LOCUS       NM_001411475            1641 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ankyrin repeat and BTB domain containing 1 (Abtb1),
            transcript variant 5, mRNA.
ACCESSION   NM_001411475 XM_006506792
VERSION     NM_001411475.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1641)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1641)
  AUTHORS   Li,J., Lin,H., Fan,T., Huang,L., Zhang,X., Tai,Y., Fang,Y., Li,Q.,
            Zhao,R., Wang,P., Zhou,L., Wan,L., Wu,Y., Zhong,H., Wei,C. and
            Yang,X.
  TITLE     BPOZ-2 is a negative regulator of the NLPR3 inflammasome
            contributing to SARS-CoV-2-induced hyperinflammation
  JOURNAL   Front Cell Infect Microbiol 13, 1134511 (2023)
   PUBMED   36936774
  REMARK    GeneRIF: BPOZ-2 is a negative regulator of the NLPR3 inflammasome
            contributing to SARS-CoV-2-induced hyperinflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1641)
  AUTHORS   Roy,A., Rangasamy,S.B., Kundu,M. and Pahan,K.
  TITLE     BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T
            Transgenic Mouse Model of Parkinson's Disease
  JOURNAL   Sci Rep 6, 22067 (2016)
   PUBMED   26916519
  REMARK    GeneRIF: BPOZ-2 was involved in a protein-protein association with
            PINK1 and therefore could stimulate PINK1-dependent autophagic
            clearance of alpha-synuclein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1641)
  AUTHORS   Zhang,F., Dang,S., Shu,R., Xiang,Y., Kuang,Y., Fei,J. and Wang,Z.
  TITLE     Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon
            Tetrachloride Administration in Mice
  JOURNAL   Int J Toxicol 34 (2), 204-210 (2015)
   PUBMED   25568138
REFERENCE   5  (bases 1 to 1641)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 1641)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 1641)
  AUTHORS   van der Zwaag,B., Burbach,J.P., Scharfe,C., Oefner,P.J.,
            Brunner,H.G., Padberg,G.W. and van Bokhoven,H.
  TITLE     Identifying new candidate genes for hereditary facial paresis on
            chromosome 3q21-q22 by RNA in situ hybridization in mouse
  JOURNAL   Genomics 86 (1), 55-67 (2005)
   PUBMED   15953540
REFERENCE   8  (bases 1 to 1641)
  AUTHORS   Unoki,M. and Nakamura,Y.
  TITLE     Growth-suppressive effects of BPOZ and EGR2, two genes involved in
            the PTEN signaling pathway
  JOURNAL   Oncogene 20 (33), 4457-4465 (2001)
   PUBMED   11494141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153923.4.
            
            On Aug 25, 2022 this sequence version replaced XM_006506792.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.43484.1,
                                           SRR13422592.288558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC153923.4         168085-168213       c
            130-192             AC153923.4         167154-167216       c
            193-248             AC153923.4         167026-167081       c
            249-393             AC153923.4         165943-166087       c
            394-553             AC153923.4         165647-165806       c
            554-599             AC153923.4         165501-165546       c
            600-716             AC153923.4         165161-165277       c
            717-835             AC153923.4         164954-165072       c
            836-934             AC153923.4         164696-164794       c
            935-1102            AC153923.4         164434-164601       c
            1103-1641           AC153923.4         162230-162768       c
FEATURES             Location/Qualifiers
     source          1..1641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.6 cM"
     gene            1..1641
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="ankyrin repeat and BTB domain containing 1"
                     /db_xref="GeneID:80283"
                     /db_xref="MGI:MGI:1933148"
     exon            1..129
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1309
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="isoform 4 is encoded by transcript variant 5;
                     ankyrin repeat and BTB/POZ domain-containing protein 1;
                     mFLJ00331 protein; ankyrin repeat and BTB (POZ) domain
                     containing 1"
                     /codon_start=1
                     /product="ankyrin repeat and BTB/POZ domain-containing
                     protein 1 isoform 4"
                     /protein_id="NP_001398404.1"
                     /db_xref="GeneID:80283"
                     /db_xref="MGI:MGI:1933148"
                     /translation="MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYAC
                     LCGHEELVRYLLANGARCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYD
                     DFLQRLLEQGIHSDVVFVVHGKPFRAHRCILGARSTYFANMLDTKWKGKSVVVLRHPL
                     INPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLDDLEAKCEKVSEFVASK
                     PGTCVKVLTIEPPPADPRLRADMALLADCALPSELRGDLGELPFPCPDGFSSCPDICF
                     RVADSSFLCYKAFFCGRSDYFRALLDDHFQESEEPAASGDPPVVTLHDISPDIFIHVL
                     YYVYSDHTELVEREDFVEAVREEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEE
                     AQQRLRALEDLLVSIGLDC"
     exon            130..192
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            193..248
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            249..393
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            394..553
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            554..599
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            600..716
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            717..835
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            836..934
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1102
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1641
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1616..1621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="hexamer: AATAAA"
     polyA_site      1641
                     /gene="Abtb1"
                     /gene_synonym="BPOZ; EF1ABP"
                     /note="major polyA site"
ORIGIN      
        1 ggtgagtgtt tacatccggc cgggcacaga cgactcccga gatcactcgg ccgggggtcc
       61 agtctctttc gccatggata ccagcgactt gtttgccagc tgcaggaaag gggacgtggg
      121 ccgtgtgcgg tacctgctgg agcagcgaga cgtggaggtg aacgtgcggg ataagtggga
      181 cagcacccct ttgtactatg cctgcctctg tgggcatgag gagttggtgc gctacctgtt
      241 ggctaatgga gcccgctgtg aggccaacac ctttgatgga gagcggtgtc tctacggagc
      301 gctaagcgac cctattcgcc gtgcactgag agactacaaa caggtcactg cgtcctgcag
      361 gaggcgggat tactatgacg atttcctgca gcggcttctg gaacagggca tccacagcga
      421 tgtggtcttt gtggtacacg gaaagccgtt ccgggcccat cgctgtatcc tcggtgctcg
      481 cagtacctac ttcgccaaca tgctggacac caagtggaag ggcaagagcg tcgtggttct
      541 caggcacccc ctgatcaacc cggtggcctt tggggctcta ctgcagtacc tgtatacagg
      601 ccgcttggac atcggtgtag aacacgtgag tgactgtgag cgcctggcca agcagtgcca
      661 gctgtgggac ctgctggatg acctggaggc taagtgcgag aaggtgtctg aatttgtggc
      721 ttccaagcct ggcacgtgtg tgaaggtgct gactattgaa cctcctccag cagatccccg
      781 gttacgggca gatatggccc tgctagctga ctgtgccctg ccatctgagc tgcggggtga
      841 ccttggagag ctgcccttcc catgtcccga tggcttcagc agctgccccg atatctgctt
      901 ccgagtggct gactccagct tcctctgcta caaggctttc ttctgtggcc gcagtgacta
      961 cttccgggcc cttctggatg accactttca agagagtgag gagcctgcag cctctggaga
     1021 tcccccagtt gtcaccctgc atgacatctc cccggacatc ttcattcacg tgttgtacta
     1081 cgtatatagt gaccataccg agctggtaga gcgggaggat ttcgtggagg ccgtgcggga
     1141 agaggcggca gctgtagcgg cccggcagga gacagactcc atcccgctcg tcgatgacat
     1201 ccgcttccat gtggccagca cggtccagac atacagtgcc attgaagagg cacagcagcg
     1261 actgcgggca ctcgaggacc tgctcgtgtc cattggcttg gactgctaag cccttccgtg
     1321 gccagggcag ccacggtgac aggcatgcgc agtgtgtgca cgcagcaaga tggcattaca
     1381 atgggcagag gggacctcac aggatgtcct tgggatgagc ctcctcctcc agtgcacaag
     1441 gaagccccaa gatttggggc aggcaccact cagggaaaac tggggtacgg taggctttga
     1501 acttagtccc atctccccca gcgtcctacc tgctccctcc tggttctcac ccagccctgg
     1561 cttgcttcgg ctatttccgc atacagggct ggacaggacg tagggggtgt gtggcaataa
     1621 agcttgaatt cactctgggg a
//
