LOCUS       NM_009338               2076 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus acetyl-Coenzyme A acetyltransferase 2 (Acat2), mRNA.
ACCESSION   NM_009338
VERSION     NM_009338.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2076)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2076)
  AUTHORS   Ma,Z., Huang,Z., Zhang,C., Liu,X., Zhang,J., Shu,H., Ma,Y., Liu,Z.,
            Feng,Y., Chen,X., Kuang,S., Zhang,Y. and Jia,Z.
  TITLE     Hepatic Acat2 overexpression promotes systemic cholesterol
            metabolism and adipose lipid metabolism in mice
  JOURNAL   Diabetologia 66 (2), 390-405 (2023)
   PUBMED   36378328
  REMARK    GeneRIF: Hepatic Acat2 overexpression promotes systemic cholesterol
            metabolism and adipose lipid metabolism in mice.
REFERENCE   3  (bases 1 to 2076)
  AUTHORS   Xu,Y., Du,X., Turner,N., Brown,A.J. and Yang,H.
  TITLE     Enhanced acyl-CoA:cholesterol acyltransferase activity increases
            cholesterol levels on the lipid droplet surface and impairs
            adipocyte function
  JOURNAL   J Biol Chem 294 (50), 19306-19321 (2019)
   PUBMED   31727739
  REMARK    GeneRIF: findings provide detailed insights into the role of free
            cholesterol in LD and adipocyte function and suggest that ACAT
            inhibitors have potential utility for managing disorders associated
            with extreme obesity
REFERENCE   4  (bases 1 to 2076)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 2076)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   6  (bases 1 to 2076)
  AUTHORS   Nerurkar,P.V., Schut,H.A., Anderson,L.M., Riggs,C.W.,
            Snyderwine,E.G., Thorgeirsson,S.S., Weber,W.W., Rice,J.M. and
            Levy,G.N.
  TITLE     DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in
            colon, bladder, and kidney of congenic mice differing in Ah
            responsiveness and N-acetyltransferase genotype
  JOURNAL   Cancer Res 55 (14), 3043-3049 (1995)
   PUBMED   7606725
REFERENCE   7  (bases 1 to 2076)
  AUTHORS   Ashworth,A.
  TITLE     Two acetyl-CoA acetyltransferase genes located in the t-complex
            region of mouse chromosome 17 partially overlap the Tcp-1 and
            Tcp-1x genes
  JOURNAL   Genomics 18 (2), 195-198 (1993)
   PUBMED   7904580
REFERENCE   8  (bases 1 to 2076)
  AUTHORS   Himmelbauer,H., Artzt,K., Barlow,D., Fischer-Lindahl,K., Lyon,M.,
            Klein,J. and Silver,L.M.
  TITLE     Encyclopedia of the mouse genome III. October 1993. Mouse
            chromosome 17
  JOURNAL   Mamm Genome 4 Spec No, S230-S252 (1993)
   PUBMED   8268678
REFERENCE   9  (bases 1 to 2076)
  AUTHORS   Dudley,K., Shanahan,F., Burtenshaw,M., Evans,E.P., Ruddy,S. and
            Lyon,M.F.
  TITLE     Isolation and characterization of a cDNA clone corresponding to the
            mouse t-complex gene Tcp-1x
  JOURNAL   Genet Res 57 (2), 147-152 (1991)
   PUBMED   2055458
REFERENCE   10 (bases 1 to 2076)
  AUTHORS   Willison,K.R., Dudley,K. and Potter,J.
  TITLE     Molecular cloning and sequence analysis of a haploid expressed gene
            encoding t complex polypeptide 1
  JOURNAL   Cell 44 (5), 727-738 (1986)
   PUBMED   3753900
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK167234.1.
            
            On Jun 10, 2007 this sequence version replaced NM_009338.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167234.1, AK166813.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2076              AK167234.1         1-2076
FEATURES             Location/Qualifiers
     source          1..2076
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.73 cM"
     gene            1..2076
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /note="acetyl-Coenzyme A acetyltransferase 2"
                     /db_xref="GeneID:110460"
                     /db_xref="MGI:MGI:87871"
     exon            1..117
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..252
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..434
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..552
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..696
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..819
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..974
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1085
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..2076
                     /gene="Acat2"
                     /gene_synonym="Tcp-1x; Tcp1-rs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagttttac ctcagtcgca gacaggacaa ggctgagagc tagcagagac cagagcgaca
       61 agatgaatgc gggctcagac cccgtggtca tcgtctcagc ggcgcgcacc gctataggct
      121 ccttcaatgg tgccctgtcc accgtgcctg tccacgaaat ggggacaact gtcatcaaag
      181 aagtcctgca gagggccaag gtggctccag aagaggtgtc cgaggtcata tttggacatg
      241 tcttgacggc aggttgtggg cagaatccta ctcgacaagc cagtgtgggt gcagggatcc
      301 cctattcggt tccagcatgg agctgccaga tgatctgtgg ctcgggccta aaagccgtgt
      361 gtcttgcagc ccagtccata gccatgggcg actccaccat tgtggtagct ggaggcatgg
      421 agaatatgag caaggctcct cacttgactc acctgagaac aggagtcagg atgggtgagg
      481 tgccactggc tgacagcata ctctgtgatg gtctgacaga tgcctttcac aactaccaca
      541 tgggcatcac agctgaaaac gtagccaaaa aatggcaagt gagcagagag gcccaggaca
      601 aggttgcagt tctgtcacag aacagggcag agcatgctca gaaagctggc cactttgaca
      661 aggagattgt gccagtgctg gtgtcttcca gaaaaggtct tactgaagtg aaaatcgatg
      721 aatttccccg tcatgggagt aaccttgaag ccatgggcaa gctgaaacct tactttctta
      781 ctgatgggac aggaactgtc accccagcga acgcatcagg aatgaacgat ggcgctgctg
      841 ctgtggtcct tatgaagaag acagaagctg agaggcggat gctgaaacct ttagcaagaa
      901 tagtctcctg gtcccaagcc ggtgtggagc cttctgttat gggagtagga ccaattccag
      961 ccataaagca agctgttgca aaggcaggct ggtccctgga ggatgttgac ctgtttgaaa
     1021 tcaatgaagc ctttgcagcg gtgtctgcgg caatagctaa agaacttgga ttaaaccccg
     1081 agaaggtcaa catcgatgga ggagccattg ccttgggcca tcctctggga gcatctggct
     1141 gcaggattct agtgaccttg ctgcacaccc tggagagagt gggcgggacc cgtggtgttg
     1201 cagccctgtg cattgggggt gggatgggag tcgcaatgtg tgttcagaga gggtgaactg
     1261 catgacagcc accaccttgg acagttcttg ttaaatcagt gcaacactaa gcagaaaggg
     1321 aaaccagagg accaaactga ggacaggaac ccaggtggac agcttgctgt actttaatgt
     1381 gagacaccca aggctacggc attgcacctg acactgttat aaataagagg gaaatccaat
     1441 cagtcatcaa gggctccaga gtgaacagca ttttcataac ttccatgttt atcgtcttta
     1501 ctttctgggt gtaattttct ctgatcattg ttttttgttt tttttgtttt tctttgtttt
     1561 tgagttaggg tctcaccata tagcctcaaa atcgttttgt agatcaggtt gactttgaac
     1621 tcccggagat ccacctttct gtgcctcctg aatacttgaa ttaaaggcat gcaccattat
     1681 gcagggcccc caaaatgatc cattcaaaac atggggattc ggcttctgtt acgaacttca
     1741 ggctcttcac tttaactatg gttggttcaa acgcccctgc gtgcctgtct ctcggtttcc
     1801 cattgatcaa atcaagacca atcctgtagt gaaagtcgga ttcagtgacc tcttccaggc
     1861 tgaggtgggg taggtattcc agctgttcta gtcagaagac tggcagtgcc aacaagtgtg
     1921 cctctggatt gttgaaaggt gggcagcaag cagcatccac gtacttattt ctctgcttga
     1981 cgggatggga tgttacctgc ttcagatatc taccttgact tccccaaaat gatgactgga
     2041 actggaactg acagtcaaat aaactctttc ctccct
//
