LOCUS       NM_025826               3348 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus acyl-Coenzyme A dehydrogenase, short/branched chain
            (Acadsb), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025826
VERSION     NM_025826.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3348)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3348)
  AUTHORS   Peng,M.Z., Shao,Y.X., Li,X.Z., Zhang,K.D., Cai,Y.N., Lin,Y.T.,
            Jiang,M.Y., Liu,Z.C., Su,X.Y., Zhang,W., Jiang,X.L. and Liu,L.
  TITLE     Mitochondrial FAD shortage in SLC25A32 deficiency affects
            folate-mediated one-carbon metabolism
  JOURNAL   Cell Mol Life Sci 79 (7), 375 (2022)
   PUBMED   35727412
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3348)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3348)
  AUTHORS   Zhang,P., Du,J., Guo,X., Wu,S., He,J., Li,X., Shen,L., Chen,L.,
            Li,B., Zhang,J., Xie,Y., Niu,L., Jiang,D., Li,X., Zhang,S. and
            Zhu,L.
  TITLE     LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle
            Fiber-Type Composition by Sponging miR-370-3p
  JOURNAL   Genes (Basel) 12 (4), 589 (2021)
   PUBMED   33920575
  REMARK    GeneRIF: LncMyoD Promotes Skeletal Myogenesis and Regulates
            Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3348)
  AUTHORS   Hong,A.E., Ryu,M.S., Kim,S.J., Hwang,S.Y. and Lim,I.K.
  TITLE     PPARalpha-Target Gene Expression Requires TIS21/BTG2 Gene in Liver
            of the C57BL/6 Mice under Fasting Condition
  JOURNAL   Mol Cells 41 (2), 140-149 (2018)
   PUBMED   29385670
REFERENCE   6  (bases 1 to 3348)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 3348)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 3348)
  AUTHORS   Ferguson,D.A., Chiang,J.T., Richardson,J.A. and Graff,J.
  TITLE     eXPRESSION: an in silico tool to predict patterns of gene
            expression
  JOURNAL   Gene Expr Patterns 5 (5), 619-628 (2005)
   PUBMED   15939374
REFERENCE   9  (bases 1 to 3348)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY296718.1, AK004889.1 and AW987640.1.
            
            On Apr 25, 2009 this sequence version replaced NM_025826.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035231.1, AK004889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BY296718.1         2-103
            103-3341            AK004889.1         4-3242
            3342-3348           AW987640.1         4-10                c
FEATURES             Location/Qualifiers
     source          1..3348
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 74.03 cM"
     gene            1..3348
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /note="acyl-Coenzyme A dehydrogenase, short/branched
                     chain"
                     /db_xref="GeneID:66885"
                     /db_xref="MGI:MGI:1914135"
     exon            1..187
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1444
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /EC_number="1.3.8.5"
                     /note="2-methylbutyryl-coenzyme A dehydrogenase; 2-methyl
                     branched chain acyl-CoA dehydrogenase"
                     /codon_start=1
                     /product="short/branched chain specific acyl-CoA
                     dehydrogenase, mitochondrial"
                     /protein_id="NP_080102.1"
                     /db_xref="CCDS:CCDS21916.1"
                     /db_xref="GeneID:66885"
                     /db_xref="MGI:MGI:1914135"
                     /translation="MAVSALQLWRMGGLLRRRFPTCLSPWKIPPRVLKSSQPEALVSL
                     TNNAVAFAPLQTLTDEEIMMKQTVKKFAQEHVAPLVSSMDENSKMEKSVIQGLFQQGL
                     MGIEVEAQYGGTEASFFCSVLVIEELAKVDASVALLCDIQNTIINNLFRKHASEEQKA
                     TYLPKLVTEKLGSFCLSEAGAGSDSFAMKTRADKSGNYYVLNGSKMWISHAEHAELFL
                     VFANVDPSSGYRGITCFLVDRDTEGFQIGKRENKMGIRASSTCQLTFENVKVPETNIL
                     GKIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERMQFGKRIFDFQGLQH
                     QVAQVATQLEATRLLTYNAARLVEAGRPFIKEASMAKYYASEVAGLTTSKCIEWMGGV
                     GYTKDYPVEKFFRDAKIGTIYEGASNIQLNTIAKHIDAEY"
     exon            188..347
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            348..448
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            449..655
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            656..826
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            827..952
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1045
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1135
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1273
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1373
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..3348
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3317..3322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /note="hexamer: AATAAA"
     polyA_site      3343
                     /gene="Acadsb"
                     /gene_synonym="1300003O09Rik; 2-MEBCAD; SBCAD"
                     /note="major polyA site"
ORIGIN      
        1 ggcagtgggc ggggactcaa aggggtgtgt gaggggcgga tgctcggagt gggcagggcc
       61 cgagcttgcc aggccgaggg agtcttgcgc aagggttcgt ggaaagcctt gcgagcttaa
      121 cagggccacc ctgcccgaag cgaggatggc ggtctctgcg ctccagctgt ggcgtatggg
      181 cgggctgctg agaagacgct tcccaacctg cttgtctcct tggaagattc ctcctcgtgt
      241 cctcaaatcc tcacaaccgg aagctctagt cagtctgaca aacaatgcag tagcctttgc
      301 acctctgcag acacttactg atgaggaaat tatgatgaag cagacagtca aaaaatttgc
      361 acaggagcac gttgctcctc tggtttcctc tatggatgag aactcaaaaa tggagaaatc
      421 ggtgatccag ggattgttcc agcaagggct gatgggcatt gaagttgaag cacaatatgg
      481 agggacagaa gcttcctttt tctgctctgt cctagtgata gaggaactag ctaaggtgga
      541 tgcttcggtg gctctcctgt gtgacatcca gaacacaata attaacaacc tgtttagaaa
      601 acacgcttca gaagaacaga aggccaccta tttgccaaag ctggttacag aaaaattagg
      661 gagcttttgc ctctctgaag ctggagccgg tagcgactct ttcgctatga aaacaagagc
      721 tgataaaagt ggaaattact acgtcctcaa tgggtcgaag atgtggatca gccatgccga
      781 gcatgcagag ctcttcctgg tcttcgccaa tgtggacccc agctctggct acagaggcat
      841 cacctgcttc ttagtagacc gagatacaga aggtttccag atagggaaac gagaaaataa
      901 aatgggcatc agagcttcat ccacctgtca gttaacattt gaaaatgtta aggttccaga
      961 gactaatatt ttggggaaaa ttgggcatgg ttataagtat gccataggaa gtcttaatga
     1021 aggtagaatc ggaattgctg cacagatgct aggactggcc caaggatgtt ttgactacac
     1081 tattccatac attaaagaaa ggatgcagtt tggcaaacga atatttgatt ttcaggggct
     1141 ccaacaccaa gtggctcagg tggccaccca gctggaagcc acacggttgc taacatacaa
     1201 cgctgctagg ctcgtagaag ccggaaggcc atttataaaa gaagcatcta tggccaaata
     1261 ttatgcatct gaggtcgctg ggctaacaac aagcaagtgc atcgagtgga tgggaggggt
     1321 cggctacacc aaagattacc ctgtggagaa attcttccga gatgccaaga tcggtacaat
     1381 atatgaagga gcttccaaca tccagctgaa caccatcgcc aagcacatcg atgcagagta
     1441 ctgatgactg tgggatgggc cctctgcgtc actgacaaac catttccagc tgctgtgcct
     1501 tattgagcag ggtctagagc agtgcagggc ttccttggac ttcccttgtc ctggtctcag
     1561 gcctggattt tgttcctgtc tctttccaat ctactctaag tctatttcta agcttctgaa
     1621 cgcatatttc tcatcctagt tgcagagtat acaaaagttt cactctagca gcatttggga
     1681 agaagaaacc atttgaggta ttggtattgc tgacagaaat agtcacttta tattcctact
     1741 aaatctttgt actgtggtat gagccagagg agcgtttgtt acacttggca atttttattc
     1801 aatactttat agattcagtg gtaagtggct aaacaaggta gaagctgata aaatttattt
     1861 ggaaaaatct agaatcttag ttctaaatat caaaaatagt agaaaataaa aagtgtagct
     1921 tgtaggccat ataattgaca ataacaaaaa gtcccaaatg ttattttaac caacaaaagg
     1981 agtatgtttg gctgctataa ttgaactata tgaaagatgt attatgtggt ggcttttagc
     2041 agcccattta aaaaacatgt ccctgtatta gttttcaact ataaagttta agtaatttgg
     2101 cctaatcatc tgaaaataat ttattagatc atgcactatt ttttggtagt atgatttatt
     2161 tctgtatttt aattgagtat tttccctcaa acttggttat tggactttat cctaaatagt
     2221 aattaattga gaaattcaat tttggttttc aaaattgatt cttaagagaa atataccccc
     2281 ataagaaaat aatatcacaa tctcataagg atagggaatg gagacttggt agtctgaaaa
     2341 catacattca gtataaatat atgtagtcat ttatatagta tattagataa ttttatattt
     2401 gtgaagacaa agatctatgt tttacaatgt aaatgaaaaa caggcaaagc ctaatcagat
     2461 atccagctgg tgaagccatt gatcagtgtt agggatttac agtcgggaga agacgctcta
     2521 gttgcagacc ctgagtcccc tggagagaga agtagacagt agacaaacga gtcgcacatt
     2581 tccagaggaa acatcacaag ttagatgtga aaaatgcccg aggctcacgc agttgctgga
     2641 aataatcgtt acttctagat agaaagtatt ttggtgcttt tgcaaaagga taatgtttat
     2701 taagaaactt gacattttct aggtaatttt gctttgcaca gttaatgttt attgagctaa
     2761 attaatttcc acaatgcaaa tcatagttaa atatgcaagg ttgtataaat acagttgaaa
     2821 taggaattac attaaaacag taggaagaaa taaaacaaat ttagaccttg aatccaaaga
     2881 gataaggtct acttgacttt caaatggggg aaatgatgaa aggcctcacc cagtctcaga
     2941 acagacagat gagtgtgata agaaaggaag gggtggatgc agaccctgac agggcagaca
     3001 ccttccactc ctgtaataat gggaaagagc agggcttaga gatgatgcag ccgcgggagt
     3061 caggatgagt aaacagcctg ccctcctttc ctagactcat ggcaatcctc ctgcttcatg
     3121 tgtaacctgg gctggccgca gattcatggc aatcctgctt tcaggcttcc agtgctgaga
     3181 ttttatgtct gcaccccagc tcccatttct gacttgttga ttttgaagtc atgcccacga
     3241 ttacagcttt gtcaattatt ctcatttatt tctatttgtt ttgctctatg tagttcccag
     3301 ttatgttttt aggggtaata aagttcatgg ctgttggatc atcttgga
//
