LOCUS       NM_130864               1758 bp    mRNA    linear   ROD 20-FEB-2025
DEFINITION  Mus musculus acetyl-Coenzyme A acyltransferase 1A (Acaa1a),
            transcript variant 1, mRNA.
ACCESSION   NM_130864
VERSION     NM_130864.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1758)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1758)
  AUTHORS   Luo,R., Fan,Y., Yang,J., Ye,M., Zhang,D.F., Guo,K., Li,X., Bi,R.,
            Xu,M., Yang,L.X., Li,Y., Ran,X., Jiang,H.Y., Zhang,C., Tan,L.,
            Sheng,N. and Yao,Y.G.
  TITLE     A novel missense variant in ACAA1 contributes to early-onset
            Alzheimer's disease, impairs lysosomal function, and facilitates
            amyloid-beta pathology and cognitive decline
  JOURNAL   Signal Transduct Target Ther 6 (1), 325 (2021)
   PUBMED   34465723
  REMARK    GeneRIF: A novel missense variant in ACAA1 contributes to
            early-onset Alzheimer's disease, impairs lysosomal function, and
            facilitates amyloid-beta pathology and cognitive decline.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1758)
  AUTHORS   Man,J.C.K., Mohan,R.A., Boogaard,M.V.D., Hilvering,C.R.E.,
            Jenkins,C., Wakker,V., Bianchi,V., Laat,W., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1758)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1758)
  AUTHORS   Boj,S.F., van Es,J.H., Huch,M., Li,V.S., Jose,A., Hatzis,P.,
            Mokry,M., Haegebarth,A., van den Born,M., Chambon,P., Voshol,P.,
            Dor,Y., Cuppen,E., Fillat,C. and Clevers,H.
  TITLE     Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic
            response to perinatal and adult metabolic demand
  JOURNAL   Cell 151 (7), 1595-1607 (2012)
   PUBMED   23260145
REFERENCE   6  (bases 1 to 1758)
  AUTHORS   Chevillard,G., Clemencet,M.C., Latruffe,N. and Nicolas-Frances,V.
  TITLE     Targeted disruption of the peroxisomal thiolase B gene in mouse: a
            new model to study disorders related to peroxisomal lipid
            metabolism
  JOURNAL   Biochimie 86 (11), 849-856 (2004)
   PUBMED   15589695
REFERENCE   7  (bases 1 to 1758)
  AUTHORS   Chevillard,G., Clemencet,M.C., Etienne,P., Martin,P., Pineau,T.,
            Latruffe,N. and Nicolas-Frances,V.
  TITLE     Molecular cloning, gene structure and expression profile of two
            mouse peroxisomal 3-ketoacyl-CoA thiolase genes
  JOURNAL   BMC Biochem 5, 3 (2004)
   PUBMED   15043762
  REMARK    GeneRIF: Molecular cloning, gene structure and tissue distribution
            of 3-ketoacyl-CoA thiolase A.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1758)
  AUTHORS   Ferdinandusse,S., Denis,S., Mooijer,P.A., Zhang,Z., Reddy,J.K.,
            Spector,A.A. and Wanders,R.J.
  TITLE     Identification of the peroxisomal beta-oxidation enzymes involved
            in the biosynthesis of docosahexaenoic acid
  JOURNAL   J Lipid Res 42 (12), 1987-1995 (2001)
   PUBMED   11734571
REFERENCE   9  (bases 1 to 1758)
  AUTHORS   Cook,W.S., Jain,S., Jia,Y., Cao,W.Q., Yeldandi,A.V., Reddy,J.K. and
            Rao,M.S.
  TITLE     Peroxisome proliferator-activated receptor alpha-responsive genes
            induced in the newborn but not prenatal liver of peroxisomal fatty
            acyl-CoA oxidase null mice
  JOURNAL   Exp Cell Res 268 (1), 70-76 (2001)
   PUBMED   11461119
REFERENCE   10 (bases 1 to 1758)
  AUTHORS   Huyghe,S., Casteels,M., Janssen,A., Meulders,L., Mannaerts,G.P.,
            Declercq,P.E., Van Veldhoven,P.P. and Baes,M.
  TITLE     Prenatal and postnatal development of peroxisomal
            lipid-metabolizing pathways in the mouse
  JOURNAL   Biochem J 353 (Pt 3), 673-680 (2001)
   PUBMED   11171065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC128702.4.
            
            On Nov 17, 2006 this sequence version replaced NM_130864.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY273811.1, BC012400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AC128702.4         46950-47341         c
            393-486             AC128702.4         46717-46810         c
            487-544             AC128702.4         45855-45912         c
            545-624             AC128702.4         44383-44462         c
            625-667             AC128702.4         44127-44169         c
            668-766             AC128702.4         42067-42165         c
            767-847             AC128702.4         40825-40905         c
            848-1038            AC128702.4         39864-40054         c
            1039-1218           AC128702.4         39535-39714         c
            1219-1274           AC128702.4         39226-39281         c
            1275-1420           AC128702.4         38998-39143         c
            1421-1758           AC128702.4         38340-38677         c
FEATURES             Location/Qualifiers
     source          1..1758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..1758
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /note="acetyl-Coenzyme A acyltransferase 1A"
                     /db_xref="GeneID:113868"
                     /db_xref="MGI:MGI:2148491"
     exon            1..392
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1496
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /EC_number="2.3.1.9"
                     /EC_number="2.3.1.16"
                     /EC_number="2.3.1.155"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 3-ketoacyl-CoA thiolase A, peroxisomal;
                     peroxisomal 3-oxoacyl-Coenzyme A thiolase;
                     beta-ketothiolase A; acetyl-CoA acyltransferase A;
                     peroxisomal 3-oxoacyl-CoA thiolase A; peroxisomal
                     3-ketoacyl-CoA thiolase; acetyl-CoA
                     C-myristoyltransferase"
                     /codon_start=1
                     /product="3-ketoacyl-CoA thiolase A, peroxisomal isoform 1
                     precursor"
                     /protein_id="NP_570934.1"
                     /db_xref="CCDS:CCDS23613.1"
                     /db_xref="GeneID:113868"
                     /db_xref="MGI:MGI:2148491"
                     /translation="MHRLQVVLGHLAGRPESSSALQAAPCSARFPQASASDVVVVHGR
                     RTPIGRASRGGFKNTTPDELLSAVLTAVLQDVRLKPEQLGDISVGNVLEPGAGAVMAR
                     IAQFLSGIPETVPLSTVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMSLSGMGN
                     PGNISSRLLESEKARDCLTPMGMTSENVAERFGISRQKQDDFALASQQKAASAQSRGC
                     FRAEIVPVTTTVLDDKGDKKTITVSQDEGVRPSTTMQGLAKLKPAFKDGGSTTAGNSS
                     QVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDVMGIGPAYAIPAALQKAGL
                     TVNDIDIFEINEAFASQAVYCVEKLGIPAEKVNPLGGAIALGHPLGCTGARQVVTLLN
                     ELKRRGRRAYGVVSMCIGTGMGAAAVFEYPGN"
     exon            393..486
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            487..544
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            545..624
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            625..667
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            668..766
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            767..847
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1038
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1218
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1274
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1420
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1758
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /note="hexamer: AGTAAA"
     polyA_site      1758
                     /gene="Acaa1a"
                     /gene_synonym="Acaa; Acaa1; D9Ertd25e; PTL"
                     /note="major polyA site"
ORIGIN      
        1 ctaattggtt gtacctagga gtgggcaggc cctctaaaga ccccatccta cctctcgcag
       61 tatcattcta ccggggttgt gatccccttt caggccttgc gacgtagaag gctgtcctgc
      121 gcctgcgccc gcgcctgcgc ctgcgcctgc gcctgccatc attcctgttc ctaaagctct
      181 gcacccagaa cctaaacgag taggtaggac ccacctccgc gatgcatcgg ctgcaggtag
      241 tgctgggcca cctggccggc cggcccgagt cgagctccgc gctgcaagct gcgccctgct
      301 ccgctaggtt cccgcaggcc tcggcctccg acgtggtggt ggtgcacgga cggcgcaccc
      361 ccatcggccg cgccagccgt ggaggcttca agaacaccac ccccgacgag cttctgtcgg
      421 ccgtgttgac cgcggttctc caggacgtga ggctaaagcc tgagcagctg ggagacatct
      481 ccgtgggcaa tgttcttgag ccaggagccg gggctgtcat ggcacgcatc gcccaatttc
      541 tgagcggcat cccagagact gtacctttgt ctacggtcaa cagacagtgt tcatcgggac
      601 tgcaggcagt ggccaacatt gctggtggca tcagaaatgg gtcttatgac attggcatgg
      661 cctgtggggt ggagtccatg tccctgtctg ggatggggaa ccctgggaat atctcttccc
      721 gcctgctgga gagtgagaaa gccagagact gcctgactcc tatggggatg acctcggaga
      781 atgtggctga gcggtttggc atttcacggc agaagcagga tgactttgcg ctggcctccc
      841 agcagaaggc agcaagcgcc cagagcagag gatgcttccg tgctgagatt gtgcctgtga
      901 caaccactgt cctggatgac aagggtgaca agaaaaccat caccgtgtct caggatgagg
      961 gtgtccgtcc cagcaccacc atgcagggcc tggccaagct gaagcctgcc ttcaaggatg
     1021 gaggctctac cacggctgga aactccagtc aggtgagtga tggagcagct gccgtcctgc
     1081 tggctcggag gtccaaggct gaagaactgg gcctccccat ccttggggtc ctgaggtcct
     1141 atgcagtggt cggggtccct cctgacgtca tgggcatcgg acctgcctat gccatccctg
     1201 cagccttgca gaaagcaggg ctgactgtga atgacataga catctttgag atcaatgagg
     1261 cctttgcaag tcaggccgtc tactgtgtgg agaagctagg aattcctgca gagaaggtga
     1321 acccgctggg gggtgcaata gccctgggcc accccctggg ctgcacggga gcaaggcagg
     1381 ttgtcacgct actcaatgaa ctgaagcgtc gtggcagacg ggcttacggc gtggtgtcca
     1441 tgtgcatcgg gactgggatg ggagctgctg cggtctttga ataccctggg aactgaggcc
     1501 tggctgcagg cggcacaacc cagagagtgc cacagtggtg tccagagagg gacgctacag
     1561 aagccgtctg cgtgggacac tcagcagtgg aggggtgtgt cacagcactt tactttagaa
     1621 aacataattg atgttggaac agagggtggg actgccccgt caggtaccct gaacagtgct
     1681 gaagtgagca tgggacaccc tggttgcaaa gccatttgta cctttgaggg agggatgcag
     1741 taaatgtgta ctgtctca
//
