LOCUS       NM_198018               5163 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus active BCR-related gene (Abr), transcript variant 1,
            mRNA.
ACCESSION   NM_198018
VERSION     NM_198018.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5163)
  AUTHORS   Farhana,F., Sakai,E., Koyanagi,Y., Yamaguchi,Y., Alam,M.I.,
            Okamoto,K. and Tsukuba,T.
  TITLE     Abr, a Rho-regulating protein, modulates osteoclastogenesis by
            enhancing lamellipodia formation by interacting with
            poly(ADP-ribose) glycohydrolase
  JOURNAL   Mol Biol Rep 50 (9), 7557-7569 (2023)
   PUBMED   37507586
  REMARK    GeneRIF: Abr, a Rho-regulating protein, modulates
            osteoclastogenesis by enhancing lamellipodia formation by
            interacting with poly(ADP-ribose) glycohydrolase.
REFERENCE   2  (bases 1 to 5163)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5163)
  AUTHORS   Um,K., Niu,S., Duman,J.G., Cheng,J.X., Tu,Y.K., Schwechter,B.,
            Liu,F., Hiles,L., Narayanan,A.S., Ash,R.T., Mulherkar,S.,
            Alpadi,K., Smirnakis,S.M. and Tolias,K.F.
  TITLE     Dynamic control of excitatory synapse development by a Rac1 GEF/GAP
            regulatory complex
  JOURNAL   Dev Cell 29 (6), 701-715 (2014)
   PUBMED   24960694
  REMARK    GeneRIF: Loss of abr expression causes defects in spine
            development.
REFERENCE   4  (bases 1 to 5163)
  AUTHORS   Gong,D., Fei,F., Lim,M., Yu,M., Groffen,J. and Heisterkamp,N.
  TITLE     Abr, a negative regulator of Rac, attenuates cockroach
            allergen-induced asthma in a mouse model
  JOURNAL   J Immunol 191 (9), 4514-4520 (2013)
   PUBMED   24058174
  REMARK    GeneRIF: These results identify Abr-regulated CD4(+) T cell
            migration as an important component of severe cockroach
            allergen-evoked allergic asthma in mice.
REFERENCE   5  (bases 1 to 5163)
  AUTHORS   Dillman,A.A., Hauser,D.N., Gibbs,J.R., Nalls,M.A., McCoy,M.K.,
            Rudenko,I.N., Galter,D. and Cookson,M.R.
  TITLE     mRNA expression, splicing and editing in the embryonic and adult
            mouse cerebral cortex
  JOURNAL   Nat Neurosci 16 (4), 499-506 (2013)
   PUBMED   23416452
REFERENCE   6  (bases 1 to 5163)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   7  (bases 1 to 5163)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 5163)
  AUTHORS   Kaartinen,V., Nagy,A., Gonzalez-Gomez,I., Groffen,J. and
            Heisterkamp,N.
  TITLE     Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs
  JOURNAL   Dev Dyn 223 (4), 517-525 (2002)
   PUBMED   11921339
  REMARK    GeneRIF: Abr and Bcr play important complementary roles during
            vestibular morphogenesis
REFERENCE   9  (bases 1 to 5163)
  AUTHORS   Kaartinen,V., Gonzalez-Gomez,I., Voncken,J.W., Haataja,L.,
            Faure,E., Nagy,A., Groffen,J. and Heisterkamp,N.
  TITLE     Abnormal function of astroglia lacking Abr and Bcr RacGAPs
  JOURNAL   Development 128 (21), 4217-4227 (2001)
   PUBMED   11684658
REFERENCE   10 (bases 1 to 5163)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591143.11 and AL663050.11.
            
            On Nov 17, 2022 this sequence version replaced NM_198018.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058708.1, SRR1660817.7722.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-459               AL591143.11        64730-65188         c
            460-558             AL591143.11        42280-42378         c
            559-744             AL591143.11        34837-35022         c
            745-852             AL591143.11        28331-28438         c
            853-913             AL591143.11        24558-24618         c
            914-966             AL591143.11        20080-20132         c
            967-1107            AL591143.11        19370-19510         c
            1108-1229           AL591143.11        17135-17256         c
            1230-1395           AL591143.11        15023-15188         c
            1396-1518           AL591143.11        12442-12564         c
            1519-1594           AL591143.11        12003-12078         c
            1595-1699           AL591143.11        11451-11555         c
            1700-1774           AL591143.11        10358-10432         c
            1775-1872           AL591143.11        8173-8270           c
            1873-2004           AL591143.11        7695-7826           c
            2005-2064           AL663050.11        101728-101787       c
            2065-2174           AL663050.11        101375-101484       c
            2175-2314           AL663050.11        100495-100634       c
            2315-2449           AL663050.11        99509-99643         c
            2450-2555           AL663050.11        98614-98719         c
            2556-2703           AL663050.11        96196-96343         c
            2704-5163           AL663050.11        93195-95654         c
FEATURES             Location/Qualifiers
     source          1..5163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..5163
                     /gene="Abr"
                     /note="active BCR-related gene"
                     /db_xref="GeneID:109934"
                     /db_xref="MGI:MGI:107771"
     exon            1..459
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            460..558
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            559..744
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            745..852
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            853..913
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            914..966
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1107
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1229
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1395
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1518
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1594
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1699
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1774
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1872
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..2004
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2064
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2174
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2314
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2449
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2555
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2703
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     exon            2704..5163
                     /gene="Abr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5123..5128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Abr"
                     /note="hexamer: AATAAA"
     polyA_site      5163
                     /gene="Abr"
                     /note="major polyA site"
ORIGIN      
        1 acatacgcag ctgacatgct attaggcggg tggagacagc agaaccgctc ctccccgact
       61 cccagcagcc tctgacggac tcagcagagc ctgtgcctgc tggagctccc acccccctcc
      121 ccaagcctgg ctgtacagcc cctgccctgg cccagggtgc atggtgcagc aggggccatg
      181 gcagccgggg gccgccgccg gcgcccactg cgctaccagt ccctggcagc cctggtggaa
      241 gactctcagt ggcctttctt gttccttgtc tcagacttca gctacggtgc ggaggactac
      301 gacgcagagg ggcatgagga gcagaagggg ccccccgagg gctcggagac catgccgtac
      361 atcgacgagt cacccaccat gtcgccccag ctcagcgccc gcagccaagg tggtggggac
      421 agcgtctcgc ccaccccacc tgagggattg gcacctgggg tggaggcagg gaagggtctg
      481 gagatgagga agctagtcct ctctgggttt ctggccagtg aagagatcta cattaaccag
      541 ctggaagctc tgttactgcc catgaaaccc ctgaaggcca cagccaccac ctcccagcct
      601 gtgctcacca tccaacagat tgagaccatc ttctacaaga tccaggacat ctacgagatc
      661 cacaaggagt tctacgacaa cctctgcccc aaggtgcagc agtgggacag ccaggtcacc
      721 atgggccatc ttttccagaa actggccagc cagcttggcg tgtacaaagc atttgtggat
      781 aactataaag tcgctctgga gacagccgag aagtgcagcc agtccaacaa ccagttccag
      841 aagatctctg aggaactcaa agtgaaaggg cccaaggact ctaaggacag ccatacatca
      901 gtcaccatgg aagctctgct gtacaagcca attgaccgag tcacccggag caccctggtc
      961 cttcacgatc tgttgaagca cacacccgtg gaccacccgg actacccgct gcttcaggat
     1021 gctctccgca tctcccagaa tttcctgtct agcattaacg aggacattga tcctcgccgg
     1081 actgcagtca caacccccaa gggagagact cggcagctgg tgaaggacgg cttcctggtg
     1141 gaaatgtctg agagctcccg gaagctgcgg catgtctttc tcttcacaga tgttctgctg
     1201 tgtgccaagc taaagaagac ctcagcagga aagcatcagc agtatgactg taagtggtac
     1261 atccctctgg ctgacttagt gttcccatcc cctgaggagt cagaggccag tccccaggtg
     1321 caccccttcc cagaccacga gctcgaggac atgaaaacga agatctctgc cctcaagagt
     1381 gagatccaga aggagaaagc caacaaagga cagagccgag ccattgagcg cctcaaaaag
     1441 aagatgtttg agaatgagtt cttactgctg ctcaattccc caacgatccc tttccggata
     1501 cacaatcgga atggaaagag ttacctgttt cttctgtctt ctgactatga gaggtcggag
     1561 tggagagaag cgattcagaa gctacagaag aaggatctcc aggcctttgt cctgagctct
     1621 gtggagctcc aggtgctcac gggatcctgt ttcaagctta ggactgtgca caacattcct
     1681 gtcaccagca ataaagatga tgatgagtct ccaggactgt acggcttcct tcatgtcatc
     1741 gtccactctg ccaagggctt taaacagtca gccaatcttt actgtactct ggaggtggat
     1801 tcctttggct attttgtcag caaagccaag accagggtgt ttcgggacac gacagagccc
     1861 aagtgggatg aggagtttga gattgagctg gagggttcac agtccctgag gatcctgtgt
     1921 tatgagaagt gctacgacaa gaccaaggtc aacaaagaca acaatgagat tgtggacaag
     1981 atcatgggca aggggcagat ccagctggat ccacagacag tagaaagcaa gaactggcat
     2041 acggacgtga ttgaaatgaa tgggatcaaa gtggaattct ccatgaaatt taccagccgt
     2101 gacatgagcc tgaagaggac cccatccaaa aagcagacag gcgtctttgg agtgaagatc
     2161 agcgtggtga ccaagcggga gcgctccaag gtgccctaca tcgtccggca atgcatagaa
     2221 gaggtggaga agaggggcat tgaggaggtt ggcatctaca ggatatcagg ggtggccacg
     2281 gacatccagg ccctgaaggc tgtctttgat gccaataaca aggacatcct actgatgctg
     2341 agcgacatgg acatcaacgc catcgctggg accctcaagc tatactttcg ggagctgcct
     2401 gagcccctcc ttacagatag actttatcca gccttcatgg agggcattgc cctgtcagac
     2461 cctgctgcca aggagaactg catgatgcac ctactccgct ccctgcctga ccccaacctc
     2521 atcaccttcc ttttcctgct ggaacacttg aaaagggttg ctgagaagga gcccatcaac
     2581 aagatgtcac ttcacaacct tgccacggtg tttggcccca cgttactgag accatcagaa
     2641 gtggagagca aagcacatct cacatcagct gcagacatct ggtcccatga tgtcatggcc
     2701 caggtccagg tcctcctcta ctacctgcag catcccccca tttccttcgc agaactgaag
     2761 cggaacacac tgtacttctc cacagacgtg tagcctgggg tgggcagctg tgggggcggc
     2821 caggggccag ccctccagcc gggccccgac atagacttga aagactgcaa cagaaactcc
     2881 ccagcctagc actccagagt ccaagggaag ccaccttcca agaactggaa catgtgcatc
     2941 ttttgtgcca ccttgtacaa agccagctga ccagcccccg cctcctcacc acaccccagc
     3001 tcctatcttc tgtacccgag tgtgtctgat gctccgtgct gtccaggaat tgttttatgt
     3061 attattgtca ttgcagaaaa ggtagtggcc gagctggtat gggcacagac agattgcttt
     3121 gttctttcat ttctcccagc actcactttc tgcctgagtc cggtccaagg acttttactt
     3181 tgcgcttcgt aactactgcc agcttctcct ctcctggccc tgctcccaga ttgcagcctc
     3241 cctgcagtgt ctgcccttgc cacctcccag cctgctgcat gcatgtgcag catgggcttt
     3301 tgctccatca ccgcaaagtt ctgcaggggc cctgggcagt gctggcctgt ctgacgtgct
     3361 gcccttggcc tccttgctct ccacgtgtgg aagcgcatct gctttccttg ctgtctgtgc
     3421 aaatgctgaa caaggagaca gacacacact aatcctcagc acagagctgg aaagctcatt
     3481 tctggaatgt tctatttgag aattgccatt tctggggttt gtctgttcta tctcctgcct
     3541 accagtcggt atcttcagct gtttcttcta ttgctggatt ttctgttcct tttccccagt
     3601 gttctgtttt ctttgagtgt aatgacccac aagtgtcctg ccattaagag aggtcaggat
     3661 tgcacctgaa gggtatggtg ggcacccagg ctgtgaagga acaagatgag tggagcggcc
     3721 agcagtggca agtcaaggga agccagtctt cagtgtaagg acccgcagtg gctatcctag
     3781 tgtacattct cctggagagc agcttctgtg gctgaatcag gtgtccaggt gaagacaggc
     3841 cctgtcctgg aacctggaat cacacatacc tcgtggtact tttgccttag attttacact
     3901 ctcaacagcc aagcactgcc acggggcagc cacaatgcca tgcgtgctcc agagcctagg
     3961 aacagcagac agaacccagt tggaatgctt ctaccctggc ttctaaattc aggcctgtgg
     4021 gtaatcccaa gtatacagga aattgtgggg taggctgtct ctcgtgaatt gagttctgct
     4081 ggggctatag agcatcgggt cggcagctgt cattcccagc tctgtgacct actgcttggt
     4141 actaaaaagg agttttcttc caaaagcact gtttccagtc tgagtaggag ctaccagcct
     4201 gtggcaatca gcagggaaag acaggtgctc ctgtcatagg ggcttgagct accacagcta
     4261 ccacacagct ttctggatct tctatatggc agttcattct tggccctcag gattggggag
     4321 accagctctc attgtgtgtg ctcagggcta agtctaaaca agggtttgct ggcccccaag
     4381 ctgttgtttg ttaggtgagg ttaagtaggg ctcttctggt cctgtgcata cctattgcct
     4441 ttgacagaac ggtacagttt gtttatgcag gaggatggca tgccaacttc ccagctgcct
     4501 actagcagtt taacaaggag ccttgctgtc tcagacaggt gaaagaaaat gtcatgcatg
     4561 taaagatcac atctgccact accttggcac tcaggtgctg gtatgtgcat tcttgcttcc
     4621 aaaggattga cagtaacaaa ttctcaaagc ttgactggag ctggctgcag ctcaaaacag
     4681 tgcctcctgc ctctttagag cggggctgct cggcagcagt gactgcagcc ccagcttgct
     4741 taagcagtgt aacagcaggg aagcgggagg agctgagaac tattagaagt tcctattatt
     4801 tataaattcc acccaaagtg gacagagtca ggtgccagac ctgatctgaa gtgcaccaag
     4861 gaagtatctg gtggttctcc tgagatgggg gccttgcagc ccagcacccc ctcactgcca
     4921 gcagggcacc aggagacagg gtccaggaat ccaggtatgc ctgtacttgc ttgagcaacg
     4981 actgagggct gccagctttt gctgacaagg taggatggga cccccaataa gtgggtatgg
     5041 atatattttt ttttgtctct gttctgttta aacttatgta gattattata aattgatgta
     5101 aaccatgtga gagggaaatg ttaataaaaa aattgcaaag cctcaacatt tgcacaaaac
     5161 tca
//
