LOCUS       NM_001411483            1981 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ankyrin repeat and BTB domain containing 1 (Abtb1),
            transcript variant 13, mRNA.
ACCESSION   NM_001411483
VERSION     NM_001411483.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1981)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1981)
  AUTHORS   Li,J., Lin,H., Fan,T., Huang,L., Zhang,X., Tai,Y., Fang,Y., Li,Q.,
            Zhao,R., Wang,P., Zhou,L., Wan,L., Wu,Y., Zhong,H., Wei,C. and
            Yang,X.
  TITLE     BPOZ-2 is a negative regulator of the NLPR3 inflammasome
            contributing to SARS-CoV-2-induced hyperinflammation
  JOURNAL   Front Cell Infect Microbiol 13, 1134511 (2023)
   PUBMED   36936774
  REMARK    GeneRIF: BPOZ-2 is a negative regulator of the NLPR3 inflammasome
            contributing to SARS-CoV-2-induced hyperinflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1981)
  AUTHORS   Roy,A., Rangasamy,S.B., Kundu,M. and Pahan,K.
  TITLE     BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T
            Transgenic Mouse Model of Parkinson's Disease
  JOURNAL   Sci Rep 6, 22067 (2016)
   PUBMED   26916519
  REMARK    GeneRIF: BPOZ-2 was involved in a protein-protein association with
            PINK1 and therefore could stimulate PINK1-dependent autophagic
            clearance of alpha-synuclein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1981)
  AUTHORS   Zhang,F., Dang,S., Shu,R., Xiang,Y., Kuang,Y., Fei,J. and Wang,Z.
  TITLE     Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon
            Tetrachloride Administration in Mice
  JOURNAL   Int J Toxicol 34 (2), 204-210 (2015)
   PUBMED   25568138
REFERENCE   5  (bases 1 to 1981)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1981)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1981)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
REFERENCE   8  (bases 1 to 1981)
  AUTHORS   Unoki,M. and Nakamura,Y.
  TITLE     Growth-suppressive effects of BPOZ and EGR2, two genes involved in
            the PTEN signaling pathway
  JOURNAL   Oncogene 20 (33), 4457-4465 (2001)
   PUBMED   11494141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153923.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.849693.1,
                                           SRR13862101.1971210.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC153923.4         168085-168213       c
            130-192             AC153923.4         167154-167216       c
            193-248             AC153923.4         167026-167081       c
            249-393             AC153923.4         165943-166087       c
            394-553             AC153923.4         165647-165806       c
            554-738             AC153923.4         165362-165546       c
            739-855             AC153923.4         165161-165277       c
            856-974             AC153923.4         164954-165072       c
            975-1073            AC153923.4         164696-164794       c
            1074-1241           AC153923.4         164434-164601       c
            1242-1442           AC153923.4         162841-163041       c
            1443-1981           AC153923.4         162230-162768       c
FEATURES             Location/Qualifiers
     source          1..1981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.6 cM"
     gene            1..1981
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="ankyrin repeat and BTB domain containing 1"
                     /db_xref="GeneID:80283"
                     /db_xref="MGI:MGI:1933148"
     exon            1..129
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            130..192
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            193..248
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            249..393
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            394..553
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            554..738
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            739..855
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            856..974
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             933..1649
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="isoform 6 is encoded by transcript variant 13;
                     ankyrin repeat and BTB/POZ domain-containing protein 1;
                     mFLJ00331 protein; ankyrin repeat and BTB (POZ) domain
                     containing 1"
                     /codon_start=1
                     /product="ankyrin repeat and BTB/POZ domain-containing
                     protein 1 isoform 6"
                     /protein_id="NP_001398412.1"
                     /db_xref="GeneID:80283"
                     /db_xref="MGI:MGI:1933148"
                     /translation="MALLADCALPSELRGDLGELPFPCPDGFSSCPDICFRVADSSFL
                     CYKAFFCGRSDYFRALLDDHFQESEEPAASGDPPVVTLHDISPDIFIHVLYYVYSDHT
                     ELPPELAYDVLSVADMYLLPGLKRLCGRSLAQLLEEDSVVGVWRIAKMFRLARLEDQC
                     TEYMAKVIEKLVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIE
                     EAQQRLRALEDLLVSIGLDC"
     exon            975..1073
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1241
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1442
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1981
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="hexamer: AATAAA"
     polyA_site      1981
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="major polyA site"
ORIGIN      
        1 ggtgagtgtt tacatccggc cgggcacaga cgactcccga gatcactcgg ccgggggtcc
       61 agtctctttc gccatggata ccagcgactt gtttgccagc tgcaggaaag gggacgtggg
      121 ccgtgtgcgg tacctgctgg agcagcgaga cgtggaggtg aacgtgcggg ataagtggga
      181 cagcacccct ttgtactatg cctgcctctg tgggcatgag gagttggtgc gctacctgtt
      241 ggctaatgga gcccgctgtg aggccaacac ctttgatgga gagcggtgtc tctacggagc
      301 gctaagcgac cctattcgcc gtgcactgag agactacaaa caggtcactg cgtcctgcag
      361 gaggcgggat tactatgacg atttcctgca gcggcttctg gaacagggca tccacagcga
      421 tgtggtcttt gtggtacacg gaaagccgtt ccgggcccat cgctgtatcc tcggtgctcg
      481 cagtacctac ttcgccaaca tgctggacac caagtggaag ggcaagagcg tcgtggttct
      541 caggcacccc ctgatcaacc cggtggcctt tggggctcta ctgcagtacc tgtatacagg
      601 tgactgaccg accccgtggg ctgggacagc agcacaccca gggtggccca gagctgatgt
      661 cacctttggg gaggaggagt gtgcccagca tgacttaacc tgtttggaga ggacaggtcc
      721 catctacaaa ttgagcaggc cgcttggaca tcggtgtaga acacgtgagt gactgtgagc
      781 gcctggccaa gcagtgccag ctgtgggacc tgctggatga cctggaggct aagtgcgaga
      841 aggtgtctga atttgtggct tccaagcctg gcacgtgtgt gaaggtgctg actattgaac
      901 ctcctccagc agatccccgg ttacgggcag atatggccct gctagctgac tgtgccctgc
      961 catctgagct gcggggtgac cttggagagc tgcccttccc atgtcccgat ggcttcagca
     1021 gctgccccga tatctgcttc cgagtggctg actccagctt cctctgctac aaggctttct
     1081 tctgtggccg cagtgactac ttccgggccc ttctggatga ccactttcaa gagagtgagg
     1141 agcctgcagc ctctggagat cccccagttg tcaccctgca tgacatctcc ccggacatct
     1201 tcattcacgt gttgtactac gtatatagtg accataccga gctgcctcct gagttggcct
     1261 acgatgttct gagtgtggct gacatgtacc ttctgcctgg cctgaagcgg ctgtgtggcc
     1321 gcagcctggc ccagctgctg gaggaggaca gtgtggtggg tgtttggcgc atagccaaga
     1381 tgttccggct ggcccggctg gaggaccagt gtaccgagta tatggccaaa gtcatagaga
     1441 agctggtaga gcgggaggat ttcgtggagg ccgtgcggga agaggcggca gctgtagcgg
     1501 cccggcagga gacagactcc atcccgctcg tcgatgacat ccgcttccat gtggccagca
     1561 cggtccagac atacagtgcc attgaagagg cacagcagcg actgcgggca ctcgaggacc
     1621 tgctcgtgtc cattggcttg gactgctaag cccttccgtg gccagggcag ccacggtgac
     1681 aggcatgcgc agtgtgtgca cgcagcaaga tggcattaca atgggcagag gggacctcac
     1741 aggatgtcct tgggatgagc ctcctcctcc agtgcacaag gaagccccaa gatttggggc
     1801 aggcaccact cagggaaaac tggggtacgg taggctttga acttagtccc atctccccca
     1861 gcgtcctacc tgctccctcc tggttctcac ccagccctgg cttgcttcgg ctatttccgc
     1921 atacagggct ggacaggacg tagggggtgt gtggcaataa agcttgaatt cactctgggg
     1981 a
//
