LOCUS       NM_198017               2895 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus BRISC complex subunit (Abraxas2), mRNA.
ACCESSION   NM_198017
VERSION     NM_198017.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2895)
  AUTHORS   Yalcinkaya,M., Liu,W., Xiao,T., Abramowicz,S., Wang,R., Wang,N.,
            Westerterp,M. and Tall,A.R.
  TITLE     Cholesterol trafficking to the ER leads to the activation of
            CaMKII/JNK/NLRP3 and promotes atherosclerosis
  JOURNAL   J Lipid Res 65 (4), 100534 (2024)
   PUBMED   38522750
REFERENCE   2  (bases 1 to 2895)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2895)
  AUTHORS   Zhang,W., Liu,K., Ren,G.M., Wang,Y., Wang,T., Liu,X., Li,D.X.,
            Xiao,Y., Chen,X., Li,Y.T., Zhan,Y.Q., Xiang,S.S., Chen,H.,
            Gao,H.Y., Zhao,K., Yu,M., Ge,C.H., Li,C.Y., Ge,Z.Q., Yang,X.M. and
            Yin,R.H.
  TITLE     BRISC is required for optimal activation of NF-kappaB in Kupffer
            cells induced by LPS and contributes to acute liver injury
  JOURNAL   Cell Death Dis 14 (11), 743 (2023)
   PUBMED   37968261
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2895)
  AUTHORS   Wang,T., Zhou,L.Y., Li,X.M., Liu,F., Liang,L., Chen,X.Z., Ju,J.,
            Ponnusamy,M., Wang,K., Liu,C.Y., Yan,K.W. and Wang,K.
  TITLE     ABRO1 arrests cardiomyocyte proliferation and myocardial repair by
            suppressing PSPH
  JOURNAL   Mol Ther 31 (3), 847-865 (2023)
   PUBMED   36639869
  REMARK    GeneRIF: ABRO1 arrests cardiomyocyte proliferation and myocardial
            repair by suppressing PSPH.
REFERENCE   5  (bases 1 to 2895)
  AUTHORS   Ren,G.M., Li,J., Zhang,X.C., Wang,Y., Xiao,Y., Zhang,X.Y., Liu,X.,
            Zhang,W., Ma,W.B., Zhang,J., Li,Y.T., Tao,S.S., Wang,T., Liu,K.,
            Chen,H., Zhan,Y.Q., Yu,M., Li,C.Y., Ge,C.H., Tian,B.X., Dou,G.F.,
            Yang,X.M. and Yin,R.H.
  TITLE     Pharmacological targeting of NLRP3 deubiquitination for treatment
            of NLRP3-associated inflammatory diseases
  JOURNAL   Sci Immunol 6 (58) (2021)
   PUBMED   33931568
REFERENCE   6  (bases 1 to 2895)
  AUTHORS   Zheng,H., Gupta,V., Patterson-Fortin,J., Bhattacharya,S.,
            Katlinski,K., Wu,J., Varghese,B., Carbone,C.J., Aressy,B.,
            Fuchs,S.Y. and Greenberg,R.A.
  TITLE     A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates
            interferon responses
  JOURNAL   Cell Rep 5 (1), 180-193 (2013)
   PUBMED   24075985
REFERENCE   7  (bases 1 to 2895)
  AUTHORS   Ambivero,C.T., Cilenti,L. and Zervos,A.S.
  TITLE     ATF4 interacts with Abro1/KIAA0157 scaffold protein and
            participates in a cytoprotective pathway
  JOURNAL   Biochim Biophys Acta 1823 (12), 2149-2156 (2012)
   PUBMED   22974638
REFERENCE   8  (bases 1 to 2895)
  AUTHORS   Somma,G., Alger,H.M., McGuire,R.M., Kretlow,J.D., Ruiz,F.R.,
            Yatsenko,S.A., Stankiewicz,P., Harrison,W., Funk,E.,
            Bergamaschi,A., Oghalai,J.S., Mikos,A.G., Overbeek,P.A. and
            Pereira,F.A.
  TITLE     Head bobber: an insertional mutation causes inner ear defects,
            hyperactive circling, and deafness
  JOURNAL   J Assoc Res Otolaryngol 13 (3), 335-349 (2012)
   PUBMED   22383091
REFERENCE   9  (bases 1 to 2895)
  AUTHORS   Cilenti,L., Balakrishnan,M.P., Wang,X.L., Ambivero,C.,
            Sterlicchi,M., del Monte,F., Ma,X.L. and Zervos,A.S.
  TITLE     Regulation of Abro1/KIAA0157 during myocardial infarction and cell
            death reveals a novel cardioprotective mechanism for Lys63-specific
            deubiquitination
  JOURNAL   J Mol Cell Cardiol 50 (4), 652-661 (2011)
   PUBMED   21195082
  REMARK    GeneRIF: Data shows that the expression of Abro1 protein
            substantially increased (at least three-fold) in the hearts of mice
            that underwent MI/R compared to sham operated controls.
REFERENCE   10 (bases 1 to 2895)
  AUTHORS   Wang,B., Matsuoka,S., Ballif,B.A., Zhang,D., Smogorzewska,A.,
            Gygi,S.P. and Elledge,S.J.
  TITLE     Abraxas and RAP80 form a BRCA1 protein complex required for the DNA
            damage response
  JOURNAL   Science 316 (5828), 1194-1198 (2007)
   PUBMED   17525340
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099627.10, AK171524.1 and AV375824.1.
            
            On Sep 23, 2011 this sequence version replaced NM_198017.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171524.1, AK146064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                AC099627.10        213327-213401
            76-2888             AK171524.1         2-2814
            2889-2895           AV375824.1         223-229
FEATURES             Location/Qualifiers
     source          1..2895
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.32 cM"
     gene            1..2895
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /note="BRISC complex subunit"
                     /db_xref="GeneID:109359"
                     /db_xref="MGI:MGI:1926116"
     exon            1..109
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1285
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /note="BRISC complex subunit Abro1; abraxas brother
                     protein 1; family with sequence similarity 175, member B"
                     /codon_start=1
                     /product="BRISC complex subunit Abraxas 2"
                     /protein_id="NP_932134.3"
                     /db_xref="CCDS:CCDS21928.3"
                     /db_xref="GeneID:109359"
                     /db_xref="MGI:MGI:1926116"
                     /translation="MMGEVEISIMAASISGYTFSAVCFHSANSNADHEGFLLGEVRQE
                     ETFSISDSQISNTEFLQVIEIHNHQPCSQLFSFYDYASKVNEESLDRILKDRRKKVIG
                     WYRFRRNTQQQMSYREQVIHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPN
                     RRYNQRISLAIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAI
                     YQVYNALQEKVQAVCADVEKSERVVESCQAEVNKLRRQITQKKNEKEQERRLQQALLS
                     RQMPSESLEPAFSPRMSYSGFSAEGRSTLAETEPSDPPPPYSDFHPNNQESTLSHSRM
                     ERSVFMPRPQAVGSSSYASTSGGLKFTGSGADLLPSQSAAGDSGEESDDSDYENLIDP
                     AESPHSEYSHSKNSRPSTHPDEDPRNTQTSQI"
     exon            110..200
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     exon            201..237
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     exon            238..304
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     exon            305..495
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     exon            496..615
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     exon            616..700
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     exon            701..815
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     exon            816..2895
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2870..2875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /note="hexamer: AATAAA"
     polyA_site      2892
                     /gene="Abraxas2"
                     /gene_synonym="Abro1; C430003P19Rik; Fam175b"
                     /note="major polyA site"
ORIGIN      
        1 tccgcggggc atgatggggg aggtggagat ttccatcatg gcggcttcca tttcgggcta
       61 caccttcagc gctgtgtgtt tccacagcgc caacagcaac gccgaccacg aaggattttt
      121 gctgggagag gtaagacaag aggaaacttt tagcatcagt gactcacaaa tcagcaacac
      181 agagtttctg caagtaattg agatccataa ccatcagcct tgttcacaac tcttcagttt
      241 ttatgattat gcgagcaaag tgaatgaaga aagtttggac agaattctga aagatcggag
      301 gaagaaagtt atcggatggt acaggttccg gcgaaacacc cagcagcaga tgtcctacag
      361 ggaacaggtc atccacaagc agctcacccg catcctcggc gtgccagacc tggtcttcct
      421 tctcttcagc ttcatctcta ccgccaacaa ttctactcat gctttagaat atgttctctt
      481 tagaccaaac cgcaggtata atcaaaggat atcacttgct attcccaatc taggcaatac
      541 tagccagcaa gagtacaaag tgtcttcagt gccaaacacg tctcagagtt atgccaaggt
      601 cattaaagag cacggtactg acttttttga caaggatgga gtcatgaagg acatcagggc
      661 aatttatcag gtttataatg cacttcagga gaaagtacag gcagtatgtg cagatgtaga
      721 aaagagtgag cgagttgttg aatcttgtca ggcagaagtg aacaaattga gaagacaaat
      781 cactcagaag aaaaatgaaa aggaacaaga aagaagattg cagcaggccc tgttaagcag
      841 acagatgcca tccgaaagtc tggagccagc gttcagccct cggatgtcct attctgggtt
      901 ttcagctgaa gggagaagta ctctggcaga aacggagccc tctgatcctc cgccccctta
      961 ctctgatttc cacccaaaca atcaagaaag tactctgagc cattctcgca tggaaaggag
     1021 tgtcttcatg ccccgtcctc aggctgtggg ctcttccagc tatgcttcca ccagtggcgg
     1081 actgaagttc actggaagtg gagcagatct tcttccttcc cagagtgcag ctggagacag
     1141 tggggaggag tcagatgaca gtgattatga aaatttgatt gatcctgcag agtcccctca
     1201 tagcgaatac tcacattcaa agaattcacg gccctcgaca catcctgacg aggaccccag
     1261 gaacactcag acctcccaga tttaagtaaa caaatgacac tctccacttg gcactacttt
     1321 tcttaatggc ttattgagtg ttgttgagga cttaatctgt ggggagacct gctttctcag
     1381 atgccgcggc tcctgagtgg agcatcctgt gcacagaact cccagaatcc tctgtccgct
     1441 ggtcctcacc tctgggtaca gtgcacaggt tcacaacaaa atcattacga taatcaaatt
     1501 gtcctaattc tggtgcgatt catggatgta ctagtgaatt taggcagagt gacccctcag
     1561 tgtagtctgt tcttaagata aatcagatca gagactgagc acaattagtc tataaatagt
     1621 ctgtacgtca gaaacttacc tctgcactat catgccttga aacttgcttt ttcaaaggga
     1681 aacgaattta gcagcagcct tcaaagaact ttctatgatg agccaaattc atctttgcca
     1741 gaaaagaaat tttgttaatt ccaagaagcc taattggaac aagtcagaca ttccttctct
     1801 catctgcatg gttttgtaag atgagaagag agggctttgt ttcaactttt ttctactagc
     1861 ctgatacgta ttgtcactta aaatggttgc ctttttaaaa tgtaggaata ctaatcccca
     1921 gcgagtactc atctggatca ggcccttgtc ttttggtgca cgccagcgat gctgcgctgc
     1981 atgcagtcat ggagggaggc cacacaccag cagatggcag aagggagaag ccaggcctga
     2041 gtctgtagtg aacagatccc agacacagtg gatttaacta agttcctatg gaaaggatgt
     2101 aatgtactta ggtgtggcgg atcctgggct agagttgtgg aggaaagacg tttttgagaa
     2161 aatatccagg aatcttggtg actacagagc tacttcaagt atgaataacc atacttcttt
     2221 tttcccctaa agttgccatt taggggataa ttgcaaatgt gcggagacca ttgggatgca
     2281 cttacgcttt tatttaatta ctgcttgttt tctagttttg cccagaatgt gtgaaaccac
     2341 taaaaaccat ttttgagtat gttgggctgc tggattggaa gtggcaagac ctaccatata
     2401 tggcaatcaa tcagcccatg atgcttggcg ctgaactgcc ttccttggac tagttaaaac
     2461 gcgtaaggat gaggataccg ttaaaaggtt tcaaaggagt catctcgttt gatagtgata
     2521 gttactcagg agctccagtg cgcagtctca gacagtggat acagtcttag agacgagatg
     2581 ctgaccgtcc tgctttgatt gtgccccagg gtctgcattg taactgctat cctggttttc
     2641 tgggctcaca ccacttccgt ttgatttgaa tgtcgagggt cactttatct gcagtgcgtt
     2701 ccagctttta tcagctacct gctagcagct tcagcacggt atgaagtcca gtctgttaaa
     2761 gtgccatcgc catctcttct gttcagattt tgacattcag gaaaatattc ttatttttat
     2821 gccatactga aatatacagt gtatatctga caaagcagtt aaatgtgaca ataaaaactt
     2881 atttaatcat gatac
//
