LOCUS       NM_001290782            3952 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus 1-aminocyclopropane-1-carboxylate synthase (inactive)
            (Accs), transcript variant 1, mRNA.
ACCESSION   NM_001290782 XM_006499759
VERSION     NM_001290782.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3952)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3952)
  AUTHORS   Zambrowicz,B.P., Abuin,A., Ramirez-Solis,R., Richter,L.J.,
            Piggott,J., BeltrandelRio,H., Buxton,E.C., Edwards,J., Finch,R.A.,
            Friddle,C.J., Gupta,A., Hansen,G., Hu,Y., Huang,W., Jaing,C.,
            Key,B.W. Jr., Kipp,P., Kohlhauff,B., Ma,Z.Q., Markesich,D.,
            Payne,R., Potter,D.G., Qian,N., Shaw,J., Schrick,J., Shi,Z.Z.,
            Sparks,M.J., Van Sligtenhorst,I., Vogel,P., Walke,W., Xu,N.,
            Zhu,Q., Person,C. and Sands,A.T.
  TITLE     Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap
            screen to identify potential targets for therapeutic intervention
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14109-14114 (2003)
   PUBMED   14610273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732472.16, AK011867.1 and BC039569.1.
            
            On Mar 20, 2014 this sequence version replaced XM_006499759.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011867.1, SRR1660819.24580.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AL732472.16        49421-49517         c
            98-693              AK011867.1         2-597
            694-1472            BC039569.1         726-1504
            1473-1578           AK011867.1         1356-1461
            1579-1755           BC039569.1         1611-1787
            1756-3952           AL732472.16        33041-35237         c
FEATURES             Location/Qualifiers
     source          1..3952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 51.62 cM"
     gene            1..3952
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /note="1-aminocyclopropane-1-carboxylate synthase
                     (inactive)"
                     /db_xref="GeneID:329470"
                     /db_xref="MGI:MGI:1919717"
     exon            1..179
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1688
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /note="isoform a is encoded by transcript variant 1;
                     1-aminocyclopropane-1-carboxylate synthase-like protein 1;
                     1-aminocyclopropane-1-carboxylate synthase homolog; ACC
                     synthase-like protein 1; 1-aminocyclopropane-1-carboxylate
                     synthase (non-functional)"
                     /codon_start=1
                     /product="1-aminocyclopropane-1-carboxylate synthase-like
                     protein 1 isoform a"
                     /protein_id="NP_001277711.1"
                     /db_xref="CCDS:CCDS71105.1"
                     /db_xref="GeneID:329470"
                     /db_xref="MGI:MGI:1919717"
                     /translation="MFCLPQQESTAPTTCTGSASTQDMDSGYGDGLQGECLRKPDQTQ
                     PKLYGVGDPTATFSSDSSCLSSRGRVIKWFWDSAEEGYRTYHMDEYDEDKNPSGIINL
                     GTSENKLCFDLLSWRLTQGDMLHVEPSLLQYPDWRGHLFLREEVAKFLSFYCKSPAPL
                     KPENVVVLNGCASLFSALATVLCEAGEALLIPTPYYGAITQHIYLYGNVRLAYVYLDS
                     KVTGLNTRPFQLTVEKLEMVLQGVSSEGVKVKGLILINPQNPLGDVYSPEELQDFLRF
                     AMRHKLHVIMDEVYMLSVFEESLGYRSVLSLERLPDPQRTHVMWATSKDFGMSGLRFG
                     VLYTENQHVATAVASLCRYHGLSGLVQHQMAQLLRDHDWISQVYLPENHARLKAAHTY
                     VSEELRALGIPFVSRGAGFFIWVDLRKYLCKGTFEEEALLWRQFLDNKVLLSSGKTFE
                     CKEPGWFRVVFSDKENRLRLGMQRMRQVLEGQSQVVEDASPCHAQEPQSQPR"
     exon            180..470
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            471..530
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            531..601
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            602..671
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            672..738
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            739..836
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            837..914
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1015
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1105
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1151
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1293
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1436
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1590
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..3952
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /note="hexamer: ATTACA"
     polyA_site      1981
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /note="major polyA site"
     polyA_site      2002
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
     regulatory      3076..3081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /note="hexamer: CATAAA"
     polyA_site      3105
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
     regulatory      3928..3933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
                     /note="hexamer: AATAAA"
     polyA_site      3951
                     /gene="Accs"
                     /gene_synonym="2610203E10Rik; Phacs"
ORIGIN      
        1 gactccagtt tctggcagac agggaagtgc tgaagaccgg agcttcctct tctgtgacca
       61 ggagtcaggg cacagactcc ttccctgtgt tcccgccaga tcgccagggg gcaggctgct
      121 ccggtatcac ggaagtccga tccggagaat atcgcgcgcg tgaaaaccca aggtccaaaa
      181 tgttctgtct tcctcagcag gaatccacgg cacctactac ctgcacaggc tcagcctcca
      241 ctcaggacat ggacagtggc tatggtgatg gcctgcaagg agaatgcctc agaaaaccag
      301 accagacgca gcccaaactc tatggagtag gtgaccccac ggccacgttc tcctctgaca
      361 gctcctgcct gtcctccaga ggaagagtca tcaaatggtt ctgggactcg gctgaggagg
      421 gctacaggac ctaccacatg gatgagtatg acgaggacaa gaaccccagt ggcatcatta
      481 acttgggcac cagtgaaaac aaactctgct ttgaccttct gtcctggcgg ctgacacagg
      541 gtgacatgct tcatgtggaa ccatctctgc tgcagtaccc tgactggaga ggacatttgt
      601 tcctccggga agaagtggca aagttcttgt ctttctattg taagagcccg gcacccctga
      661 aaccagagaa tgtggttgtt ctgaatggct gtgcctctct cttttccgct ctggccacag
      721 tgctgtgtga ggcaggggag gctctcttga tccccacacc ttactacgga gccatcactc
      781 agcacatcta tctctatggc aacgtccgac tggcttatgt ctacctagac agcaaggtaa
      841 ctggattgaa tacacgcccc ttccagctca ccgtagagaa gctggagatg gtcctgcaag
      901 gagtcagttc tgagggtgtc aaggtcaaag gccttatcct catcaacccc caaaaccctc
      961 tgggtgacgt ctactccccg gaagagctgc aggactttct gagatttgcc atgaggcaca
     1021 agctgcacgt gatcatggat gaggtttaca tgctctctgt gtttgaagag tcccttggct
     1081 accgcagtgt cctcagcctg gagaggctgc ctgaccccca gaggacacac gtgatgtggg
     1141 ccaccagcaa ggactttggg atgtcggggc tacgcttcgg tgtactgtac acggagaacc
     1201 agcacgtggc tactgctgtg gcctccctct gccgctatca tggcctcagt ggcctggtcc
     1261 aacaccagat ggcacagctg ctccgggacc atgactggat cagccaggtg tacctgccag
     1321 aaaaccatgc ccggctcaag gctgcccaca cctatgtctc agaggaactc agagccctgg
     1381 ggatcccctt tgtgagtcgc ggggcaggct tcttcatctg ggttgacttg agaaagtatc
     1441 tgtgcaaagg cacctttgag gaggaggcgt tattgtggcg ccaatttttg gacaacaagg
     1501 tgctgctgtc ctccggtaag acctttgagt gcaaagaacc cggctggttc cgcgtggtct
     1561 tctcggacaa ggagaaccgg cttcgcctgg gaatgcaaag gatgcggcag gtgcttgaag
     1621 gacaatctca agtggtagaa gatgcctctc cctgtcacgc tcaggaacca caaagccagc
     1681 ccagatgagc tgcccattgc ctctcactgt tcctgtgacc tggccctgtg gggctacagg
     1741 agactgagtg tggatgcgcc atttgtcagt gggactcacg acttggcttt gaccttgaag
     1801 gactttttcc tgccctctgc tgacagtggg agtctgttta aactgatatt catcttgggc
     1861 tgttgctgcc ctgtattcaa caggattagg atcagcagga tgactttgtg aacagtgtac
     1921 agtttggaga gtcgtgactg ctcctaatta cagctccttt ctaggataca agagtgaaaa
     1981 agcaactctt cattctttgt gatggtgcct tcctgcctct ttccttgttt ccagggaaac
     2041 aagccagagg atcagcacac cgcgcacgta cacacacaca cacacacaca cacacacaca
     2101 cacacacaca cacgatagca ttccaaggat gttattccaa agcatgttcc aatggatgga
     2161 atgaattctg tttattcagg tctttggagg cccggacagg cctcagcttg ggatgtagag
     2221 agaaatactt catggtgggc gttaggaaga tcttcttggt ggagctgaaa tgcctggatc
     2281 aagttctggg attcacttct tacctgggaa ggagatgcct ttattgctgt tcccgaagat
     2341 atggcctagc aatggctagg gaaggggaag ggacaggagg ctatatttct gaaccaaggc
     2401 tgtctggggg ccaggcaaag attggtcttt ctgtgctaag aaagcctacg aaggagctgc
     2461 ctgttccatt tgaggggtgc gttagtgaag atcccaaatg aatgtctggt tggtggcctg
     2521 catgtacagt acctagagtc acagctgcaa gagtagctga ggcaggagga ttacttgcac
     2581 ctgtaagttt gagatcaacc tgggcaggag tcacagatgc aacataaaca gtggaaatca
     2641 gaaaattact cctgacccca gaatgaaccc actacaagtg tgtcagtgaa aacagcatag
     2701 cccaggctga cccagacagt cagcccaggc tggcccagac agtcagttgt gccttgcagg
     2761 cgcccttcgc tgtgctcagg atatcctctc gcagatgagg aaacttagtc ttagatgaaa
     2821 taatattcca aacctcacag ctacacactc aaggacccaa gtgagagtag tttgccttgg
     2881 ttcagaatct gtgtgtggtg ggttggagag atggctcaga gcttaagaac atttgctttt
     2941 cttctgagga cttgagttcc catggtgggg ctcataacca tctgtaactc cagttctagg
     3001 gatctaattc cccctctggc cctgtgggca ctgtatacac atgtgcgcgc gcacacacac
     3061 acacacacac aaagccataa aaaggaatca catgtgtact gtttatttgt gcgttgcttt
     3121 ctgctgtttt cttggttggt ctgtagattg cctatatttt ctgttttgtt tttctctgtc
     3181 attagtttaa ttttcttcct tttcttagat tttttttttt ttgatttccc ctcttcatct
     3241 tctactcatt ttaccatatg ctgtattttc ctgctggctg ttatcctaga atataacacc
     3301 tacaaacaat ttgttaatag gaaagcaaac atgcctcagc tttccctata gcaatgggag
     3361 accccaaatc cctggtgacc cctggctggg tttgtggtct gtgttcattt gtgcttttca
     3421 gttttgaccc tgcaaagtct tgttttacac aggtgacgtt tgcttcaggt gatcacagag
     3481 ttatcccaag catccactgg gagccacgtg tcttctgtct gttgtgcagc tcctggggtg
     3541 ggattggaga gtttgcaaga gacagacttt caatccctgc ttgtctgagg atgccagttt
     3601 tgctcccttt ttggaacata actttactgg ttatagaatt ctgtagttag tggttatttt
     3661 ctgatttcct ctgttgatgt tgcatctgca actccttcca agacaacgtg tcaactcact
     3721 cctgtcccag tttcttcatg cctttaaagg acagtatcag gctgccaaga tgggtcagcg
     3781 gtgaagagca ccagaagctc taacagagga actgaattca gttcccagca accatgtagt
     3841 ggctcacaac catctataat gggatctgat gccctcttct gacatgcacc acacaaacac
     3901 acaaaacagt catatataaa taataataat aaaaaacatt atcattggtg ac
//
