LOCUS       NM_133225               3487 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus acyl-Coenzyme A binding domain containing 3 (Acbd3),
            mRNA.
ACCESSION   NM_133225
VERSION     NM_133225.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3487)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3487)
  AUTHORS   Yamaguchi,H., Meyer,M.D., He,L. and Komatsu,Y.
  TITLE     Disruption of Trip11 in cranial neural crest cells is associated
            with increased ER and Golgi stress contributing to skull defects in
            mice
  JOURNAL   Dev Dyn 251 (7), 1209-1222 (2022)
   PUBMED   35147267
REFERENCE   3  (bases 1 to 3487)
  AUTHORS   Shin,H.J., Ku,K.B., Kim,S., Kim,H.S., Kim,Y.S., Kim,B.T., Kim,S.J.
            and Kim,C.
  TITLE     A Crucial Role of ACBD3 Required for Coxsackievirus Infection in
            Animal Model Developed by AAV-Mediated CRISPR Genome Editing
            Technique
  JOURNAL   Viruses 13 (2), 237 (2021)
   PUBMED   33546322
  REMARK    GeneRIF: A Crucial Role of ACBD3 Required for Coxsackievirus
            Infection in Animal Model Developed by AAV-Mediated CRISPR Genome
            Editing Technique.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3487)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3487)
  AUTHORS   Chen,Y., Bang,S., Park,S., Shi,H. and Kim,S.F.
  TITLE     Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism
            through activating poly(ADP-ribose) polymerase 1
  JOURNAL   Biochem J 469 (2), 189-198 (2015)
   PUBMED   25940138
  REMARK    GeneRIF: these findings suggest that ACBD3 has prominent impacts on
            cellular NAD(+) metabolism via regulating PARP1
            activation-dependent auto-modification and thus cell metabolism and
            function.
REFERENCE   6  (bases 1 to 3487)
  AUTHORS   Liu,J., Rone,M.B. and Papadopoulos,V.
  TITLE     Protein-protein interactions mediate mitochondrial cholesterol
            transport and steroid biosynthesis
  JOURNAL   J Biol Chem 281 (50), 38879-38893 (2006)
   PUBMED   17050526
REFERENCE   7  (bases 1 to 3487)
  AUTHORS   Wendler,G., Lindemann,P., Lacapere,J.J. and Papadopoulos,V.
  TITLE     Protoporphyrin IX binding and transport by recombinant mouse PBR
  JOURNAL   Biochem Biophys Res Commun 311 (4), 847-852 (2003)
   PUBMED   14623258
  REMARK    GeneRIF: These results suggest that PBR, in addition to its role in
            cholesterol and coproporphyrinogen III transport, is also directing
            the mitochondrial PPIX import, a function that can be ascribed to
            the 18kDa PBR protein alone
REFERENCE   8  (bases 1 to 3487)
  AUTHORS   Liu,J., Cavalli,L.R., Haddad,B.R. and Papadopoulos,V.
  TITLE     Molecular cloning, genomic organization, chromosomal mapping and
            subcellular localization of mouse PAP7: a PBR and PKA-RIalpha
            associated protein
  JOURNAL   Gene 308, 1-10 (2003)
   PUBMED   12711385
REFERENCE   9  (bases 1 to 3487)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3487)
  AUTHORS   Li,H., Degenhardt,B., Tobin,D., Yao,Z.X., Tasken,K. and
            Papadopoulos,V.
  TITLE     Identification, localization, and function in steroidogenesis of
            PAP7: a peripheral-type benzodiazepine receptor- and PKA
            (RIalpha)-associated protein
  JOURNAL   Mol Endocrinol 15 (12), 2211-2228 (2001)
   PUBMED   11731621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030371.1, BC060602.1 and BU756506.1.
            
            On May 8, 2009 this sequence version replaced NM_133225.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030371.1, SRR1660819.52586.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-701               AK030371.1         2-702
            702-1026            BC060602.1         657-981
            1027-3142           AK030371.1         1028-3143
            3143-3434           BC060602.1         3098-3389
            3435-3487           BU756506.1         1-53                c
FEATURES             Location/Qualifiers
     source          1..3487
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.46 cM"
     gene            1..3487
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /note="acyl-Coenzyme A binding domain containing 3"
                     /db_xref="GeneID:170760"
                     /db_xref="MGI:MGI:2181074"
     exon            1..336
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1637
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /note="PBR associated protein; golgi phosphoprotein 1;
                     PBR- and PKA-associated protein 7; golgi
                     complex-associated protein 1; acyl-CoA-binding
                     domain-containing protein 3; peripheral benzodiazepine
                     receptor-associated protein PAP7; golgi complex associated
                     protein 1, 60 kDa; peripherial benzodiazepine receptor
                     associated protein"
                     /codon_start=1
                     /product="Golgi resident protein GCP60"
                     /protein_id="NP_573488.2"
                     /db_xref="CCDS:CCDS15572.1"
                     /db_xref="GeneID:170760"
                     /db_xref="MGI:MGI:2181074"
                     /translation="MAAQLNVEQLEVSLDGLTLSPDSEERPGAEGAPPQTPPSSAPGN
                     GLGSGASGQQREPGEAAAEGAAEEARRMEQHWGFGLEELYGLALRFYKIKDGKAFHPT
                     YEEKLKFVALHKQVLLGPYNPDTSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVK
                     LLNKCCPLLSAYVASHRIEKEEEEKRRKAEEERRQREEEERERLQKEEEKRKREEEDR
                     LRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQ
                     LQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVMAGASLPASSKVNTAGASDTLSVNGQ
                     AKTHTENSEKVLEPEAAEEALENGPKDSLPVIAAPSMWTRPQIKDFKEKIRQDADSVI
                     TVRRGEVVTVRVPTHEEGSYLFWEFATDSYDIGFGVYFEWTDSPNAAVSVHVSESSDE
                     EEEEEENVTCEEKAKKNANKPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNS
                     YSLWRSKSVYYRVYYTR"
     exon            337..478
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /inference="alignment:Splign:2.1.0"
     exon            479..619
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /inference="alignment:Splign:2.1.0"
     exon            620..778
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /inference="alignment:Splign:2.1.0"
     exon            779..953
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1140
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1425
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..3471
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3164..3169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /note="hexamer: AATAAA"
     polyA_site      3183
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
     regulatory      3415..3420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /note="hexamer: ATTAAA"
     polyA_site      3434
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /note="major polyA site"
     regulatory      3453..3458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /note="hexamer: AATACA"
     polyA_site      3471
                     /gene="Acbd3"
                     /gene_synonym="60kDa; 8430407O11Rik; D1Ertd10e; GCP60;
                     Gocap1; GOLPH1; Pap7"
                     /note="major polyA site"
ORIGIN      
        1 agcaggaagt cgatacgtgg ccgccgcctg tccccgccga ggaggcgctg cgagcggaga
       61 tggcggcgca gctgaacgta gagcagctcg aggtgtcgct cgacggtctc acgctgagcc
      121 cggactcgga ggagaggccc ggcgcggagg gggccccgcc gcagacgccg ccgtcctcgg
      181 ccccggggaa tggactgggc tccggcgcct cggggcagca gcgggagccc ggggaggcgg
      241 cggctgaggg cgcggccgag gaggcgcggc ggatggagca gcactggggc tttggcctgg
      301 aggagcttta cggcctggcg ctgcgcttct acaaaataaa agatggcaaa gcctttcatc
      361 caacttatga agaaaaactg aagttcgtgg cactgcataa gcaagttctt ttgggcccat
      421 ataacccaga cacgtcccct gaggttggat tctttgatgt gttggggaat gataggagga
      481 gagaatgggc agctctggga aacatgtcca aggaggatgc catggtagag tttgtgaagc
      541 ttctaaataa gtgttgtcct ctcctctcgg catatgttgc gtcccacaga atagagaagg
      601 aagaagaaga gaaaagaaga aaggcggagg aggagcgaag gcagcgtgaa gaggaagaac
      661 gagagcggct gcaaaaggaa gaagagaagc ggaagcgaga ggaggaagac cggctgagac
      721 gggaggagga agagaggcgg cggatagagg aagagaggct tcggctggaa cagcaaaagc
      781 agcagataat ggcagcttta aactcgcaga ctgccgtgca attccagcag tatgcagccc
      841 agcagtatcc agggaactac gaacaacagc agattctcat ccgccagctg caggagcagc
      901 actatcagca gtatatgcag cagttatatc aagtccagct tgcacaacaa caggcagcat
      961 tacagaaaca gcaagaagta gtgatggctg gggcatcatt gcctgcatca tcaaaggtga
     1021 acacagctgg agcaagtgat acactgtcag ttaatggaca ggccaaaacc cacactgaaa
     1081 attccgaaaa agtccttgag ccagaagctg cagaagaagc cttggaaaat ggaccaaaag
     1141 actctcttcc agtgattgca gctccatcca tgtggacaag accacaaatc aaagacttta
     1201 aagagaagat tcggcaggat gcagattctg tgattacagt acgtcgagga gaagtcgtca
     1261 ccgtccgagt cccgactcat gaggaaggat catacctatt ttgggaattt gccacagaca
     1321 gttatgacat tgggtttggg gtttattttg aatggacaga ctctccaaat gctgctgtca
     1381 gtgtgcatgt cagtgagtcc agtgacgagg aggaggagga ggaagaaaat gtcacttgtg
     1441 aagaaaaagc aaaaaagaac gccaacaagc ctctgctgga tgagattgta cctgtgtacc
     1501 ggcgggactg tcacgaggaa gtatatgcag gcagccacca gtatccaggg aggggagtct
     1561 atctcctcaa gtttgataat tcctactctc tgtggaggtc caagtccgtc tactacagag
     1621 tctattatac tagatagagc tgctgttcca gggtcgggag tctagggttg agcacaacat
     1681 gacgtttaat ttcctttgac ttttgtggcg cataggagtc cgtgtttatc ttctcgattt
     1741 tgttctgagg gtttatgaac tcattgagaa ccaggattcc ttgagactct ttagcattag
     1801 tgctctgagg ttaaaagcag ttcggaagac tcatctagcc cttgggtgct gaccagcaga
     1861 gctgctagtg gatattggag ttacatgagc tacgtgttaa tattcagtct ccagaataaa
     1921 cgtcccagcg ttgccctgac ctggctggag ggcgcattgc tgtctgtgcc tgtgttgtgc
     1981 acagccacag ttagtaactg gggaagcttc tgtactagtc tccttcaacg cagctggctt
     2041 tgactgagtg ctttgacagt ttgagacttc accaagtata gtagaaaaac aaatggcctc
     2101 aacttgatct tacctgagta accaaggctg cttttgcttt gggtacagct atttagttag
     2161 ttgtgttaca aagaattatt ttctgagaga atcttaaact tagaatattc agatgcagta
     2221 gatactggcg tgtggagatt cacagacgac ctcagcaccc atcccaccag gtccctggac
     2281 tcacggcctt tccttcattt gccattcaca ttgctgctca caaaacagaa ctcggtgact
     2341 ttgttttgat atagttttgt ggaccatctc aaattaaaac tattttctgt aaaaaatcta
     2401 tagccaggag ttttataaac tcacctggca cctactgagc taaaatatgc aaaatctgaa
     2461 ctaaaatatg caaaatcact ttaatataat ttgacatttg aggagtacca ttgcactaac
     2521 aggaaatcac tgccggagac agcccacatt tccttgtagt tgttattagg gcacaaacca
     2581 ctccacagtc ccagtgtgga gtcacagtct agagagaatt ggaaatgcac gtgcttaaat
     2641 gatacagctt taatctgtat tatgactgct ggtggtaaga ggaatatctt taaatttctt
     2701 atgaaaacaa atccacattc attatttcac atttgtctaa gaggttaagt atctgaaggg
     2761 agggtagtgt agatagcaaa tgacagagac agtacacacc tagtgtattg tcactgaagt
     2821 cttaggttta actttgacat cacaggtccc ttccaggggt accactgggt agctgcagtg
     2881 tgcaccggtc actacattca ggctatttga ggttttcata tgctgcattt ctttgttttt
     2941 aacacctggt tttataggtt ctctttcgtt tgttaagaaa ctggattctt ttctcctaac
     3001 cagtgcttaa tttgtgtttt tggattttct ttcagaagta gtcaaatgtc tatgctgtta
     3061 catccagaat attcattagg ctgccccaca gctcttctgt atatatagag accacagagt
     3121 taggattttt tttaatgaga aaaatactgt atttaaaatg taaaataaac ttttaaaaag
     3181 caagcactaa tatatatttc tttcagcctt tgattacagt tttgtccttg cacatgttaa
     3241 gataaattat cttctaaaac cttgttcttg ggagcagtga atgtcacttt acatggctgt
     3301 ttctgtcaca tgttcatatc tgaacatttt tggttataac ttttttattg cctttggctg
     3361 ttgattagta caagtgcaat ttcaaaaaga tcttgaaagt aatatattta atcaattaaa
     3421 atgtttctct gtaagtcgtc gatgtttctg ttaatacagt ttcctgaagc aaaaaaaaaa
     3481 aaaaaaa
//
