LOCUS       NM_028037               3621 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus acyl-Coenzyme A dehydrogenase family, member 10
            (Acad10), mRNA.
ACCESSION   NM_028037
VERSION     NM_028037.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3621)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3621)
  AUTHORS   Shim,S.M., Choi,H.R., Kwon,S.C., Kim,H.Y., Sung,K.W., Jung,E.J.,
            Mun,S.R., Bae,T.H., Kim,D.H., Son,Y.S., Jung,C.H., Lee,J.,
            Lee,M.J., Park,J.W. and Kwon,Y.T.
  TITLE     The Cys-N-degron pathway modulates pexophagy through the N-terminal
            oxidation and arginylation of ACAD10
  JOURNAL   Autophagy 19 (6), 1642-1661 (2023)
   PUBMED   36184612
  REMARK    GeneRIF: The Cys-N-degron pathway modulates pexophagy through the
            N-terminal oxidation and arginylation of ACAD10.
REFERENCE   3  (bases 1 to 3621)
  AUTHORS   Bloom,K., Karunanidhi,A., Tobita,K., Hoppel,C., Thiels,E., Peet,E.,
            Wang,Y., Basu,S. and Vockley,J.
  TITLE     ACAD10 protein expression and Neurobehavioral assessment of
            Acad10-deficient mice
  JOURNAL   PLoS One 15 (12), e0242445 (2020)
   PUBMED   33301490
  REMARK    GeneRIF: ACAD10 protein expression and Neurobehavioral assessment
            of Acad10-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3621)
  AUTHORS   Bloom,K., Mohsen,A.W., Karunanidhi,A., El Demellawy,D.,
            Reyes-Mugica,M., Wang,Y., Ghaloul-Gonzalez,L., Otsubo,C.,
            Tobita,K., Muzumdar,R., Gong,Z., Tas,E., Basu,S., Chen,J.,
            Bennett,M., Hoppel,C. and Vockley,J.
  TITLE     Investigating the link of ACAD10 deficiency to type 2 diabetes
            mellitus
  JOURNAL   J Inherit Metab Dis 41 (1), 49-57 (2018)
   PUBMED   28120165
  REMARK    GeneRIF: Acad10 mice accumulate excess abdominal adipose tissue,
            develop an early inflammatory liver process, exhibit fasting
            rhabdomyolysis, and have abnormal skeletal muscle mitochondria.
            Identify Acad10 as a genetic determinant of type 2 diabetes in
            mice.
REFERENCE   5  (bases 1 to 3621)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ136937.1 and AK050332.1.
            
            On Aug 24, 2007 this sequence version replaced NM_028037.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-650               CJ136937.1         6-655
            651-3621            AK050332.1         855-3825
FEATURES             Location/Qualifiers
     source          1..3621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.88 cM"
     gene            1..3621
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /note="acyl-Coenzyme A dehydrogenase family, member 10"
                     /db_xref="GeneID:71985"
                     /db_xref="MGI:MGI:1919235"
     exon            1..218
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            219..418
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..3441
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /EC_number="1.2.1.3"
                     /note="ACAD-10"
                     /codon_start=1
                     /product="acyl-CoA dehydrogenase family member 10"
                     /protein_id="NP_082313.2"
                     /db_xref="CCDS:CCDS51643.1"
                     /db_xref="GeneID:71985"
                     /db_xref="MGI:MGI:1919235"
                     /translation="MLVRRLFQPSTLHWAWRTTALNHPLGRHQGGLRWTHSGGRSYRA
                     VIFDTGGVLVPSPGTVAVGWEVQNHVPSGTIVKAFIRGGDSGPWIRFIKGEITTEHFL
                     EEFGRLCSEIAKTSVPVSSYFSLLTSEQVTKQFPVMTQAISQIRAKGLQTAVLTNNFH
                     LSSGESFLPLDRKQFDVVVESCLEGICKPDPRIFQLCLQRLSLQPSEAIFLDDLGSNL
                     KVAASLGIHTIKVDRPETAVKELEALLGFPLHLGVPNTRPVRKTMAIPQDALEKYLKG
                     LLGTHSTGPMELLQFDHGQSNPTYYIRLADRQLVLRKKPSGTLLPSAHAIEREFRIMK
                     ALANAGVPVPTVLDLCEDSSIIGTPFYLMEYCPGIIYKDPSLPGLEPSRREAIYTAMN
                     QVLCRIHSVDLQATSLDSFGKQGDYIPRQVQTWTKQYRAAETSSIPAMERLIQWLPLH
                     LPRQQRTTLVHGDFRLDNLIFHPEKAEVLAVLDWELSTLGDPFADVAYSCLAYYLPSS
                     FPILRGFRDQDVTKLGIPTVEEYFRMYCLNMGIPPIDNWNFYMAFSFFRVAAILQGVY
                     KRSLTGQASSATAQQSGKLTESMAELAWDFATKEGFRVFKEMPATKTLSRSYHAWAGP
                     RSPRTPKGVRGHSTVAAASPSHEAKGGLVISPEGLSPAVRKLYEQLVQFIEQKVYPLE
                     PELQRHQASADRWSPSPLIEDLKEKAKAEGLWNLFLPLETDPEKKYGAGLTNVEYAHL
                     CEVMGMSLYASEIFNCSAPDTGNMEILVRYGTEEQKARWLVPLLEGRIRSCFAMTEPQ
                     VASSDASNIEASIKEEDGCYVINGHKWWTSGILDPRCKLCVFMGKTDPQAPRHQQQSM
                     LLVPMDSPGITVIRPLSVFGLEDPPGGHGEVRFKDVRVPKENILLGPGRGFEIAQGRL
                     GPGRIHHCMRLIGYSERALALMKTRVMSRTAFGKPLVEQGTILADIARSRVEIEQARL
                     LVLKAAHLMDVAGNKTAALDIAMIKMVVPSMAYHVIDRAIQAFGAAGLSSDYPLAQFF
                     GWARALRFADGPDEVHQLTVAKMELKNQSRMQEPAVPRV"
     exon            419..567
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            568..762
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            763..921
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1081
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1223
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1292
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1474
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1625
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1771
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1945
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2346
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2487
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2625
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2716
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..2875
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..3048
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3192
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3270
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3271..3621
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3603..3608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acad10"
                     /gene_synonym="2410021P16Rik"
                     /note="putative"
ORIGIN      
        1 gctttcgaca gctgcttctg cccccttggc tgaccgtctg gacagggtcc gaggagcgtg
       61 cgcagagcac gcaaagacgc ctggctccta ttttgcgttt gacccctctc tacgtttgtc
      121 ctccttagtt ttcccgcagg gctcaccgag agtctatggg tccgcagaga ctctgaggct
      181 tcctgggtct tcgacctcag ggttgtaact ttctgcagcc tccatctcac catgttggta
      241 agaagacttt tccagccttc cactctgcac tgggcatgga ggaccacggc cctgaaccat
      301 cccctgggca ggcatcaggg aggcctccgc tggacacatt ctggaggccg aagctacaga
      361 gcagtcattt ttgacacggg cggagttctc gtgccttctc cagggacagt ggctgtgggc
      421 tgggaggtgc agaatcatgt cccttctgga actatagtga aggctttcat cagaggtggc
      481 gacagtgggc cctggataag gtttataaaa ggagagataa cgaccgagca cttcttggaa
      541 gaattcggga gactgtgctc tgaaatcgca aagacttccg tgcccgtgag ctcctatttc
      601 tctctgctga ccagtgagca ggtgacaaag cagttcccgg tgatgactca ggccatctct
      661 cagatcagag caaaaggcct ccagactgca gtcctcacca acaactttca tctttccagc
      721 ggggaaagct tcctgcccct ggaccggaaa cagtttgatg tggtggttga gtcctgcctg
      781 gaaggcatct gtaagccaga tcccaggata ttccagctgt gcctgcagag gctgagcctg
      841 cagccctcag aggctatttt tcttgatgat ctgggatcca atctaaaagt ggctgccagc
      901 ctgggcattc acaccatcaa ggttgacagg cccgagacag cagtgaagga gctggaggct
      961 ctactgggtt tcccactgca cttgggcgtt cccaacaccc ggcctgtgag gaagaccatg
     1021 gcgattccac aagatgcctt ggagaagtac ctgaagggct tgctggggac ccactccacc
     1081 ggccccatgg agctccttca gtttgatcat ggacagtcaa acccaacgta ctacatcagg
     1141 ctggctgacc gtcagctggt cctgaggaag aaaccctcgg ggaccctcct cccctctgcc
     1201 catgccatag aaagggaatt caggatcatg aaagcccttg caaatgcagg agtccctgtc
     1261 cctactgttc ttgacctctg tgaagactca agcatcatcg gcaccccctt ctacttgatg
     1321 gagtactgcc cgggcatcat ctacaaagac ccctccctgc ccggcttgga gcccagccgg
     1381 cgggaagcca tatacactgc catgaaccaa gtcctgtgca gaattcacag tgtggacctg
     1441 caggccacca gcctggacag cttcggcaag caaggggact atattcctcg acaggtgcaa
     1501 acctggacca agcagtaccg agcagcagaa accagcagca tcccagcaat ggagaggctt
     1561 atccagtggc tgccactgca ccttcccagg caacagagaa ccacgctggt gcatggtgac
     1621 ttcaggctgg acaacctgat attccatcct gaaaaggcgg aagtgctcgc tgtcctggac
     1681 tgggaacttt ccaccttagg agaccccttt gctgatgtgg cctacagctg cctggcctac
     1741 tacctgccat ccagctttcc cattctgaga gggttcagag accaggatgt gacaaagctg
     1801 ggcatcccca ctgtggagga atacttcagg atgtactgtc ttaacatggg catcccaccc
     1861 atcgacaact ggaacttcta catggctttc tcctttttcc gggtggctgc aatcctacag
     1921 ggagtctaca agcggtcact cacaggccag gcaagctcag caacagccca acaaagtgga
     1981 aagctcactg agtccatggc tgagctggcc tgggattttg ccaccaaaga agggttccgg
     2041 gttttcaaag agatgccagc caccaaaaca ctgagcagat cctaccatgc ctgggcggga
     2101 ccgaggtccc cgaggactcc caagggtgtg aggggtcaca gcactgtagc agctgcttcc
     2161 ccttctcacg aggcaaaggg aggcctggtc atctctccag agggcctgtc tcctgcggtc
     2221 agaaagttgt atgagcagct ggtgcagttt atagaacaga aggtgtaccc cctggagcca
     2281 gagctgcaga gacaccaggc ctcggccgac aggtggagcc cttccccgct gatagaagac
     2341 ctcaaggaga aagccaaggc tgagggactt tggaaccttt tcctaccctt ggagactgat
     2401 cctgagaaaa agtacggagc agggctgact aacgtggaat atgcacatct gtgtgaagtg
     2461 atgggcatgt ctctgtatgc ttctgagata tttaattgct ctgccccgga tacggggaat
     2521 atggagatcc tggtgcggta tggcactgag gagcagaagg cccgctggct ggtgccactg
     2581 ttggagggca ggatccgttc ttgctttgcc atgactgagc ctcaggtggc ctcctcagat
     2641 gcctctaaca tcgaggcttc catcaaagag gaagatggct gctatgtcat aaatggtcac
     2701 aagtggtgga cctcaggcat cctggatcct cgatgcaaac tctgtgtgtt tatggggaaa
     2761 acagacccac aggccccaag gcaccagcaa caatctatgc tcttggttcc catggactcg
     2821 ccaggaatca cagtcatccg gcctctgtca gtgtttggtt tggaggatcc tccaggtggc
     2881 cacggtgaag tacggttcaa ggacgtgcgt gtgcccaagg aaaacatact cctgggccct
     2941 ggccgaggct ttgagatcgc tcagggcagg ctggggcctg gccggattca tcactgcatg
     3001 aggttgattg ggtattcaga gagggccctg gcactcatga agacacgggt gatgtcccgc
     3061 acggccttcg ggaagcccct tgtggagcag ggcaccatcc tggcagacat tgcccggtca
     3121 cgtgtggaga tcgagcaggc ccggctgctg gtgctgaaag ctgctcacct catggatgtg
     3181 gccggaaata agactgcagc tttagacatt gcaatgatta aaatggtcgt cccttccatg
     3241 gcctatcacg taattgaccg cgctattcag gcctttggag cagcgggcct cagcagtgac
     3301 taccccctgg ctcagttctt tggctgggcc cgagccctgc gcttcgctga tggccctgat
     3361 gaagtacacc agctgacagt ggctaagatg gaactgaaga atcagtccag gatgcaggaa
     3421 ccagcagtgc ccagagtgta gatgctgagt ttggcatggt ctgctatgtg tggtcctcac
     3481 atcctatcca gcaactcagt ctgggacagt tactgtgacc tgaacctcct agggtctttt
     3541 caagaagata ttctctgggg tctcttcaga gacctgcctg cctctgcttt ccacgtgctg
     3601 gaattaaata catttgcaac t
//
