LOCUS       NM_001403527            8699 bp    mRNA    linear   ROD 20-FEB-2025
DEFINITION  Mus musculus acetyl-Coenzyme A carboxylase beta (Acacb), transcript
            variant 1, mRNA.
ACCESSION   NM_001403527 XM_006530111
VERSION     NM_001403527.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8699)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 8699)
  AUTHORS   Deja,S., Fletcher,J.A., Kim,C.W., Kucejova,B., Fu,X., Mizerska,M.,
            Villegas,M., Pudelko-Malik,N., Browder,N., Inigo-Vollmer,M.,
            Menezes,C.J., Mishra,P., Berglund,E.D., Browning,J.D.,
            Thyfault,J.P., Young,J.D., Horton,J.D. and Burgess,S.C.
  TITLE     Hepatic malonyl-CoA synthesis restrains gluconeogenesis by
            suppressing fat oxidation, pyruvate carboxylation, and amino acid
            availability
  JOURNAL   Cell Metab 36 (5), 1088-1104 (2024)
   PUBMED   38447582
REFERENCE   3  (bases 1 to 8699)
  AUTHORS   Guilherme,A., Rowland,L.A., Wetoska,N., Tsagkaraki,E., Santos,K.B.,
            Bedard,A.H., Henriques,F., Kelly,M., Munroe,S., Pedersen,D.J.,
            Ilkayeva,O.R., Koves,T.R., Tauer,L., Pan,M., Han,X., Kim,J.K.,
            Newgard,C.B., Muoio,D.M. and Czech,M.P.
  TITLE     Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte
            thermogenic program
  JOURNAL   Cell Rep 42 (5), 112488 (2023)
   PUBMED   37163372
REFERENCE   4  (bases 1 to 8699)
  AUTHORS   Yeudall,S., Upchurch,C.M., Seegren,P.V., Pavelec,C.M., Greulich,J.,
            Lemke,M.C., Harris,T.E., Desai,B.N., Hoehn,K.L. and Leitinger,N.
  TITLE     Macrophage acetyl-CoA carboxylase regulates acute inflammation
            through control of glucose and lipid metabolism
  JOURNAL   Sci Adv 8 (47), eabq1984 (2022)
   PUBMED   36417534
REFERENCE   5  (bases 1 to 8699)
  AUTHORS   Habeos,G.I., Filippopoulou,F., Habeos,E.E., Kalaitzopoulou,E.,
            Skipitari,M., Papadea,P., Lagoumintzis,G., Niarchos,A.,
            Georgiou,C.D. and Chartoumpekis,D.V.
  TITLE     Maternal Calorie Restriction Induces a Transcriptional
            Cytoprotective Response in Embryonic Liver Partially Dependent on
            Nrf2
  JOURNAL   Antioxidants (Basel) 11 (11), 2274 (2022)
   PUBMED   36421460
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8699)
  AUTHORS   Beigneux,A.P., Kosinski,C., Gavino,B., Horton,J.D., Skarnes,W.C.
            and Young,S.G.
  TITLE     ATP-citrate lyase deficiency in the mouse
  JOURNAL   J Biol Chem 279 (10), 9557-9564 (2004)
   PUBMED   14662765
REFERENCE   7  (bases 1 to 8699)
  AUTHORS   Abu-Elheiga,L., Oh,W., Kordari,P. and Wakil,S.J.
  TITLE     Acetyl-CoA carboxylase 2 mutant mice are protected against obesity
            and diabetes induced by high-fat/high-carbohydrate diets
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10207-10212 (2003)
   PUBMED   12920182
  REMARK    GeneRIF: ACC2 plays an essential role in controlling fatty acid
            oxidation and is a potential target in therapy against obesity and
            related diseases.
REFERENCE   8  (bases 1 to 8699)
  AUTHORS   Abu-Elheiga,L., Matzuk,M.M., Abo-Hashema,K.A. and Wakil,S.J.
  TITLE     Continuous fatty acid oxidation and reduced fat storage in mice
            lacking acetyl-CoA carboxylase 2
  JOURNAL   Science 291 (5513), 2613-2616 (2001)
   PUBMED   11283375
REFERENCE   9  (bases 1 to 8699)
  AUTHORS   Abu-Elheiga,L., Brinkley,W.R., Zhong,L., Chirala,S.S.,
            Woldegiorgis,G. and Wakil,S.J.
  TITLE     The subcellular localization of acetyl-CoA carboxylase 2
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1444-1449 (2000)
   PUBMED   10677481
REFERENCE   10 (bases 1 to 8699)
  AUTHORS   Bird,M.I. and Saggerson,E.D.
  TITLE     Binding of malonyl-CoA to isolated mitochondria. Evidence for high-
            and low-affinity sites in liver and heart and relationship to
            inhibition of carnitine palmitoyltransferase activity
  JOURNAL   Biochem J 222 (3), 639-647 (1984)
   PUBMED   6487267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122282.5.
            
            On Mar 31, 2022 this sequence version replaced XM_006530111.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.6119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC122282.5         20189-20327
            140-771             AC122282.5         39011-39642
            772-904             AC122282.5         57552-57684
            905-1043            AC122282.5         61833-61971
            1044-1153           AC122282.5         63578-63687
            1154-1235           AC122282.5         63832-63913
            1236-1334           AC122282.5         64657-64755
            1335-1444           AC122282.5         65354-65463
            1445-1555           AC122282.5         65576-65686
            1556-1765           AC122282.5         68726-68935
            1766-1936           AC122282.5         69137-69307
            1937-2098           AC122282.5         70162-70323
            2099-2262           AC122282.5         71679-71842
            2263-2413           AC122282.5         73742-73892
            2414-2517           AC122282.5         73998-74101
            2518-2599           AC122282.5         75401-75482
            2600-2745           AC122282.5         76892-77037
            2746-2896           AC122282.5         78174-78324
            2897-3031           AC122282.5         80738-80872
            3032-3178           AC122282.5         83255-83401
            3179-3367           AC122282.5         84407-84595
            3368-3430           AC122282.5         85140-85202
            3431-3531           AC122282.5         86153-86253
            3532-3620           AC122282.5         86814-86902
            3621-3745           AC122282.5         87115-87239
            3746-3859           AC122282.5         90103-90216
            3860-3973           AC122282.5         90313-90426
            3974-4063           AC122282.5         91151-91240
            4064-4182           AC122282.5         92364-92482
            4183-4320           AC122282.5         96734-96871
            4321-4420           AC122282.5         97310-97409
            4421-4528           AC122282.5         97491-97598
            4529-4585           AC122282.5         99076-99132
            4586-4627           AC122282.5         99356-99397
            4628-4843           AC122282.5         100179-100394
            4844-4999           AC122282.5         102033-102188
            5000-5203           AC122282.5         103233-103436
            5204-5359           AC122282.5         104217-104372
            5360-5482           AC122282.5         106349-106471
            5483-5752           AC122282.5         106585-106854
            5753-5850           AC122282.5         108955-109052
            5851-5971           AC122282.5         110009-110129
            5972-6082           AC122282.5         112120-112230
            6083-6226           AC122282.5         113194-113337
            6227-6347           AC122282.5         114046-114166
            6348-6444           AC122282.5         115425-115521
            6445-6541           AC122282.5         117988-118084
            6542-6677           AC122282.5         118590-118725
            6678-6855           AC122282.5         119380-119557
            6856-6968           AC122282.5         119933-120045
            6969-7123           AC122282.5         121666-121820
            7124-7294           AC122282.5         122086-122256
            7295-7431           AC122282.5         122377-122513
            7432-8699           AC122282.5         122996-124263
FEATURES             Location/Qualifiers
     source          1..8699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..8699
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /note="acetyl-Coenzyme A carboxylase beta"
                     /db_xref="GeneID:100705"
                     /db_xref="MGI:MGI:2140940"
     exon            1..139
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            140..771
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..7558
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /EC_number="6.4.1.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ACC-beta; acetyl-CoA carboxylase 2"
                     /codon_start=1
                     /product="acetyl-CoA carboxylase 2 isoform 1"
                     /protein_id="NP_001390456.1"
                     /db_xref="GeneID:100705"
                     /db_xref="MGI:MGI:2140940"
                     /translation="MVLLLFLTCLVFSCLTFSWLKIWGKMTDSKPLTNSKVEANLLSS
                     EESLSASELSGEQLQEHGDHSCLSYRGPRDASQQRNSLPSSCQRPPRNPLSSNDTWPS
                     PELQTNWTAAPGPEVPDANGLSFPARPPSQRTVSPSREDRKQAHIKRQLMTSFILGSL
                     DDNSSDEDPSAGSFQNSSRKSSRASLGTLSQEAALNTSDPESHAPTMRPSMSGLHLVK
                     RGREHKKLDLHRDFTVASPAEFVTRFGGNRVIEKVLIANNGIAAVKCMRSIRRWAYEM
                     FRNERAIRFVVMVTPEDLKANAEYIKMADQYVPVPGGPNNNNYANVELIIDIAKRIPV
                     QAVWAGWGHASENPKLPELLCKHEIAFLGPPSEAMWALGDKIASTIVAQTLQIPTLPW
                     SGSGLTVEWTEDSRHQGKCISVPEDVYEQGCVKDVDEGLQAAEKIGFPLMIKASEGGG
                     GKGIRKAESAEDFPMLFRQVQSEIPGSPIFLMKLAQNARHLEVQVLADQYGNAVSLFG
                     RDCSIQRRHQKIIEEAPATIAAPAVFEFMEQCAVLLAKMVGYVSAGTVEYLYSQDGSF
                     HFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPIP
                     FETPLSPPIARGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGYFSVAAAGGL
                     HEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLVNLLETESFQNND
                     IDTGWLDHLIAQRVQAEKPDIMLGVVCGALNVADAMFRTCMTEFLHSLERGQVLPADS
                     LLNIVDVELIYGGIKYALKVARQSLTMFVLIMNGCHIEIDAHRLNDGGLLLSYNGSSY
                     TTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLMQYTVEDGDHVEAGSSYAE
                     MEVMKMIMTLNVQESGRVKYIKRPGVILEAGCVVARLELDDPSKVHAAQPFTGELPAQ
                     QTLPILGEKLHQVFHGVLENLTNVMSGYCLPEPFFSMKLKDWVQKLMMTLRHPSLPLL
                     ELQEIMTSVAGRIPAPVEKAVRRVMAQYASNITSVLCQFPSQQCWASGTLGKHSTTEL
                     HPELLKIATILDCHAATLQRKADREVFFMNTQSIVQLVQRYRSGTRGYMKAVVLDLLR
                     KYLNVEHHFQQAHYDKCVINLREQFKPDMTQVLDCIFSHSQVAKKNQLVTMLIDELCG
                     PDPTLSDELTSILCELTQLSRSEHCKVALRARQVLIASHLPSYELRHNQVESIFLSAI
                     DMYGHQFCPENLKKLILSETTIFDVLPTFFYHENKVVCMASLEVYVRRGYIAYELNSL
                     QHRELPDGTCVVEFQFMLPSSHPNRMAVPISVSNPDLLRHSTELFMDSGFSPLCQRMG
                     AMVAFRRFEEFTRNFDEVISCFANVQTDTLLFSKACTSLYSEEDSKSLREEPIHILNV
                     AIQCADHMEDEALVPVFRAFVQSKKHILVDYGLRRITFLVAQEREFPKFFTFRARDEF
                     AEDRIYRHLEPALAFQLELSRMRNFDLTAVPCANHKMHLYLGAAKVKEGLEVTDHRFF
                     IRAIIRHSDLITKEASFEYLQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPT
                     VIMDPLKIEESVRDMVMRYGSRLWKLRVLQAEVKINIRQTTSDSAIPIRLFITNESGY
                     YLDISLYREVTDSRSGNIMFHSFGNKQGSLHGMLINTPYVTKDLLQAKRFQAQSLGTT
                     YVYDFPEMFRQALFKLWGSPEKYPKDILTYTELVLDSQGQLVEMNRLPGCNEVGMVAF
                     KMRFKTPEYPEGRDAVVIGNDITFQIGSFGIGEDFLYLRASEMARTEGIPQIYLAANS
                     GARMGLAEEIKQIFQVAWVDPEDPHKGFRYLYLTPQDYTQISSQNSVHCKHIEDEGES
                     RYVIVDVIGKDANLGVENLRGSGMIAGEASLAYEKTVTISMVTCRALGIGAYLVRLGQ
                     RVIQVENSHIILTGAGALNKVLGREVYTSNNQLGGVQIMHTNGVSHVTVPDDFEGVCT
                     ILEWLSFIPKDNRSPVPITTPSDPIDREIEFTPTKAPYDPRWMLAGRPHPTLKGTWQS
                     GFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVETRTVEVAVPADPANLDSEAKI
                     IQQAGQVWFPDSAYKTAQVIRDFNKERLPLMIFANWRGFSGGMKDMYEQMLKFGAYIV
                     DGLRLYEQPILIYIPPCAELRGGSWVVLDSTINPLCIEMYADKESRGGVLEPEGTVEI
                     KFRKKDLVKTIRRIDPVCKKLVGQLGKAQLPDKDRKELEGQLKAREELLLPIYHQVAV
                     QFADLHDTPGHMLEKGIISDVLEWKTARTFFYWRLRRLLLEAQVKQEILRASPELNHE
                     HTQSMLRRWFVETEGAVKAYLWDSNQVVVQWLEQHWSAKDGLRSTIRENINYLKRDSV
                     LKTIQSLVQEHPEVIMDCVAYLSQHLTPAERIQVAQLLSTTESPASS"
     exon            772..904
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1043
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1153
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1235
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1334
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1444
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1555
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1765
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1936
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2098
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2262
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2413
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2517
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2599
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2745
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2896
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3031
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3178
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3367
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3368..3430
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3531
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3620
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3621..3745
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3859
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3860..3973
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4063
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4182
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4320
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            4321..4420
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            4421..4528
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            4529..4585
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            4586..4627
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            4628..4843
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            4844..4999
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            5000..5203
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            5204..5359
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            5360..5482
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..5752
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            5753..5850
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            5851..5971
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            5972..6082
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            6083..6226
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            6227..6347
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            6348..6444
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            6445..6541
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            6542..6677
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            6678..6855
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            6856..6968
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            6969..7123
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            7124..7294
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            7295..7431
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     exon            7432..8699
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8676..8681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /note="hexamer: AATAAA"
     polyA_site      8699
                     /gene="Acacb"
                     /gene_synonym="Acc2; Accb"
                     /note="major polyA site"
ORIGIN      
        1 gacatttaca gtcacagcgg agagcagcct gccggggcag cttagatccg ggccccagcc
       61 aacaaggagc ttgaaaaatg tcaaccctgg aaacgcagtt tggaagccat ggggaatgca
      121 aggccaaagt gtgaacacag ttgcctgaat ggtcttgctt ctctttctga cttgcctggt
      181 tttctcctgc ctgacctttt cctggctaaa aatctggggg aagatgacag actcgaagcc
      241 gctcaccaac agtaaggtgg aagccaatct cctttcaagc gaggagtccc tttcagcctc
      301 agagctgtca ggggaacagc tgcaggaaca tggcgaccac agctgtctgt cctacagagg
      361 tcccagagac gccagtcagc agaggaactc cctgccaagc tcatgccaga ggcctccgag
      421 gaacccactg tcttccaatg acacctggcc ctccccagaa ctccaaacca actggacagc
      481 cgccccgggc ccagaggttc cagatgctaa tgggttgtcc ttcccagcca ggcccccgag
      541 ccagaggaca gtatccccct ccagagagga caggaagcag gcacacatca agagacagct
      601 gatgaccagc tttatcctgg gctccctgga tgacaactcc tctgatgagg accctagtgc
      661 cggctccttc cagaactcct cccggaagag cagcagggct agcctgggca ctctgtccca
      721 ggaggctgca ttgaacacaa gtgatcctga atctcacgcg cctactatga ggcccagcat
      781 gtctggactc catctggtga agagaggccg agaacacaag aaactggacc tgcacagaga
      841 tttcaccgtc gcgtccccag ccgagtttgt cactcggttt ggaggcaaca gggtcataga
      901 gaaggtgctc atcgccaaca atggcatcgc tgcggtcaag tgtatgcgct ccatccgccg
      961 ctgggcctac gagatgttcc gtaatgaacg tgccatccgg ttcgtggtca tggtgacgcc
     1021 cgaggatctg aaggccaacg cagagtacat caagatggcc gatcagtacg tccctgtccc
     1081 aggaggaccc aataacaaca actatgccaa tgttgagctg atcatagaca ttgccaagag
     1141 aatccctgta caggccgtgt gggctggctg gggccacgct tcggaaaacc ccaaacttcc
     1201 agagctgctg tgtaaacacg agattgcttt cctaggtccc cccagtgagg ccatgtgggc
     1261 cctgggagac aagatcgcct ccaccatcgt agcgcagaca ctgcaaatcc caaccttacc
     1321 ctggagtgga agcggtctca cagtggagtg gacggaggac agccggcacc agggcaaatg
     1381 catcagtgtc cccgaagacg tttacgagca gggctgtgtg aaggatgtgg acgaaggctt
     1441 gcaggcagca gaaaaaatag gatttccttt gatgatcaaa gcctccgaag gcggaggcgg
     1501 gaaaggtatc cgcaaggctg agagtgcaga ggacttcccg atgcttttcc gacaagtgca
     1561 gagtgagatt ccgggctcgc cgatctttct aatgaagctg gcccagaacg cacggcacct
     1621 ggaggtccag gtcttggcag atcagtatgg aaacgcggtg tcactgttcg gacgggactg
     1681 ttccattcag aggcggcacc agaagatcat tgaggaggct ccggccacca tcgccgcgcc
     1741 tgccgtgttt gagttcatgg aacagtgtgc tgtcctcctg gccaagatgg tgggttatgt
     1801 gagcgcgggg actgtggagt acttatacag ccaggatggc agcttccact tcctggagct
     1861 gaacccacgc ctgcaggtgg agcatccgtg cactgaaatg atcgcagatg tcaacctgcc
     1921 tgctgcgcag ttgcagatcg ccatgggcgt gcccctgcac cgactgaagg acatacggct
     1981 tctgtacgga gagtccccct ggggagtgac ccccattcct tttgaaaccc ccttgagccc
     2041 tcccattgcc cgaggccacg tcattgcagc caggatcacc agcgaaaacc cagatgaggg
     2101 ctttaagcca agctcgggga cagtgcagga gctgaacttc cgcagcaaca agaacgtgtg
     2161 gggttacttc agcgtggccg ctgctggggg cttgcacgag ttcgccgatt cccagtttgg
     2221 gcactgcttc tcctggggcg agaaccgtga agaggccatt tcgaacatgg tagtggcttt
     2281 gaaggaactg tccatccggg gtgacttccg gaccactgtg gagtatctcg ttaaccttct
     2341 ggagaccgag agcttccaga acaacgatat cgacacgggg tggctggacc acctcatcgc
     2401 tcagcgggtg caggcagaga agccggacat catgcttggg gtggtgtgtg gggccttgaa
     2461 tgtggcagac gcgatgttca gaacctgcat gacggaattc ttgcactccc tggaaagggg
     2521 tcaggtcctc cctgctgatt ctctgctgaa cattgtggac gttgaattga tttacggcgg
     2581 catcaagtat gctctcaagg tagcccgaca gtccctgact atgtttgtcc tcatcatgaa
     2641 cggctgccac atcgagatcg atgcccaccg gctgaacgat ggggggctgc tcctgtccta
     2701 caatggcagc agttacacta cgtacatgaa ggaagaggtt gacagttacc ggatcactat
     2761 cggcaataag acttgcgtgt ttgaaaagga aaacgacccc actgtcctga gatccccctc
     2821 ggctgggaag ctgatgcagt atacggtgga ggacggagac cacgtggaag ctgggagcag
     2881 ctacgcggag atggaggtga tgaagatgat catgaccctg aacgtgcagg agagcggccg
     2941 ggtgaagtac atcaagcggc caggggttat actggaggct ggctgcgtgg tggcgaggct
     3001 agaactcgat gacccttcaa aagtgcacgc ggcccagccg tttactgggg agctccctgc
     3061 ccagcagact ctgcccatcc tcggggagaa gctacaccaa gtgttccacg gcgtcttgga
     3121 aaatctgacc aatgtcatga gtggctactg cctgcccgag cccttcttca gcatgaagct
     3181 gaaggactgg gtccagaagc tcatgatgac gctccggcat ccctccctac ctctgctgga
     3241 gctacaggag atcatgacca gtgtggccgg ccgcatcccc gccccggtgg agaaggcagt
     3301 ccgcagggtg atggcccagt acgccagtaa catcacctcc gtgctatgcc agttccccag
     3361 ccagcagtgc tgggcctcag gcacgctagg caagcactct accactgagc tacatcccga
     3421 gctcctgaag atagccacca tcctggactg ccatgccgcc accctgcagc gtaaggcgga
     3481 ccgagaggtc ttcttcatga acacacagag catcgtgcag ctggtccaga gataccgcag
     3541 cgggacccgt ggctacatga aggctgtggt gctggacctc ctgaggaaat atctaaacgt
     3601 ggagcaccat tttcagcaag cccactatga caagtgtgtg atcaacctga gggagcagtt
     3661 caagccggac atgacccagg tgctggactg catcttctca cactcccagg tggccaagaa
     3721 gaaccagctg gtgaccatgc tgatagatga gctgtgcggc ccagacccca ccctgtcaga
     3781 cgagctgacc tccatcctct gtgagctcac gcagctgagc agaagcgagc actgcaaggt
     3841 tgccctcaga gccagacagg tcctgatcgc ctcccacctc ccctcctacg agctgcggca
     3901 caaccaggtg gagtccatct tcctgtccgc catcgacatg tacggccacc agttctgccc
     3961 agaaaatctc aagaaactaa tactttcaga aacgaccata ttcgacgtcc tgcccacttt
     4021 cttctatcac gagaacaagg ttgtctgtat ggcgtccctg gaggtttacg tgcggagagg
     4081 ctacatcgcc tacgagctaa acagcctgca gcaccgggag ctcccagatg gcacctgtgt
     4141 ggtggagttc cagttcatgc tgccctcttc ccaccccaac cggatggccg tgcccatcag
     4201 tgtctccaac cccgacctgc tgaggcacag cacagaactc ttcatggaca gtggcttctc
     4261 cccactgtgc cagcggatgg gggccatggt ggccttcagg agatttgaag aattcaccag
     4321 gaactttgat gaagtcatct cctgctttgc caacgtgcag acagacactc ttctcttcag
     4381 taaggcgtgc acttccctgt actcagagga agacagcaag agcctccgag aggaacccat
     4441 ccacatcctg aatgtggcca tccagtgtgc cgaccacatg gaggacgagg cgctggtgcc
     4501 agtcttccgt gcctttgtac agtccaagaa gcacatcctt gtggattacg gactccgaag
     4561 aatcacattc cttgttgccc aagagagaga attccccaag ttcttcacgt tcagagcgag
     4621 ggatgagttt gcagaagacc ggatttatcg ccacttggag cctgccctgg ccttccagct
     4681 ggagctgagc cggatgcgca actttgacct gaccgctgtg ccctgtgcca accacaagat
     4741 gcatctttac ctgggagccg ctaaggtgaa ggaagggttg gaggtgaccg accacaggtt
     4801 ctttatccga gccattatcc ggcactcaga cctgatcacc aaggaagcct ccttcgagta
     4861 cctgcagaac gaaggtgagc ggctgctgct ggaagccatg gacgagctgg aggtggcgtt
     4921 caacaacacc agtgtgcgca ctgactgcaa ccacatcttc ctcaactttg tgcccacagt
     4981 catcatggac ccgctcaaga tcgaggagtc ggtgcgtgac atggtcatgc gctatggcag
     5041 ccgtctgtgg aagctccgag tgctgcaggc cgaggttaag atcaacatcc gtcagacaac
     5101 ctcagatagt gccatcccca tccgcctctt catcaccaac gagtctggct actacctgga
     5161 catcagcctc tatagagaag tgacggactc cagatccgga aatatcatgt ttcattcctt
     5221 tggcaacaag caaggtagcc tgcatgggat gctgatcaat acaccctatg tcaccaagga
     5281 cctgctccag gctaagcgat tccaggcaca gtccctcggg accacctatg tgtacgactt
     5341 cccagagatg ttcaggcagg ctctctttaa actgtggggc tccccagaga agtaccccaa
     5401 agatatcctg acatacacag agctggtgtt ggactctcaa ggtcagctgg tggagatgaa
     5461 ccggcttcct ggttgtaacg aggtgggcat ggtggccttc aaaatgaggt tcaagacccc
     5521 ggagtatcca gaaggccggg acgccgttgt catcggcaat gacatcacct tccaaatcgg
     5581 ctctttcggc ataggggagg acttcctgta cctgcgagcg tctgagatgg cccggacaga
     5641 gggcatcccc caaatctacc tggcagctaa cagcggggcc cgtatgggcc tggctgagga
     5701 gatcaaacag atattccaag tggcttgggt ggacccagag gatccccaca aaggatttag
     5761 atacctgtac ctgacgcccc aagactacac ccagatcagt tcccagaact cagtgcactg
     5821 caagcacatc gaagatgaag gcgaatccag atacgtcatc gtggatgtca tcgggaagga
     5881 tgccaacctg ggtgtggaga acctgagggg ctcgggcatg attgcaggag aagcttccct
     5941 ggcttatgag aaaacggtca ccatcagcat ggtgacctgc cgcgcccttg gaatcggggc
     6001 ttacctggtg aggcttggcc agcgggtgat ccaggtggaa aactcccaca tcatcctcac
     6061 cggagccggt gctctcaaca aggtcctggg aagagaggtc tacacgtcca acaaccagct
     6121 aggtggcgtg cagatcatgc ataccaacgg ggtctcccac gtcaccgtgc cagatgactt
     6181 cgagggggtc tgcaccattc tggaatggct gtcatttata ccgaaggaca atcgcagccc
     6241 ggtccccatc accactcctt ctgaccccat cgacagggaa attgaattca ccccaaccaa
     6301 agctccctac gaccccaggt ggatgcttgc aggcaggcct cacccaactc tgaaggggac
     6361 ctggcagagt ggattcttcg accatggcag tttcaaggaa atcatggcac cctgggccca
     6421 gactgtggtg acgggacgag caaggctggg gggcatccct gtgggagtga ttgctgtgga
     6481 gactcggact gtggaggtgg ctgtccccgc tgaccctgcc aacttggatt ctgaggccaa
     6541 gatcatccag caggcgggcc aggtgtggtt cccggactcg gcctacaaga cggcgcaggt
     6601 catcagggac ttcaacaagg agcgcctgcc tctcatgatc ttcgccaact ggaggggctt
     6661 ctccggaggc atgaaggaca tgtatgagca gatgctgaag tttggcgcct acatcgtgga
     6721 tggtctccgc ctgtacgagc agcccattct catctacatc cctccctgtg cggagctccg
     6781 tgggggctcc tgggttgtcc tggactccac catcaacccc ctgtgcatag agatgtatgc
     6841 agacaaagag agcagggggg gtgttctgga gccggagggc acggtggaga ttaagttccg
     6901 gaagaaagat ctggtgaaaa ccataaggag gatagaccca gtgtgtaaga agctcgtggg
     6961 acagctgggg aaagcccagc ttcccgacaa ggaccggaag gagctggagg gccagctgaa
     7021 ggcccgggag gaactgctgc ttcccatcta ccaccaggtg gcagtgcagt tcgcagacct
     7081 gcacgacacc ccgggccaca tgctggagaa aggaatcatt tctgatgtgc tggaatggaa
     7141 gactgcccgc accttcttct actggaggct gcgccggctg ctgctggagg cccaggtgaa
     7201 gcaggagata ctccgagcca gccccgagct gaaccacgag cacacacagt ccatgctgcg
     7261 acgctggttc gtggagactg agggcgctgt caaggcctac ctgtgggaca gcaaccaggt
     7321 ggtggtccag tggctggaac agcactggtc agccaaggac ggcttgcgct ccaccatccg
     7381 tgaaaacatc aattatctga agcgggactc tgtcctcaag accatccaaa gtctggtcca
     7441 agaacatcca gaggtcatca tggactgcgt ggcctacctg agccagcacc tcacgccagc
     7501 cgagcggata caggtggctc agctgctgtc taccacggag agcccagctt cctcctgatg
     7561 agcaactctg gccatcccca ggaccctgga cggtgggatg gccatgcggc aggccttcga
     7621 gggacacggg cttattttgg gaaaactcac ggagccactc caaatgtagc tgcggttcct
     7681 gaccagcgac ttctggacag aaggcccctg ggcccctgct aaggcgggcc cagcctctcc
     7741 tcacctgggg acttcagggt ttgtcccagt ggataattct gccactgcct ctctgaggcc
     7801 aactgaacca ggcacaccga gttccttgtg gtttttgcct gaggtgggga tccggtgtct
     7861 gatcacaaga cacttgttct accacgttgg tttgcactca gctccttgtg tccctcagcc
     7921 gagtaaatgg gccaaagaga acgccagatg agacccaaga aaacgtcttt ttgtgatgag
     7981 gcttattaga cacttagcaa gagcaaaaat gatttccttt tttgttgttg ttgttgtttt
     8041 tcatttaaga gaataaagtg acattttatt ctccaagtgg ccctagtgag tcaggacaac
     8101 catctgtccc attagagagg ttctccagag ataaaggaca aacagacagg acacctagca
     8161 ttcagcatgg ctggaggaga gttactgcct cggttcccag gctctgtaag ccctctcttc
     8221 ccaagtggag caaggactgg acctccgtgc ctcctgcaga ttggccaccc acagggtact
     8281 gagtgcccta ctgcctgagt gcagagaggc tgtccctcac ccctcccaga acctctggcc
     8341 aatatacttc ctcaccttgt gccttgatac cacggcagga gccaacagcg ctggaccagt
     8401 gacccagggc tgtgcctcga acactctgga tccgcttaca gagactttcc cagcactgcc
     8461 aggcaccgca gcatcaggac ccgaatgaga tgctccggcc aggggtgggg tggggatgtt
     8521 ggggtagtgg agaaccccac tctgtcgctg cccttcttgg gggataaagg gttcttctgg
     8581 gcaaggtcct cttgatgtgg aggaaagccc agaccgacac tggctgccac cctgaccact
     8641 tgggtgcgct gaagaggctg ctgaaagagc tgcaaaataa actatttttt ttgaaggaa
//
