LOCUS       NM_172678               3934 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus acyl-Coenzyme A dehydrogenase family, member 9
            (Acad9), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_172678
VERSION     NM_172678.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3934)
  AUTHORS   Sinsheimer,A., Mohsen,A.W., Bloom,K., Karunanidhi,A., Bharathi,S.,
            Wu,Y.L., Schiff,M., Wang,Y., Goetzman,E.S., Ghaloul-Gonzalez,L. and
            Vockley,J.
  TITLE     Development and characterization of a mouse model for Acad9
            deficiency
  JOURNAL   Mol Genet Metab 134 (1-2), 156-163 (2021)
   PUBMED   34556413
REFERENCE   2  (bases 1 to 3934)
  AUTHORS   Cajigas,I., Chakraborty,A., Swyter,K.R., Luo,H., Bastidas,M.,
            Nigro,M., Morris,E.R., Chen,S., VanGompel,M.J.W., Leib,D.,
            Kohtz,S.J., Martina,M., Koh,S., Ay,F. and Kohtz,J.D.
  TITLE     The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially
            Organizes Megabase Distant Genes in the Developing Forebrain
  JOURNAL   Mol Cell 71 (6), 956-972 (2018)
   PUBMED   30146317
REFERENCE   3  (bases 1 to 3934)
  AUTHORS   Swigonova,Z., Mohsen,A.W. and Vockley,J.
  TITLE     Acyl-CoA dehydrogenases: Dynamic history of protein family
            evolution
  JOURNAL   J Mol Evol 69 (2), 176-193 (2009)
   PUBMED   19639238
REFERENCE   4  (bases 1 to 3934)
  AUTHORS   Exil,V.J., Gardner,C.D., Rottman,J.N., Sims,H., Bartelds,B.,
            Khuchua,Z., Sindhal,R., Ni,G. and Strauss,A.W.
  TITLE     Abnormal mitochondrial bioenergetics and heart rate dysfunction in
            mice lacking very-long-chain acyl-CoA dehydrogenase
  JOURNAL   Am J Physiol Heart Circ Physiol 290 (3), H1289-H1297 (2006)
   PUBMED   16199475
  REMARK    GeneRIF: We conclude that disturbed mitochondrial bioenergetics in
            BAT is a critical contributing factor for the cold sensitivity in
            VLCAD deficiency
REFERENCE   5  (bases 1 to 3934)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158934.4, AK031820.1 and AK145423.1.
            
            On Oct 5, 2017 this sequence version replaced NM_172678.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145423.1, AK075984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AC158934.4         107398-107689       c
            293-1747            AK031820.1         204-1658
            1748-3934           AK145423.1         1635-3821
FEATURES             Location/Qualifiers
     source          1..3934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 17.41 cM"
     gene            1..3934
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /note="acyl-Coenzyme A dehydrogenase family, member 9"
                     /db_xref="GeneID:229211"
                     /db_xref="MGI:MGI:1914272"
     exon            1..292
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2008
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /note="very-long-chain acyl-CoA dehydrogenase VLCAD
                     homolog; acyl-CoA dehydrogenase family member 9,
                     mitochondrial"
                     /codon_start=1
                     /product="complex I assembly factor ACAD9, mitochondrial"
                     /protein_id="NP_766266.3"
                     /db_xref="CCDS:CCDS17310.1"
                     /db_xref="GeneID:229211"
                     /db_xref="MGI:MGI:1914272"
                     /translation="MSGCVLLSRGATAAAAAARASRVLREFTARRRPLHTSLQSCSFA
                     KELFLGNIEQKGVFPFPEVSQHELSEINQFVGPLEKFFTEEVDSRKIDQEGKIPVDTL
                     EKLKSLGLFGIQVPEEYGGLGLSNTMYARLGEIISLDASITVTLAAHQAIGLKGIILV
                     GNEEQKAKYLPKLSSGEHIAAFCLTEPASGSDAASIQTRATLSEDKKYFILNGSKVWI
                     TNGGLANIFTVFAKTEVVDSDGSKTDKMTAFIVERDFGGITNGKPEDKLGIRGSNTCE
                     VHFENTRVPVENVLGEVGGGFKVAMNILNSGRFSMGSAVAGMLKKLIELTAEYACTRK
                     QFNRNLSEFGLIQEKFALMAQKAYVMESMAYLTSGMLDQPGFPDCSIEAAMVKVFSSE
                     AAWQCVSEALQILGGSGYMKDYPYERMLRDARILLIFEGTNEILRLFIALTGLQHAGR
                     ILTSRIKELKSGNVTTVMETIGRKLRDSLGRTVDLGLTGDLGVVHPSLGDSANKLEEN
                     VHYFGRTVETLLLRFGKNIVEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLRNHD
                     HEVLLANMFCVEAYFQNLFSLSQLDKNAPENLDEQIKKVSRQILEKRAYICAHPLDRA
                     S"
     exon            293..386
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            387..488
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            489..595
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            596..696
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            697..775
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            776..950
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1024
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1100
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1171
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1291
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1420
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1500
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1627
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1705
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1834
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1907
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..3934
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /note="hexamer: AATAAA"
     polyA_site      2537
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /note="major polyA site"
     regulatory      3899..3904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /note="hexamer: AATGAA"
     regulatory      3915..3920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
                     /note="hexamer: AATAAA"
     polyA_site      3929
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
     polyA_site      3933
                     /gene="Acad9"
                     /gene_synonym="2600017P15Rik; 4732402K02; C630012L17Rik;
                     NPD002"
ORIGIN      
        1 aggaagtgcg agctagcttc cggttgcagc ggtgcagggt gagactttgg atgcccggac
       61 gcgggtgatt ggcgtcattg ggaggagcgg cggggcttcc agcgacttga agtctgaagt
      121 caggagcagc atgtctggct gtgtgctgct ctcgcgtggg gcgactgcgg cggcggctgc
      181 ggcgcgagct tcccgggtgc tgagggaatt cacggcgagg cgccgcccgc tgcacaccag
      241 cctgcagagc tgctcgttcg ccaaggagct cttcctgggc aacatcgagc agaaaggagt
      301 tttcccattt ccagaggtca gtcaacatga acttagtgaa atcaatcagt tcgtgggacc
      361 gctggaaaaa ttcttcactg aagaagtgga ctctcgaaaa attgaccagg agggaaaaat
      421 cccagttgac accttagaga agttgaagag cctgggactt tttggcatac aggtcccaga
      481 agaatatggt ggcctgggcc tctccaacac gatgtatgct cggctcgggg agatcatcag
      541 cctggatgcc tctatcacgg tgaccctggc agcacaccag gctatcggcc tcaaggggat
      601 tatcttggtc ggcaatgagg aacagaaggc caagtatctg cccaaactgt cgtctgggga
      661 acacatcgca gccttctgcc taacagagcc agccagtggg agtgatgctg cgtccatcca
      721 gaccagagct acgttaagtg aagataagaa gtacttcata ctcaatggct ccaaggtttg
      781 gatcaccaat ggaggactgg ccaatatttt tactgtgttt gcaaaaaccg aggtggtcga
      841 ttctgatggt tcgaaaacag acaaaatgac cgcattcata gtagaaagag acttcggcgg
      901 aatcactaat gggaaacctg aagataaatt aggcattcga ggctccaaca catgtgaggt
      961 ccattttgaa aataccagag tgcctgtgga aaatgtcctt ggagaagttg gagggggctt
     1021 taaggtagcc atgaacatcc tgaacagtgg gcgattcagc atgggcagtg ctgtggccgg
     1081 gatgctgaag aagctgatcg aactgactgc tgagtatgcc tgtacgagga aacagttcaa
     1141 caggaatctc agtgaatttg ggttgatcca ggaaaagttt gcgctcatgg ctcagaaggc
     1201 atacgtaatg gagagtatgg cttacctcac ttcagggatg ctagaccaac caggatttcc
     1261 cgactgctct atcgaggcag ccatggtgaa ggtgtttagc tctgaggctg cctggcagtg
     1321 tgtgagcgag gctctgcaga tccttggggg ctcaggctac atgaaggact acccctatga
     1381 gcgcatgctg cgtgatgccc gcattctcct aatctttgag ggaaccaatg agattcttcg
     1441 gttgttcatt gccctgacag gcctgcagca tgctggacgc atcctgacct cgaggatcaa
     1501 agagcttaaa agtggcaatg tgaccacagt catggagacg attggtcgga aacttcggga
     1561 ttctctgggc cgaactgtgg acctggggct aacaggcgat cttggtgttg tccaccccag
     1621 ccttggcgac agtgccaaca agcttgagga aaatgtccat tactttggcc ggactgttga
     1681 gaccctgtta ctccgttttg gaaagaacat tgtagaggaa cagctggtgt taaagcgggt
     1741 agccaacatc ctcatcaact tgtatggcat gactgctgtg ctgtcgagag ccagccgctc
     1801 catcagaatt gggctcagga atcatgatca cgaggttctg ttggccaaca tgttctgtgt
     1861 ggaagcttat ttccagaatc tcttcagcct gtctcagctg gacaagaacg ctccagaaaa
     1921 cctggatgag cagattaaga aagtgtctcg gcagatcctt gagaagcgag cctatatctg
     1981 tgcccacccg ctggacagag catcctgagg ctggaaccat gtacctgcct agcccgggtt
     2041 aacatcattc acaagacaga ccttgaggtc atctgtgtgg actgtatgtt atctgcatac
     2101 actaaaaaca ctttcttctc tgagcaaaag caatagttag gttttggtct ctaggccctg
     2161 tatctagagg gatcccatct cctggaagga aggaagtacc agccaaatcg ttgaagaaag
     2221 aaagaaaaag gaagaaccaa attgtggatg gctcctgtgt gtggctgcat gatacatctc
     2281 agtggacatg ggcccgcctt taagacacaa ggctcacagt aaactaagat ttgggcagct
     2341 attccttcta aaccatgtat aaagaaactc ctgagaagtt gagtctatac cactcaccga
     2401 gactgtttcc aatctacgta cggaatcatt taacaaagta tataaagttt atgtccacct
     2461 agactttatg ttcttcagtc catgaccgtg aggggccata acaataaaat cccttcttga
     2521 gtgttttaaa cttcaaattg tagtgctcct ccacttcctt tgttaggctt atcccaaggg
     2581 gctggttagg tgctttactt tactagaatg ttgtttgatt ctttgatagt tttatacatt
     2641 taatgatgtg tcttggtcat atctatccta actcctccgt cctgttttat ggcatcctaa
     2701 catgcccagc tccctacttc ttcttttcaa ctcactgtgt ccccttagtg ctgagtggga
     2761 atattaactt tctgacttgc tctcctgcat cgatgatttt taccctctct taaaaagtgt
     2821 tctcttggcc ccttggtctt gcaaacttta tatgccccag tacaggggaa acactagggc
     2881 caagaagtgg gagtggatgg gtagggaagc agggggccac ggggaggata taggggactt
     2941 ttgggatagc atttgaaatg taaatgaagt aaatacctaa taaaaaattg gaaaaaaaaa
     3001 tgttctcttg ggagggggtt aacgtggctg gcccactgag agctgagtac ccagtagttc
     3061 ttagtctttt gtagccttct gagttccaca ggtccttcac cttatacact caatctaaga
     3121 atcagcattg cttgccactg ttgattttgt agtgtttgtt ttaacttcct ctcttgctta
     3181 gtgttattgt agcaagattt attctttcct gaggccttag agatttgttt ctttttcttc
     3241 agtctgaaat attccttcaa ttatcttctg tagagctggc ctgtggtcag aaattccttt
     3301 ttacataaga aaatcaagaa ggaagaccaa tgcgtggata cttcattcct ccctagaaaa
     3361 gggaataaaa tactcctaga agcagttaca gagacaaagt ttggagataa gacaaaagga
     3421 tggaccatcc ggagactgtc ccacccaggg gtccatccca taatcagcca ccaaatgcag
     3481 acactattgc atatgccagc aagattttgc tgaaaggacc ctgatatagc tgtctcctga
     3541 gaggctatgc cagtgcctgg caaatacaga agtggatgct cacagtcatc tataagatgg
     3601 aacacagggc ccccaatgta ggagctagag aaagtaccca agagctgaag aggtctgcaa
     3661 ccctataggt ggaacaacaa tatgaactaa tcagtaccct cagaactcgt gtctcttgct
     3721 gcatatgtag cagaagatgg cctagttggc catcattggg aagagagacc ccttggtcaa
     3781 gcaaacttca tatgcccact acaggggaac ggcagggcca agaagtggga gtgagtgggt
     3841 aggggagcag ggcaggggga aaggtgtagg ggacttttgg gatagcattt gaaatgtaaa
     3901 tgaagagatt gtctaataaa aatattaaag aaat
//
