LOCUS       NM_146230               1642 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus acetyl-Coenzyme A acyltransferase 1B (Acaa1b),
            transcript variant 1, mRNA.
ACCESSION   NM_146230
VERSION     NM_146230.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1642)
  AUTHORS   Man,J.C.K., Mohan,R.A., Boogaard,M.V.D., Hilvering,C.R.E.,
            Jenkins,C., Wakker,V., Bianchi,V., Laat,W., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1642)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   3  (bases 1 to 1642)
  AUTHORS   Fidaleo,M., Arnauld,S., Clemencet,M.C., Chevillard,G., Royer,M.C.,
            De Bruycker,M., Wanders,R.J., Athias,A., Gresti,J., Clouet,P.,
            Degrace,P., Kersten,S., Espeel,M., Latruffe,N., Nicolas-Frances,V.
            and Mandard,S.
  TITLE     A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the
            control of PPARalpha-mediated upregulation of SREBP-2 target genes
            in the liver
  JOURNAL   Biochimie 93 (5), 876-891 (2011)
   PUBMED   21352884
  REMARK    GeneRIF: acetyl-Coenzyme A acyltransferase 1B is involved in the
            regulation of genes encoding cholesterol biosynthesis enzymes in
            the liver
REFERENCE   4  (bases 1 to 1642)
  AUTHORS   Arnauld,S., Fidaleo,M., Clemencet,M.C., Chevillard,G., Athias,A.,
            Gresti,J., Wanders,R.J., Latruffe,N., Nicolas-Frances,V. and
            Mandard,S.
  TITLE     Modulation of the hepatic fatty acid pool in peroxisomal
            3-ketoacyl-CoA thiolase B-null mice exposed to the selective
            PPARalpha agonist Wy14,643
  JOURNAL   Biochimie 91 (11-12), 1376-1386 (2009)
   PUBMED   19772884
REFERENCE   5  (bases 1 to 1642)
  AUTHORS   Chevillard,G., Clemencet,M.C., Latruffe,N. and Nicolas-Frances,V.
  TITLE     Targeted disruption of the peroxisomal thiolase B gene in mouse: a
            new model to study disorders related to peroxisomal lipid
            metabolism
  JOURNAL   Biochimie 86 (11), 849-856 (2004)
   PUBMED   15589695
  REMARK    GeneRIF: The region of the peroxisomal 3-ketoacyl-CoA thiolase B
            gene encoding the catalytic site was disrupted by homologous
            recombination in order to analyze the phenotype of these thiolase
            B-deficient mice.
REFERENCE   6  (bases 1 to 1642)
  AUTHORS   Chevillard,G., Clemencet,M.C., Etienne,P., Martin,P., Pineau,T.,
            Latruffe,N. and Nicolas-Frances,V.
  TITLE     Molecular cloning, gene structure and expression profile of two
            mouse peroxisomal 3-ketoacyl-CoA thiolase genes
  JOURNAL   BMC Biochem 5, 3 (2004)
   PUBMED   15043762
  REMARK    GeneRIF: Molecular cloning, gene structure and tissue distribution
            of 3-ketoacyl-CoA thiolase B.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055818.9.
            
            On Aug 13, 2022 this sequence version replaced NM_146230.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019882.1, AY273812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AC055818.9         72933-73175
            244-337             AC055818.9         73315-73408
            338-395             AC055818.9         74197-74254
            396-475             AC055818.9         75994-76073
            476-518             AC055818.9         76287-76329
            519-617             AC055818.9         78085-78183
            618-698             AC055818.9         79095-79175
            699-889             AC055818.9         80209-80399
            890-1069            AC055818.9         80549-80728
            1070-1125           AC055818.9         80982-81037
            1126-1271           AC055818.9         81120-81265
            1272-1642           AC055818.9         81586-81956
FEATURES             Location/Qualifiers
     source          1..1642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..1642
                     /gene="Acaa1b"
                     /note="acetyl-Coenzyme A acyltransferase 1B"
                     /db_xref="GeneID:235674"
                     /db_xref="MGI:MGI:3605455"
     exon            1..243
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            244..337
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            338..395
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            396..475
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            476..518
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            519..617
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            618..698
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            699..889
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1069
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1125
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1271
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1642
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acaa1b"
                     /note="hexamer: AGTAAA"
     polyA_site      1642
                     /gene="Acaa1b"
                     /note="major polyA site"
ORIGIN      
        1 gcaagcccgc gtccttaatt cactggggtg agcgcccaga gcgctggcaa atcggtggga
       61 cccacctccg cgatgcatcg gctgcaggta gtgctgggtc acctggccgg ccggcccgag
      121 tcgagctccg cgctgcaagc tgcgccctgc tccgctggct tcctgcaggc ctcggcctcc
      181 gacgtggtgg tggtgcacgg acggcgcact cccattggcc gcgccagccg tggctgcttc
      241 aaggacacca cccccgacga gcttctgtcg gccgtgttga ccgcggttct ccaggacgtg
      301 aagctaaagc ctgagcagct gggagacatc tccgtgggca atgtgcttca gcccggggct
      361 ggagccatta tggcacgcat cgcccagttc ctgagcggca tcccagagac tgtacctttg
      421 tctacggtca acagacagtg ttcatcggga ctgcaggcag tggccaacat tgctggtggc
      481 atcagaaatg ggtcttatga cattggcatg gcctgtgggg tggagtccat gaccctgtcc
      541 cagagaggga accatgggaa tatttcttcc cgcctgctgg agaacgagaa ggccagagac
      601 tgcctgattc ctatggggat aacttcggag aatgtggctg agcggtttgg cgtttcacgg
      661 cagaagcagg atgcctttgc gctggcctcc cagcagaagg cagcaagcgc ccagagcaga
      721 ggatgcttcc atgctgagat tgtgcctgtg acaaccactg tcctgaatga caagggtgac
      781 aagaaaacca tcactgtgtc tcaggatgag ggtgtccgcc ccagcaccac catgcagggc
      841 ctggccaagc tgaagcctgc cttcaaggat ggaggctcta ccacggctgg aaactccagt
      901 caggtgagtg atggagcagc tgccgtcctg ctggctcgga ggtccaaggc tgaagaactg
      961 ggcctcccca tccttggggt cctgaggtcc tatgcagtgg tcggggtccc tcctgacgtc
     1021 atgggcatcg gacctgccta tgccatccct gcagccttgc agaaagcagg gctgactgtg
     1081 aatgacatag acatctttga gatcaatgag gcctttgcaa gtcaggccgt ctactgtgtg
     1141 gagaagttag gaattcctgc agagaaggtg aacccgctgg ggggtgcaat agccctgggc
     1201 caccccctgg gctgcacggg agcaaggcag gttgtcacgc tactcaatga actgaagcgc
     1261 cgtggcagac gggcttacgg cgtggtatcc atgtgcatcg ggactgggat gggagctgct
     1321 gcggtctttg aataccctgg gaactgaggc ctggctgcag gcggcacaac ccagagagtg
     1381 ccacagtggt gtccagagag ggacgctaca gaagccgtct gcgtgggaca ctcagcagtg
     1441 gaggggtgtg tcacagcact ttaatttaga aaatgtaatt gcagcatggg tacacgtggg
     1501 cactggggca tccaatccgg ttctctcggt cgaaccaaag acagtgcatg ctatgcttga
     1561 ccacaggaca acattcattt ctgtgggacg gtgccttcat gaatggtgga tgtgatgggc
     1621 acagtaaacg tgggtgaact ga
//
