LOCUS       NM_177470               1500 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus acetyl-CoA acyltransferase 2 (Acaa2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_177470
VERSION     NM_177470.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1500)
  AUTHORS   Huang,X., Liu,X., Li,X., Zhang,Y., Gao,J., Yang,Y., Jiang,Y.,
            Gao,H., Sun,C., Xuan,L., Zhao,L., Song,J., Bao,H., Zhou,Z., Li,S.,
            Zhang,X., Lu,Y., Zhong,X., Yang,B. and Pan,Z.
  TITLE     Cullin-associated and neddylation-dissociated protein 1 (CAND1)
            alleviates NAFLD by reducing ubiquitinated degradation of ACAA2
  JOURNAL   Nat Commun 14 (1), 4620 (2023)
   PUBMED   37528093
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1500)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1500)
  AUTHORS   Son,J.S., Chae,S.A., Zhao,L., Wang,H., de Avila,J.M., Zhu,M.J.,
            Jiang,Z. and Du,M.
  TITLE     Maternal exercise intergenerationally drives muscle-based
            thermogenesis via activation of apelin-AMPK signaling
  JOURNAL   EBioMedicine 76, 103842 (2022)
   PUBMED   35081489
REFERENCE   4  (bases 1 to 1500)
  AUTHORS   Wang,W. and Ledee,D.
  TITLE     ACAA2 is a ligand-dependent coactivator for thyroid hormone
            receptor beta1
  JOURNAL   Biochem Biophys Res Commun 576, 15-21 (2021)
   PUBMED   34474245
  REMARK    GeneRIF: ACAA2 is a ligand-dependent coactivator for thyroid
            hormone receptor beta1.
REFERENCE   5  (bases 1 to 1500)
  AUTHORS   Choi,S., Pfleger,J., Jeon,Y.H., Yang,Z., He,M., Shin,H., Sayed,D.,
            Astrof,S. and Abdellatif,M.
  TITLE     Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2
            selectively associate with H2A.Z-occupied promoters and are
            required for histone modifications
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1862 (10), 194436 (2019)
   PUBMED   31682939
  REMARK    GeneRIF: chromatin immunoprecipitation-deep sequencing, confirmed
            the predominant association of OGDH and ACAA2 with H2A.Z-occupied
            transcription start sites and enhancers, the former of which we
            confirmed is conserved in both mouse and human tissue
REFERENCE   6  (bases 1 to 1500)
  AUTHORS   Golas,A., Dzieza,A., Kuzniarz,K. and Styrna,J.
  TITLE     Gene mapping of sperm quality parameters in recombinant inbred
            strains of mice
  JOURNAL   Int J Dev Biol 52 (2-3), 287-293 (2008)
   PUBMED   18311719
REFERENCE   7  (bases 1 to 1500)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   8  (bases 1 to 1500)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   9  (bases 1 to 1500)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1500)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK050101.1.
            
            On Apr 6, 2007 this sequence version replaced NM_177470.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050101.1, AK146007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1500              AK050101.1         3-1502
FEATURES             Location/Qualifiers
     source          1..1500
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.76 cM"
     gene            1..1500
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /note="acetyl-CoA acyltransferase 2"
                     /db_xref="GeneID:52538"
                     /db_xref="MGI:MGI:1098623"
     exon            1..54
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1232
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /EC_number="2.3.1.9"
                     /EC_number="2.3.1.16"
                     /EC_number="3.1.2.2"
                     /EC_number="3.1.2.1"
                     /note="beta-ketothiolase; acetyl-CoA acyltransferase;
                     mitochondrial 3-oxoacyl-CoA thiolase; acetyl-CoA
                     acetyltransferase; acyl-CoA hydrolase, mitochondrial;
                     acetyl-Coenzyme A acyltransferase 2 (mitochondrial
                     3-oxoacyl-Coenzyme A thiolase)"
                     /codon_start=1
                     /product="3-ketoacyl-CoA thiolase, mitochondrial"
                     /protein_id="NP_803421.1"
                     /db_xref="CCDS:CCDS29342.1"
                     /db_xref="GeneID:52538"
                     /db_xref="MGI:MGI:1098623"
                     /translation="MALLRGVFIVAAKRTPFGAYGGLLKDFSATDLTEFAARAALSAG
                     KVPPETIDSVIVGNVMQSSSDAAYLARHVGLRVGVPTETGALTLNRLCGSGFQSIVSG
                     CQEICSKDAEVVLCGGTESMSQSPYCVRNVRFGTKFGLDLKLEDTLWAGLTDQHVKLP
                     MGMTAENLAAKYNISREDCDRYALQSQQRWKAANEAGYFNEEMAPIEVKTKKGKQTMQ
                     VDEHARPQTTLEQLQKLPSVFKKDGTVTAGNASGVSDGAGAVIIASEDAVKKHNFTPL
                     ARVVGYFVSGCDPTIMGIGPVPAINGALKKAGLSLKDMDLIDVNEAFAPQFLSVQKAL
                     DLDPSKTNVSGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIALI
                     IQNTA"
     exon            55..221
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     exon            222..350
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     exon            351..467
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     exon            468..615
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     exon            616..791
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     exon            792..921
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     exon            922..992
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1147
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1500
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1500
                     /gene="Acaa2"
                     /gene_synonym="0610011L04Rik; D18Ertd240e"
                     /note="putative"
ORIGIN      
        1 gttgctgaga gagccccgcg gaatagctga gcttcgccat ggccctgcta cgaggtgtgt
       61 tcatcgtcgc tgcgaagcga acaccctttg gagcttacgg gggccttctc aaggacttct
      121 ctgccaccga tttaactgaa tttgctgcca gggctgctct gtctgctggc aaagttccac
      181 ctgaaaccat cgatagtgtc atcgtgggca atgtcatgca gagctcttca gatgcggcat
      241 acctggcgag gcatgtgggt ttgcgagtgg gagtcccaac agagactggg gcccttaccc
      301 tcaacaggct ctgtggctct ggtttccagt ccatcgtgag cggatgtcag gaaatctgtt
      361 ctaaagatgc tgaggtcgtc ttgtgtggag gaacagagag catgagccag tccccctact
      421 gtgtcagaaa tgtgcgcttc ggaaccaaat ttggattaga tctcaagctg gaagatactt
      481 tgtgggcagg attaacggat caacatgtta agctgcccat gggaatgact gcagagaacc
      541 ttgctgcaaa atacaacata agcagagaag actgtgacag atacgccttg cagtctcagc
      601 agaggtggaa agctgctaac gaggctggct acttcaatga ggagatggca cccattgagg
      661 tgaagacgaa gaaaggcaaa cagaccatgc aagtggacga gcacgctcga ccccaaacca
      721 ccctggagca actgcagaag ctcccgtccg tgttcaagaa agacgggaca gtcacagcag
      781 ggaacgcctc gggggtgtct gacggtgctg gggccgtcat catagccagc gaagatgctg
      841 tcaaaaaaca taacttcacg cccctggcca gagtcgtggg ctacttcgtg tccggatgcg
      901 atcctactat catgggtatt ggtccagtcc ctgctatcaa tggagcattg aagaaagctg
      961 ggctgagtct taaggacatg gatttgatag acgtgaacga agcttttgcc cctcagttct
     1021 tgtctgttca gaaggccctg gatcttgacc ccagcaaaac caatgtgagt ggaggcgcca
     1081 ttgccctggg tcacccgctg ggaggatctg gctccagaat caccgcacac ctggttcatg
     1141 agttaaggcg tcgaggtgga aagtacgcag tgggatcagc ttgcattgga ggtggccaag
     1201 gcatcgcctt gatcatccag aacacagcct gaaggcatca caagcacact gcccacactt
     1261 actgggccag gccacggaac acaggagacc ttcgagtcag ccctgctgag acagtgattg
     1321 tatgtgacca agccttgatg aggcaagatg cattgggttc tgtctacttc atacctgtct
     1381 gacgtgttag aataaaaaca ccaaccatcg gaggccttaa gagaaatggt atctgtcagt
     1441 agtcaccact gtatgccttc catggagtaa tacaaactga ataaatgttg ccttaactcc
//
