LOCUS       NM_207223               4438 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus ArfGAP with coiled-coil, ankyrin repeat and PH domains
            3 (Acap3), mRNA.
ACCESSION   NM_207223 XM_131838
VERSION     NM_207223.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4438)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4438)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4438)
  AUTHORS   Miura,Y. and Kanaho,Y.
  TITLE     ACAP3, the GTPase-activating protein specific to the small GTPase
            Arf6, regulates neuronal migration in the developing cerebral
            cortex
  JOURNAL   Biochem Biophys Res Commun 493 (2), 1089-1094 (2017)
   PUBMED   28919417
  REMARK    GeneRIF: ACAP3 is involved in neuronal migration in the developing
            cerebral cortex of mice. Knockdown of ACAP3 in the developing
            cortical neurons of mice in utero significantly abrogated neuronal
            migration in the cortical layer, which was restored by ectopic
            expression of wild type of ACAP3, but not by its GTPase-activating
            protein - inactive mutant.
REFERENCE   4  (bases 1 to 4438)
  AUTHORS   Miura,Y., Hongu,T., Yamauchi,Y., Funakoshi,Y., Katagiri,N.,
            Ohbayashi,N. and Kanaho,Y.
  TITLE     ACAP3 regulates neurite outgrowth through its GAP activity specific
            to Arf6 in mouse hippocampal neurons
  JOURNAL   Biochem J 473 (17), 2591-2602 (2016)
   PUBMED   27330119
  REMARK    GeneRIF: cycling between active and inactive forms of Arf6, which
            is precisely regulated by ACAP3 in concert with a
            guanine-nucleotide-exchange factor(s), seems to be required for
            neurite outgrowth of hippocampal neurons
REFERENCE   5  (bases 1 to 4438)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 4438)
  AUTHORS   Shubina,D.M., Suchkova,I.O., Slominskaia,N.A., Alenina,N., Bader,M.
            and Patkin,E.L.
  TITLE     [CENTB5 gene expression in human and mouse]
  JOURNAL   Mol Biol (Mosk) 43 (3), 407-413 (2009)
   PUBMED   19548526
  REMARK    GeneRIF: minisatellite locus UPS29 can regulate an activity of
            CENTB5, SCNN1D and ACOT7 in nervous system cells.
REFERENCE   7  (bases 1 to 4438)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 4438)
  AUTHORS   Bachmanov,A.A., Li,X., Reed,D.R., Ohmen,J.D., Li,S., Chen,Z.,
            Tordoff,M.G., de Jong,P.J., Wu,C., West,D.B., Chatterjee,A.,
            Ross,D.A. and Beauchamp,G.K.
  TITLE     Positional cloning of the mouse saccharin preference (Sac) locus
  JOURNAL   Chem Senses 26 (7), 925-933 (2001)
   PUBMED   11555487
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC067016.1.
            
            On Aug 30, 2004 this sequence version replaced XM_131838.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067016.1, AK147505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.66 cM"
     gene            1..4438
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /note="ArfGAP with coiled-coil, ankyrin repeat and PH
                     domains 3"
                     /db_xref="GeneID:140500"
                     /db_xref="MGI:MGI:2153589"
     exon            1..567
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     CDS             521..3022
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /note="centaurin, beta 5"
                     /codon_start=1
                     /product="arf-GAP with coiled-coil, ANK repeat and PH
                     domain-containing protein 3"
                     /protein_id="NP_997106.1"
                     /db_xref="CCDS:CCDS38997.1"
                     /db_xref="GeneID:140500"
                     /db_xref="MGI:MGI:2153589"
                     /translation="MTVEFEECIKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMI
                     EAGKAYVTTNRLFVSGVRDLSQQCQGDTVISECLQRFGDSLQEMVNYHTILFDQAQRS
                     VRQQLHNFVKEDVRKFKETKKQFDKVREDMELSLVRNAQAPRHRPHEVEEATGALTVT
                     RKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQYSFFQQGYSLLHQLDPYMKKL
                     AAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDEPKVEFDVDAPSGVVMEGYLF
                     KRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEV
                     VSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDST
                     TDSRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV
                     HCSKVRSLTLDSWEPELLKLMCELGNSTVNQIYEAQCEGPGVRKPTASSSRQDKEAWI
                     KDKYVEKKFLRKLTSAPAREPPRRWRAQKCQRPHSSPHAPTTRRKVRLEPVLPSVAAL
                     SSAATMERKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLA
                     FGTGSVVDSVTEEEGAESEESSSEVDGEAEAWSLADVRELHPGLLAHQAARTRDLPAL
                     AAALAHGAEVNWADAADEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSLGRAPLHH
                     ATLLGRTGQVCLFLKRGADQHALDQEQQDPLTIAVQAANADIVTLLRLARMAEEMREA
                     EAPPGQPGPLPGSSPTELQYRRCIQEFIGLHLEES"
     exon            568..625
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            626..745
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            746..799
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            800..858
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1042
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1087
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1183
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1258
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1270
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1383
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1435
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1536
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1648
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1857
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1927
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2022
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2225
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2333
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2432
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2653
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            2654..2763
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2874
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..4313
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4293..4298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /note="hexamer: AATAAA"
     polyA_site      4313
                     /gene="Acap3"
                     /gene_synonym="Centb5; Kiaa1716-hp; mKIAA1716"
                     /note="major polyA site"
ORIGIN      
        1 gtcctcggcc tcacaggggc gcgatgatgg gtcgcttccg cacaagcgac cttaattcgt
       61 tcactcccga tctccccgcc gccgtcgcgg agtgtgtccg tcggcagcat tccagccgag
      121 ttcaccaccg ccgtgatgcc tgaagtgggc gagccgtgcc cttccctgtc ccgcgaccga
      181 gccaaaccac tccgaagccc aaccgccgag gccggcccag ctcccagacc gtggtgaccg
      241 aggacagagc gcagcgacag gcgaggggat gcagcggcgc ttttagcgac gctccccgga
      301 ggtgacagcg ggtggcgcag gcagaggctg actttggcga cgctccccag cggtgacagg
      361 cggggcgggg ccgcggcgcg ccgggctcag accgaggcgg gcaggcgggc gggcgggcgc
      421 ggagcgcagc tcggcgcggg cgccacagac ggtccacggg ccggggatgc cgctcgacgc
      481 gccttggtcc tccgcacagt gagcaccgct cgccgcagcc atgacggtag agttcgagga
      541 atgcatcaag gactcgccgc gcttcagggc aactattgat gaggtagaaa cagatgtggt
      601 tgagatcgag gctaaactgg acaagctggt caaactgtgc agtggtatga ttgaagccgg
      661 caaagcctac gtcaccacca acaggctctt tgtgagcggt gtccgagacc tgtctcagca
      721 gtgccagggc gacaccgtca tctcggaatg tctgcagagg tttggagaca gcctacagga
      781 gatggtcaac tatcacacga tcctgtttga ccaggcccag agatcggtgc ggcagcagct
      841 ccacaacttt gtcaaagagg atgtgcggaa gttcaaagag acaaagaagc agtttgacaa
      901 agtgcgggag gacatggagt tgtccttggt gaggaatgcc caagccccaa ggcaccggcc
      961 ccatgaagta gaggaggcca caggtgccct cactgtcacc cggaagtgct tccgccactt
     1021 ggcgctggac tatgtgctgc agatcaatgt cctccaggcc aagaagaagt ttgaaatctt
     1081 agattctatg ctgtccttca tgcatgccca gtacagcttc ttccagcagg ggtatagcct
     1141 cctacatcag ctggacccct acatgaagaa gctggcagct gagttggacc agcttgtgat
     1201 cgactctgca gtggaaaagc gagagatgga gcgcaagcat gctgccatcc agcaacggac
     1261 actcctgcag gacttttcct atgatgaacc caaagtggag tttgatgtgg atgcaccaag
     1321 tggtgtggta atggagggct atctcttcaa gagagccagc aatgccttca agacatggaa
     1381 ccgacggtgg ttctccattc aaaacagcca gctggtctac cagaagaaac tcaaggatgc
     1441 actcactgtg gtggtagatg accttcgcct atgctctgtg aaaccatgtg aggacattga
     1501 acggaggttc tgctttgaag tcgtgtcacc taccaagagc tgtatgctgc aggctgactc
     1561 ggagaagctg cgacaggctt gggttcaagc tgtgcaggct agcatcgcct ctgcctaccg
     1621 ggaaagtcca gatagctgct acagtgagag gctggaccgt acagcgtcgc catcaacaag
     1681 tagcattgat tccaccacgg actctcggga gcgtggagtc aagggcgaga gcgtgctgca
     1741 gcgtgtgcag agtgtggctg gcaacagcca gtgtggcgac tgtggccagc cagatccccg
     1801 ctgggccagc atcaacttgg gtgtgctgct ctgtattgag tgctcaggca tccacaggag
     1861 cttgggcgtc cactgctcta aggtacgatc tctgacactg gactcctggg agccagagct
     1921 gctaaagctg atgtgtgagc ttggaaacag caccgtgaac cagatctatg aagcccagtg
     1981 tgagggccca ggcgttagga aacccacagc cagcagttcc aggcaggaca aagaggcatg
     2041 gatcaaggac aaatacgttg aaaagaagtt tctacggaag ttgacttctg caccagcccg
     2101 ggaaccccca agacgctgga gggcacagaa gtgccagcgc cctcacagct ccccccacgc
     2161 ccccactacc cgccgcaagg tccggcttga gcccgtcctg ccctccgttg ctgctttgtc
     2221 ctcagctgct actatggagc gcaagttccg ccgagactcc ctcttctgcc ctgatgagct
     2281 ggactccctc ttctcttact ttgatgcagg ggctgctggg gctggtccac gcagtctaag
     2341 cagtgacagt ggtctaggag gcagctctga tggcagttca gatgttcttg ccttcggcac
     2401 aggctcagtg gtggacagtg tcaccgagga agagggtgcc gagtccgagg agtccagcag
     2461 tgaggtcgat ggagaagcag aggcctggag cttggcagat gtgcgtgagc tgcatcctgg
     2521 gctgctggca catcaggcag ctcgtacccg tgacctccca gcactggctg cagcgctggc
     2581 ccatggagct gaagtcaact gggccgatgc agcagatgag ggcaagaccc cattggtgca
     2641 ggctgtacta gggggttcct tgattgtctg tgagttcctt ctgcaaaacg gagctgatgt
     2701 gaaccaaaga gacagccttg gccgggcccc cttgcaccat gctacactct tgggccgtac
     2761 cggccaggtc tgtctgttcc tgaagcgggg ggctgaccag catgccctgg accaggagca
     2821 acaggaccca ctgaccatcg cagttcaagc agcgaatgct gacattgtca cattgcttcg
     2881 cctggcccgc atggctgagg agatgagaga agctgaggcg ccccctggtc agccgggacc
     2941 cctgccgggc agcagtccta cagagctgca gtaccgcagg tgcatccagg agttcattgg
     3001 cctccacctg gaggaaagct aggacctgaa aggccgggca gctgcgggag ccctaccctg
     3061 accccagcct acccggccca gaaatgttgc atgtccctga agaccctagc ccctcatcta
     3121 gccacagccc tgcctgtgac aactgtgggc tcatcccaac agcccaggac cctggtcttc
     3181 ctggagtcct cactcctgct tttccctcct tccggctgcc ctgatgctca gccagaggac
     3241 aggaacccga gcactacatc atttgaagcc tcacacttgt gggtgctgca tctcgtctgg
     3301 tgcccctcat ttcacccggg ggaacctgtt ttcaggtggt ccttccttcg ggggcctggg
     3361 ctgtccatga tgtcaccctg tgccccgctg ccctcagggc ccgtttcaac ttgtgcccct
     3421 atgtttactg tccccaaacc ctggcctgct agctaggtcc ttcctccagc ctagggctgg
     3481 tggctggcca ccagcacctt ccctggcagg agtggcagcc cacccaggga gtcaccctga
     3541 gtaccttgct cgtgacccca gcatctgggt tgcgctttga tggtgctggg aggtggagct
     3601 ttggcccagg tcttccaccc agcctggacg caggcgtccc aaagccacgt ggctggccac
     3661 ttgggtcctt gtgcccgagg gctcaagtcc acccctgcct cctccagagg cactgtctgg
     3721 tttacctggg ccagcaccca tgcctaaagc agctggtact ctccaccctg tgcccaatgt
     3781 tctttgttac tgagaggatt ttctacaaca acctcattct gactttgtct gcgtcttttt
     3841 tctgtggacg ctcaaggacc atcctgatcc cggctctgcc tgctgctggg gaggcccaca
     3901 tagatttccc ccctgccctg cccccgagct tcactccttg ggctgggcct ctgatatagg
     3961 tccagtggtc ccttatgtgg ggggcccacc aatgccttca atttctttct ttctggagga
     4021 gtcccaggac agaggctggg tccctctgca tactatgggg cccttggcta ggtcaagggc
     4081 actcagctgg tcactatgca aacactgccc tgggagcatc catggacagt aatgtcggca
     4141 ctgggtcagg gcctctgact cccttgcttg atggctgtgg ccctacagag cagaatcagc
     4201 ttctccgtcc tgcttgagct ctgcccacca cctaccctgc cacctttggg ctggcaggga
     4261 cccactcctt cctgctctga tcacactcac ttaataaatc tctgccgctt gcaaaaaaaa
     4321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4381 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
