LOCUS       NM_153788               2482 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus ArfGAP with coiled-coil, ankyrin repeat and PH domains
            1 (Acap1), mRNA.
ACCESSION   NM_153788
VERSION     NM_153788.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2482)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2482)
  AUTHORS   Qu,X., Harmelink,C. and Baldwin,H.S.
  TITLE     Tie2 regulates endocardial sprouting and myocardial trabeculation
  JOURNAL   JCI Insight 5 (13), 96002 (2019)
   PUBMED   31112136
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2482)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 2482)
  AUTHORS   Miura,Y., Hongu,T., Yamauchi,Y., Funakoshi,Y., Katagiri,N.,
            Ohbayashi,N. and Kanaho,Y.
  TITLE     ACAP3 regulates neurite outgrowth through its GAP activity specific
            to Arf6 in mouse hippocampal neurons
  JOURNAL   Biochem J 473 (17), 2591-2602 (2016)
   PUBMED   27330119
REFERENCE   5  (bases 1 to 2482)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2482)
  AUTHORS   Boles,M.K., Wilkinson,B.M., Wilming,L.G., Liu,B., Probst,F.J.,
            Harrow,J., Grafham,D., Hentges,K.E., Woodward,L.P., Maxwell,A.,
            Mitchell,K., Risley,M.D., Johnson,R., Hirschi,K., Lupski,J.R.,
            Funato,Y., Miki,H., Marin-Garcia,P., Matthews,L., Coffey,A.J.,
            Parker,A., Hubbard,T.J., Rogers,J., Bradley,A., Adams,D.J. and
            Justice,M.J.
  TITLE     Discovery of candidate disease genes in ENU-induced mouse mutants
            by large-scale sequencing, including a splice-site mutation in
            nucleoredoxin
  JOURNAL   PLoS Genet 5 (12), e1000759 (2009)
   PUBMED   20011118
REFERENCE   7  (bases 1 to 2482)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   8  (bases 1 to 2482)
  AUTHORS   Kile,B.T., Hentges,K.E., Clark,A.T., Nakamura,H., Salinger,A.P.,
            Liu,B., Box,N., Stockton,D.W., Johnson,R.L., Behringer,R.R.,
            Bradley,A. and Justice,M.J.
  TITLE     Functional genetic analysis of mouse chromosome 11
  JOURNAL   Nature 425 (6953), 81-86 (2003)
   PUBMED   12955145
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL596185.12
            and AL845465.2.
            
            On Nov 17, 2006 this sequence version replaced NM_153788.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031462.1, AK154449.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AL596185.12        6931-7184           c
            255-312             AL596185.12        6245-6302           c
            313-432             AL596185.12        2509-2628           c
            433-486             AL596185.12        2234-2287           c
            487-545             AL596185.12        2079-2137           c
            546-729             AL845465.2         37046-37229         c
            730-774             AL845465.2         36867-36911         c
            775-870             AL845465.2         36665-36760         c
            871-945             AL845465.2         36483-36557         c
            946-1055            AL845465.2         36284-36393         c
            1056-1107           AL845465.2         34203-34254         c
            1108-1208           AL845465.2         34015-34115         c
            1209-1332           AL845465.2         32740-32863         c
            1333-1544           AL845465.2         32440-32651         c
            1545-1614           AL845465.2         31843-31912         c
            1615-1709           AL845465.2         31633-31727         c
            1710-1879           AL845465.2         31369-31538         c
            1880-2052           AL845465.2         30631-30803         c
            2053-2162           AL845465.2         29632-29741         c
            2163-2273           AL845465.2         29429-29539         c
            2274-2323           AL845465.2         29029-29078         c
            2324-2482           AL845465.2         28614-28772         c
FEATURES             Location/Qualifiers
     source          1..2482
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.91 cM"
     gene            1..2482
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /note="ArfGAP with coiled-coil, ankyrin repeat and PH
                     domains 1"
                     /db_xref="GeneID:216859"
                     /db_xref="MGI:MGI:2388270"
     exon            1..254
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..2424
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /note="centaurin, beta 1; cnt-b1"
                     /codon_start=1
                     /product="arf-GAP with coiled-coil, ANK repeat and PH
                     domain-containing protein 1"
                     /protein_id="NP_722483.2"
                     /db_xref="CCDS:CCDS24919.1"
                     /db_xref="GeneID:216859"
                     /db_xref="MGI:MGI:2388270"
                     /translation="MTVKLDFEECLKDSPRFRASIELVETEVSELETRLEKLLKLGSC
                     LLESGQHYLAAGRAFVVGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQ
                     HTLQQQIQTLVKEGLRGFREARRDFWRGAENLEAALTHNAEVPRRRVQEAEEAGTALR
                     TARAGYRSRALDYALQVNVIEDKRKFDIMEFVLRLVEAQATYFQQGHEELNRLAQYRK
                     ELGTQLHNLVLNSARQKRDMEQRHVLLKQKELGGEEPEPSLKEGPSGLVMEGHLFKRA
                     SNAFKTWSRRWFTIQNNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVST
                     SKSCFLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQVSGYHAPGSAATLAC
                     GGAARGRESGGVGQVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSL
                     GVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEA
                     WIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPPIRPHSGIVRSKSECPSDDM
                     GSLHPGALLFQAAGHPPSLPTMADALAHGADVNWVNVGQGNATPLIRATAANSLLACE
                     FLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDTEGRDPLTIAME
                     TTNADIVTLLRLAKMREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRRSHDLHTL
                     "
     exon            255..312
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            313..432
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..486
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            487..545
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..729
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..774
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..870
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..945
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1055
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1107
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1208
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1332
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1544
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1614
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1709
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1879
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2052
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2162
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2273
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2323
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2482
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2463..2468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /note="hexamer: ATTAAA"
     polyA_site      2482
                     /gene="Acap1"
                     /gene_synonym="Centb1"
                     /note="major polyA site"
ORIGIN      
        1 gagctgccta gaagtggtgg ggttagagct cctcctgggt taccccgttc cctttgggga
       61 aagaattcca gacccaggct cttcctacca gaggattctt ctccattaat acccctcttg
      121 gggggtgggg agtgcatctg cctacatccc cacctacctg acctccaggg ccccccaggc
      181 ccccaaagca agtcatctga gatgacggtc aagctagatt ttgaagaatg tctcaaggac
      241 tcaccccgct tccgagcctc gattgaactg gtggaaactg aagtgtcaga attggagacc
      301 cgcctggaaa agctgctaaa gctgggttcc tgcctcctgg agagcggaca gcattacctt
      361 gctgccggtc gtgccttcgt tgttggcatc tgtgacctgg ctcgcctggg tccaccagag
      421 cccatgatgg cggagtgtct ggaaaaattc accgtgagtc tgaaccacaa actggacagc
      481 catgctgagc ttcttgatgc tactcaacat acactgcagc agcaaatcca gactctggtc
      541 aaggaaggtc tccggggctt ccgagaggct cgcagggatt tctggcgagg ggctgagaac
      601 ctggaggctg ctcttaccca caatgcagag gtccccaggc gccgtgtcca agaagcagag
      661 gaggctggaa ctgctttgag gaccgctcga gctgggtacc ggagtcgggc attagattat
      721 gccctgcagg tcaatgtgat tgaggataag aggaagtttg acatcatgga attcgtactg
      781 cgtttggttg aggcccaggc cacttatttc cagcagggcc atgaagagct aaacaggctg
      841 gctcagtatc ggaaggaatt gggtacccag ttgcacaacc tggtcttgaa ctcagctcga
      901 cagaagagag acatggaaca gaggcatgtg ttactgaagc agaaggagct aggtggcgag
      961 gagccagagc caagcctaaa ggaggggcct agtggcttgg taatggaagg acatcttttc
     1021 aaacgtgcca gcaatgcatt taagacctgg agcagacgct ggttcaccat tcagaacaac
     1081 cagctggttt accagaagaa atataaggac cctgtaaccg tggtggtaga cgaccttcgt
     1141 ctctgtacag tgaagctctg tccagactca gaaaggcgtt tctgtttcga agtagtgtcc
     1201 accagcaagt cctgtttcct ccaggctgac tctgagcgtc tcctgcagct gtgggtcagt
     1261 gctgtccaga gcagcattgc ctcagccttc agccaggctc acctggagaa cagccctcgg
     1321 gggccaggcc aggtctcagg ataccatgcc ccgggctctg ctgcaactct ggcctgtggc
     1381 ggggcagcca gaggaaggga gtctggagga gttggtcagg tggcggccca ggtacaaagc
     1441 gtggatggaa atgcgcaatg ctgcgactgc agggagccag ccccagagtg ggccagcatc
     1501 aaccttggcg tcactctctg cattcagtgt tctggcatcc acaggagcct cggagttcat
     1561 ttctccaaag tccgctctct gacccttgac tcctgggaac cagaactggt gaagcttatg
     1621 tgcgagctgg ggaatgtcat catcaaccag atctatgagg cccgggtgga ggccatggcg
     1681 gtgaagaagc cagggcccag ctgctcccgg caggaaaagg aagcctggat tcatgccaag
     1741 tatgtggaga aaaagttcct gaccaaactt cctgaaatcc gtggacgaag aggtggcagg
     1801 ggacccccaa gaggacatcc tcctgtgccc ccaaagcctc ccatcaggcc acactcgggc
     1861 attgtcagat ccaaatcaga gtgcccgtct gatgacatgg gaagcctgca ccctggggcc
     1921 ctgctgtttc aagctgctgg acatccccca tctcttccta ccatggctga tgccctggcc
     1981 catggagctg atgtcaactg ggtcaatgtg ggccagggga atgccacacc tctgatccgg
     2041 gccacagctg ctaactctct tctggcctgc gagtttctcc tccaaaatgg ggcgaatgtg
     2101 aaccaagcag acagtgccgg ccggggtcct ctccaccatg ccaccattct tggtcacaca
     2161 gggctcgctt gcctgttcct gaaacggggt gctgatctgg gggctcgaga cacagaaggc
     2221 agggaccctc tgactatcgc aatggaaacc actaatgctg acatcgtaac cctgctacga
     2281 ttggcaaaga tgagggaggc tgaagcggcc cagggccagg caggagacga gacgtatctc
     2341 gacatattcc gagacttctc cctcatggcg tcggacgacc cagagaaact gagccgtcgc
     2401 agtcacgacc tccatactct gtgattccag gctcctcccc accctgcccc attgaagtct
     2461 ccattaaagt ctctcagctt gg
//
