LOCUS       NM_001410625            1599 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus acetyl-Coenzyme A acyltransferase 1B (Acaa1b),
            transcript variant 2, mRNA.
ACCESSION   NM_001410625 XM_006512114
VERSION     NM_001410625.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1599)
  AUTHORS   Man,J.C.K., Mohan,R.A., Boogaard,M.V.D., Hilvering,C.R.E.,
            Jenkins,C., Wakker,V., Bianchi,V., Laat,W., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1599)
  AUTHORS   Georgas,K.M., Chiu,H.S., Lesieur,E., Rumballe,B.A. and Little,M.H.
  TITLE     Expression of metanephric nephron-patterning genes in
            differentiating mesonephric tubules
  JOURNAL   Dev Dyn 240 (6), 1600-1612 (2011)
   PUBMED   21491542
REFERENCE   3  (bases 1 to 1599)
  AUTHORS   Fidaleo,M., Arnauld,S., Clemencet,M.C., Chevillard,G., Royer,M.C.,
            De Bruycker,M., Wanders,R.J., Athias,A., Gresti,J., Clouet,P.,
            Degrace,P., Kersten,S., Espeel,M., Latruffe,N., Nicolas-Frances,V.
            and Mandard,S.
  TITLE     A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the
            control of PPARalpha-mediated upregulation of SREBP-2 target genes
            in the liver
  JOURNAL   Biochimie 93 (5), 876-891 (2011)
   PUBMED   21352884
  REMARK    GeneRIF: acetyl-Coenzyme A acyltransferase 1B is involved in the
            regulation of genes encoding cholesterol biosynthesis enzymes in
            the liver
REFERENCE   4  (bases 1 to 1599)
  AUTHORS   Arnauld,S., Fidaleo,M., Clemencet,M.C., Chevillard,G., Athias,A.,
            Gresti,J., Wanders,R.J., Latruffe,N., Nicolas-Frances,V. and
            Mandard,S.
  TITLE     Modulation of the hepatic fatty acid pool in peroxisomal
            3-ketoacyl-CoA thiolase B-null mice exposed to the selective
            PPARalpha agonist Wy14,643
  JOURNAL   Biochimie 91 (11-12), 1376-1386 (2009)
   PUBMED   19772884
REFERENCE   5  (bases 1 to 1599)
  AUTHORS   Chevillard,G., Clemencet,M.C., Latruffe,N. and Nicolas-Frances,V.
  TITLE     Targeted disruption of the peroxisomal thiolase B gene in mouse: a
            new model to study disorders related to peroxisomal lipid
            metabolism
  JOURNAL   Biochimie 86 (11), 849-856 (2004)
   PUBMED   15589695
  REMARK    GeneRIF: The region of the peroxisomal 3-ketoacyl-CoA thiolase B
            gene encoding the catalytic site was disrupted by homologous
            recombination in order to analyze the phenotype of these thiolase
            B-deficient mice.
REFERENCE   6  (bases 1 to 1599)
  AUTHORS   Chevillard,G., Clemencet,M.C., Etienne,P., Martin,P., Pineau,T.,
            Latruffe,N. and Nicolas-Frances,V.
  TITLE     Molecular cloning, gene structure and expression profile of two
            mouse peroxisomal 3-ketoacyl-CoA thiolase genes
  JOURNAL   BMC Biochem 5, 3 (2004)
   PUBMED   15043762
  REMARK    GeneRIF: Molecular cloning, gene structure and tissue distribution
            of 3-ketoacyl-CoA thiolase B.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055818.9.
            
            On Aug 13, 2022 this sequence version replaced XM_006512114.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.114766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AC055818.9         72933-73175
            244-337             AC055818.9         73315-73408
            338-395             AC055818.9         74197-74254
            396-475             AC055818.9         75994-76073
            476-574             AC055818.9         78085-78183
            575-655             AC055818.9         79095-79175
            656-846             AC055818.9         80209-80399
            847-1026            AC055818.9         80549-80728
            1027-1082           AC055818.9         80982-81037
            1083-1228           AC055818.9         81120-81265
            1229-1599           AC055818.9         81586-81956
FEATURES             Location/Qualifiers
     source          1..1599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..1599
                     /gene="Acaa1b"
                     /note="acetyl-Coenzyme A acyltransferase 1B"
                     /db_xref="GeneID:235674"
                     /db_xref="MGI:MGI:3605455"
     exon            1..243
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            244..337
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            338..395
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            396..475
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            476..574
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            575..655
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            656..846
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1026
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1082
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1228
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1599
                     /gene="Acaa1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1580..1585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acaa1b"
                     /note="hexamer: AGTAAA"
     polyA_site      1599
                     /gene="Acaa1b"
                     /note="major polyA site"
ORIGIN      
        1 gcaagcccgc gtccttaatt cactggggtg agcgcccaga gcgctggcaa atcggtggga
       61 cccacctccg cgatgcatcg gctgcaggta gtgctgggtc acctggccgg ccggcccgag
      121 tcgagctccg cgctgcaagc tgcgccctgc tccgctggct tcctgcaggc ctcggcctcc
      181 gacgtggtgg tggtgcacgg acggcgcact cccattggcc gcgccagccg tggctgcttc
      241 aaggacacca cccccgacga gcttctgtcg gccgtgttga ccgcggttct ccaggacgtg
      301 aagctaaagc ctgagcagct gggagacatc tccgtgggca atgtgcttca gcccggggct
      361 ggagccatta tggcacgcat cgcccagttc ctgagcggca tcccagagac tgtacctttg
      421 tctacggtca acagacagtg ttcatcggga ctgcaggcag tggccaacat tgctgggtgg
      481 agtccatgac cctgtcccag agagggaacc atgggaatat ttcttcccgc ctgctggaga
      541 acgagaaggc cagagactgc ctgattccta tggggataac ttcggagaat gtggctgagc
      601 ggtttggcgt ttcacggcag aagcaggatg cctttgcgct ggcctcccag cagaaggcag
      661 caagcgccca gagcagagga tgcttccatg ctgagattgt gcctgtgaca accactgtcc
      721 tgaatgacaa gggtgacaag aaaaccatca ctgtgtctca ggatgagggt gtccgcccca
      781 gcaccaccat gcagggcctg gccaagctga agcctgcctt caaggatgga ggctctacca
      841 cggctggaaa ctccagtcag gtgagtgatg gagcagctgc cgtcctgctg gctcggaggt
      901 ccaaggctga agaactgggc ctccccatcc ttggggtcct gaggtcctat gcagtggtcg
      961 gggtccctcc tgacgtcatg ggcatcggac ctgcctatgc catccctgca gccttgcaga
     1021 aagcagggct gactgtgaat gacatagaca tctttgagat caatgaggcc tttgcaagtc
     1081 aggccgtcta ctgtgtggag aagttaggaa ttcctgcaga gaaggtgaac ccgctggggg
     1141 gtgcaatagc cctgggccac cccctgggct gcacgggagc aaggcaggtt gtcacgctac
     1201 tcaatgaact gaagcgccgt ggcagacggg cttacggcgt ggtatccatg tgcatcggga
     1261 ctgggatggg agctgctgcg gtctttgaat accctgggaa ctgaggcctg gctgcaggcg
     1321 gcacaaccca gagagtgcca cagtggtgtc cagagaggga cgctacagaa gccgtctgcg
     1381 tgggacactc agcagtggag gggtgtgtca cagcacttta atttagaaaa tgtaattgca
     1441 gcatgggtac acgtgggcac tggggcatcc aatccggttc tctcggtcga accaaagaca
     1501 gtgcatgcta tgcttgacca caggacaaca ttcatttctg tgggacggtg ccttcatgaa
     1561 tggtggatgt gatgggcaca gtaaacgtgg gtgaactga
//
