LOCUS       NM_178890               4595 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus ankyrin repeat and BTB domain containing 2 (Abtb2),
            mRNA.
ACCESSION   NM_178890
VERSION     NM_178890.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4595)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4595)
  AUTHORS   Knoedler,J.R., Inoue,S., Bayless,D.W., Yang,T., Tantry,A.,
            Davis,C.H., Leung,N.Y., Parthasarathy,S., Wang,G., Alvarado,M.,
            Rizvi,A.H., Fenno,L.E., Ramakrishnan,C., Deisseroth,K. and
            Shah,N.M.
  TITLE     A functional cellular framework for sex and estrous cycle-dependent
            gene expression and behavior
  JOURNAL   Cell 185 (4), 654-671 (2022)
   PUBMED   35065713
  REMARK    Erratum:[Cell. 2024 Jul 11;187(14):3781. doi:
            10.1016/j.cell.2024.05.045.. PMID: 38810647]
REFERENCE   3  (bases 1 to 4595)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4595)
  AUTHORS   Tian,C. and Johnson,K.R.
  TITLE     TBX1 is required for normal stria vascularis and semicircular canal
            development
  JOURNAL   Dev Biol 457 (1), 91-103 (2020)
   PUBMED   31550482
REFERENCE   5  (bases 1 to 4595)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4595)
  AUTHORS   Siletti,K., Tarchini,B. and Hudspeth,A.J.
  TITLE     Daple coordinates organ-wide and cell-intrinsic polarity to pattern
            inner-ear hair bundles
  JOURNAL   Proc Natl Acad Sci U S A 114 (52), E11170-E11179 (2017)
   PUBMED   29229865
REFERENCE   7  (bases 1 to 4595)
  AUTHORS   Roy,A. and Pahan,K.
  TITLE     Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the
            aggregation of alpha-synuclein: implications for Parkinson's
            disease
  JOURNAL   FEBS Lett 587 (21), 3567-3574 (2013)
   PUBMED   24076025
  REMARK    GeneRIF: Ankyrin repeat and BTB/POZ domain containing protein-2
REFERENCE   8  (bases 1 to 4595)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4595)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   10 (bases 1 to 4595)
  AUTHORS   Zhang,F., Shu,R., Wu,X., Zhao,X., Feng,D., Wang,L., Lu,S., Liu,Q.,
            Xiang,Y., Fei,J., Huang,L. and Wang,Z.
  TITLE     Delayed liver injury and impaired hepatocyte proliferation after
            carbon tetrachloride exposure in BPOZ2-deficient mice
  JOURNAL   Toxicol Lett 188 (3), 201-207 (2009)
   PUBMED   19393728
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC054399.1.
            
            On Jun 29, 2004 this sequence version replaced NM_178890.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054399.1, AK151620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.43 cM"
     gene            1..4595
                     /gene="Abtb2"
                     /note="ankyrin repeat and BTB domain containing 2"
                     /db_xref="GeneID:99382"
                     /db_xref="MGI:MGI:2139365"
     exon            1..1300
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..3492
                     /gene="Abtb2"
                     /note="ankyrin repeat and BTB (POZ) domain containing 2"
                     /codon_start=1
                     /product="ankyrin repeat and BTB/POZ domain-containing
                     protein 2"
                     /protein_id="NP_849221.2"
                     /db_xref="CCDS:CCDS16479.1"
                     /db_xref="GeneID:99382"
                     /db_xref="MGI:MGI:2139365"
                     /translation="MAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNS
                     SAQQHRGAAWWCYSGSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEG
                     DVARVLRKSVGGRRLPSFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQS
                     AVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTR
                     ISVRIHEYAAISLTACMENLVEEIRARVLASQSPDGGGAGGGEVSAEALEMVINNDAE
                     LWGVLQPYEHLICGKNANGVLSLPAYFSPYNGGSLGHDERADAYAQLELRTLEQSLLA
                     TCVGSISELSDLVSRAMHHMQGRHPLCPGTSPARQARQPPQPITWSPDALHTLYYFLR
                     CPQMESMENPNLDPPRMTLNNERPFMLLPPLMEWMRVAITYAEHRRSPTVDSGDIRQA
                     ARLLLPGLDCEPRQLKPECCFSSFRRLDARAATERFNQDLGFRMLNCGRTDLISQAIE
                     ALGPDGVNTMDDQGMTPLMYACAAGDEAMVQMLIDAGANLDIQVPSHSPRHPSVHPDS
                     RHWTSLTFAVLHGHISVVQLLLDAGAHVEGSAVNSGEDSYAETPLQLASAAGNYELVS
                     LLLSRGADPLLSMLEANGMASSLHEEMNCFSHSAAHGHRNVLRKLLTQPQQAKADVLS
                     LEEILAEGVEESDTSSQGSSEGPVRLSRTRTKALQEAMYYSAEHGYLDITMELRALGV
                     PWKLHIWIESLRTSFSQSRYSVVQSLLKDFSSIKEEEYNEELVTEGLQLMFDILKTSK
                     NDSVLQQLATIFTHCYGTSPIPSIPEIRKTLPARLDPHFLNNKEMSDVTFLVEGKLFY
                     AHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDIKYHIFQMLMQYLYYGGTESMEI
                     PTADILQLLSAANLFQLDALQRHCEILCSQTLSVESAVNTYKYAKIHNAPELALFCEG
                     FFLKHMKALLEQDAFRQLIYGRSSKVQGLDPLQDLQSTLAERVHSVYVTSRV"
     exon            1301..1447
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1661
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1814
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1980
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2070
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2172
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2269
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2405
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2632
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2811
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2917
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3020
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3111
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3180
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3294
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..4558
                     /gene="Abtb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4538..4543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abtb2"
                     /note="hexamer: AATAAA"
     polyA_site      4558
                     /gene="Abtb2"
                     /note="major polyA site"
ORIGIN      
        1 gtagaagttt gtggagcgct ttctcagcgg ctggtcccag acggacctcg ggcgcctcgc
       61 tcttcggtgg ccgccccgtt ttctcgggat tctttctgtg gtgatggact ctccggacgc
      121 tctgtaaggg aagctgagag ctggcggcgc gagttcagag gaggagggct gggaagtccg
      181 ttcgctgaca gcggcgcgac tgaacgcgga cggcgtcggg ctccggccgg ctgagagctt
      241 cgcctacctt cccgcggcct gtgcgcgggc gatgctgcgg ccccgaggcg cggcgcggcg
      301 agcacggagg gcgcctccga gagcctagag ctggtttccg cccccttccc ccggggcaag
      361 tgggcatgga acagtgagag cccctcgctc ggcgaggccg cgcgcggagg ctcccccatg
      421 gccgggacat acagctccac attgaagact ctggaggact tgaccttgga ctccgggtat
      481 ggggccggcg actcctgccg ctcgctcagc ctttcgtctt ccaagtccaa ctcgcaggcg
      541 ctcaactctt cggcgcagca gcaccgcggg gcggcctggt ggtgctactc cggctccatg
      601 aacagccgcc acaacagctg ggacacggtg aacacagtgc tgcccgagga tcccgaagtg
      661 gccgacctct tctcccgctg cccgcggctc ccggagctgg aggagttccc ttggaccgag
      721 ggagacgtgg cccgggtgct ccgcaaaagc gtcggcggcc ggaggctgcc ctcgttctcc
      781 gccgaggctg tgagacgctt ggccggactc ctccgccggg cgctcatccg cgtggcccgg
      841 gaggcgcagc gccttagcgt gctgcacgct aagtgcaccc gcttcgaggt gcagagtgcg
      901 gtgcgcctgg tgcacagctg ggcgctggcc gagagctgcg cactggcagc ggtcaaggcg
      961 ttgtccctct acagcatgag cgctggggat gggctgcgcc gcggcaagtc ggcgcgctgc
     1021 ggcctcactt tctccgtggg ccgcttcttc cgttggatgg tggacactcg catctccgtg
     1081 cgcatccatg agtacgcggc catctcgcta acggcttgca tggagaacct ggtggaggag
     1141 atccgggcca gggtgctggc gagccagagc ccagatggcg gaggggcagg aggtggagag
     1201 gtatccgctg aggccttgga gatggtcatc aacaacgacg ccgagctctg gggagtcctg
     1261 caaccctatg agcatctcat ctgtggcaag aacgccaatg gtgtcctctc tctccctgcc
     1321 tacttcagtc cctacaatgg tgggtccctg ggccacgatg agcgagcaga tgcctatgct
     1381 cagctggaac ttcggacact ggagcagtca ctcctggcca cgtgtgtggg cagcatctcc
     1441 gagctcagtg atctggtctc tcgagccatg caccacatgc agggccgcca ccccctgtgc
     1501 ccaggcacca gccctgctcg ccaggcccgc cagccaccac agcccatcac gtggtccccc
     1561 gatgctctcc acacactcta ctacttcctg aggtgtccac agatggagtc catggagaac
     1621 cccaacctgg atcccccaag aatgactctg aataatgaac ggcccttcat gctgctgcca
     1681 ccgctgatgg agtggatgcg ggttgcaatc acctatgcag aacaccgtcg cagccccact
     1741 gtggacagtg gcgatatccg gcaggcagcc cggctactgc tgccaggcct ggactgtgag
     1801 ccccggcaac tcaaacccga gtgctgcttc agttccttcc ggaggctgga tgctcgagct
     1861 gctactgaac gcttcaacca ggacctgggc ttccgcatgc tcaactgtgg gagaacagac
     1921 ctcatcagcc aggccatcga ggccctgggc ccggatgggg tgaacacaat ggatgaccag
     1981 ggtatgacgc cgcttatgta cgcctgtgct gctggggacg aagccatggt ccagatgctg
     2041 attgatgctg gagctaactt agatatccag gttccaagcc actctcccag gcatccgtcc
     2101 gtccaccccg acagcaggca ttggacctcc ctgacatttg cggtgctaca tggacacatc
     2161 tctgtggtgc agctgctact tgatgccggt gcccatgtgg agggctcagc tgtgaacagt
     2221 ggggaggaca gctacgccga gacacccctg cagctggcct ctgcagccgg gaactatgag
     2281 ctggtcagct tgctgctgag ccggggtgct gaccccctcc tcagcatgct ggaagccaac
     2341 ggcatggcat cttccctcca cgaggagatg aactgcttca gccactccgc tgcccacggc
     2401 cacagaaatg tcctgagaaa gctcctgact cagccacagc aggctaaagc agatgtgctg
     2461 tctctagaag agatcctggc tgagggtgtg gaggaaagcg acacatcgag ccagggcagc
     2521 agtgaggggc ctgtgaggct aagccgaacc cgaacgaagg ccctgcagga agccatgtac
     2581 tacagcgctg agcacggtta cctggacatc accatggagc tgagggcact gggtgttccc
     2641 tggaagctgc acatctggat agagtcgctg cggacctcct tctcacagtc acggtactca
     2701 gtggtgcaga gcctcctgaa ggatttcagc tccatcaagg aagaggagta caacgaggag
     2761 ctggtgacag aaggcttgca gctcatgttt gatatcctca agaccagcaa aaacgactcc
     2821 gtcctccagc agctggccac catcttcaca cactgctatg gcaccagccc catccccagc
     2881 atcccggaga tccggaagac cctgccagcc aggctagatc ctcactttct gaacaacaag
     2941 gagatgtctg atgtaacctt cctagtggaa ggaaagctgt tttatgcaca caaagtcctt
     3001 ttggtgacag catctaacag gttcaagacc ttaatgacca acaaatcaga acaagatggg
     3061 gacagcagca aaaccattga gatcagcgac atcaagtacc acatctttca gatgctgatg
     3121 cagtacctgt actacggagg aaccgagtcc atggaaatcc ccactgctga catcctgcag
     3181 ctgctgtcag ctgccaacct gttccagcta gatgccctgc agagacactg tgagatcctg
     3241 tgctcccaga cccttagtgt ggaaagtgct gtcaacacct acaaatatgc caagatccac
     3301 aacgccccgg agctggccct cttctgtgaa ggcttcttcc tcaagcacat gaaggccctg
     3361 ctagagcagg atgccttccg gcagctcatc tatggccgaa gcagcaaagt ccagggcctg
     3421 gacccactgc aggatctgca gagcacccta gcagagcgag tgcattctgt ctacgtcacc
     3481 tcccgggtgt gaggcaggat ggagggggac tgttatctga gggcgtgcaa aggtctgtta
     3541 aggccagaaa ccaccagtga cacccccagt ggaaggaggc ttgtaggctt taggggtact
     3601 tcctgctctt cccctagata accaatcatc tgtggtgttg accgaccctt gggtgaacag
     3661 agtccacttc actgttgctc aaccagtaac tggcaagggg gtgtaacata gttgcacctt
     3721 gagggccacc ctgtgccctc tcccctccag tggctcagca gcaagctcac ctcagctcca
     3781 gctctcgcca tcctggctgg actgttaggg gcatgggcat tcttatgaat gtagaaaatg
     3841 gatcctgagc cccaggccac tggatgcagt agctggtatg ctttgttttc ctaaacagag
     3901 aagaaagggt ttccaaatcc tgtcctccaa gctgtgcctt tgaaagggct ggtgaggtgg
     3961 cccctgtctg tgaagactgg acctctagtc gcctgcccca cgagactact atgttaggag
     4021 tctgagctca gagcttccga gctgatgatg ggctacagta caggaactca aggacttccg
     4081 ctcttgctgc tacaactggc agccaaagtg aagaggttgg ttctaggtcg ggcctagctc
     4141 taatgtgtct gcaggctgag gcagcagagt gccttccagt taggacaggg gtgcaagagc
     4201 acacttgtca cctgggatct gtgactctgg ggcatgaagg acaaggcctc ggtggaagag
     4261 aagctatgtc ccctcccatc ctgtcctcag tcttggctcc ccatcctctg gcctgtttgt
     4321 ggacagatgc tgggacagca tcaagaacag ctaccttaga aactatttat tcatcagaag
     4381 cccccagggc ttgcaatcct ggaaagatat tttcaacttg ctgcttgtgc gggatgtaca
     4441 aaggaatgaa tggtatttta ttgctgtaat attgtataat actgtaacta taccttaatg
     4501 ttgttactta ctgtaaatgt gctatggttt tatcaacaat aaacactcat taacattgaa
     4561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
