LOCUS       NM_007383               1881 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus acyl-Coenzyme A dehydrogenase, short chain (Acads),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_007383
VERSION     NM_007383.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1881)
  AUTHORS   Deng,D., Yang,S., Yu,X., Zhou,R., Liu,Y., Zhang,H., Cui,D.,
            Feng,X., Wu,Y., Qi,X. and Su,Z.
  TITLE     Aging-induced short-chain acyl-CoA dehydrogenase promotes
            age-related hepatic steatosis by suppressing lipophagy
  JOURNAL   Aging Cell 23 (10), e14256 (2024)
   PUBMED   38898632
  REMARK    GeneRIF: Aging-induced short-chain acyl-CoA dehydrogenase promotes
            age-related hepatic steatosis by suppressing lipophagy.
REFERENCE   2  (bases 1 to 1881)
  AUTHORS   Wang,S., Zeng,Y., He,X., Liu,F., Pei,P. and Zhang,T.
  TITLE     Folate-deficiency induced acyl-CoA synthetase short-chain family
            member 2 increases lysine crotonylome involved in neural tube
            defects
  JOURNAL   Front Mol Neurosci 15, 1064509 (2023)
   PUBMED   36743291
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1881)
  AUTHORS   Peng,M.Z., Shao,Y.X., Li,X.Z., Zhang,K.D., Cai,Y.N., Lin,Y.T.,
            Jiang,M.Y., Liu,Z.C., Su,X.Y., Zhang,W., Jiang,X.L. and Liu,L.
  TITLE     Mitochondrial FAD shortage in SLC25A32 deficiency affects
            folate-mediated one-carbon metabolism
  JOURNAL   Cell Mol Life Sci 79 (7), 375 (2022)
   PUBMED   35727412
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1881)
  AUTHORS   Wilkerson,A., Bhat,N., Quoc Hai Pham,H., Yuksel,S. and Butovich,I.
  TITLE     Physiological effects of inactivation and the roles of
            Elovl3/ELOVL3 in maintaining ocular homeostasis
  JOURNAL   FASEB J 35 (2), e21327 (2021)
   PUBMED   33455016
REFERENCE   5  (bases 1 to 1881)
  AUTHORS   Su,Z., Leduc,M.S., Korstanje,R. and Paigen,B.
  TITLE     Untangling HDL quantitative trait loci on mouse chromosome 5 and
            identifying Scarb1 and Acads as the underlying genes
  JOURNAL   J Lipid Res 51 (9), 2706-2713 (2010)
   PUBMED   20562441
REFERENCE   6  (bases 1 to 1881)
  AUTHORS   Guerra,C., Koza,R.A., Walsh,K., Kurtz,D.M., Wood,P.A. and
            Kozak,L.P.
  TITLE     Abnormal nonshivering thermogenesis in mice with inherited defects
            of fatty acid oxidation
  JOURNAL   J Clin Invest 102 (9), 1724-1731 (1998)
   PUBMED   9802886
REFERENCE   7  (bases 1 to 1881)
  AUTHORS   Kelly,C.L., Hinsdale,M.E. and Wood,P.A.
  TITLE     Cloning and characterization of the mouse short-chain acyl-CoA
            dehydrogenase cDNA
  JOURNAL   Genomics 18 (1), 137-140 (1993)
   PUBMED   8276399
REFERENCE   8  (bases 1 to 1881)
  AUTHORS   Amendt,B.A., Freneaux,E., Reece,C., Wood,P.A. and Rhead,W.J.
  TITLE     Short-chain acyl-coenzyme A dehydrogenase activity, antigen, and
            biosynthesis are absent in the BALB/cByJ mouse
  JOURNAL   Pediatr Res 31 (6), 552-556 (1992)
   PUBMED   1635815
REFERENCE   9  (bases 1 to 1881)
  AUTHORS   Schiffer,S.P., Prochazka,M., Jezyk,P.F., Roderick,T.H., Yudkoff,M.
            and Patterson,D.F.
  TITLE     Organic aciduria and butyryl CoA dehydrogenase deficiency in
            BALB/cByJ mice
  JOURNAL   Biochem Genet 27 (1-2), 47-58 (1989)
   PUBMED   2712823
REFERENCE   10 (bases 1 to 1881)
  AUTHORS   Wood,P.A., Amendt,B.A., Rhead,W.J., Millington,D.S., Inoue,F. and
            Armstrong,D.
  TITLE     Short-chain acyl-coenzyme A dehydrogenase deficiency in mice
  JOURNAL   Pediatr Res 25 (1), 38-43 (1989)
   PUBMED   2919115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY077302.1, AK169428.1 and
            BE993251.1.
            
            On Nov 28, 2012 this sequence version replaced NM_007383.2.
            
            Summary: This gene encodes a homotetrameric mitochondrial
            flavoprotein and is a member of the acyl-CoA dehydrogenase family.
            Members of this family catalyze the first step of fatty acid
            beta-oxidation, forming a C2-C3 trans-double bond in a
            FAD-dependent reaction. As beta-oxidation cycles through its four
            steps, each member of the Acyl-CoA dehydrogenase family works at an
            optimum fatty acid chain-length. This enzyme has its optimum at
            C(four)-CoA. In mice, deficiency of this gene has been linked to
            cold sensitivity and increased high-density lipoprotein levels.
            [provided by RefSeq, Nov 2012].
            
            Sequence Note: The transit peptide annotated at aa 1-24 is inferred
            by similarity to the cleavage site in the orthologous rat protein
            as described in PMID: 2777793. The software program TargetP1.1
            predicts that the transit peptide in mouse is aa 1-48.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016259.1, AK155361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                BY077302.1         2-64
            64-1865             AK169428.1         1-1802
            1866-1881           BE993251.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..1881
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..1881
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /note="acyl-Coenzyme A dehydrogenase, short chain"
                     /db_xref="GeneID:11409"
                     /db_xref="MGI:MGI:87868"
     exon            1..122
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1315
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /EC_number="1.3.8.1"
                     /note="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial; butyryl-CoA dehydrogenase"
                     /codon_start=1
                     /product="short-chain specific acyl-CoA dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_031409.2"
                     /db_xref="CCDS:CCDS19579.1"
                     /db_xref="GeneID:11409"
                     /db_xref="MGI:MGI:87868"
                     /translation="MAAALLARARGPLRRALGVRDWRRLHTVYQSVELPETHQMLRQT
                     CRDFAEKELVPIAAQLDREHLFPTAQVKKMGELGLLAMDVPEELSGAGLDYLAYSIAL
                     EEISRACASTGVIMSVNNSLYLGPILKFGSAQQKQQWITPFTNGDKIGCFALSEPGNG
                     SDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMP
                     TPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIA
                     SQALGIAQASLDCAVKYAENRNAFGAPLTKLQNIQFKLADMALALESARLLTWRAAML
                     KDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYE
                     GTSEIQRLVIAGHLLRSYRS"
     exon            123..286
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            287..436
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            437..548
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            549..700
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            701..871
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1009
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1105
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1162
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1870
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1848..1853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /note="hexamer: AATAAA"
     polyA_site      1870
                     /gene="Acads"
                     /gene_synonym="Bcd-1; Bcd1; Hdlq8; SCAD"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcgtgg cccaggccct gcccctgccg tccggaactc cagagctgct gcaggaggtc
       61 ctggaggtct gtgcccatgg ctgccgcctt gctcgcccgg gcccgtggcc ctctccgtag
      121 agctctcggt gttcgggact ggcgacggtt acacactgtt taccagtctg tggagctgcc
      181 tgagacacac cagatgttgc gtcagacatg ccgtgacttt gccgagaagg agttggtccc
      241 cattgcggcc cagctggaca gggagcatct cttccccaca gctcaggtta agaagatggg
      301 tgagctcggg ctgctggcca tggatgtgcc agaggagctg agtggtgcag gcttggatta
      361 cctggcctac tccatcgccc tggaggagat cagccgtgcc tgcgcctcca cgggagttat
      421 catgagcgtc aacaattctc tctacttggg acccattctg aagtttggat ccgcacagca
      481 gaagcaacag tggatcaccc ctttcaccaa tggtgacaaa atcggctgtt ttgccctcag
      541 tgagccaggc aatggcagtg atgctggagc cgcttccacc actgcccggg aagagggtga
      601 ctcatgggtc ctcaacggca ccaaagcttg gatcaccaac tcctgggagg cttccgccac
      661 ggtggtattt gccagcacag acaggtcccg gcagaacaag ggtatcagtg ccttcctggt
      721 tcccatgcca actcctgggc tcacgctggg caagaaggaa gacaagctgg gcatccgggc
      781 ctcctccaca gctaacctca tctttgagga ctgccggatc cccaaggaga acctgcttgg
      841 ggagcctggg atgggcttca aaatagccat gcaaaccctg gacatgggtc gcattggcat
      901 cgcctcccag gccctgggca tcgcccaggc ctccctggat tgtgctgtga agtatgccga
      961 gaaccgcaat gcctttgggg caccgctcac caagctccaa aatatccagt tcaagctggc
     1021 agacatggcc ctggccctgg agagtgcccg cctgctgacc tggcgtgctg ccatgttgaa
     1081 agacaacaag aaacctttca ccaaggagtc cgccatggcc aaactggctg catcggaggc
     1141 tgcaaccgcc attagccacc aggccatcca gatcctgggc ggcatggggt atgtgacaga
     1201 gatgccggct gagcggtact accgagatgc ccgcatcact gagatctacg aagggaccag
     1261 cgaaatccag agactggtga tcgctgggca tctgctccgg agctaccgga gctgagcccc
     1321 tcctcgggga cttgcctgcc tgcagaccga ggcagagggc agagagcctc atggcttaac
     1381 tttgaggcct ggtcagacca gaaagggact tgcctttcat tctgcctgtt ctgctccgtc
     1441 cctcactgta gacccctagt cagactgggg ggaagtctat ctcagggaga ggggaggcca
     1501 gatgctgtga cctgcaaccg agaagaaatc agttgtcagc tcagagctga gcttggctgc
     1561 ctctttaccc cccaccaaca gtgcctcttt cttcatttga gccgcccttg gagagctgaa
     1621 tgaccctggc cctctcagtg ctgttcccat gagccctcgg aggcaagaac acaagggaca
     1681 ggacaggggt caggaggggg agggggtggg ggtggcccag atggcacgga gtttcagtgt
     1741 ttgagtcccc agggttgctg tgggacggct gggggctggg tcatagggcc ctcgctggag
     1801 gtcaagtgcg cgcaggtgcg tgttctgctg tagaactgcc cgcggccaat aaagctcacc
     1861 tgtgccctga aaaaaaaaaa a
//
