LOCUS       NM_017366               2205 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus acyl-Coenzyme A dehydrogenase, very long chain
            (Acadvl), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017366
VERSION     NM_017366.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2205)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2205)
  AUTHORS   Lefort,B., Gelinas,R., Forest,A., Bouchard,B., Daneault,C.,
            Robillard Frayne,I., Roy,J., Oger,C., Greffard,K., Galano,J.M.,
            Durand,T., Labarthe,F., Bilodeau,J.F., Ruiz,M. and Des Rosiers,C.
  TITLE     Remodeling of lipid landscape in high fat fed very-long chain
            acyl-CoA dehydrogenase null mice favors pro-arrhythmic
            polyunsaturated fatty acids and their downstream metabolites
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (8), 166843 (2023)
   PUBMED   37558007
  REMARK    GeneRIF: Remodeling of lipid landscape in high fat fed very-long
            chain acyl-CoA dehydrogenase null mice favors pro-arrhythmic
            polyunsaturated fatty acids and their downstream metabolites.
REFERENCE   3  (bases 1 to 2205)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   4  (bases 1 to 2205)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2205)
  AUTHORS   Cox,K.B., Hamm,D.A., Millington,D.S., Matern,D., Vockley,J.,
            Rinaldo,P., Pinkert,C.A., Rhead,W.J., Lindsey,J.R. and Wood,P.A.
  TITLE     Gestational, pathologic and biochemical differences between very
            long-chain acyl-CoA dehydrogenase deficiency and long-chain
            acyl-CoA dehydrogenase deficiency in the mouse
  JOURNAL   Hum Mol Genet 10 (19), 2069-2077 (2001)
   PUBMED   11590124
REFERENCE   6  (bases 1 to 2205)
  AUTHORS   Andresen,B.S., Corydon,T.J., Wilsbech,M., Bross,P., Schroeder,L.D.,
            Hindkjaer,T.F., Bolund,L. and Gregersen,N.
  TITLE     Characterization of mouse Clpp protease cDNA, gene, and protein
  JOURNAL   Mamm Genome 11 (4), 275-280 (2000)
   PUBMED   10754102
REFERENCE   7  (bases 1 to 2205)
  AUTHORS   Kurtz,D.M., Rinaldo,P., Rhead,W.J., Tian,L., Millington,D.S.,
            Vockley,J., Hamm,D.A., Brix,A.E., Lindsey,J.R., Pinkert,C.A.,
            O'Brien,W.E. and Wood,P.A.
  TITLE     Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene
            reveals crucial roles for fatty acid oxidation
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15592-15597 (1998)
   PUBMED   9861014
REFERENCE   8  (bases 1 to 2205)
  AUTHORS   Cox,K.B., Johnson,K.R. and Wood,P.A.
  TITLE     Chromosomal locations of the mouse fatty acid oxidation genes
            Cpt1a, Cpt1b, Cpt2, Acadvl, and metabolically related Crat gene
  JOURNAL   Mamm Genome 9 (8), 608-610 (1998)
   PUBMED   9680378
REFERENCE   9  (bases 1 to 2205)
  AUTHORS   Orii,K.O., Aoyama,T., Saito-Ohara,F., Ikeuchi,T., Orii,T., Kondo,N.
            and Hashimoto,T.
  TITLE     Molecular characterization of the mouse very-long-chain acyl-CoA
            dehydrogenase gene
  JOURNAL   Mamm Genome 8 (7), 516-518 (1997)
   PUBMED   9195999
REFERENCE   10 (bases 1 to 2205)
  AUTHORS   Orii,K.O., Saito-Ohara,F., Ikeuchi,T., Orii,T., Kondo,N., Aoyama,T.
            and Hashimoto,T.
  TITLE     Assignment of the gene for very-long-chain acyl-CoA dehydrogenase
            (Acadvl) to mouse chromosome band 11B2-B5 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 78 (1), 25-26 (1997)
   PUBMED   9345900
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU067294.1, AK076037.1 and
            AI843782.1.
            
            On Nov 29, 2012 this sequence version replaced NM_017366.2.
            
            Summary: This gene encodes a homodimeric mitochondrial flavoprotein
            and is a member of the acyl-CoA dehydrogenase family. Members of
            this family catalyze the first step of fatty acid beta-oxidation,
            forming a C2-C3 trans-double bond in a FAD-dependent reaction. As
            beta-oxidation cycles through its four steps, each member of the
            acyl-CoA dehydrogenase family works at an optimum fatty acid
            chain-length. This enzyme has its optimum length between C16- and
            C20-acylCoA and localizes to the inner mitochondrial membrane
            (unlike related acyl-CoA dehydrogenases). In mice, deficiency of
            this gene can cause ventricular arrhythmias as well as fasting and
            cold intolerance. [provided by RefSeq, Nov 2012].
            
            Sequence Note: The transit peptide annotated at aa 1-41 is inferred
            by similarity to the cleavage site in the orthologous rat protein
            as described in PMID: 8034667. The software program TargetP1.1
            predicts that the transit peptide in mouse is aa 1-27.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026559.1, AK076037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AU067294.1         1-143
            144-2183            AK076037.1         105-2144
            2184-2205           AI843782.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.96 cM"
     gene            1..2205
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /note="acyl-Coenzyme A dehydrogenase, very long chain"
                     /db_xref="GeneID:11370"
                     /db_xref="MGI:MGI:895149"
     exon            1..166
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2075
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /EC_number="1.3.8.9"
                     /note="very long-chain specific acyl-CoA dehydrogenase,
                     mitochondrial; MVLCAD"
                     /codon_start=1
                     /product="very long-chain specific acyl-CoA dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_059062.1"
                     /db_xref="CCDS:CCDS24931.1"
                     /db_xref="GeneID:11370"
                     /db_xref="MGI:MGI:895149"
                     /translation="MQSARMTPSVGRQLLRLGARSSRSTTVLQGQPRPISAQRLYARE
                     ATQAVLDKPETLSSDASTREKPARAESKSFAVGMFKGQLTIDQVFPYPSVLSEEQAQF
                     LKELVGPVARFFEEVNDPAKNDALEKVEDDTLQGLKELGAFGLQVPSELGGLGLSNTQ
                     YARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQREKYLPRVASGQALAAFCLT
                     EPSSGSDVASIRSSAIPSPCGKYYTLNGSKIWISNGGLADIFTVFAKTPIKDAATGAV
                     KEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPSENVLGEVGDGFKVA
                     VNILNNGRFGMAATLAGTMKSLIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAILQY
                     VTESMAYMLSANMDQGFKDFQIEAAISKIFCSEAAWKVADECIQIMGGMGFMKEPGVE
                     RVLRDIRIFRIFEGANDILRLFVALQGCMDKGKELTGLGNALKNPFGNVGLLMGEAGK
                     QLRRRTGIGSGLSLSGIVHPELSRSGELAVQALDQFATVVEAKLVKHKKGIVNEQFLL
                     QRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQS
                     SPQHQELFRNFRSISKAMVENGGLVTGNPLGI"
     exon            167..245
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            246..311
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            312..384
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            385..449
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            450..584
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            585..729
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            730..859
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            860..985
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1184
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1289
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1376
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1439
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1541
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1639
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1712
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1785
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1858
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1934
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2188
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2163..2168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /note="hexamer: AATAAA"
     polyA_site      2183
                     /gene="Acadvl"
                     /gene_synonym="vlcad"
                     /note="major polyA site"
ORIGIN      
        1 agtgcattgt ggagcatgag tcagggccca gacacacaac ctttgggcag gcgagacgcg
       61 aagagaagag gtcagtggtc aagacttcgg cggcggcttt ggagatgcag tcggctcgga
      121 tgaccccgag tgtggggcga cagctgctgc ggctgggggc ccgaagctcg cgatctacta
      181 ctgtgcttca gggacaaccc cggcctatct ctgcccagcg actttatgcc agggaggcca
      241 ctcaggcagt tctggacaag ccagaaaccc tctcctctga tgcttccacc agagaaaaac
      301 cagccagggc agaatcgaag tcctttgctg tggggatgtt caaaggccag cttaccattg
      361 atcaggtgtt cccataccca tctgtgctca gtgaagaaca ggcacaattt ctcaaagagc
      421 tggtgggacc agtggcccgg ttctttgagg aagtgaatga ccctgccaag aacgacgcct
      481 tggagaaggt ggaggacgac actttgcagg gactcaagga actgggggca tttggcctgc
      541 aagtacccag cgagctgggt ggtttgggcc tctctaatac ccagtatgct cgcttggcag
      601 agattgtggg catgcatgac cttggtgtta gcgttaccct gggagctcat cagagcatcg
      661 gtttcaaagg catcttgctc tatggcacaa aggcccagag agaaaaatac cttcccagag
      721 tggcatctgg gcaggctttg gctgctttct gcctaacaga gccctcgagt ggatccgatg
      781 tagcctccat ccgaagctca gccataccca gcccctgtgg aaaatattac actctcaatg
      841 ggagcaagat ctggatcagt aatgggggcc tggctgacat tttcactgtc tttgccaaga
      901 cgccaattaa agatgcagcc acgggggccg tgaaagagaa gatcacagct tttgtagtgg
      961 aaaggagctt cggaggggtt acccatgggc tccctgaaaa gaagatgggc atcaaagcat
     1021 ctaacacgtc agaggtgtac tttgatggag tgaaggtgcc atcagagaat gtgctaggag
     1081 aggtgggaga tggcttcaag gttgctgtca acatcctcaa caacggaaga ttcgggatgg
     1141 ctgcaaccct cgcaggcacc atgaaatccc tcattgccaa ggcggttgat catgctacta
     1201 atcgtaccca gtttggggac aaaattcaca actttggggt gatccaggaa aagctggctc
     1261 ggatggctat tctgcagtat gtgactgagt ccatggctta catgctgagt gccaacatgg
     1321 accagggatt caaagacttc cagatagaag ccgccatcag caaaatcttt tgctcggagg
     1381 cggcctggaa agtggcagat gagtgcatcc aaataatggg gggcatgggc ttcatgaagg
     1441 aaccaggggt ggagcgtgtg ctccgagata ttcgaatctt ccggatcttt gaaggggcaa
     1501 atgacattct tcgactgttt gtggctctgc aaggctgtat ggacaaagga aaggaactca
     1561 ctgggctggg caatgccctg aagaatcctt ttggaaacgt tggcctcctg atgggagaag
     1621 caggcaaaca gctgagacgg aggacaggaa tcggcagtgg tttgagtctg tcagggattg
     1681 tccacccaga gttaagtcgc agtggtgaac tggcagtgca ggctctggat caatttgcca
     1741 ccgtggtgga ggccaagctg gtgaaacaca agaaagggat tgtcaacgag cagttcctgc
     1801 tgcagcgact ggcggacggc gccattgacc tctatgccat ggtggtggtt ctgtccagag
     1861 cctcaaggtc cctgagtgag ggctacccga cggcacagca tgagaaaatg ctctgtgata
     1921 gctggtgcat tgaggctgca actcggatcc gagaaaacat ggccagtctg cagtccagcc
     1981 ctcagcatca ggagctcttc cggaacttca gaagcatctc caaggccatg gtggagaatg
     2041 gtggcctggt caccggtaac cccctgggaa tctgagactc ccaatcaggc cctggcaagg
     2101 tcatgtgcct tctctgatgc caaaaccctt tatgggggtg atggagtact tattgcctta
     2161 acaataaatt ttctaccaag tcactgtcaa aaaaaaaaaa aaaaa
//
