LOCUS       NM_172405               2499 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus BRCA1 A complex subunit (Abraxas1), mRNA.
ACCESSION   NM_172405
VERSION     NM_172405.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2499)
  AUTHORS   Tian X, Liu C, Wang X, Wang F, Wang L, Xu L, Ma J, Gao Y, Bao Y,
            Wang F, Sun L, Wei J, Lin C, Zhang H, Zhu G, Guan X, Fu S and Zhang
            C.
  TITLE     Sei-1 promotes double minute chromosomes formation through
            activation of the PI3K/Akt/BRCA1-Abraxas pathway and induces
            double-strand breaks in NIH-3T3 fibroblasts
  JOURNAL   Cell Death Dis 9 (3), 341 (2018)
   PUBMED   29497033
  REMARK    GeneRIF: Sei-1 promotes double minute chromosomes formation through
            activation of the PI3K/Akt/BRCA1-Abraxas pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2499)
  AUTHORS   Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J,
            Li L, You MJ, Zou L, Yao J and Wang B.
  TITLE     The BRCA1-interacting protein Abraxas is required for genomic
            stability and tumor suppression
  JOURNAL   Cell Rep 8 (3), 807-817 (2014)
   PUBMED   25066119
REFERENCE   3  (bases 1 to 2499)
  AUTHORS   Wang B.
  TITLE     BRCA1 tumor suppressor network: focusing on its tail
  JOURNAL   Cell Biosci 2 (1), 6 (2012)
   PUBMED   22369660
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2499)
  AUTHORS   Patterson-Fortin J, Shao G, Bretscher H, Messick TE and Greenberg
            RA.
  TITLE     Differential regulation of JAMM domain deubiquitinating enzyme
            activity within the RAP80 complex
  JOURNAL   J Biol Chem 285 (40), 30971-30981 (2010)
   PUBMED   20656689
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161510.10.
            
            [WARNING] On Jan 3, 2024 this sequence was replaced by NM_172405.4.
            
            On May 1, 2007 this sequence version replaced NM_172405.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051816.1, AK167540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC161510.10        24838-24942
            106-196             AC161510.10        27166-27256
            197-233             AC161510.10        27775-27811
            234-300             AC161510.10        30545-30611
            301-494             AC161510.10        33571-33764
            495-614             AC161510.10        35898-36017
            615-699             AC161510.10        36130-36214
            700-811             AC161510.10        38883-38994
            812-2499            AC161510.10        39284-40971
FEATURES             Location/Qualifiers
     source          1..2499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.52 cM"
     gene            1..2499
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /note="BRCA1 A complex subunit"
                     /db_xref="GeneID:70681"
                     /db_xref="MGI:MGI:1917931"
     exon            1..105
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1242
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /note="coiled-coil domain-containing protein 98; family
                     with sequence similarity 175, member A; coiled-coil domain
                     containing 98"
                     /codon_start=1
                     /product="BRCA1-A complex subunit Abraxas 1"
                     /protein_id="NP_765993.1"
                     /db_xref="CCDS:CCDS19469.1"
                     /db_xref="GeneID:70681"
                     /db_xref="MGI:MGI:1917931"
                     /translation="MEGESTLGVLSGFVLGALTFHHLNTDSDTEGFLLGEMKGEAKNS
                     ITDSQMDNVKVVYTIDIQKYIPCYRLFSFYNSLGEVNEHALKKVLSNVRKTVVGWYKF
                     RRHSDQIMTFREQLLHRNLQTHLSSPELVFLLLTPSITTESCSTHCLEHALYKPQRGL
                     FHRVPLVVTNLGMSDQLGYKTEPASCTSTVFSRAVRTHSSQFFNEDGSLKEVHKINEM
                     YAAVQEELKSICQKVEQSEREVEKLLMDVNQLKEVRRTQQARATGAGEKNVQRNPQEN
                     ILLCQALRTFFPESEVLHSCVISLKNRHISPSGCNVNHHVDVVDQLTLMVEYVYSPEA
                     SPVPTAQLRKRKALDTHDQGSVKRPRLLETESRPSVAASRSRHQDKASSSSLDIDIEM
                     GSPEDDADYPRSPTF"
     exon            106..196
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
     exon            197..233
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
     exon            234..300
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
     exon            301..494
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
     exon            495..614
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
     exon            615..699
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
     exon            700..811
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
     exon            812..2499
                     /gene="Abraxas1"
                     /gene_synonym="3830405G04Rik; 5630400M01Rik; Ccdc98;
                     Fam175a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcgaccgag gcggcagtat ggagggcgag agcacgttgg gggtgctgtc tggcttcgtg
       61 ctcggcgcgc tcactttcca tcatctcaac acagactcag acacggaagg ttttctcctc
      121 ggtgaaatga aaggtgaagc caagaatagc attactgatt cacagatgga caacgttaaa
      181 gttgtttata caattgacat tcagaaatat atcccatgct accggctttt tagcttttat
      241 aattctttag gtgaagtaaa cgaacatgca ctgaagaagg ttctttcaaa tgtcagaaag
      301 actgtggtgg gttggtataa attccgtcgt cactcggatc agatcatgac atttagagag
      361 cagttactcc acagaaactt acagacacat ctttcaagcc ctgagctggt tttcctgttg
      421 ttaacaccga gtataacaac agaaagctgc tccactcact gcctggaaca cgccttatat
      481 aaacctcaaa gggggctttt tcatagggta ccattggtgg ttaccaatct gggaatgtct
      541 gatcaactgg gttataaaac agaacctgct tcctgtacgt ccactgtctt tagtagagct
      601 gtgaggacac acagttctca gttctttaat gaagatggat cattaaagga agtccataag
      661 ataaatgaaa tgtatgctgc tgtacaagaa gagttaaaga gtatatgcca aaaagttgaa
      721 caaagtgaac gagaagtaga gaaactattg atggatgtaa accaattaaa agaagttaga
      781 agaacccagc aagcacgggc tacaggagca ggagagaaga atgtccagag aaacccacag
      841 gagaacatcc ttctttgtca agctttgcga acattttttc cagagtctga agttcttcat
      901 tcttgcgtta tttctttgaa aaatagacac atttctccca gtgggtgtaa cgttaaccac
      961 catgttgatg tagtggatca gctgacctta atggtagagt atgtgtacag ccctgaagct
     1021 agtccagtgc ccacagccca gctacgtaaa cggaaggctc tagacacaca cgaccagggg
     1081 tctgtgaaga gaccacggct gctggagaca gaaagcagac cttctgtggc agcgtcccgc
     1141 agcaggcacc aagacaaggc ttcctcaagc agcctagata tagacataga gatggggagc
     1201 ccagaagatg atgctgacta tcctcgctct cccacatttt aatttttttt agacgacatt
     1261 tcttactaga ctgaggtttc gggcacttgt tttattttta ctctttgcct tctggattaa
     1321 tacacagaaa agtttgtttt tactctattc acctgtttgt aatacatgga tatttttact
     1381 gttcaactgc ttataatata taggtaagtt aatattttat acagtatctt aattcttact
     1441 tatatctcac attgtaaatg ctttgtaaat gtgtacatat gtagatgcat agctataaat
     1501 acatatataa gcttgtggtt tgggaactgt gaatggtagg caacttctct accactgagc
     1561 tccagtccaa aggtgtttgg ttttggtttt gtttgtttgt ttgtttgttt gtttgtttgt
     1621 ttgtttgttt gtttgttttg tgggttgagg ggtgcattgg gatagggtct ctctgtgtag
     1681 ctctgggtgt tctaaatctc acaaatatcc acctccctct gcctcctgtg ctgagattaa
     1741 aggtgtgtgc caataagatg attttatttc aaagccacaa acctttccgc tcctcccacc
     1801 cccaaattgt cgagggaaag acttaaatag atacattctt ttcaactaga atattcttca
     1861 agttgggaaa agagaaacta gccttttttc acaacctgga aagaagcaca gatgttcgta
     1921 agcccaggcg ggcctcagac ttggttcagc tggcacgggt atctcctatc aagactgatg
     1981 acctgagttg gatttttgaa actcccacag tgaaggaaag aaccaactct cacaaccttt
     2041 cctgacttca tatattgacc atggcatata catgaaaccc ccataaataa atgtagtgaa
     2101 aaatgtaaag tttgtaatat cttattttta tagattttaa gatttaagtt tttaagattc
     2161 ttactgaaga gagaacccag cagtgcttga ggcccttcct gaggactgta actccagctc
     2221 tggggatcca gtgtcctctc gtgccctcca gagcatgcac acatgtgcac actcacacat
     2281 acatacatgt gcataaagca cacagagttt tgttctgttt aaacctgggc ttagtggtgc
     2341 tcacatggag cccagcactg tcaatgcaga ggtaggaggc tgcccgggac ttgttaatca
     2401 tctggtctag cctaagtgaa ctttataatc ggtagagaca cattacggaa gacacctgat
     2461 atcaatctct ggccttcata aactcctgtg cacacgtac
//
