LOCUS       NM_144784               3373 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus acetyl-Coenzyme A acetyltransferase 1 (Acat1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_144784
VERSION     NM_144784.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3373)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3373)
  AUTHORS   Sugi,T., Katoh,Y., Ikeda,T., Seta,D., Iwata,T., Nishio,H.,
            Sugawara,M., Kato,D., Katoh,K., Kawana,K., Yaguchi,T., Kawakami,Y.
            and Hirai,S.
  TITLE     SCD1 inhibition enhances the effector functions of CD8+ T cells via
            ACAT1-dependent reduction of esterified cholesterol
  JOURNAL   Cancer Sci 115 (1), 48-58 (2024)
   PUBMED   37879607
  REMARK    GeneRIF: SCD1 inhibition enhances the effector functions of CD8[+]
            T cells via ACAT1-dependent reduction of esterified cholesterol.
REFERENCE   3  (bases 1 to 3373)
  AUTHORS   Rogers,M.A., Chang,C.C.Y., Maue,R.A., Melton,E.M., Peden,A.A.,
            Garver,W.S., Lee,J., Schroen,P., Huang,M. and Chang,T.Y.
  TITLE     Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and
            ameliorates functional deficiencies in multiple organelles of
            mutant cells
  JOURNAL   Proc Natl Acad Sci U S A 119 (18), e2201646119 (2022)
   PUBMED   35507892
REFERENCE   4  (bases 1 to 3373)
  AUTHORS   Terasaki,M., Yashima,H., Mori,Y., Saito,T., Matsui,T., Hiromura,M.,
            Kushima,H., Osaka,N., Ohara,M., Fukui,T., Hirano,T. and
            Yamagishi,S.I.
  TITLE     A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of
            Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1
            Expression
  JOURNAL   Int J Mol Sci 21 (13), 4811 (2020)
   PUBMED   32646003
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3373)
  AUTHORS   Xu,J., Zhou,Y., Yang,Y., Lv,C., Liu,X. and Wang,Y.
  TITLE     Involvement of ABC-transporters and acyltransferase 1 in
            intracellular cholesterol-mediated autophagy in bovine alveolar
            macrophages in response to the Bacillus Calmette-Guerin (BCG)
            infection
  JOURNAL   BMC Immunol 21 (1), 26 (2020)
   PUBMED   32397995
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3373)
  AUTHORS   Uelmen,P.J., Oka,K., Sullivan,M., Chang,C.C., Chang,T.Y. and
            Chan,L.
  TITLE     Tissue-specific expression and cholesterol regulation of
            acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice.
            Molecular cloning of mouse ACAT cDNA, chromosomal localization, and
            regulation of ACAT in vivo and in vitro
  JOURNAL   J Biol Chem 270 (44), 26192-26201 (1995)
   PUBMED   7592824
REFERENCE   7  (bases 1 to 3373)
  AUTHORS   Nerurkar,P.V., Schut,H.A., Anderson,L.M., Riggs,C.W.,
            Snyderwine,E.G., Thorgeirsson,S.S., Weber,W.W., Rice,J.M. and
            Levy,G.N.
  TITLE     DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in
            colon, bladder, and kidney of congenic mice differing in Ah
            responsiveness and N-acetyltransferase genotype
  JOURNAL   Cancer Res 55 (14), 3043-3049 (1995)
   PUBMED   7606725
REFERENCE   8  (bases 1 to 3373)
  AUTHORS   Takakubo,F. and Dahl,H.H.
  TITLE     Analysis of pyruvate dehydrogenase expression in embryonic mouse
            brain: localization and developmental regulation
  JOURNAL   Brain Res Dev Brain Res 77 (1), 63-76 (1994)
   PUBMED   7510589
REFERENCE   9  (bases 1 to 3373)
  AUTHORS   Masuno,M., Kano,M., Fukao,T., Yamaguchi,S., Osumi,T., Hashimoto,T.,
            Takahashi,E., Hori,T. and Orii,T.
  TITLE     Chromosome mapping of the human mitochondrial acetoacetyl-coenzyme
            A thiolase gene to 11q22.3----q23.1 by fluorescence in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 60 (2), 121-122 (1992)
   PUBMED   1351831
REFERENCE   10 (bases 1 to 3373)
  AUTHORS   Leader,D.P., Gall,I., Campbell,P. and Frischauf,A.M.
  TITLE     Isolation and characterization of cDNA clones from mouse skeletal
            muscle actin mRNA
  JOURNAL   DNA 5 (3), 235-238 (1986)
   PUBMED   3013550
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156640.2.
            
            On Nov 17, 2006 this sequence version replaced NM_144784.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081715.1, AK032097.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC156640.2         795-932
            139-186             AC156640.2         13013-13060
            187-304             AC156640.2         15745-15862
            305-400             AC156640.2         16356-16451
            401-501             AC156640.2         16639-16739
            502-645             AC156640.2         19034-19177
            646-796             AC156640.2         19688-19838
            797-892             AC156640.2         21872-21967
            893-1006            AC156640.2         23579-23692
            1007-1071           AC156640.2         26241-26305
            1072-1229           AC156640.2         27551-27708
            1230-3373           AC156640.2         28480-30623
FEATURES             Location/Qualifiers
     source          1..3373
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.12 cM"
     gene            1..3373
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /note="acetyl-Coenzyme A acetyltransferase 1"
                     /db_xref="GeneID:110446"
                     /db_xref="MGI:MGI:87870"
     exon            1..138
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            139..186
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            187..304
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            305..400
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            401..501
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            502..645
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            646..796
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            797..892
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1006
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1071
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1229
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..3373
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /note="hexamer: AATAAA"
     polyA_site      1521
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /note="major polyA site"
     regulatory      2182..2187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /note="hexamer: AATAAA"
     regulatory      2196..2201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
                     /note="hexamer: AATGAA"
     polyA_site      2203
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
     polyA_site      2213
                     /gene="Acat1"
                     /gene_synonym="6330585C21Rik; Acat"
ORIGIN      
        1 gacgtcgcaa gctctgcggt ggggaagtgg aggccgcggc gcgtctctct gcccttgaca
       61 gcctttcgcg tctccatggc tgccctggtg gctctgcacg gcgtcgtccg caggcctctg
      121 cttcgcgggc tgctgcagga agtaagatgc ctggaacgaa gttatgcatc caaacccact
      181 ttgaatgaag tggttatagt aagtgctata agaactccca ttggatcctt cctgggcagc
      241 cttgcctctc agccggccac taaacttggt actgctgcaa ttcagggagc cattgagaag
      301 gcagggattc caaaagaaga agtgaaggaa gtctacatgg gcaatgtcat ccaagggggt
      361 gaaggacagg cccctaccag gcaagcaaca ctgggcgcag gtttacctat ttccactcca
      421 tgcaccacag taaacaaggt ttgtgcttca ggaatgaaag ccatcatgat ggcctctcaa
      481 agtcttatgt gtggacatca ggatgtgatg gtggcaggcg ggatggagag catgtccaat
      541 gtcccatacg taatgagcag aggagcaaca ccatatggtg gggtaaaact tgaagacctg
      601 attgtaaaag acgggctaac tgatgtctac aataaaattc atatgggtaa ctgtgctgag
      661 aatactgcaa agaagatgaa tatctcacgg caggaacagg atacgtacgc tctcagctct
      721 tacaccagaa gtaaagaagc gtgggacgca gggaagtttg ccagtgagat tactcccatc
      781 accatctcag tgaaaggtaa accagatgtg gtggtgaaag aagatgaaga atacaagcgt
      841 gttgacttta gtaaagtgcc aaagctcaag accgtgttcc agaaagaaaa tggcacaata
      901 acagctgcca atgccagcac actgaacgat ggagcagctg ctctggttct catgactgca
      961 gaggcagccc agaggctcaa tgttaagcca ttggcacgaa ttgcagcatt tgctgatgct
     1021 gccgtagacc ccattgattt tccacttgcg cctgcatatg ccgtacctaa ggttcttaaa
     1081 tatgcaggac tgaaaaaaga agacattgcc atgtgggaag taaatgaagc attcagtgtg
     1141 gttgtgctag ccaacattaa aatgctggag attgaccccc aaaaagtaaa tatccacgga
     1201 ggagctgttt ctctgggcca tccaattggg atgtctggag cccggattgt tgttcatatg
     1261 gctcatgccc tgaagccagg agagttcggt ctggctagta tttgcaacgg aggaggaggt
     1321 gcttccgccc tgctgattga gaagctgtag acaacctgtt ttaggagaca gttccatgtg
     1381 accggctgaa gtaaatgtga ctcccttggg ccaggttata ttcagcataa gctatttcat
     1441 tttttattat tttctactaa aatttttaaa aaatcatatc caaaaaacac acttaaatta
     1501 caaataaaaa tttcttcttt attttatttt atttttttgt aaacttaaac agttggatac
     1561 tctattattt gaaataccaa tataggtatt tgaggcatgg ctcagcagtt aagagaattt
     1621 gttgctagtt gggtggtaca tggctttaat cccagcactt ggagatagag gcaagtggat
     1681 ctttctgagt ttaaggctag cctggtccac agagctactt ctatgacagc caagaataca
     1741 catagaagta gaaactctgg aaacaaacaa acgaacaaaa gagcatctgt tgctcacaca
     1801 gaaaacattt ggttcccagg acccacactg ggtgacacag cagggaggac ttggacactg
     1861 cactgcacgc agaaaccaga gaaatgaggt cctgtgcttt tctacctcac tgctgccggt
     1921 acagcagaag ccagccttgg ggataacctg taaccgggtt ctctcctgat gaaggcaggg
     1981 taaagttcca gcatttttac atctaaatac accaaagaaa tgagaatatc acaatagcag
     2041 caacaaagtt ccttgactct cccaagcccc aaaataatct aacatccatg gacttctatt
     2101 ctgccattag aatgaacact ggctgtttat gttttgtttt gttttcgaac tttaatcctt
     2161 ggacagtcaa aattggtttc aaataaagtt atgtgaatga aaattttaaa aaatatggtt
     2221 aagtcttcca agtgagcaca agttatagca atctatgtcc accaagccaa catagaagct
     2281 ctttaaagga gtcctgcaaa caaaacagag caggaagcag cagtcacaga cctaagagca
     2341 caacaaagaa tacattccag gagaggaact gagagccagg agagagacag accatgccca
     2401 actcagtaaa ccagaagagc tatagaatga ggaaggaaga aaaaatagta ttcaagccag
     2461 ccagagaatc aacagaatta ctgtaatgag aaaatatcct cagcccaaac ttttaatggg
     2521 ctcaacataa aatttaaaaa tactatctca aaaacatgat ccactgggtg tgcatgcctt
     2581 taaatcccag cacttgggag gaagaggcag gaggatccga gtctacatag ccagcttggt
     2641 gtacataatg agttccaaga cagccaggac tacacagaga aaaaaattct ctcttgaaaa
     2701 gatcaacaaa gtattgtctt acaagagacc tcattggcaa agactcatag actaaaagtg
     2761 gcagaatggg aagccacgtg ctctcaagta gcacaaaatc aagtaggtgt agctttgtcc
     2821 gtcagttata aaagctaggt ttgaagcagc ttgtcagaga agacaaagaa tgtcactaaa
     2881 catcaatgaa gggaacaatc accaagaaga cagaagagga ctggggaggt agctcagtcg
     2941 gtagtgttgg cccagcagac ctaaagccct gggttctttc tttctatccc tgcactacag
     3001 aaacaagcag ggaaggaggt ggagtagaga ctccatagag agaaacgaac cgagaaacga
     3061 tccaaaaaac ttgtggtgtg ctgcagtttc gtacctcttc aatggactcg ggctgattgg
     3121 caaagtgatg tcagcgagac agatgctcat gctgagacaa gacccaggcc cgcagaggac
     3181 ttgggatgtt tagaggcctg tgatgttagg cccagcagac agtgacggag gtttggttgg
     3241 gcttgcttat atacctagct gtgcaacact tgtgggtctg gagtcttcac tggtatttcc
     3301 cactacctct agtgggaggt gggccaaaag ggatgttaaa gcgttcaaga accatcatta
     3361 aaaatgggtg ttg
//
