LOCUS       NM_175456               1762 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus actin-binding Rho activating protein (Abra), mRNA.
ACCESSION   NM_175456
VERSION     NM_175456.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1762)
  AUTHORS   Sadler,K.J., Gatta,P.A.D., Naim,T., Wallace,M.A., Lee,A., Zaw,T.,
            Lindsay,A., Chung,R.S., Bello,L., Pegoraro,E., Lamon,S., Lynch,G.S.
            and Russell,A.P.
  TITLE     Striated muscle activator of Rho signalling (STARS) overexpression
            in the mdx mouse enhances muscle functional capacity and regulates
            the actin cytoskeleton and oxidative phosphorylation pathways
  JOURNAL   Exp Physiol 106 (7), 1597-1611 (2021)
   PUBMED   33963617
  REMARK    GeneRIF: Striated muscle activator of Rho signalling (STARS)
            overexpression in the mdx mouse enhances muscle functional capacity
            and regulates the actin cytoskeleton and oxidative phosphorylation
            pathways.
REFERENCE   2  (bases 1 to 1762)
  AUTHORS   Xia,M., Luo,W., Jin,H. and Yang,Z.
  TITLE     HAND2-mediated epithelial maintenance and integrity in cardiac
            outflow tract morphogenesis
  JOURNAL   Development 146 (13) (2019)
   PUBMED   31201155
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1762)
  AUTHORS   Filipova,D., Henry,M., Rotshteyn,T., Brunn,A., Carstov,M.,
            Deckert,M., Hescheler,J., Sachinidis,A., Pfitzer,G. and
            Papadopoulos,S.
  TITLE     Distinct transcriptomic changes in E14.5 mouse skeletal muscle
            lacking RYR1 or Cav1.1 converge at E18.5
  JOURNAL   PLoS One 13 (3), e0194428 (2018)
   PUBMED   29543863
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1762)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1762)
  AUTHORS   Wallace,M.A. and Russell,A.P.
  TITLE     Striated muscle activator of Rho signaling is required for myotube
            survival but does not influence basal protein synthesis or
            degradation
  JOURNAL   Am J Physiol Cell Physiol 305 (4), C414-C426 (2013)
   PUBMED   23720020
  REMARK    GeneRIF: STARS expression signaling is necessary for skeletal
            myotube survival but does not influence protein synthesis or
            degradation.
REFERENCE   6  (bases 1 to 1762)
  AUTHORS   Troidl,K., Ruding,I., Cai,W.J., Mucke,Y., Grossekettler,L.,
            Piotrowska,I., Apfelbeck,H., Schierling,W., Volger,O.L.,
            Horrevoets,A.J., Grote,K., Schmitz-Rixen,T., Schaper,W. and
            Troidl,C.
  TITLE     Actin-binding rho activating protein (Abra) is essential for fluid
            shear stress-induced arteriogenesis
  JOURNAL   Arterioscler Thromb Vasc Biol 29 (12), 2093-2101 (2009)
   PUBMED   19778941
  REMARK    Erratum:[Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):e181]
REFERENCE   7  (bases 1 to 1762)
  AUTHORS   Kuwahara,K., Teg Pipes,G.C., McAnally,J., Richardson,J.A.,
            Hill,J.A., Bassel-Duby,R. and Olson,E.N.
  TITLE     Modulation of adverse cardiac remodeling by STARS, a mediator of
            MEF2 signaling and SRF activity
  JOURNAL   J Clin Invest 117 (5), 1324-1334 (2007)
   PUBMED   17415416
  REMARK    GeneRIF: Modulates the responsiveness of the heart to stress
            signaling by functioning as a cytoskeletal intermediary between
            myocyte enhancer factor-2 and serum response factor.
REFERENCE   8  (bases 1 to 1762)
  AUTHORS   Barrientos,T., Frank,D., Kuwahara,K., Bezprozvannaya,S.,
            Pipes,G.C., Bassel-Duby,R., Richardson,J.A., Katus,H.A., Olson,E.N.
            and Frey,N.
  TITLE     Two novel members of the ABLIM protein family, ABLIM-2 and -3,
            associate with STARS and directly bind F-actin
  JOURNAL   J Biol Chem 282 (11), 8393-8403 (2007)
   PUBMED   17194709
  REMARK    GeneRIF: ABLIM-2 and -3 associate with STARS and directly bind
            F-actin
REFERENCE   9  (bases 1 to 1762)
  AUTHORS   Kuwahara,K., Barrientos,T., Pipes,G.C., Li,S. and Olson,E.N.
  TITLE     Muscle-specific signaling mechanism that links actin dynamics to
            serum response factor
  JOURNAL   Mol Cell Biol 25 (8), 3173-3181 (2005)
   PUBMED   15798203
REFERENCE   10 (bases 1 to 1762)
  AUTHORS   Arai,A., Spencer,J.A. and Olson,E.N.
  TITLE     STARS, a striated muscle activator of Rho signaling and serum
            response factor-dependent transcription
  JOURNAL   J Biol Chem 277 (27), 24453-24459 (2002)
   PUBMED   11983702
  REMARK    GeneRIF: a novel striated muscle activator of Rho signaling and
            serum response factor-dependent transcription (striated muscle
            activator of Rho signaling; STARS)
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC129212.4.
            
            On May 2, 2007 this sequence version replaced NM_175456.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081696.1, AK045186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-702               AC129212.4         11906-12607
            703-1762            AC129212.4         15274-16333
FEATURES             Location/Qualifiers
     source          1..1762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 16.42 cM"
     gene            1..1762
                     /gene="Abra"
                     /gene_synonym="C130068O12Rik; STARS"
                     /note="actin-binding Rho activating protein"
                     /db_xref="GeneID:223513"
                     /db_xref="MGI:MGI:2444891"
     exon            1..702
                     /gene="Abra"
                     /gene_synonym="C130068O12Rik; STARS"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1180
                     /gene="Abra"
                     /gene_synonym="C130068O12Rik; STARS"
                     /note="striated muscle activator of Rho-dependent
                     signaling"
                     /codon_start=1
                     /product="actin-binding Rho-activating protein"
                     /protein_id="NP_780665.1"
                     /db_xref="CCDS:CCDS27449.1"
                     /db_xref="GeneID:223513"
                     /db_xref="MGI:MGI:2444891"
                     /translation="MAPGEREREAGPAKSALRKVRTATLVINLARGWQQWANENSTKQ
                     AQEPAGWLPGATHDLPNAPKEAGPYQHAPKTLSPKPDRDGEGQHSEEATEVSHIKRKE
                     VTRTVVSKAYERGGDVNYLSHRYENDGGVSEAIQPENDIDRILLSHDSPTRRRKCTNL
                     VSELTKGWKVMEQEEPTWKSDSVDTEDSGYGGDMEERPEQDAAPVAPARIKRPLLSQA
                     NRYSETLNCKAHRKYSQVDNLKGRWQQWADEHVQSQKLNPFSDEFDYDLAMSTRLHKG
                     DEGYGRPKEGSKTAERAKRAEEHIYREIMELCFVIRTMARHRRDGKIQVTFGELFDRY
                     VRISDKVVGILMRARKHGLVHFEGEMLWQGRDDHVVITLLE"
     exon            703..1762
                     /gene="Abra"
                     /gene_synonym="C130068O12Rik; STARS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1262..1267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abra"
                     /gene_synonym="C130068O12Rik; STARS"
                     /note="hexamer: ATTAAA"
     polyA_site      1281
                     /gene="Abra"
                     /gene_synonym="C130068O12Rik; STARS"
                     /note="major polyA site"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abra"
                     /gene_synonym="C130068O12Rik; STARS"
                     /note="hexamer: AATAAA"
     polyA_site      1575
                     /gene="Abra"
                     /gene_synonym="C130068O12Rik; STARS"
ORIGIN      
        1 acattcccct ttagctggtg cccaggctgt cagcagagaa gaaacaggta gcatggctcc
       61 aggagaaagg gaaagggagg cggggccggc caagagtgcc ctccggaagg tccgcacagc
      121 aaccctggtt atcaatttgg cccgaggttg gcagcagtgg gcgaatgaga acagtaccaa
      181 acaggcccag gagcctgcag gctggctgcc gggagcaact catgacctac ctaacgctcc
      241 taaagaagcc ggtccttacc agcatgcccc caaaactctg tctccaaagc cagatcgaga
      301 cggagaggga caacactcag aagaagccac cgaggtctcc cacattaaaa ggaaagaggt
      361 gaccagaacg gttgtcagca aggcttatga gaggggagga gatgtgaact acctgagcca
      421 caggtatgag aatgatggcg gcgtgtctga agctattcag ccagagaatg acattgacag
      481 aatccttctt agtcacgact cgccaacacg gagaagaaaa tgcaccaacc tggtgtctga
      541 gctgaccaaa ggctggaaag tgatggaaca ggaagagccc acgtggaaga gtgacagcgt
      601 agacacagag gacagtggct acggagggga tatggaggag aggcctgagc aagatgcagc
      661 gcctgtggct cctgccagga tcaaacgccc cttgctctcc caggcaaaca ggtactctga
      721 gacactcaac tgtaaggccc atcggaaata cagccaagtg gacaacttga aagggaggtg
      781 gcagcagtgg gccgatgaac acgtccagtc ccagaagctc aatcccttca gtgacgaatt
      841 tgactatgat ctagccatgt ccactcggct ccacaaggga gacgagggct atggccgccc
      901 caaagaggga agcaagacag ctgaaagggc caagcgagcg gaagagcaca tctatcggga
      961 aattatggaa ctgtgctttg ttatccgcac aatggctcgc cacagacgag atggcaagat
     1021 ccaggttact ttcggagaac tctttgatcg ctatgttcga atttctgata aagtcgtggg
     1081 catcctcatg cgtgccagga aacacggact ggtgcacttt gaaggagaga tgctatggca
     1141 aggccgagac gaccatgttg tgattactct ccttgagtaa gcccgcaaca aatccactca
     1201 ccgctgataa atagtaatgt gttacaagct ccaaggcaag ctgctctgca atgttatcaa
     1261 tattaaatga ttttatataa atggcttttg gtactgtttc tatgaggtta ctatgtgaag
     1321 attttgacga agacactcga ctttttggaa gaatgtatta agactatcaa acatagtata
     1381 ttgatatttg gaattccact taccttttta agcaaaaatt tctggccttc attgataaaa
     1441 ttattataaa ttgaaaagta cacattacag gtaagaaaac tgaccttaga taaagtagga
     1501 caacatcgca atgtaatatt ttaggggaaa aaattccatt aagctgaata aaattggaag
     1561 tttggcctaa aaaaatcctc accagctcag aatggcctcc aactctattt aacgaaggat
     1621 gacttcaaac cgttatgtca gctcatcctc tgtagtgctg ggacagcagg cttacatgca
     1681 atcatttcca ctttgttaaa gtggtagggc tcatgcctgc ccaggaagta ctctatttct
     1741 gagaatattc tccactcttt tg
//
