LOCUS       NM_001411478            1919 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ankyrin repeat and BTB domain containing 1 (Abtb1),
            transcript variant 8, mRNA.
ACCESSION   NM_001411478 XM_030255680
VERSION     NM_001411478.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1919)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1919)
  AUTHORS   Li,J., Lin,H., Fan,T., Huang,L., Zhang,X., Tai,Y., Fang,Y., Li,Q.,
            Zhao,R., Wang,P., Zhou,L., Wan,L., Wu,Y., Zhong,H., Wei,C. and
            Yang,X.
  TITLE     BPOZ-2 is a negative regulator of the NLPR3 inflammasome
            contributing to SARS-CoV-2-induced hyperinflammation
  JOURNAL   Front Cell Infect Microbiol 13, 1134511 (2023)
   PUBMED   36936774
  REMARK    GeneRIF: BPOZ-2 is a negative regulator of the NLPR3 inflammasome
            contributing to SARS-CoV-2-induced hyperinflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1919)
  AUTHORS   Roy,A., Rangasamy,S.B., Kundu,M. and Pahan,K.
  TITLE     BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T
            Transgenic Mouse Model of Parkinson's Disease
  JOURNAL   Sci Rep 6, 22067 (2016)
   PUBMED   26916519
  REMARK    GeneRIF: BPOZ-2 was involved in a protein-protein association with
            PINK1 and therefore could stimulate PINK1-dependent autophagic
            clearance of alpha-synuclein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1919)
  AUTHORS   Zhang,F., Dang,S., Shu,R., Xiang,Y., Kuang,Y., Fei,J. and Wang,Z.
  TITLE     Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon
            Tetrachloride Administration in Mice
  JOURNAL   Int J Toxicol 34 (2), 204-210 (2015)
   PUBMED   25568138
REFERENCE   5  (bases 1 to 1919)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1919)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1919)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
REFERENCE   8  (bases 1 to 1919)
  AUTHORS   Unoki,M. and Nakamura,Y.
  TITLE     Growth-suppressive effects of BPOZ and EGR2, two genes involved in
            the PTEN signaling pathway
  JOURNAL   Oncogene 20 (33), 4457-4465 (2001)
   PUBMED   11494141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153923.4.
            
            On Aug 25, 2022 this sequence version replaced XM_030255680.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.345802.1,
                                           SRR7345562.763209.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC153923.4         168463-168668       c
            207-269             AC153923.4         167154-167216       c
            270-325             AC153923.4         167026-167081       c
            326-470             AC153923.4         165943-166087       c
            471-630             AC153923.4         165647-165806       c
            631-676             AC153923.4         165501-165546       c
            677-793             AC153923.4         165161-165277       c
            794-912             AC153923.4         164954-165072       c
            913-1011            AC153923.4         164696-164794       c
            1012-1179           AC153923.4         164434-164601       c
            1180-1380           AC153923.4         162841-163041       c
            1381-1919           AC153923.4         162230-162768       c
FEATURES             Location/Qualifiers
     source          1..1919
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.6 cM"
     gene            1..1919
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="ankyrin repeat and BTB domain containing 1"
                     /db_xref="GeneID:80283"
                     /db_xref="MGI:MGI:1933148"
     exon            1..206
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            207..269
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            270..325
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            326..470
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            471..630
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..1587
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="isoform 2 is encoded by transcript variant 8;
                     ankyrin repeat and BTB/POZ domain-containing protein 1;
                     mFLJ00331 protein; ankyrin repeat and BTB (POZ) domain
                     containing 1"
                     /codon_start=1
                     /product="ankyrin repeat and BTB/POZ domain-containing
                     protein 1 isoform 2"
                     /protein_id="NP_001398407.1"
                     /db_xref="GeneID:80283"
                     /db_xref="MGI:MGI:1933148"
                     /translation="MLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVS
                     DCERLAKQCQLWDLLDDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLRADMALL
                     ADCALPSELRGDLGELPFPCPDGFSSCPDICFRVADSSFLCYKAFFCGRSDYFRALLD
                     DHFQESEEPAASGDPPVVTLHDISPDIFIHVLYYVYSDHTELPPELAYDVLSVADMYL
                     LPGLKRLCGRSLAQLLEEDSVVGVWRIAKMFRLARLEDQCTEYMAKVIEKLVEREDFV
                     EAVREEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGL
                     DC"
     exon            631..676
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            677..793
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            794..912
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1011
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1179
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1380
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1919
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1894..1899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="hexamer: AATAAA"
     polyA_site      1919
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="major polyA site"
ORIGIN      
        1 gggctgagcc tgaagtaggc tgggaaaagt cctggtgggc gaggcctcgg cctgatgtgc
       61 gggacctgaa ccgagctaga ctcaggactg acaagcgttc caagcctgtg ggaggtgctg
      121 ttttcagaac ggatcccaag aaatgtgggc ggggcctgca gcgaactgct cttccggtga
      181 agctcttctg aggaggcggg gtcttggtac ctgctggagc agcgagacgt ggaggtgaac
      241 gtgcgggata agtgggacag cacccctttg tactatgcct gcctctgtgg gcatgaggag
      301 ttggtgcgct acctgttggc taatggagcc cgctgtgagg ccaacacctt tgatggagag
      361 cggtgtctct acggagcgct aagcgaccct attcgccgtg cactgagaga ctacaaacag
      421 gtcactgcgt cctgcaggag gcgggattac tatgacgatt tcctgcagcg gcttctggaa
      481 cagggcatcc acagcgatgt ggtctttgtg gtacacggaa agccgttccg ggcccatcgc
      541 tgtatcctcg gtgctcgcag tacctacttc gccaacatgc tggacaccaa gtggaagggc
      601 aagagcgtcg tggttctcag gcaccccctg atcaacccgg tggcctttgg ggctctactg
      661 cagtacctgt atacaggccg cttggacatc ggtgtagaac acgtgagtga ctgtgagcgc
      721 ctggccaagc agtgccagct gtgggacctg ctggatgacc tggaggctaa gtgcgagaag
      781 gtgtctgaat ttgtggcttc caagcctggc acgtgtgtga aggtgctgac tattgaacct
      841 cctccagcag atccccggtt acgggcagat atggccctgc tagctgactg tgccctgcca
      901 tctgagctgc ggggtgacct tggagagctg cccttcccat gtcccgatgg cttcagcagc
      961 tgccccgata tctgcttccg agtggctgac tccagcttcc tctgctacaa ggctttcttc
     1021 tgtggccgca gtgactactt ccgggccctt ctggatgacc actttcaaga gagtgaggag
     1081 cctgcagcct ctggagatcc cccagttgtc accctgcatg acatctcccc ggacatcttc
     1141 attcacgtgt tgtactacgt atatagtgac cataccgagc tgcctcctga gttggcctac
     1201 gatgttctga gtgtggctga catgtacctt ctgcctggcc tgaagcggct gtgtggccgc
     1261 agcctggccc agctgctgga ggaggacagt gtggtgggtg tttggcgcat agccaagatg
     1321 ttccggctgg cccggctgga ggaccagtgt accgagtata tggccaaagt catagagaag
     1381 ctggtagagc gggaggattt cgtggaggcc gtgcgggaag aggcggcagc tgtagcggcc
     1441 cggcaggaga cagactccat cccgctcgtc gatgacatcc gcttccatgt ggccagcacg
     1501 gtccagacat acagtgccat tgaagaggca cagcagcgac tgcgggcact cgaggacctg
     1561 ctcgtgtcca ttggcttgga ctgctaagcc cttccgtggc cagggcagcc acggtgacag
     1621 gcatgcgcag tgtgtgcacg cagcaagatg gcattacaat gggcagaggg gacctcacag
     1681 gatgtccttg ggatgagcct cctcctccag tgcacaagga agccccaaga tttggggcag
     1741 gcaccactca gggaaaactg gggtacggta ggctttgaac ttagtcccat ctcccccagc
     1801 gtcctacctg ctccctcctg gttctcaccc agccctggct tgcttcggct atttccgcat
     1861 acagggctgg acaggacgta gggggtgtgt ggcaataaag cttgaattca ctctgggga
//
