gtgtgccacg cctctgcctg
     1141 ggacttctac aaccggaagg acttccggat taagcaatgc acacgggtca cgatggaaca
     1201 gctggccaca gtacaccacg agatgggcca cgtgcagtac tacctccagt acaaggacct
     1261 gcacgtctct ctgcgtagag gtgccaaccc tggcttccat gaggccattg gggatgtgct
     1321 tgcactctcc gtctctaccc ctgcacatct gcacaaaatc ggcctactgg accatgttac
     1381 caatgacata gagagtgaca tcaattacct gctaaagatg gccctagaga aaatcgcctt
     1441 cttgcccttt ggctacctgg tggaccagtg gcgttggggg gtcttcagtg gacggacccc
     1501 accctctcgc tacaacttcg actggtggta tcttcgaacc aagtatcagg ggatctgccc
     1561 accagttgcc cggaatgaaa cccattttga tgctggagcc aagtttcaca tcccaaacgt
     1621 gacaccgtac atcaggtact tcgtgagctt tgtgctgcag ttccagttcc atcaagcact
     1681 gtgcaaggag gcaggccacc agggcccact acaccagtgt gacatctacc agtccgccca
     1741 ggcgggggcc aagctcaagc aggtgttgca ggctggctgc tccaggccct ggcaggaggt
     1801 actgaaggac ctggtaggct cagatgccct ggatgccaag gcactgctgg agtacttcca
     1861 accggtcagc cagtggctgg aagagcagaa tcagcggaat ggcgaagtcc taggctggcc
     1921 agagaatcag tggcgtccac cgttacccga caactatcca gagggcattg acctagagac
     1981 tgatgaagcc aaggctgaca ggttcgtgga agagtatgac cggacagccc aagtgttgtt
     2041 gaacgagtac gcagaggcca actggcaata taacaccaac attaccatag agggcagcaa
     2101 gatcctgctt gagaaaagca cggaggtatc caatcacacc ctgaaatatg gcacccgggc
     2161 caagacattt gatgtgagca actttcaaaa ctcttccatc aagcggatca taaagaagct
     2221 tcagaacctg gaccgggcag tgctgcctcc caaggaatta gaagagtaca accagatcct
     2281 gctagacatg gagacaactt acagcttatc caacatttgc tacacaaatg gcacttgtat
     2341 gcccctggaa cctgatctaa caaacatgat ggccacatcc cggaaatatg aagaattgct
     2401 atgggcatgg aagagctgga gagacaaggt ggggagagcc atccttcctt ttttcccaaa
     2461 gtatgtggag ttctccaaca agattgccaa gctcaatggc tacacggatg caggggattc
     2521 atggagatcc ttatacgagt ctgacaacct ggagcaagac ctggaaaaac tgtaccagga
     2581 gctgcagcca ctctacctga acctgcatgc ctatgtgcgt cgttccctgc accgccacta
     2641 tgggtccgag tacatcaacc tggatggccc cattcctgcc catctgctag ggaacatgtg
     2701 ggcgcagacc tggtccaaca tctatgattt ggtggcgccc ttcccttccg cccccaatat
     2761 agatgccacg gaagccatga taaagcaggg atggacaccc agaaggatat ttaaggaagc
     2821 tgacaatttc tttacctccc tggggctgtt acctgtgccc cctgagttct ggaacaagtc
     2881 gatgttagag aagcccaccg atggaaggga ggtggtgtgc catccctcag cctgggactt
     2941 ctacaacggc aaggacttca ggatcaagca gtgtacctct gtgaacatgg aggacttggt
     3001 gatagcgcac cacgaaatgg gccacatcca gtatttcatg cagtacaaag acttacccgt
     3061 gactttccgg gagggtgcca accctggttt tcatgaagct attggagata taatggctct
     3121 ctcagtgtct acccccaagc atctatacag tctcaacctg cttagcactg agggcagtgg
     3181 ctacgagtat gacatcaact ttctaatgaa gatggccctc gacaagatcg cctttatccc
     3241 cttcagctac ctcatcgacc agtggcgctg gagggtcttt gatggaagca tcaccaagga
     3301 gaactataac caggagtggt ggagcctcag gctgaagtat cagggtctgt gccccccagt
     3361 gccaagatcc caaggtgact ttgacccagg gtccaagttc cacgttcctg cgaacgtgcc
     3421 atacgtcagg tactttgtca gcttcatcat ccagttccag ttccacgagg cgctgtgtcg
     3481 cgcagccggg cacacgggtc ccctgcacaa gtgtgacatc taccaatcca aggaagcagg
     3541 gaagctcctg gcggatgcca tgaagctggg ctacagtaag ccgtggccag aggccatgaa
     3601 gctgatcaca ggccagccta acatgtcagc ctccgccatg atgaattact tcaagccact
     3661 gacagaatgg ctcgtcaccg agaacaggag acatggagag acactgggct ggccggagta
     3721 caactgggcg ccaaacaccg ctcgcgcaga aggctccacc gcagagtcca accgcgtcaa
     3781 tttcctgggc ctgtacctgg agccacagca ggcccgcgtg ggccagtggg tgctgctctt
     3841 cctgggcgtc gccctgctcg tggccaccgt gggtctcgcc catcggctct acaacatccg
     3901 taaccatcac agcctccgcc ggccccaccg tgggccccag tttgggtctg aggtggagct
     3961 cagacactcc tgaggtgacc ctgctggcaa ggccagcaga ggagtgtccc ataagaaact
     4021 ggatggggga catggtgttt gagtggaaca taccctagct gagccttcct cctttgctgt
     4081 ccccatccac tctgccccac ccccaccccc caggcccagc ccccattctc tggataccca
     4141 gtgtctaaca ccgacttccc tgcccagtct ctgtgaatac aattaaaggt cctcccccac
     4201 acctgagtct gtgtcccttg tgggaagcca gggacaggac cggctgcttg cctgtctcct
     4261 gacagtccca gcacgaccct ttactggttg tcttcgcagt cttcctccaa gcaggaagct
     4321 aatcccaatt cctctggacc ccatccccca caacctttcc caccagcctt cctaacagcc
     4381 caggtgaggt ggctcctgtc ttgcagaccc atgaacttgc cagggaggag cctaggaaac
     4441 agaggggaag gaagcaggta ggctgcctcc tttatgtgtg gatacactat agatggctca
     4501 tcctgtccca tgtgacctct ctgtggctgg gtgtcttgga ggaaggctct ggatgccctt
     4561 ccctgctaca gggtgagggc cctggaaggg cgtgcctcac tgagcatgct gaagcggcca
     4621 gtatataagt ggacagcctg ggttccctga cggagccacg taggctctgc ccacaggaaa
     4681 gagcattaat ccgtgaccac acagtgggtt cactgctact gcccacctcc tcatcccgga
     4741 acacatcccc tcagcctcag ccatcctttg gaaggcctat ttggatttta gggggtgtca
     4801 cttgaagtaa ctttttatct acatatttat gtagtaaatt tggaaaatct gaataaaaag
     4861 cccatggtag caacattaag aaatataagc actgttgaag ttt
//
