LOCUS       NM_007381               1948 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus acyl-Coenzyme A dehydrogenase, long-chain (Acadl),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_007381
VERSION     NM_007381.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1948)
  AUTHORS   Wang,C., Qiao,S., Zhao,Y., Tian,H., Yan,W., Hou,X., Wang,R.,
            Zhang,B., Yang,C., Zhu,F., Jiao,Y., Jin,J., Chen,Y. and Tian,W.
  TITLE     The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling
            during cardiac hypertrophy in male mice
  JOURNAL   Nat Commun 14 (1), 959 (2023)
   PUBMED   36810848
  REMARK    GeneRIF: The KLF7/PFKL/ACADL axis modulates cardiac metabolic
            remodelling during cardiac hypertrophy in male mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1948)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1948)
  AUTHORS   Ghnaimawi,S., Zhang,S., Baum,J.I. and Huang,Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1948)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1948)
  AUTHORS   Bjorkegren,J., Veniant,M., Kim,S.K., Withycombe,S.K., Wood,P.A.,
            Hellerstein,M.K., Neese,R.A. and Young,S.G.
  TITLE     Lipoprotein secretion and triglyceride stores in the heart
  JOURNAL   J Biol Chem 276 (42), 38511-38517 (2001)
   PUBMED   11481337
REFERENCE   6  (bases 1 to 1948)
  AUTHORS   Kurtz,D.M., Rinaldo,P., Rhead,W.J., Tian,L., Millington,D.S.,
            Vockley,J., Hamm,D.A., Brix,A.E., Lindsey,J.R., Pinkert,C.A.,
            O'Brien,W.E. and Wood,P.A.
  TITLE     Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene
            reveals crucial roles for fatty acid oxidation
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15592-15597 (1998)
   PUBMED   9861014
REFERENCE   7  (bases 1 to 1948)
  AUTHORS   Guerra,C., Koza,R.A., Walsh,K., Kurtz,D.M., Wood,P.A. and
            Kozak,L.P.
  TITLE     Abnormal nonshivering thermogenesis in mice with inherited defects
            of fatty acid oxidation
  JOURNAL   J Clin Invest 102 (9), 1724-1731 (1998)
   PUBMED   9802886
REFERENCE   8  (bases 1 to 1948)
  AUTHORS   Kurtz,D.M., Tolwani,R.J. and Wood,P.A.
  TITLE     Structural characterization of the mouse long-chain acyl-CoA
            dehydrogenase gene and 5' regulatory region
  JOURNAL   Mamm Genome 9 (5), 361-365 (1998)
   PUBMED   9545492
REFERENCE   9  (bases 1 to 1948)
  AUTHORS   Ruiz-Lozano,P., Smith,S.M., Perkins,G., Kubalak,S.W., Boss,G.R.,
            Sucov,H.M., Evans,R.M. and Chien,K.R.
  TITLE     Energy deprivation and a deficiency in downstream metabolic target
            genes during the onset of embryonic heart failure in RXRalpha-/-
            embryos
  JOURNAL   Development 125 (3), 533-544 (1998)
   PUBMED   9425147
REFERENCE   10 (bases 1 to 1948)
  AUTHORS   Hinsdale,M.E., Farmer,S.C., Johnson,K.R., Davisson,M.T., Hamm,D.A.,
            Tolwani,R.J. and Wood,P.A.
  TITLE     RNA expression and chromosomal location of the mouse long-chain
            acyl-CoA dehydrogenase gene
  JOURNAL   Genomics 28 (2), 163-170 (1995)
   PUBMED   8530022
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124389.4, AK005140.1 and
            AK151845.1.
            
            On Nov 29, 2012 this sequence version replaced NM_007381.3.
            
            Summary: This gene encodes a homotetrameric mitochondrial
            flavoprotein and is a member of the acyl-CoA dehydrogenase family.
            Members of this family catalyze the first step of fatty acid
            beta-oxidation, forming a C2-C3 trans-double bond in a
            FAD-dependent reaction. As beta-oxidation cycles through its four
            steps, each member of the acyl-CoA dehydrogenase family works at an
            optimum fatty acid chain-length. This enzyme has its optimum length
            between C12- and C16-acylCoA. In mice, deficiency of this gene can
            cause sudden death, cardiomyopathy as well as fasting and cold
            intolerance. [provided by RefSeq, Nov 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. The transit
            peptide annotated at aa 1-30 is inferred by similarity to the
            cleavage site in the orthologous rat protein as described in PMID:
            2777793. The software program TargetP1.1 predicts that the transit
            peptide in mouse is aa 1-27.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151845.1, AK005140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC124389.4         103321-103362       c
            43-1934             AK005140.1         2-1893
            1935-1948           AK151845.1         1904-1917
FEATURES             Location/Qualifiers
     source          1..1948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 33.64 cM"
     gene            1..1948
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /note="acyl-Coenzyme A dehydrogenase, long-chain"
                     /db_xref="GeneID:11363"
                     /db_xref="MGI:MGI:87866"
     exon            1..137
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1353
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /EC_number="1.3.8.8"
                     /note="long-chain specific acyl-CoA dehydrogenase,
                     mitochondrial; acetyl-Coenzyme A dehydrogenase,
                     long-chain"
                     /codon_start=1
                     /product="long-chain specific acyl-CoA dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_031407.2"
                     /db_xref="CCDS:CCDS15023.1"
                     /db_xref="GeneID:11363"
                     /db_xref="MGI:MGI:87866"
                     /translation="MAARLLLRSLRVLSARSAPRPLPSARCSHSGAEARLETPSAKKL
                     TDIGIRRIFSSEHDIFRESVRKFFQEEVIPHHTEWEKAGEVSREVWEKAGKQGLLGIN
                     IAEKHGGIGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEKFIPQ
                     MTAGKCIGAIAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAV
                     TNREARSPAHGISLFLVENGMKGFIKGRKLHKMGMKAQDTAELFFEDVRLPANALLGE
                     ENKGFYYLMQELPQERLLIAELAISACEFMFEETRNYVKQRKAFGKTVAHIQTVQHKL
                     AELKTHICVTRAFVDSCLQLHETKRLDSGSASMAKYWASELQNSVAYECVQLHGGWGY
                     MWEYPIAKAYVDARVQPIYGGTNEIMKELIARQIVSDS"
     exon            138..293
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            294..431
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            432..596
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            597..663
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            664..828
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            829..930
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1044
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1172
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1259
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1948
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1491..1496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /note="hexamer: AATAGA"
     polyA_site      1510
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /note="major polyA site"
     regulatory      1915..1920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /note="hexamer: AATAAA"
     polyA_site      1935
                     /gene="Acadl"
                     /gene_synonym="LCAD"
                     /note="major polyA site"
ORIGIN      
        1 tctgtccgcc tgcccccgcc gcggagcccg ccagtcccgt ccgccgccgt ccatcccgcc
       61 atggctgcgc gcctgctcct ccgctccctg cgcgtcctga gcgcccgctc ggcgccacgc
      121 ccgctgccct ccgcccgatg ttctcattct ggagcagaag cgcgtctaga aactccttct
      181 gctaaaaaat taactgacat tggaatcagg agaatctttt cctcggagca tgacattttc
      241 cgggagagtg taaggaagtt tttccaagaa gaagtgattc ctcaccacac agaatgggag
      301 aaagctggag aagtgagtag agaggtctgg gaaaaagctg gcaagcaggg cttgcttggc
      361 atcaacatcg cagagaaaca tggcggcatt ggtggggact tgctctcaac agcagttact
      421 tgggaagagc aagcgtactc caattgcaca ggccctggct tcagcctcca ctcagatatt
      481 gtcatgccct atattgcgaa ttacggcaca aaagaacaga tcgagaagtt catcccccag
      541 atgacggcgg gcaagtgtat cggtgccata gccatgacag agcctggggc tggaagtgac
      601 ttacaaggag taagaacgaa cgccaaaaga tctgggagtg attggattct caatggaagc
      661 aaggtgttca tcactaatgg ctggttaagt gatctcgtga tcgtcgtggc cgtcaccaac
      721 cgtgaagctc gatcgcctgc ccatggcatt agcctctttt tggtggaaaa cggaatgaaa
      781 ggatttatca agggccggaa gctgcataag atgggaatga aagctcagga cacagcagaa
      841 ctattctttg aagatgtccg attgccagct aatgccttac ttggagaaga gaataaaggc
      901 ttctactacc tcatgcaaga gcttccacag gaaaggctct taattgctga gttggcgatt
      961 tctgcctgtg agttcatgtt tgaagaaacc aggaactacg tgaagcaaag aaaagctttt
     1021 gggaaaacag ttgcacacat acagacggtg cagcataaac tagcagaatt aaagacacac
     1081 atatgtgtca ccagagcttt tgtggacagc tgtctgcagt tgcatgaaac caaacgtctg
     1141 gactccggtt ctgcttccat ggcaaaatac tgggcatctg aattacaaaa cagtgtagct
     1201 tatgaatgtg tgcaactcca cggaggctgg gggtacatgt gggagtaccc gattgcaaaa
     1261 gcttacgtgg atgctcgggt gcagccgatc tacggtggta ccaacgaaat aatgaaagag
     1321 ctgatcgcaa gacagatcgt cagtgacagc tagacatctg cctacatcct ggaatcctat
     1381 tacatgcagc taatgcggat tctaatctac ttgagataaa gtgtaacctg gaaaaggggg
     1441 ggaaatggta aagctggttt tatgtatgat tgttacagag aaagaaataa aatagaattc
     1501 taaagattaa cacagggaga gagaaatttt tgagcccaag agtctaaagt tttgtcatga
     1561 aaggtataac cttttttcat gcatatacag tgaatataaa agattttcta actgaagagc
     1621 cttttaatgt cttacttgtc tttcaaattc tgaagagcat aagttggctt tcattcttaa
     1681 agttgaggca gaatttaata ttaataatac ttacaagact ttggaaaggt caaataattg
     1741 taacttatat gaagtcattt cagctacttt ttgctccata ttcccccagg acattggttc
     1801 ccaccatgtt acccccaacc ccatgttttt taaagtaatg aacagaaccc ttcagaaaaa
     1861 agtggaccgt actgtatata atgcacatag aggcaattgt gtatcaatat taaaaataaa
     1921 gtaaaactta aagcatgtgt agaccgtg
//
